Chris Lau, PhD
Professor
Medicine
School of Medicine
Education & Training
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- PH.D. GENETICS MD ANDERSON CANCER CENTER-UTHEALTH 06/1979
- M.S. CELL BIOLOGY MD ANDERSON CANCER CENTER-UTHEALTH 06/1976
- B.A. CHEMISTRY HARPUR COLLEGE-SUNY 06/1973
Interests
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- Liver Cancer
- Prostate Cancer
- Molecular Genetics
- Sex Determination
- Genomics
- Transgenic Mouse Models
- Sexual Dimorphism
- Y chromosome Genes
- Cardiovascular Disease
- Germ Cell Tumors
Websites
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- Lau Lab (laulab.ucsf.edu)
- Profile at UCSF Cancer Center (cancer.ucsf.edu)
- Cell & Bioscience Journal (cellandbioscience.biomedcentral.com)
Grants and Projects
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- Research Career Scientist Award, Department of Veterans Affairs, 2019-2024
- Molecular Mechanisms of a Male-Specific Positive Feedback Loop in Liver Cancer, Department of Veterans Affairs, 2019-2024
- Single-Cell Next-Generation Sequencing Library Preparation System, Department of Veterans Affairs, 2019-2020
- Research Career Scientist Award, VA, 1994-2019
- The Genetic Basis of Sex Differences in Liver Cancer, Department of Defense, 2016-2019
- Role of genetic biomarkers in clinical assessment of prostate cancer, NIH, 2012-2016
- Role of the Y-Located TSPY Gene in Human Oncogenesis, NIH, 2010-2014
- Sex Chromosomes and Gender Disparity in HBV-Related Hepatocellular Carcinoma, NIH, 2010-2014
- Sex Chromosomes and Gender Disparity in HBV-Related Heaptocellular Carcinoma, NIH, 2010-2013
- The Role of the Y-Located TSPY Gene in Prostatic Oncogenesis, VA, 2006-2010
- Y Chromosome Regulation of Autism Susceptibility Genes, Department of Defense Autism Research Program, 2008-2010
- Functions of Sry and Sry Interactive Protein Genes, NIH, 2000-2007
- Mitochondrial Structure and Reactive Oxygen Species in Mammary Oncogneesis, Department of Defense Breast Cancer Research Program, 2003-2006
- The Role of the Y-Located TSPY Gene in Prostatic Oncogenesis, Department of Defense Prostate Cancer Research Program, 2003-2006
- Roles of the Y Chromosome Genes in Prostate Cancer, Department of Defense Prostate Cancer Research Program, 2000-2004
- Molecular Genetics of Male Hypertension, VA, 1998-2001
- Functions of the Testis Determining Genes, NIH, 1990-1999
- International Workshop on Human Y Chromosome, NIH, 1997-1998
- Molecular Biology of Myocardial Ischemia, VA, 1994-1997
- International Workshops on Human Y Chromosome, NIH, 1994-1996
- U.S.-Argentina Cooperative Science Program: Characterizationof Genes Involved in Sex Determination and Sex Reversal in Akodon (Cricetidae) Rodents, NSF, 1992-1995
- Functions of Zinc Finger Genes on Sex Chromosomes, NIH, 1990-1994
- Molecular Biology of the Male Enhanced Antigen Genes, NIH, 1988-1994
Publications (122)
Top publication keywords:
Chromosomes, Human, YDNA-Binding ProteinsSex-Determining Region Y ProteinDisorders of Sex DevelopmentTestisCarcinogenesisGenesGonadoblastomaCell Cycle ProteinsNeoplasms, Germ Cell and EmbryonalTesticular NeoplasmsGonadsNuclear ProteinsSex Determination ProcessesY Chromosome
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Sex chromosome DSD individuals with mosaic 45,X0 and aberrant Y chromosomes in 46,XY cells: distinct gender phenotypes and germ cell tumour risks§.
Systems biology in reproductive medicine 2022 Vogt PH, Besikoglu B, Bettendorf M, Frank-Herrmann P, Zimmer J, Bender U, Knauer-Fischer S, Choukair D, Sinn P, Doerr HG, Woelfle J, Heidemann PH, Lau YC, Strowitzki T -
The 2020 Ming K. Jeang awards for excellence in Cell & Bioscience.
Cell & bioscience 2021 Lau YC -
Y chromosome in health and diseases.
Cell & bioscience 2020 Lau YC -
Potential dual functional roles of the Y-linked RBMY in hepatocarcinogenesis.
Cancer science 2020 Kido T, Tabatabai ZL, Chen X, Lau YC -
Battle of the sexes: contrasting roles of testis-specific protein Y-encoded (TSPY) and TSPX in human oncogenesis.
Asian journal of andrology 2019 Lau YC, Li Y, Kido T
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Gonadoblastoma Y locus genes expressed in germ cells of individuals with dysgenetic gonads and a Y chromosome in their karyotypes include DDX3Y and TSPY.
Human reproduction (Oxford, England) 2019 Vogt PH, Besikoglu B, Bettendorf M, Frank-Herrmann P, Zimmer J, Bender U, Knauer-Fischer S, Choukair D, Sinn P, Lau YC, Heidemann PH, Strowitzki T -
The Y-linked proto-oncogene TSPY contributes to poor prognosis of the male hepatocellular carcinoma patients by promoting the pro-oncogenic and suppressing the anti-oncogenic gene expression.
Cell & bioscience 2019 Kido T, Lau YC -
The X-linked tumor suppressor TSPX downregulates cancer-drivers/oncogenes in prostate cancer in a C-terminal acidic domain dependent manner.
Oncotarget 2019 Kido T, Li Y, Tanaka Y, Dahiya R, Chris Lau YF -
Aberrant activation of the human sex-determining gene in early embryonic development results in postnatal growth retardation and lethality in mice.
Scientific reports 2017 Kido T, Sun Z, Lau YC -
The Y-located proto-oncogene TSPY exacerbates and its X-homologue TSPX inhibits transactivation functions of androgen receptor and its constitutively active variants.
Human molecular genetics 2017 Li Y, Zhang DJ, Qiu Y, Kido T, Lau YC -
Identification of a TSPY co-expression network associated with DNA hypomethylation and tumor gene expression in somatic cancers.
Journal of genetics and genomics = Yi chuan xue bao 2016 Kido T, Lau YC -
Functional role of DNA mismatch repair gene PMS2 in prostate cancer cells.
Oncotarget 2015 Fukuhara S, Chang I, Mitsui Y, Chiyomaru T, Yamamura S, Majid S, Saini S, Deng G, Gill A, Wong DK, Shiina H, Nonomura N, Lau YF, Dahiya R, Tanaka Y -
Roles of the Y chromosome genes in human cancers.
Asian journal of andrology 2015 Kido T, Lau YF -
SRY interference of normal regulation of the RET gene suggests a potential role of the Y-chromosome gene in sexual dimorphism in Hirschsprung disease.
Human molecular genetics 2014 Li Y, Kido T, Garcia-Barcelo MM, Tam PK, Tabatabai ZL, Lau YF -
The sex-determining factors SRY and SOX9 regulate similar target genes and promote testis cord formation during testicular differentiation.
Cell reports 2014 Li Y, Zheng M, Lau YF -
The potential contributions of a Y-located protooncogene and its X homologue in sexual dimorphisms in hepatocellular carcinoma.
Human pathology 2014 Kido T, Lo RC, Li Y, Lee J, Tabatabai ZL, Ng IO, Lau YF -
The Y-located gonadoblastoma gene TSPY amplifies its own expression through a positive feedback loop in prostate cancer cells.
Biochemical and biophysical research communications 2014 Kido T, Lau YF -
Expression of a Y-located human proto-oncogene TSPY in a transgenic mouse model of prostate cancer.
Cell & bioscience 2014 Kido T, Schubert S, Hatakeyama S, Ohyama C, Schmidtke J, Lau YF -
Application of the simple and efficient Mpeak modeling in binding peak identification in ChIP-chip studies.
Methods in molecular biology (Clifton, N.J.) 2013 Zheng M, Li Y, Lau YF -
Isolation of fetal gonads from embryos of timed-pregnant mice for morphological and molecular studies.
Methods in molecular biology (Clifton, N.J.) 2012 Li Y, Taketo T, Lau YF -
The X-linked tumor suppressor TSPX interacts and promotes degradation of the hepatitis B viral protein HBx via the proteasome pathway.
PloS one 2011 Kido T, Ou JH, Lau YF -
Expression of the human TSPY gene in the brains of transgenic mice suggests a potential role of this Y chromosome gene in neural functions.
Journal of genetics and genomics = Yi chuan xue bao 2011 Kido T, Schubert S, Schmidtke J, Chris Lau YF -
Role of the Y-located putative gonadoblastoma gene in human spermatogenesis.
Systems biology in reproductive medicine 2011 Lau YF, Li Y, Kido T -
Expression of the Y-Encoded TSPY is Associated with Progression of Prostate Cancer.
Genes 2010 Kido T, Hatakeyama S, Ohyama C, Lau YF -
GonadSAGE: a comprehensive SAGE database for transcript discovery on male embryonic gonad development.
Bioinformatics (Oxford, England) 2009 Lee TL, Li Y, Cheung HH, Claus J, Singh S, Sastry C, Rennert OM, Lau YF, Chan WY -
Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery.
The Journal of biological chemistry 2009 Peng H, Ivanov AV, Oh HJ, Lau YF, Rauscher FJ -
Regulation of monoamine oxidase A by the SRY gene on the Y chromosome.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Wu JB, Chen K, Li Y, Lau YF, Shih JC -
Developmental staging of male murine embryonic gonad by SAGE analysis.
Journal of genetics and genomics = Yi chuan xue bao 2009 Lee TL, Li Y, Alba D, Vong QP, Wu SM, Baxendale V, Rennert OM, Lau YF, Chan WY -
The human and mouse sex-determining SRY genes repress the Rspol/beta-catenin signaling.
Journal of genetics and genomics = Yi chuan xue bao 2009 Lau YF, Li Y -
Gonadoblastoma locus and the TSPY gene on the human Y chromosome.
Birth defects research. Part C, Embryo today : reviews 2009 Lau YF, Li Y, Kido T -
Fast predictions of thermodynamics and kinetics of protein-protein recognition from structures: from molecular design to systems biology.
Molecular bioSystems 2009 Dell'Orco D -
Intratubular transplantation as a strategy for establishing animal models of testicular germ cell tumours.
International journal of experimental pathology 2008 Li Y, Kido T, Luo J, Fukuda M, Dobrinski I, Lau YF -
The human Y-encoded testis-specific protein interacts functionally with eukaryotic translation elongation factor eEF1A, a putative oncoprotein.
International journal of cancer 2008 Kido T, Lau YF -
TSPY and its X-encoded homologue interact with cyclin B but exert contrasting functions on cyclin-dependent kinase 1 activities.
Oncogene 2008 Li Y, Lau YF -
PIAS1 interacts with and represses SOX9 transactivation activity.
Molecular reproduction and development 2007 Oh HJ, Kido T, Lau YF -
JKT-1 is not a human seminoma cell line.
International journal of andrology 2007 de Jong J, Stoop H, Gillis AJ, van Gurp RJ, van Drunen E, Beverloo HB, Lau YF, Schneider DT, Sherlock JK, Baeten J, Hatakeyama S, Ohyama C, Oosterhuis JW, Looijenga LH -
Impact of the Y-containing cell line on histological differentiation patterns in dysgenetic gonads.
Clinical endocrinology 2007 Cools M, Boter M, van Gurp R, Stoop H, Poddighe P, Lau YF, Drop SL, Wolffenbuttel KP, Looijenga LH -
Y Chromosome and Male Germ Cell Biology in Health and Diseases
Y Chromosome and Male Germ Cell Biology in Health and Diseases 2007 LAU YFC CHAN WY -
The Y-encoded TSPY protein: a significant marker potentially plays a role in the pathogenesis of testicular germ cell tumors.
Human pathology 2007 Li Y, Tabatabai ZL, Lee TL, Hatakeyama S, Ohyama C, Chan WY, Looijenga LH, Lau YF -
Testis-specific protein Y-encoded gene is expressed in early and late stages of gonadoblastoma and testicular carcinoma in situ.
Urologic oncology 2007 Li Y, Vilain E, Conte F, Rajpert-De Meyts E, Lau YF -
The rat Tspy is preferentially expressed in elongated spermatids and interacts with the core histones.
Biochemical and biophysical research communications 2006 Kido T, Lau YF -
The poly(ADP-ribose) polymerase 1 interacts with Sry and modulates its biological functions.
Molecular and cellular endocrinology 2006 Li Y, Oh HJ, Lau YF -
TSPY potentiates cell proliferation and tumorigenesis by promoting cell cycle progression in HeLa and NIH3T3 cells.
BMC cancer 2006 Oram SW, Liu XX, Lee TL, Chan WY, Lau YF -
Structural characterization and expression studies of Dby and its homologs in the mouse.
Journal of andrology 2006 Vong QP, Li Y, Lau YF, Dym M, Rennert OM, Chan WY -
New evidence for the origin of intracranial germ cell tumours from primordial germ cells: expression of pluripotency and cell differentiation markers.
The Journal of pathology 2006 Hoei-Hansen CE, Sehested A, Juhler M, Lau YF, Skakkebaek NE, Laursen H, Rajpert-de Meyts E -
Germ cell lineage differentiation in non-seminomatous germ cell tumours.
The Journal of pathology 2006 Honecker F, Stoop H, Mayer F, Bokemeyer C, Castrillon DH, Lau YF, Looijenga LH, Oosterhuis JW -
KRAB: a partner for SRY action on chromatin.
Molecular and cellular endocrinology 2006 Oh HJ, Lau YF -
Maturation delay of germ cells in fetuses with trisomy 21 results in increased risk for the development of testicular germ cell tumors.
Human pathology 2006 Cools M, Honecker F, Stoop H, Veltman JD, de Krijger RR, Steyerberg E, Wolffenbuttel KP, Bokemeyer C, Lau YF, Drop SL, Looijenga LH -
A Cre gene directed by a human TSPY promoter is specific for germ cells and neurons.
Genesis (New York, N.Y. : 2000) 2005 Kido T, Lau YF -
Expression of SRY proteins in both normal and sex-reversed XY fetal mouse gonads.
Developmental dynamics : an official publication of the American Association of Anatomists 2005 Taketo T, Lee CH, Zhang J, Li Y, Lee CY, Lau YF -
Unopposed c-MYC expression in benign prostatic epithelium causes a cancer phenotype.
The Prostate 2005 Williams K, Fernandez S, Stien X, Ishii K, Love HD, Lau YF, Roberts RL, Hayward SW -
Identification of germ cells at risk for neoplastic transformation in gonadoblastoma: an immunohistochemical study for OCT3/4 and TSPY.
Human pathology 2005 Kersemaekers AM, Honecker F, Stoop H, Cools M, Molier M, Wolffenbuttel K, Bokemeyer C, Li Y, Lau YF, Oosterhuis JW, Looijenga LH -
Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein.
Biology of reproduction 2004 Oh HJ, Li Y, Lau YF -
Expression pattern of a gonadoblastoma candidate gene suggests a role of the Y chromosome in prostate cancer.
Cytogenetic and genome research 2003 Lau YF, Lau HW, Kömüves LG -
Protein transduction as a strategy for evaluating important factors in mammalian sex determination and differentiation.
Cytogenetic and genome research 2003 Li Y, Yue L, Taketo T, Lau YF -
Characterization of the Xp21-23 region in the wood lemming, a region involved in XY sex reversal.
The Journal of experimental zoology 2001 Liu WS, Nordqvist K, Lau YF, Fredga K -
Sry promoters from domesticus (Tirano) and C57BL/6 mice function similarly in embryos and adult animals.
The Journal of experimental zoology 2001 Xian M, Zhang J, Lau YF -
Y-chromosome transfer induces changes in blood pressure and blood lipids in SHR.
Hypertension (Dallas, Tex. : 1979) 2001 Kren V, Qi N, Krenova D, Zidek V, Sladká M, Jáchymová M, Míková B, Horky K, Bonne A, Van Lith HA, Van Zutphen BF, Lau YF, Pravenec M, St Lezin E -
Neonatal mouse cardiac myocytes exhibit cardioprotection induced by hypoxic and pharmacologic preconditioning and by transgenic overexpression of human Cu/Zn superoxide dismutase.
Journal of molecular and cellular cardiology 2000 Karliner JS, Honbo N, Epstein CJ, Xian M, Lau YF, Gray MO -
Expression analysis of thirty one Y chromosome genes in human prostate cancer.
Molecular carcinogenesis 2000 Lau YF, Zhang J -
The green fluorescent protein is an efficient biological marker for cardiac myocytes.
Journal of molecular and cellular cardiology 1999 Xian M, Honbo N, Zhang J, Liew CC, Karliner JS, Lau YF -
In vitro binding and expression studies demonstrate a role for the mouse Sry Q-rich domain in sex determination.
The International journal of developmental biology 1999 Zhang J, Coward P, Xian M, Lau YF -
Gonadoblastoma, testicular and prostate cancers, and the TSPY gene.
American journal of human genetics 1999 Lau YF -
Suppression subtractive hybridization: a versatile method for identifying differentially expressed genes.
Methods in enzymology 1999 Diatchenko L, Lukyanov S, Lau YF, Siebert PD -
Sry interactive proteins: implication for the mechanisms of sex determination.
Cytogenetics and cell genetics 1998 Lau YF, Zhang J -
The Wilms' tumor gene WT1 can regulate genes involved in sex determination and differentiation: SRY, Müllerian-inhibiting substance, and the androgen receptor.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997 Shimamura R, Fraizer GC, Trapman J, Saunders GF -
Cytogenetic and molecular studies of a familial paracentric inversion of Y chromosome present in a patient with ambiguous genitalia.
American journal of medical genetics 1997 Liou JD, Ma YY, Gibson LH, Su H, Charest N, Lau YF, Yang-Feng TL -
Report of the Third International Workshop on Y Chromosome Mapping 1997. Heidelberg, Germany, April 13-16, 1997.
Cytogenetics and cell genetics 1997 Vogt PH, Affara N, Davey P, Hammer M, Jobling MA, Lau YF, Mitchell M, Schempp W, Tyler-Smith C, Williams G, Yen P, Rappold GA -
Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries.
Proceedings of the National Academy of Sciences of the United States of America 1996 Diatchenko L, Lau YF, Campbell AP, Chenchik A, Moqadam F, Huang B, Lukyanov S, Lukyanov K, Gurskaya N, Sverdlov ED, Siebert PD -
Report of the Second International Workshop on Y Chromosome Mapping 1995.
Cytogenetics and cell genetics 1996 Affara N, Bishop C, Brown W, Cooke H, Davey P, Ellis N, Graves JM, Jones M, Mitchell M, Rappold G, Tyler-Smith C, Yen P, Lau YF -
Functional comparison of the Mus musculus molossinus and Mus musculus domesticus Sry genes.
Molecular endocrinology (Baltimore, Md.) 1995 Dubin RA, Coward P, Lau YF, Ostrer H -
Polymorphism of a CAG trinucleotide repeat within Sry correlates with B6.YDom sex reversal.
Nature genetics 1994 Coward P, Nagai K, Chen D, Thomas HD, Nagamine CM, Lau YF -
Report and abstracts of the First International Workshop on Y Chromosome Mapping 1994. Cambridge, England, April 2-5, 1994.
Cytogenetics and cell genetics 1994 Affara NA, Lau YF, Briggs H, Davey P, Jones MH, Khwaja O, Mitchell M, Sargent C -
A testis-specific gene encoding a nuclear high-mobility-group box protein located in elongating spermatids.
Molecular and cellular biology 1993 Boissonneault G, Lau YF -
Identification of the transcriptional unit, structural organization, and promoter sequence of the human sex-determining region Y (SRY) gene, using a reverse genetic approach.
American journal of human genetics 1993 Su H, Lau YF -
Molecular isolation and characterization of an expressed gene from the human Y chromosome.
Human molecular genetics 1992 Zhang JS, Yang-Feng TL, Muller U, Mohandas TK, de Jong PJ, Lau YF -
Demonstration of a stage-specific expression of the ZFY protein in fetal mouse testis using anti-peptide antibodies.
Molecular reproduction and development 1992 Su H, Lau YF -
Isolation of a phylogenetically conserved and testis-specific gene using a monoclonal antibody against the serological H-Y antigen.
Journal of reproductive immunology 1992 Su H, Kozak CA, Veerhuis R, Lau YF, Wiberg U -
The musculus-type Y chromosome of the laboratory mouse is of Asian origin.
Mammalian genome : official journal of the International Mammalian Genome Society 1992 Nagamine CM, Nishioka Y, Moriwaki K, Boursot P, Bonhomme F, Lau YF -
Unusual distribution of Zfy and Zfx sequences on the sex chromosomes of the wood lemming, a species exhibiting XY sex reversal.
Cytogenetics and cell genetics 1992 Lau YF, Yang-Feng TL, Elder B, Fredga K, Wiberg UH -
American Academy of Pediatrics Committee on Drugs: Prescription drug advertising direct to the consumer.
Pediatrics 1991 -
Molecular cloning of an acrosomal sperm antigen gene and the production of its recombinant protein for immunocontraceptive vaccine.
Molecular reproduction and development 1990 Liu MS, Chan KM, Lau YF, Lee CY -
Regional assignments of the zinc finger Y-linked gene (ZFY) and related sequences on human and mouse chromosomes.
Cytogenetics and cell genetics 1990 Leung WY, Lindgren V, Lau YF, Yang-Feng YL -
Stage-specific expression of the lactate dehydrogenase-X gene in adult and developing mouse testes.
Molecular reproduction and development 1990 Jen J, Deschepper CF, Shackleford GM, Lee CY, Lau YF -
The two candidate testis-determining Y genes (Zfy-1 and Zfy-2) are differentially expressed in fetal and adult mouse tissues.
Genes & development 1990 Nagamine CM, Chan K, Hake LE, Lau YF -
The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues.
American journal of human genetics 1989 Lau YF, Chan KM -
Male-enhanced antigen gene is phylogenetically conserved and expressed at late stages of spermatogenesis.
Proceedings of the National Academy of Sciences of the United States of America 1989 Lau YF, Chan KM, Sparkes R -
A PCR artifact: generation of heteroduplexes.
American journal of human genetics 1989 Nagamine CM, Chan K, Lau YF -
Isolation and chromosomal localization of the human En-2 gene.
Genomics 1989 Poole SJ, Law ML, Kao FT, Lau YF -
Chromosome mapping and expression of a putative testis-determining gene in mouse.
Science (New York, N.Y.) 1989 Nagamine CM, Chan KM, Kozak CA, Lau YF -
The anonymous PAS45 probe detects RFLPs in 13q31.
Annales de genetique 1989 Gross MS, Sefiani A, de Tand MF, Lau YF, Saidi-Mehtar N, Hors-Cayla MC, Frezal J, Van Cong N -
Assignment of human gene encoding testis-specific lactate dehydrogenase C to chromosome 11, region p14.3-p15.5.
Somatic cell and molecular genetics 1988 Kao FT, Wu KC, Law ML, Hartz JA, Lau YF -
Endocrine Genes: Analytical Methods, Experimental Approaches and Selected Systems
Endocrine Genes: Analytical Methods, Experimental Approaches and Selected Systems 1988 LAU YF -
Sequences contained within the promoter of the human thymidine kinase gene can direct cell-cycle regulation of heterologous fusion genes.
Proceedings of the National Academy of Sciences of the United States of America 1988 Kim YK, Wells S, Lau YF, Lee AS -
Method of genomic DNA cloning by the combination of cosmid shuttle vector and monoclonal antibody.
Microbiology and immunology 1988 Tagawa M, Ito T, Kanno M, Okitsu A, Sakamoto T, Imai K, Kuwabara I, Koseki H, Matsubara H, Lau YF -
Platelet glycoprotein IIb. Chromosomal localization and tissue expression.
The Journal of clinical investigation 1987 Bray PF, Rosa JP, Johnston GI, Shiu DT, Cook RG, Lau C, Kan YW, McEver RP, Shuman MA -
The testis-specific phosphoglycerate kinase gene pgk-2 is a recruited retroposon.
Molecular and cellular biology 1987 Boer PH, Adra CN, Lau YF, McBurney MW -
Molecular isolation and sequence determination of the cDNA for the mouse sperm-specific lactate dehydrogenase-X gene.
Biochemical and biophysical research communications 1987 Wu KC, Chan K, Lee CY, Lau YF -
Expression of herpes simplex virus thymidine kinase gene in aquatic filamentous fungus Achlya ambisexualis.
Gene 1987 Manavathu EK, Suryanarayana K, Hasnain SE, Leung M, Lau YF, Leung WC -
Male-enhanced expression and genetic conservation of a gene isolated with an anti-H-Y antibody.
Transactions of the Association of American Physicians 1987 Lau YF, Chan KM, Kan YW, Goldberg E -
Expression of the human apolipoprotein E gene in cultured mammalian cells.
The Journal of biological chemistry 1986 Reardon CA, Lau YF, Paik YK, Weisgraber KH, Mahley RW, Taylor JM -
Cloning and expression of the human apolipoprotein E gene.
Methods in enzymology 1986 Reardon CA, Paik YK, Chang DJ, Davies GE, Mahley RW, Lau YF, Taylor JM -
Cosmid vectors for high efficiency DNA-mediated transformation and gene amplification in mammalian cells: studies with the human growth hormone gene.
Gene 1986 Choo KH, Filby G, Greco S, Lau YF, Kan YW -
Flow-sorting analysis of normal and abnormal human genomes.
Cold Spring Harbor symposia on quantitative biology 1986 Lebo RV, Anderson LA, Lau YF, Flandermeyer R, Kan YW -
Identification of a case of Y:18 translocation using a Y-specific repetitive DNA probe.
Human genetics 1985 Lau YF, Ying KL, Donnell GN -
A male-specific DNA probe detects heterochromatin sequences in a familial Yq- chromosome.
American journal of human genetics 1984 Lau YF, Schonberg S -
Amplification and expression of human alpha-globin genes in Chinese hamster ovary cells.
Molecular and cellular biology 1984 Lau YF, Lin CC, Kan YW -
A rapid screening test for antenatal sex determination.
Lancet (London, England) 1984 Lau YF, Huang JC, Dozy AM, Kan YW -
Direct isolation of the functional human thymidine kinase gene with a cosmid shuttle vector.
Proceedings of the National Academy of Sciences of the United States of America 1984 Lau YF, Kan YW -
Versatile cosmid vectors for the isolation, expression, and rescue of gene sequences: studies with the human alpha-globin gene cluster.
Proceedings of the National Academy of Sciences of the United States of America 1983 Lau YF, Kan YW -
Amplification of the human alpha-globin gene enhances its expression.
Transactions of the Association of American Physicians 1983 Lau YF, Lin CC, Kan YW -
Studies of mammalian chromosome replication. II. Evidence for the existence of defined chromosome replicating units.
Chromosoma 1981 Lau YF, Arrighi FE -
Cell cycle analysis and drug inhibition studies of silver staining in synchronous HeLa cells.
Experimental cell research 1980 Hubbell HR, Lau YF, Brown RL, Hsu TC -
Nucleolar activity in differentiated cells after stimulation.
Cytogenetics and cell genetics 1980 Arrighi FE, Lau YF, Spallone A -
Studies of mammalian chromosome replication. I. BrdU-induced differential staining patterns in interphase and metaphase chromosomes.
Cytogenetics and cell genetics 1980 Lau YF, Arrighi FE -
Cytological analyses of 14p+ variant by means of N-banding and combinations of silver staining and chromosome bandings.
Human genetics 1979 Lau YF, Wertelecki W, Pfeiffer RA, Arrighi FE -
Combination of silver and fluorescent staining for metaphase chromosomes.
American journal of human genetics 1978 Lau YF, Pfeiffer RA, Arrighi FE, Hsu TC -
Induction of premature chromosome condensation in CHO cells fused with polyethylene glycol.
Experimental cell research 1977 Lau YF, Brown RL, Arrighi FE -
Studies of the squirel monkey, Saimiri sciureus, genome. II. C-band characterization and DNA replication patterns.
Cytogenetics and cell genetics 1977 Lau YF, Arrighi FE, Chuang CR -
Variable modes of Robertsonian fusions.
Cytogenetics and cell genetics 1977 Lau YF, Hsu TC -
Sister chromatid differential staining pattern in prematurely condensed chromosomes.
Experientia 1976 Lau YF, Hittelman WN, Arrighi FE -
Studies of the squirrel monkey, Saimiri sciureus, genome. I. Cytological characterization of chromosomal heterozygosity.
Cytogenetics and cell genetics 1976 Lau YF, Arrighi FE