Chloe Atreya, MD, PhD
Associate Professor
Medicine
School of Medicine

Dr. Chloe E. Atreya specializes in gastrointestinal cancer, particularly colorectal cancer, at the UCSF Helen Diller Comprehensive Cancer Center. She also co-directs the Integrative Onolcogy Program and Research Hub. Her research focuses on the interplay of tumor genetics and response to therapies for colorectal cancer, with the goal of improving patient outcomes and quality of life by personalizing treatment.

Awards

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• Clinical Innovation Center Inside Out Accelerator Award, 2017
• The Marcus Program in Precision Medicine Innovation Seeding Bold Ideas Award, 2017
• The Ernest H. Rosenbaum MD Commitment to Patient Care Award, UCSF Symptom Management Service, 2014
• Alliance for Clinical Trials in Oncology Foundation Investigator Award, 2012
• American Cancer Society Postdoctoral Fellowship 11-183-01-TBG, 2011
• Conquer Cancer Foundation of the American Society of Clinical Oncology Young Investigator Award, 2011

Education & Training

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• Diversity, Equity, and Inclusion Champion Training University of California 2019
• Diversity, Equity, and Inclusion Champion Training University of California 11/2019
• MD, PhD School of Medicine Yale University 2005
• BA Princeton University 1998

Interests

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• UCSF Osher Center for Integrative Medicine Affiliated Faculty Member

Websites

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• Anticancer Lifestyle Program Interview (anticancerlifestyle.org)
• Cancer Center profile (cancer.ucsf.edu)

Grants and Projects

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• Understanding Intrinsic Resistance to Direct KRAS Inhibition In colorectal Cancers, NIH-NCI, 2022-2026
• Optimization of a remote intervention to improve nutrition and physical activity in colorectal cancer survivors, NIH/NCI, 2020-2025
• Kinome-guided Targeting of Cooperative Dependencies in BRAF and KRAS Mutated Colorectal Cancer, NIH, 2019-2024
• (PQ10) Harnessing the human gut microbiome to predict chemotherapy outcomes, NIH, 2018-2021
• Targeting of Aberrant Signaling in Patient-Derived Colorectal Cancer Models, NIH, 2013-2019

Publications (59)

Top publication keywords:
Neurotoxicity SyndromesTransplant RecipientsColorectal NeoplasmsHospice and Palliative Care NursingMicrobiotaCancer SurvivorsColonic NeoplasmsFluorouracilMicrosatellite InstabilityProto-Oncogene Proteins B-rafIntegrative OncologyAscitesAdvance DirectivesMolecular Targeted TherapyGastrointestinal Neoplasms

• Associations between the Gut Microbiota, Race, and Ethnicity of Patients with Colorectal Cancer: A Pilot and Feasibility Study.
  Cancers 2023 Piawah S, Kyaw TS, Trepka K, Stewart AL, Mora RV, Stanfield D, Levine K, Van Blarigan EL, Venook A, Turnbaugh PJ, Nguyen T, Atreya CE
• Integrative Oncology Care of Symptoms of Anxiety and Depression in Adults With Cancer: Society for Integrative Oncology-ASCO Guideline.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2023 Carlson LE, Ismaila N, Addington EL, Asher GN, Atreya C, Balneaves LG, Bradt J, Fuller-Shavel N, Goodman J, Hoffman CJ, Huston A, Mehta A, Paller CJ, Richardson K, Seely D, Siwik CJ, Temel JS, Rowland…
• Variety of Fruit and Vegetables and Alcohol Intake are Associated with Gut Microbial Species and Gene Abundance in Colorectal Cancer Survivors.
  The American journal of clinical nutrition 2023 Kyaw TS, Upadhyay V, Tolstykh I, Van Loon K, Laffan A, Stanfield D, Gempis D, Kenfield SA, Chan JM, Piawah S, Atreya CE, Ng K, Venook A, Kidder W, Turnbaugh PJ, Van Blarigan EL
• Sexual function remains persistently low in women after treatment for colorectal cancer and anal squamous cell carcinoma.
  The journal of sexual medicine 2023 Savoie MB, Paciorek A, Van Loon K, Anwar M, Atreya CE, Johnson PC, Kenfield SA, Laffan A, Levin AO, Smith JF, Stanfield D, Venook A, Zhang L, Van Blarigan EL, Rowen T
• Quality of life among colorectal cancer survivors participating in a pilot randomized controlled trial of a web-based dietary intervention with text messages.
  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2023 Wang L, Langlais C, Kenfield SA, Van Loon K, Laffan A, Atreya CE, Chan JM, Zhang L, Allen IE, Miaskowski C, Fukuoka Y, Meyerhardt JA, Venook AP, Van Blarigan EL

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• A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAFV600E colorectal tumors.
  Nature cancer 2023 Ruiz-Saenz A, Atreya CE, Wang C, Pan B, Dreyer CA, Brunen D, Prahallad A, Muñoz DP, Ramms DJ, Burghi V, Spassov DS, Fewings E, Hwang YC, Cowdrey C, Moelders C, Schwarzer C, Wolf DM, Hann B, VandenBerg…
• Phase I prospective trial of TAS-102 (trifluridine and tipiracil) and radioembolization with 90Y resin microspheres for chemo-refractory colorectal liver metastases.
  BMC cancer 2022 Fidelman N, Atreya CE, Griffith M, Milloy MA, Carnevale J, Cinar P, Venook AP, Van Loon K
• Optimizing intervention tools to improve nutrition and physical activity for colorectal cancer survivors (Tools To Be Fit): Study protocol of a randomized factorial experiment.
  Contemporary clinical trials 2022 Kenfield SA, Philip EJ, Phillips SM, Meyerhardt JA, Chan JM, Atreya CE, Kim MO, Harris Q, Steiding P, Macaire G, McCullough ML, Piawah S, Johnson WY, Kurttila FA, Lewis WL, Pesmen C, Watson Y, Van …
• Association between adherence to the American Cancer Society Nutrition and Physical Activity Guidelines and stool frequency among colon cancer survivors: a cohort study.
  Journal of cancer survivorship : research and practice 2022 Greenberg AL, Tolstykh IV, Van Loon K, Laffan A, Stanfield D, Steiding P, Kenfield SA, Chan JM, Atreya CE, Piawah S, Kidder W, Venook AP, Van Blarigan EL, Varma MG
• Host and gut bacteria share metabolic pathways for anti-cancer drug metabolism.
  Nature microbiology 2022 Spanogiannopoulos P, Kyaw TS, Guthrie BGH, Bradley PH, Lee JV, Melamed J, Malig YNA, Lam KN, Gempis D, Sandy M, Kidder W, Van Blarigan EL, Atreya CE, Venook A, Gerona RR, Goga A, Pollard KS, Turnbaugh…
• mHealth Interventions to Promote a Healthy Diet and Physical Activity among Cancer Survivors: A Systematic Review of Randomized Controlled Trials.
  Cancers 2022 Wang L, Langlais CS, Kenfield SA, Chan JM, Graff RE, Allen IE, Atreya CE, Van Blarigan EL
• The Gut Microbiome in Colorectal Cancer.
  Hematology/oncology clinics of North America 2022 Piawah S, Walker EJ, Van Blarigan EL, Atreya CE
• Quality of life of colorectal cancer survivors participating in a pilot randomized controlled trial of physical activity trackers and daily text messages.
  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2022 Chan H, Van Loon K, Kenfield SA, Chan JM, Mitchell E, Zhang L, Paciorek A, Joseph G, Laffan A, Atreya C, Fukuoka Y, Miaskowski C, Meyerhardt JA, Venook AP, Van Blarigan EL
• Feasibility and Acceptability of a Physical Activity Tracker and Text Messages to Promote Physical Activity During Chemotherapy for Colorectal Cancer: Pilot Randomized Controlled Trial (Smart Pace II).
  JMIR cancer 2022 Van Blarigan EL, Dhruva A, Atreya CE, Kenfield SA, Chan JM, Milloy A, Kim I, Steiding P, Laffan A, Zhang L, Piawah S, Fukuoka Y, Miaskowski C, Hecht FM, Kim MO, Venook AP, Van Loon K
• Characteristics and Growth Rate of Lung Metastases in Patients With Primary Gastrointestinal Malignancies and Lung-dominant Metastatic Disease: A Retrospective Cohort Analysis.
  American journal of clinical oncology 2022 Burns S, Vella M, Paciorek A, Zhang L, Atreya CE, Feng M, Kelley RK, Tempero MA, Van Loon K, Ko AH
• Discovering dominant tumor immune archetypes in a pan-cancer census.
  Cell 2021 Combes AJ, Samad B, Tsui J, Chew NW, Yan P, Reeder GC, Kushnoor D, Shen A, Davidson B, Barczak AJ, Adkisson M, Edwards A, Naser M, Barry KC, Courau T, Hammoudi T, Argüello RJ, Rao AA, Olshen AB, …
• Being Present 2.0: Online Mindfulness-Based Program for Metastatic Gastrointestinal Cancer Patients and Caregivers.
  Global advances in health and medicine 2021 Dragomanovich HM, Dhruva A, Ekman E, Schoenbeck KL, Kubo A, Van Blarigan EL, Borno HT, Esquivel M, Chee B, Campanella M, Philip EJ, Rettger JP, Rosenthal B, Van Loon K, Venook AP, Boscardin C, Moran P…
• Molecular and Radiological Features of Microsatellite Stable Colorectal Cancer Cases With Dramatic Responses to Immunotherapy.
  Anticancer research 2021 Keenan BP, VAN Loon K, Khilnani AD, Fidelman N, Behr SC, Atreya CE, Oh DY
• Randomized Trial of Irinotecan and Cetuximab With or Without Vemurafenib in BRAF-Mutant Metastatic Colorectal Cancer (SWOG S1406).
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2020 Kopetz S, Guthrie KA, Morris VK, Lenz HJ, Magliocco AM, Maru D, Yan Y, Lanman R, Manyam G, Hong DS, Sorokin A, Atreya CE, Diaz LA, Allegra C, Raghav KP, Wang SE, Lieu CH, McDonough SL, Philip PA, …
• Molecular Insights in Transmission of Cancer From an Organ Donor to Four Transplant Recipients.
  Journal of the National Comprehensive Cancer Network : JNCCN 2020 Atreya CE, Collisson EA, Park M, Grenert JP, Behr SC, Gonzalez A, Chou J, Maisel S, Friedlander TW, Freise CE, Shoji J, Semrad TJ, Van Ziffle J, Chin-Hong P
• Association of Diet Quality With Survival Among People With Metastatic Colorectal Cancer in the Cancer and Leukemia B and Southwest Oncology Group 80405 Trial.
  JAMA network open 2020 Van Blarigan EL, Zhang S, Ou FS, Venlo A, Ng K, Atreya C, Van Loon K, Niedzwiecki D, Giovannucci E, Wolfe EG, Lenz HJ, Innocenti F, O'Neil BH, Shaw JE, Polite BN, Hochster HS, Atkins JN, Goldberg RM, …
• ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal-Anal Task Forces whitepaper.
  Nature reviews. Clinical oncology 2020 Dasari A, Morris VK, Allegra CJ, Atreya C, Benson AB, Boland P, Chung K, Copur MS, Corcoran RB, Deming DA, Dwyer A, Diehn M, Eng C, George TJ, Gollub MJ, Goodwin RA, Hamilton SR, Hechtman JF, Hochster…
• Factors Impacting Differential Outcomes in the Definitive Radiation Treatment of Anal Cancer Between HIV-Positive and HIV-Negative Patients.
  The oncologist 2020 Susko M, Wang CJ, Lazar AA, Kim S, Laffan A, Feng M, Ko A, Venook AP, Atreya CE, Van Loon K, Anwar M
• Probing the tumor micro(b)environment.
  Science (New York, N.Y.) 2020 Atreya CE, Turnbaugh PJ
• Embedded palliative care for patients with metastatic colorectal cancer: a mixed-methods pilot study.
  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2020 Bischoff KE, Zapata C, Sedki S, Ursem C, O'Riordan DL, England AE, Thompson N, Alfaro A, Rabow MW, Atreya CE
• BRAF-Mutant Transcriptional Subtypes Predict Outcome of Combined BRAF, MEK, and EGFR Blockade with Dabrafenib, Trametinib, and Panitumumab in Patients with Colorectal Cancer.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2020 Middleton G, Yang Y, Campbell CD, André T, Atreya CE, Schellens JHM, Yoshino T, Bendell JC, Hollebecque A, McRee AJ, Siena S, Gordon MS, Tabernero J, Yaeger R, O'Dwyer PJ, De Vos F, Van Cutsem E, …
• Clinicopathologic Characteristics and Impact of Oophorectomy for Ovarian Metastases from Colorectal Cancer.
  The oncologist 2020 Ursem C, Zhou M, Paciorek A, Atreya CE, Ko AH, Venook A, Zhang L, Van Loon K
• Postoperative Exacerbation of Oxaliplatin-induced Neurotoxicity in Gastrointestinal Cancers: A Case Series.
  Anticancer research 2020 Gonzalez A, Walker EJ, Van Loon K, Cinar P, Atreya CE
• Feasibility and Acceptability of a Web-Based Dietary Intervention with Text Messages for Colorectal Cancer: A Randomized Pilot Trial.
  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2020 Van Blarigan EL, Kenfield SA, Chan JM, Van Loon K, Paciorek A, Zhang L, Chan H, Savoie MB, Bocobo AG, Liu VN, Wong LX, Laffan A, Atreya CE, Miaskowski C, Fukuoka Y, Meyerhardt JA, Venook AP
• Vitamin D Levels in Patients with Colorectal Cancer Before and After Treatment Initiation.
  Journal of gastrointestinal cancer 2019 Savoie MB, Paciorek A, Zhang L, Van Blarigan EL, Sommovilla N, Abrams D, Atreya CE, Bergsland EK, Chern H, Kelley RK, Ko A, Laffan A, Sarin A, Varma MG, Venook AP, Van Loon K
• Phase II Open-Label Study of Pembrolizumab in Treatment-Refractory, Microsatellite Instability-High/Mismatch Repair-Deficient Metastatic Colorectal Cancer: KEYNOTE-164.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2019 Le DT, Kim TW, Van Cutsem E, Geva R, Jäger D, Hara H, Burge M, O'Neil B, Kavan P, Yoshino T, Guimbaud R, Taniguchi H, Elez E, Al-Batran SE, Boland PM, Crocenzi T, Atreya CE, Cui Y, Dai T, Marinello P,…
• A multi-modal data resource for investigating topographic heterogeneity in patient-derived xenograft tumors.
  Scientific data 2019 Rajaram S, Roth MA, Malato J, VandenBerg S, Hann B, Atreya CE, Altschuler SJ, Wu LF
• Hormone receptor expression of colorectal cancer diagnosed during the peri-partum period.
  Endocrine connections 2019 Silverstein J, Kidder W, Fisher S, Hope TA, Maisel S, Ng D, Van Ziffle J, Atreya CE, Van Loon K
• Improving Access to Integrative Oncology Through Group Medical Visits: A Pilot Implementation Project.
  Journal of alternative and complementary medicine (New York, N.Y.) 2019 Thompson-Lastad A, Atreya CE, Chao MT, Pollak C, Dhruva A, Santana T, Abrams DI
• Self-monitoring and reminder text messages to increase physical activity in colorectal cancer survivors (Smart Pace): a pilot randomized controlled trial.
  BMC cancer 2019 Van Blarigan EL, Chan H, Van Loon K, Kenfield SA, Chan JM, Mitchell E, Zhang L, Paciorek A, Joseph G, Laffan A, Atreya CE, Fukuoka Y, Miaskowski C, Meyerhardt JA, Venook AP
• Of Microbes and Microsatellites.
  Cancer immunology research 2018 Atreya CE, Venook AP
• Applying New Models of Care to Meet Patient Needs in Integrative Oncology.
  Journal of alternative and complementary medicine (New York, N.Y.) 2018 Dhruva A, Atreya CE, Chao MT
• Being Present: A single-arm feasibility study of audio-based mindfulness meditation for colorectal cancer patients and caregivers.
  PloS one 2018 Atreya CE, Kubo A, Borno HT, Rosenthal B, Campanella M, Rettger JP, Joseph G, Allen IE, Venook AP, Altschuler A, Dhruva A
• Emerging treatment options for BRAF-mutant colorectal cancer.
  Gastrointestinal cancer : targets and therapy 2018 Ursem C, Atreya CE, Van Loon K
• Combined BRAF, EGFR, and MEK Inhibition in Patients with BRAFV600E-Mutant Colorectal Cancer.
  Cancer discovery 2018 Corcoran RB, André T, Atreya CE, Schellens JHM, Yoshino T, Bendell JC, Hollebecque A, McRee AJ, Siena S, Middleton G, Muro K, Gordon MS, Tabernero J, Yaeger R, O'Dwyer PJ, Humblet Y, De Vos F, Jung AS…
• Genomic Landscape of Cell-Free DNA in Patients with Colorectal Cancer.
  Cancer discovery 2017 Strickler JH, Loree JM, Ahronian LG, Parikh AR, Niedzwiecki D, Pereira AAL, McKinney M, Korn WM, Atreya CE, Banks KC, Nagy RJ, Meric-Bernstam F, Lanman RB, Talasaz A, Tsigelny IF, Corcoran RB, Kopetz …
• Sampling strategies to capture single-cell heterogeneity.
  Nature methods 2017 Rajaram S, Heinrich LE, Gordan JD, Avva J, Bonness KM, Witkiewicz AK, Malter JS, Atreya CE, Warren RS, Wu LF, Altschuler SJ
• Prolonged Response to HER2-Directed Therapy in a Patient With HER2-Amplified, Rapidly Progressive Metastatic Colorectal Cancer.
  Journal of the National Comprehensive Cancer Network : JNCCN 2017 Parikh A, Atreya C, Korn WM, Venook AP
• Systemic Therapy for Metastatic Colorectal Cancer: From Current Standards to Future Molecular Targeted Approaches.
  American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting 2017 Atreya CE, Yaeger R, Chu E
• Differential Radiographic Appearance of BRAF V600E-Mutant Metastatic Colorectal Cancer in Patients Matched by Primary Tumor Location.
  Journal of the National Comprehensive Cancer Network : JNCCN 2016 Atreya CE, Greene C, McWhirter RM, Ikram NS, Allen IE, Van Loon K, Venook AP, Yeh BM, Behr SC
• Radioembolization with 90Y glass microspheres for the treatment of unresectable metastatic liver disease from chemotherapy-refractory gastrointestinal cancers: final report of a prospective pilot study.
  Journal of gastrointestinal oncology 2016 Fidelman N, Kerlan RK, Hawkins RA, Pampaloni M, Taylor AG, Kohi MP, Kolli KP, Atreya CE, Bergsland EK, Kelley RK, Ko AH, Korn WM, Van Loon K, McWhirter RM, Luan J, Johanson C, Venook AP
• Role of Biologics in Colon Cancer: Still Not Clear.
  Journal of oncology practice 2016 Atreya CE, Venook AP
• A phase II study of axitinib in advanced neuroendocrine tumors.
  Endocrine-related cancer 2016 Strosberg JR, Cives M, Hwang J, Weber T, Nickerson M, Atreya CE, Venook A, Kelley RK, Valone T, Morse B, Coppola D, Bergsland EK
• Combined BRAF and MEK Inhibition With Dabrafenib and Trametinib in BRAF V600-Mutant Colorectal Cancer.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2015 Corcoran RB, Atreya CE, Falchook GS, Kwak EL, Ryan DP, Bendell JC, Hamid O, Messersmith WA, Daud A, Kurzrock R, Pierobon M, Sun P, Cunningham E, Little S, Orford K, Motwani M, Bai Y, Patel K, Venook …
• Cell-Free DNA Next-Generation Sequencing in Pancreatobiliary Carcinomas.
  Cancer discovery 2015 Zill OA, Greene C, Sebisanovic D, Siew LM, Leng J, Vu M, Hendifar AE, Wang Z, Atreya CE, Kelley RK, Van Loon K, Ko AH, Tempero MA, Bivona TG, Munster PN, Talasaz A, Collisson EA
• Expanded RAS: refining the patient population.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2015 Atreya CE, Corcoran RB, Kopetz S
• Potent antitumor activity of cabozantinib, a c-MET and VEGFR2 inhibitor, in a colorectal cancer patient-derived tumor explant model.
  International journal of cancer 2014 Song EK, Tai WM, Messersmith WA, Bagby S, Purkey A, Quackenbush KS, Pitts TM, Wang G, Blatchford P, Yahn R, Kaplan J, Tan AC, Atreya CE, Eckhardt G, Kelley RK, Venook A, Kwak EL, Ryan D, Arcaroli JJ
• Association of TP53 mutational status and gender with survival after adjuvant treatment for stage III colon cancer: results of CALGB 89803.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Warren RS, Atreya CE, Niedzwiecki D, Weinberg VK, Donner DB, Mayer RJ, Goldberg RM, Compton CC, Zuraek MB, Ye C, Saltz LB, Bertagnolli MM
• Cancer Medicine
  PTEN Expression is Consistent in Colorectal Cancer Primaries and Metastases and Associates with Patient Survival. 2013 Atreya CE, Sangale Z, Xu N, Matli MR, Tikishvili E, Welbourn W, Stone S, Shokat KM, and Warren RS.
• PTEN expression is consistent in colorectal cancer primaries and metastases and associates with patient survival.
  Cancer medicine 2013 Atreya CE, Sangale Z, Xu N, Matli MR, Tikishvili E, Welbourn W, Stone S, Shokat KM, Warren RS
• Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors.
  Oncogene 2013 Ducker GS, Atreya CE, Simko JP, Hom YK, Matli MR, Benes CH, Hann B, Nakakura EK, Bergsland EK, Donner DB, Settleman J, Shokat KM, Warren RS
• Personalized Medicine in Oncology
  KRAS and Colorectal Cancer: Shades of Gray. 2012 Atreya CE, Ostrem JM, and Kelley RK.
• Predictive biomarkers in advance of a companion drug: ahead of their time?
  Journal of the National Comprehensive Cancer Network : JNCCN 2012 Kelley RK, Atreya C, Venook AP, Febbo PG
• Combination of ATP-competitive mammalian target of rapamycin inhibitors with standard chemotherapy for colorectal cancer.
  Investigational new drugs 2012 Atreya CE, Ducker GS, Feldman ME, Bergsland EK, Warren RS, Shokat KM