Chester Chamberlain, PhD
Associate Researcher
Diabetes Center
School of Medicine

Publications (21)

Top publication keywords:
Diabetes Mellitus, Type 1PyrimidinesXenograft Model Antitumor AssaysIslets of LangerhansNeural Tuberac GTP-Binding ProteinsProto-Oncogene ProteinsDrug Resistance, Neoplasmras ProteinsBenzoxazolesEverolimusNotochordNeuroendocrine TumorsPancreatic NeoplasmsPyrazoles

• Gain-of-function mutation in SKAP2 leads to type 1 diabetes and broader autoimmunity through hyperactive integrin signaling in myeloid cells.
  bioRxiv : the preprint server for biology 2026 Tamaki CM, Chamberlain CE, Abram CL, Poojary S, Bridge J, Matsuda JL, Tamaki W, Rutsch N, Spector L, Dixon W, Proekt I, Letourneau-Freiberg LR, Philipson LH, German MS, Anderson MS, Lowell CA
• Monogenic Type 1 Diabetes: A High Yield Pool in Which to Discover New Mechanisms and Candidate Therapeutics for Type 1 Diabetes.
  Cold Spring Harbor perspectives in medicine 2026 Chamberlain CE, German MS, Philipson LH, Anderson MS
• The Role of Imatinib in Pediatric Type 1 Diabetes.
  JCEM case reports 2024 Lavelle K, Chamberlain C, German M, Anderson M, Nip A, Gitelman SE
• A genomic data archive from the Network for Pancreatic Organ donors with Diabetes.
  Scientific data 2023 Perry DJ, Shapiro MR, Chamberlain SW, Kusmartseva I, Chamala S, Balzano-Nogueira L, Yang M, Brant JO, Brusko M, Williams MD, McGrail KM, McNichols J, Peters LD, Posgai AL, Kaddis JS, Mathews CE, …
• ABCC8-Related Monogenic Diabetes Presenting Like Type 1 Diabetes in an Adolescent.
  AACE clinical case reports 2023 Grier AE, McGill JB, Lord SM, Speake C, Greenbaum C, Chamberlain CE, German MS, Anderson MS, Hirsch IB

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• Diabetes With Multiple Autoimmune and Inflammatory Conditions Linked to an Activating SKAP2 Mutation.
  Diabetes care 2021 Rutsch N, Chamberlain CE, Dixon W, Spector L, Letourneau-Freiberg LR, Lwin WW, Philipson LH, Zarbock A, Saintus K, Wang J, German MS, Anderson MS, Lowell CA
• Elastase 3B mutation links to familial pancreatitis with diabetes and pancreatic adenocarcinoma.
  The Journal of clinical investigation 2019 Moore PC, Cortez JT, Chamberlain CE, Alba D, Berger AC, Quandt Z, Chan A, Cheng MH, Bautista JL, Peng J, German MS, Anderson MS, Oakes SA
• A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-resistant Tumors.
  Molecular cancer therapeutics 2018 Chamberlain CE, German MS, Yang K, Wang J, VanBrocklin H, Regan M, Shokat KM, Ducker GS, Kim GE, Hann B, Donner DB, Warren RS, Venook AP, Bergsland EK, Lee D, Wang Y, Nakakura EK
• Pancreatic neuro-insular network in young mice revealed by 3D panoramic histology.
  Diabetologia 2017 Tang SC, Shen CN, Lin PY, Peng SJ, Chien HJ, Chou YH, Chamberlain CE, Pasricha PJ
• Human pancreatic neuro-insular network in health and fatty infiltration.
  Diabetologia 2017 Tang SC, Baeyens L, Shen CN, Peng SJ, Chien HJ, Scheel DW, Chamberlain CE, German MS
• Follicle dynamics and global organization in the intact mouse ovary.
  Developmental biology 2015 Faire M, Skillern A, Arora R, Nguyen DH, Wang J, Chamberlain C, German MS, Fung JC, Laird DJ
• Menin determines K-RAS proliferative outputs in endocrine cells.
  The Journal of clinical investigation 2014 Chamberlain CE, Scheel DW, McGlynn K, Kim H, Miyatsuka T, Wang J, Nguyen V, Zhao S, Mavropoulos A, Abraham AG, O'Neill E, Ku GM, Cobb MH, Martin GR, German MS
• Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning.
  Development (Cambridge, England) 2008 Chamberlain CE, Jeong J, Guo C, Allen BL, McMahon AP
• Treatment of cultured myotubes with the proteasome inhibitor beta-lactone increases the expression of the transcription factor C/EBPbeta.
  American journal of physiology. Cell physiology 2006 Wei W, Yang H, Menconi M, Cao P, Chamberlain CE, Hasselgren PO
• Degradation of C/EBPbeta in cultured myotubes is calpain-dependent.
  Journal of cellular physiology 2006 Wei W, Yang H, Cao P, Menconi M, Chamberlain C, Petkova V, Hasselgren PO
• Spatial and temporal analysis of Rac activation during live neutrophil chemotaxis.
  Current biology : CB 2002 Gardiner EM, Pestonjamasp KN, Bohl BP, Chamberlain C, Hahn KM, Bokoch GM
• Galpha i3 binding to calnuc on Golgi membranes in living cells monitored by fluorescence resonance energy transfer of green fluorescent protein fusion proteins.
  Proceedings of the National Academy of Sciences of the United States of America 2001 Weiss TS, Chamberlain CE, Takeda T, Lin P, Hahn KM, Farquhar MG
• Localized Rac activation dynamics visualized in living cells.
  Science (New York, N.Y.) 2000 Kraynov VS, Chamberlain C, Bokoch GM, Schwartz MA, Slabaugh S, Hahn KM
• Watching proteins in the wild: fluorescence methods to study protein dynamics in living cells.
  Traffic (Copenhagen, Denmark) 2000 Chamberlain C, Hahn KM
• Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas.
  The Journal of biological chemistry 2000 Subauste MC, Von Herrath M, Benard V, Chamberlain CE, Chuang TH, Chu K, Bokoch GM, Hahn KM
• Imaging spatiotemporal dynamics of Rac activation in vivo with FLAIR.
  Methods in enzymology 2000 Chamberlain CE, Kraynov VS, Hahn KM