Charles Craik, PhD
Professor
Pharmaceutical Chemistry
School of Pharmacy

A particular emphasis of our work is on identifying the roles and regulating the activity of key proteins associated with infectious diseases, neurodegeneration and cancer. I am also interested in developing novel methods to biophysically characterize challenging proteins as well as their complexes. These studies coupled with our global substrate profiling, antibody engineering and noninvasive imaging efforts are providing a better understanding of both the chemical make-up and the biological importance of these critical proteins to aid in the rapid detection, monitoring and control of infectious disease, neurological disorders and cancer. This in turn is leading to the development of strategies for regulating these activities as a means of therapeutic intervention. Further study of these proteins holds promise for better understanding, rapid detection and eventual control of infectious diseases, cancer and neurodegeneration.

• Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors.
  Protein science : a publication of the Protein Society 2023 Fink EA, Bardine C, Gahbauer S, Singh I, Detomasi TC, White K, Gu S, Wan X, Chen J, Ary B, Glenn I, O'Connell J, O'Donnell H, Fajtová P, Lyu J, Vigneron S, Young NJ, Kondratov IS, Alisoltani A, Simons…
• A Prototype Assay Multiplexing SARS-CoV-2 3CL-Protease and Angiotensin-Converting Enzyme 2 for Saliva-Based Diagnostics in COVID-19.
  Biosensors 2023 Suresh V, Sheik DA, Detomasi TC, Zhao T, Zepeda T, Saladi S, Rajesh UC, Byers K, Craik CS, Davisson VJ
• The E3 Ubiquitin Ligase, CHIP/STUB1, Inhibits Aggregation of Phosphorylated Proteoforms of Microtubule-associated Protein Tau (MAPT).
  Journal of molecular biology 2023 Nadel CM, Thwin AC, Callahan M, Lee K, Connelly E, Craik CS, Southworth DR, Gestwicki JE
• Correction: Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.
  Molecular neurodegeneration 2023 Sampognaro PJ, Arya S, Knudsen GM, Gunderson EL, Sandoval-Perez A, Hodul M, Bowles K, Craik CS, Jacobson MP, Kao AW
• Discovery and Characterization of Antibody Probes of Module 2 of the 6-Deoxyerythronolide B Synthase.
  Biochemistry 2023 Guzman KM, Cogan DP, Brodsky KL, Soohoo AM, Li X, Sevillano N, Mathews II, Nguyen KP, Craik CS, Khosla C
• Perturbations in podocyte transcriptome and biological pathways induced by FSGS associated circulating factors.
  Annals of translational medicine 2023 Rashmi P, Sigdel TK, Rychkov D, Damm I, Da Silva AA, Vincenti F, Lourenco AL, Craik CS, Reiser J, Sarwal MM
• Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.
  Molecular neurodegeneration 2023 Sampognaro PJ, Arya S, Knudsen GM, Gunderson EL, Sandoval-Perez A, Hodul M, Bowles K, Craik CS, Jacobson MP, Kao AW
• High-throughput optofluidic screening of single B cells identifies novel cross-reactive antibodies as inhibitors of uPAR with antibody-dependent effector functions.
  mAbs 2023 Lourenço AL, Chuo SW, Bohn MF, Hann B, Khan S, Yevalekar N, Patel N, Yang T, Xu L, Lv D, Drakas R, Lively S, Craik CS
• Multiplex substrate profiling by mass spectrometry for proteases.
  Methods in enzymology 2022 Rohweder PJ, Jiang Z, Hurysz BM, O'Donoghue AJ, Craik CS
• Accurate Identification of Mucinous Pancreatic Cystic Lesions Using Small-Volume Analytes.
  The Journal of surgical research 2022 Caiazza F, Conroy PC, Ivry SL, York T, Lin J, Hernandez S, Hoffmann TJ, Francis SS, Park WG, Yip-Schneider MT, Schmidt CM, Brand R, Craik CS, Kirkwood K
• Incidence and Prevalence of Coronavirus Disease 2019 Within a Healthcare Worker Cohort During the First Year of the Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2022 Doernberg SB, Holubar M, Jain V, Weng Y, Lu D, Bollyky JB, Sample H, Huang B, Craik CS, Desai M, Rutherford GW, Maldonado Y, CHART Study Consortium
• A covalent inhibitor of K-Ras(G12C) induces MHC class I presentation of haptenated peptide neoepitopes targetable by immunotherapy.
  Cancer cell 2022 Zhang Z, Rohweder PJ, Ongpipattanakul C, Basu K, Bohn MF, Dugan EJ, Steri V, Hann B, Shokat KM, Craik CS
• Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3.
  Nature communications 2022 Peters CE, Schulze-Gahmen U, Eckhardt M, Jang GM, Xu J, Pulido EH, Bardine C, Craik CS, Ott M, Gozani O, Verba KA, Hüttenhain R, Carette JE, Krogan NJ
• Structure-Based Identification of Naphthoquinones and Derivatives as Novel Inhibitors of Main Protease Mpro and Papain-like Protease PLpro of SARS-CoV-2.
  Journal of chemical information and modeling 2022 Santos LH, Kronenberger T, Almeida RG, Silva EB, Rocha REO, Oliveira JC, Barreto LV, Skinner D, Fajtová P, Giardini MA, Woodworth B, Bardine C, Lourenço AL, Craik CS, Poso A, Podust LM, McKerrow JH, …
• Translation of a Protease Turnover Assay for Clinical Discrimination of Mucinous Pancreatic Cysts.
  Diagnostics (Basel, Switzerland) 2022 Suresh V, Byers K, Rajesh UC, Caiazza F, Zhu G, Craik CS, Kirkwood K, Davisson VJ, Sheik DA
• Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine.
  Cell chemical biology 2022 Hulce KR, Jaishankar P, Lee GM, Bohn MF, Connelly EJ, Wucherer K, Ongpipattanakul C, Volk RF, Chuo SW, Arkin MR, Renslo AR, Craik CS
• Structure-based identification of naphthoquinones and derivatives as novel inhibitors of main protease Mpro and papain-like protease PLpro of SARS-CoV-2.
  bioRxiv : the preprint server for biology 2022 Santos LH, Kronenberger T, Almeida RG, Silva EB, Rocha REO, Oliveira JC, Barreto LV, Skinner D, Fajtová P, Giardini MA, Woodworth B, Bardine C, Lourenço AL, Craik CS, Poso A, Podust LM, McKerrow JH, …
• Colloidal Aggregators in Biochemical SARS-CoV-2 Repurposing Screens.
  Journal of medicinal chemistry 2021 O'Donnell HR, Tummino TA, Bardine C, Craik CS, Shoichet BK
• Design of a population-based longitudinal cohort study of SARS-CoV-2 incidence and prevalence among adults in the San Francisco Bay Area.
  Annals of epidemiology 2021 Lindan CP, Desai M, Boothroyd D, Judson T, Bollyky J, Sample H, Weng Y, Cheng Y, Dahlen A, Hedlin H, Grumbach K, Henne J, Garcia S, Gonzales R, Craik CS, Rutherford G, Maldonado Y
• Mapping the catalytic conformations of an assembly-line polyketide synthase module.
  Science (New York, N.Y.) 2021 Cogan DP, Zhang K, Li X, Li S, Pintilie GD, Roh SH, Craik CS, Chiu W, Khosla C
• A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Mahoney M, Damalanka VC, Tartell MA, Chung DH, Lourenço AL, Pwee D, Mayer Bridwell AE, Hoffmann M, Voss J, Karmakar P, Azouz NP, Klingler AM, Rothlauf PW, Thompson CE, Lee M, Klampfer L, Stallings CL,…
• Immunotargeting of Nanocrystals by SpyCatcher Conjugation of Engineered Antibodies.
  ACS nano 2021 Pedroso CCS, Mann VR, Zuberbühler K, Bohn MF, Yu J, Altoe V, Craik CS, Cohen BE
• Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential.
  Nature communications 2021 Meyer B, Chiaravalli J, Gellenoncourt S, Brownridge P, Bryne DP, Daly LA, Grauslys A, Walter M, Agou F, Chakrabarti LA, Craik CS, Eyers CE, Eyers PA, Gambin Y, Jones AR, Sierecki E, Verdin E, Vignuzzi…
• In Vivo Measurement of Granzyme Proteolysis from Activated Immune Cells with PET.
  ACS central science 2021 Zhao N, Bardine C, Lourenço AL, Wang YH, Huang Y, Cleary SJ, Wilson DM, Oh DY, Fong L, Looney MR, Evans MJ, Craik CS
• Colloidal aggregators in biochemical SARS-CoV-2 repurposing screens.
  bioRxiv : the preprint server for biology 2021 Oâ Donnell HR, Tummino TA, Bardine C, Craik CS, Shoichet BK
• Re-emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery.
  Journal of medicinal chemistry 2021 Kryštufek R, Šácha P, Starková J, Brynda J, Hradilek M, Tloušt'ová E, Grzymska J, Rut W, Boucher MJ, Drag M, Majer P, Hájek M, Rezácová P, Madhani HD, Craik CS, Konvalinka J
• Identification of recombinant Fabs for structural and functional characterization of HIV-host factor complexes.
  PloS one 2021 Sevillano N, Green EM, Votteler J, Kim DY, Ren X, Yang B, Liu X, Lourenço AL, Hurley JH, Farr-Jones S, Gross JD, Cheng Y, Craik CS
• Beginning at the End(s): A Latent End-Binding Network at the Host-Pathogen Interface.
  Biochemistry 2021 Ravalin M, Craik CS
• A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells.
  bioRxiv : the preprint server for biology 2021 Mahoney M, Damalanka VC, Tartell MA, Chung DH, Lourenco AL, Pwee D, Mayer Bridwell AE, Hoffmann M, Voss J, Karmakar P, Azouz N, Klingler AM, Rothlauf PW, Thompson CE, Lee M, Klampfer L, Stallings C, …
• Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia.
  Cell 2021 Asarnow D, Wang B, Lee WH, Hu Y, Huang CW, Faust B, Ng PML, Ngoh EZX, Bohn M, Bulkley D, Pizzorno A, Ary B, Tan HC, Lee CY, Minhat RA, Terrier O, Soh MK, Teo FJ, Yeap YYC, Seah SGK, Chan CEZ, Connelly…
• Global Protease Activity Profiling Identifies HER2-Driven Proteolysis in Breast Cancer.
  ACS chemical biology 2021 Salcedo EC, Winter MB, Khuri N, Knudsen GM, Sali A, Craik CS
• Platform to Discover Protease-Activated Antibiotics and Application to Siderophore-Antibiotic Conjugates.
  Journal of the American Chemical Society 2020 Boyce JH, Dang B, Ary B, Edmondson Q, Craik CS, DeGrado WF, Seiple IB
• Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients.
  eLife 2020 Miller-Vedam LE, Bräuning B, Popova KD, Schirle Oakdale NT, Bonnar JL, Prabu JR, Boydston EA, Sevillano N, Shurtleff MJ, Stroud RM, Craik CS, Schulman BA, Frost A, Weissman JS
• Structure of an affinity-matured inhibitory recombinant fab against urokinase plasminogen activator reveals basis of potency and specificity.
  Biochimica et biophysica acta. Proteins and proteomics 2020 Sevillano N, Bohn MF, Zimanyi M, Chen Y, Petzold C, Gupta S, Ralston CY, Craik CS
• An Opaque Cell-Specific Expression Program of Secreted Proteases and Transporters Allows Cell-Type Cooperation in Candida albicans.
  Genetics 2020 Lohse MB, Brenes LR, Ziv N, Winter MB, Craik CS, Johnson AD
• An Analysis of Isoclonal Antibody Formats Suggests a Role for Measuring PD-L1 with Low Molecular Weight PET Radiotracers.
  Molecular imaging and biology 2020 Wei J, Wang YH, Lee CY, Truillet C, Oh DY, Xu Y, Ruggero D, Flavell RR, VanBrocklin HF, Seo Y, Craik CS, Fong L, Wang CI, Evans MJ
• Antibody Probes of Module 1 of the 6-Deoxyerythronolide B Synthase Reveal an Extended Conformation During Ketoreduction.
  Journal of the American Chemical Society 2020 Cogan DP, Li X, Sevillano N, Mathews II, Matsui T, Craik CS, Khosla C
• Bivalent binding of a fully human IgG to the SARS-CoV-2 spike proteins reveals mechanisms of potent neutralization.
  bioRxiv : the preprint server for biology 2020 Wang B, Asarnow D, Lee WH, Huang CW, Faust B, Ng PML, Ngoh EZX, Bohn M, Bulkley D, Pizzorno A, Tan HC, Lee CY, Minhat RA, Terrier O, Soh MK, Teo FJ, Yeap YYC, Hu Y, Seah SGK, Maurer-Stroh S, Renia L, …
• Combination of Antifungal Drugs and Protease Inhibitors Prevent Candida albicans Biofilm Formation and Disrupt Mature Biofilms.
  Frontiers in microbiology 2020 Lohse MB, Gulati M, Craik CS, Johnson AD, Nobile CJ
• A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
  Nature 2020 Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, …
• Monitoring protease activity in biological tissues using antibody prodrugs as sensing probes.
  Scientific reports 2020 Vasiljeva O, Menendez E, Nguyen M, Craik CS, Michael Kavanaugh W
• A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing.
  bioRxiv : the preprint server for biology 2020 Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, O'Meara MJ, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, …
• Isoforms of Cathepsin B1 in Neurotropic Schistosomula of Trichobilharzia regenti Differ in Substrate Preferences and a Highly Expressed Catalytically Inactive Paralog Binds Cystatin.
  Frontiers in cellular and infection microbiology 2020 Dvoráková H, Leontovyc R, Machácek T, O'Donoghue AJ, Šedo O, Zdráhal Z, Craik CS, Caffrey CR, Horák P, Mikeš L
• Further Evidence That the Soluble Urokinase Plasminogen Activator Receptor Does Not Directly Injure Mice or Human Podocytes.
  Transplantation 2020 Harel E, Shoji J, Abraham V, Miller L, Laszik ZG, King A, Dobi D, Szabo G, Hann B, Sarwal MM, Craik CS, Vincenti F
• The lysosomal aminopeptidase tripeptidyl peptidase 1 displays increased activity in malignant pancreatic cysts.
  Biological chemistry 2019 Ivry SL, Knudsen GM, Caiazza F, Sharib JM, Jaradeh K, Ravalin M, O'Donoghue AJ, Kirkwood KS, Craik CS
• End-Binding E3 Ubiquitin Ligases Enable Protease Signaling.
  ACS chemical biology 2019 Ravalin M, Basu K, Gestwicki JE, Craik CS
• Antibody-Drug Conjugates Targeting the Urokinase Receptor (uPAR) as a Possible Treatment of Aggressive Breast Cancer.
  Antibodies (Basel, Switzerland) 2019 Harel ET, Drake PM, Barfield RM, Lui I, Farr-Jones S, Van't Veer L, Gartner ZJ, Green EM, Lourenço AL, Cheng Y, Hann BC, Rabuka D, Craik CS
• KH-Type Splicing Regulatory Protein Controls Colorectal Cancer Cell Growth and Modulates the Tumor Microenvironment.
  The American journal of pathology 2019 Caiazza F, Oficjalska K, Tosetto M, Phelan JJ, Noonan S, Martin P, Killick K, Breen L, O'Neill F, Nolan B, Furney S, Power R, Fennelly D, Craik CS, O'Sullivan J, Sheahan K, Doherty GA, Ryan EJ
• Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases.
  Nature chemical biology 2019 Ravalin M, Theofilas P, Basu K, Opoku-Nsiah KA, Assimon VA, Medina-Cleghorn D, Chen YF, Bohn MF, Arkin M, Grinberg LT, Craik CS, Gestwicki JE
• Why recombinant antibodies - benefits and applications.
  Current opinion in biotechnology 2019 Basu K, Green EM, Cheng Y, Craik CS
• Identifying a potential biomarker for primary focal segmental glomerulosclerosis and its association with recurrence after transplantation.
  Clinical transplantation 2019 Harel E, Shoji J, Abraham V, Miller L, Laszik Z, Thurison T, King A, Olshen A, Leung J, Szabo G, Hann B, Høyer-Hansen G, Craik CS, Vincenti F
• Progranulin Stimulates the In Vitro Maturation of Pro-Cathepsin D at Acidic pH.
  Journal of molecular biology 2019 Butler VJ, Cortopassi WA, Argouarch AR, Ivry SL, Craik CS, Jacobson MP, Kao AW
• Discovery of Selective Matriptase and Hepsin Serine Protease Inhibitors: Useful Chemical Tools for Cancer Cell Biology.
  Journal of medicinal chemistry 2019 Damalanka VC, Han Z, Karmakar P, O'Donoghue AJ, La Greca F, Kim T, Pant SM, Helander J, Klefström J, Craik CS, Janetka JW
• Predicting CD4 T-cell epitopes based on antigen cleavage, MHCII presentation, and TCR recognition.
  PloS one 2018 Schneidman-Duhovny D, Khuri N, Dong GQ, Winter MB, Shifrut E, Friedman N, Craik CS, Pratt KP, Paz P, Aswad F, Sali A
• Discovery and Characterization of a Thioesterase-Specific Monoclonal Antibody That Recognizes the 6-Deoxyerythronolide B Synthase.
  Biochemistry 2018 Li X, Sevillano N, La Greca F, Hsu J, Mathews II, Matsui T, Craik CS, Khosla C
• A Preclinical Assessment of 89Zr-atezolizumab Identifies a Requirement for Carrier Added Formulations Not Observed with 89Zr-C4.
  Bioconjugate chemistry 2018 Moroz A, Lee CY, Wang YH, Hsiao JC, Sevillano N, Truillet C, Craik CS, Fong L, Wang CI, Evans MJ
• Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin.
  Scientific reports 2018 Debela M, Magdolen V, Skala W, Elsässer B, Schneider EL, Craik CS, Biniossek ML, Schilling O, Bode W, Brandstetter H, Goettig P
• Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module.
  Journal of the American Chemical Society 2018 Li X, Sevillano N, La Greca F, Deis L, Liu YC, Deller MC, Mathews II, Matsui T, Cane DE, Craik CS, Khosla C
• SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties.
  PLoS neglected tropical diseases 2018 Leontovyc A, Ulrychová L, O'Donoghue AJ, Vondrášek J, Marešová L, Hubálek M, Fajtová P, Chanová M, Jiang Z, Craik CS, Caffrey CR, Mareš M, Dvorák J, Horn M
• Substrate Specificity of Cysteine Proteases Beyond the S2 Pocket: Mutagenesis and Molecular Dynamics Investigation of Fasciola hepatica Cathepsins L.
  Frontiers in molecular biosciences 2018 Corvo I, Ferraro F, Merlino A, Zuberbühler K, O'Donoghue AJ, Pastro L, Pi-Denis N, Basika T, Roche L, McKerrow JH, Craik CS, Caffrey CR, Tort JF
• Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors.
  PLoS pathogens 2018 Binning JM, Smith AM, Hultquist JF, Craik CS, Caretta Cartozo N, Campbell MG, Burton L, La Greca F, McGregor MJ, Ta HM, Bartholomeeusen K, Peterlin BM, Krogan NJ, Sevillano N, Cheng Y, Gross JD
• Cryo-EM structures of the TMEM16A calcium-activated chloride channel.
  Nature 2017 Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbühler K, Ye W, Qi L, Chen T, Craik CS, Jan YN, Minor DL, Cheng Y, Jan LY
• Global substrate specificity profiling of post-translational modifying enzymes.
  Protein science : a publication of the Protein Society 2017 Ivry SL, Meyer NO, Winter MB, Bohn MF, Knudsen GM, O'Donoghue AJ, Craik CS
• Immunoproteasome functions explained by divergence in cleavage specificity and regulation.
  eLife 2017 Winter MB, La Greca F, Arastu-Kapur S, Caiazza F, Cimermancic P, Buchholz TJ, Anderl JL, Ravalin M, Bohn MF, Sali A, O'Donoghue AJ, Craik CS
• Imaging PD-L1 Expression with ImmunoPET.
  Bioconjugate chemistry 2017 Truillet C, Oh HLJ, Yeo SP, Lee CY, Huynh LT, Wei J, Parker MFL, Blakely C, Sevillano N, Wang YH, Shen YS, Olivas V, Jami KM, Moroz A, Jego B, Jaumain E, Fong L, Craik CS, Chang AJ, Bivona TG, Wang CI…
• Biochemical Basis for Distinct Roles of the Heterochromatin Proteins Swi6 and Chp2.
  Journal of molecular biology 2017 Isaac RS, Sanulli S, Tibble R, Hornsby M, Ravalin M, Craik CS, Gross JD, Narlikar GJ
• Allosteric Inhibitors, Crystallography, and Comparative Analysis Reveal Network of Coordinated Movement across Human Herpesvirus Proteases.
  Journal of the American Chemical Society 2017 Acker TM, Gable JE, Bohn MF, Jaishankar P, Thompson MC, Fraser JS, Renslo AR, Craik CS
• Analysis of the substrate specificity of Factor VII activating protease (FSAP) and design of specific and sensitive peptide substrates.
  Thrombosis and haemostasis 2017 Kara E, Manna D, Løset GÅ, Schneider EL, Craik CS, Kanse S
• Matriptase Induction of Metalloproteinase-Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms.
  Arthritis & rheumatology (Hoboken, N.J.) 2017 Wilkinson DJ, Wang H, Habgood A, Lamb HK, Thompson P, Hawkins AR, Désilets A, Leduc R, Steinmetzer T, Hammami M, Lee MS, Craik CS, Watson S, Lin H, Milner JM, Rowan AD
• Substrate Profiling and High Resolution Co-complex Crystal Structure of a Secreted C11 Protease Conserved across Commensal Bacteria.
  ACS chemical biology 2017 Roncase EJ, Moon C, Chatterjee S, González-Páez GE, Craik CS, O'Donoghue AJ, Wolan DW
• Global Protease Activity Profiling Provides Differential Diagnosis of Pancreatic Cysts.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2017 Ivry SL, Sharib JM, Dominguez DA, Roy N, Hatcher SE, Yip-Schneider MT, Schmidt CM, Brand RE, Park WG, Hebrok M, Kim GE, O'Donoghue AJ, Kirkwood KS, Craik CS
• Synthesis and mechanistic evaluation of novel N'-benzylidene-carbohydrazide-1H-pyrazolo[3,4-b]pyridine derivatives as non-anionic antiplatelet agents.
  European journal of medicinal chemistry 2017 Lourenço AL, Salvador RRS, Silva LA, Saito MS, Mello JFR, Cabral LM, Rodrigues CR, Vera MAF, Muri EMF, de Souza AMT, Craik CS, Dias LRS, Castro HC, Sathler PC
• Multiplex Substrate Profiling by Mass Spectrometry for Kinases as a Method for Revealing Quantitative Substrate Motifs.
  Analytical chemistry 2017 Meyer NO, O'Donoghue AJ, Schulze-Gahmen U, Ravalin M, Moss SM, Winter MB, Knudsen GM, Craik CS
• Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases.
  Cell 2017 Guo CJ, Chang FY, Wyche TP, Backus KM, Acker TM, Funabashi M, Taketani M, Donia MS, Nayfach S, Pollard KS, Craik CS, Cravatt BF, Clardy J, Voigt CA, Fischbach MA
• Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence.
  PLoS pathogens 2016 Clarke SC, Dumesic PA, Homer CM, O'Donoghue AJ, La Greca F, Pallova L, Majer P, Madhani HD, Craik CS
• Clustering of disulfide-rich peptides provides scaffolds for hit discovery by phage display: application to interleukin-23.
  BMC bioinformatics 2016 Barkan DT, Cheng XL, Celino H, Tran TT, Bhandari A, Craik CS, Sali A, Smythe ML
• Global Identification of Biofilm-Specific Proteolysis in Candida albicans.
  mBio 2016 Winter MB, Salcedo EC, Lohse MB, Hartooni N, Gulati M, Sanchez H, Takagi J, Hube B, Andes DR, Johnson AD, Craik CS, Nobile CJ
• Procathepsin E is highly abundant but minimally active in pancreatic ductal adenocarcinoma tumors.
  Biological chemistry 2016 O'Donoghue AJ, Ivry SL, Chaudhury C, Hostetter DR, Hanahan D, Craik CS
• Cysteine and Aspartyl Proteases Contribute to Protein Digestion in the Gut of Freshwater Planaria.
  PLoS neglected tropical diseases 2016 Goupil LS, Ivry SL, Hsieh I, Suzuki BM, Craik CS, O'Donoghue AJ, McKerrow JH
• Label-Free Electrical Detection of Enzymatic Reactions in Nanochannels.
  ACS nano 2016 Duan C, Alibakhshi MA, Kim DK, Brown CM, Craik CS, Majumdar A
• Design of Selective Substrates and Activity-Based Probes for Hydrolase Important for Pathogenesis 1 (HIP1) from Mycobacterium tuberculosis.
  ACS infectious diseases 2016 Lentz CS, Ordonez AA, Kasperkiewicz P, La Greca F, O'Donoghue AJ, Schulze CJ, Powers JC, Craik CS, Drag M, Jain SK, Bogyo M
• Intracellular Action of a Secreted Peptide Required for Fungal Virulence.
  Cell host & microbe 2016 Homer CM, Summers DK, Goranov AI, Clarke SC, Wiesner DL, Diedrich JK, Moresco JJ, Toffaletti D, Upadhya R, Caradonna I, Petnic S, Pessino V, Cuomo CA, Lodge JK, Perfect J, Yates JR, Nielsen K, Craik …
• Matriptase activation connects tissue factor-dependent coagulation initiation to epithelial proteolysis and signaling.
  Blood 2016 Le Gall SM, Szabo R, Lee M, Kirchhofer D, Craik CS, Bugge TH, Camerer E
• Site-Specific Radiofluorination of Biomolecules with 8-[(18)F]-Fluorooctanoic Acid Catalyzed by Lipoic Acid Ligase.
  ACS chemical biology 2016 Drake CR, Sevillano N, Truillet C, Craik CS, VanBrocklin HF, Evans MJ
• Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Julien O, Zhuang M, Wiita AP, O'Donoghue AJ, Knudsen GM, Craik CS, Wells JA
• Structure- and function-based design of Plasmodium-selective proteasome inhibitors.
  Nature 2016 Li H, O'Donoghue AJ, van der Linden WA, Xie SC, Yoo E, Foe IT, Tilley L, Craik CS, da Fonseca PC, Bogyo M
• Fragment-Based Protein-Protein Interaction Antagonists of a Viral Dimeric Protease.
  ChemMedChem 2016 Gable JE, Lee GM, Acker TM, Hulce KR, Gonzalez ER, Schweigler P, Melkko S, Farady CJ, Craik CS
• Complementary Proteomic and Biochemical Analysis of Peptidases in Lobster Gastric Juice Uncovers the Functional Role of Individual Enzymes in Food Digestion.
  Marine biotechnology (New York, N.Y.) 2015 Bibo-Verdugo B, O'Donoghue AJ, Rojo-Arreola L, Craik CS, García-Carreño F
• Evolutionary Selection on Barrier Activity: Bar1 Is an Aspartyl Protease with Novel Substrate Specificity.
  mBio 2015 Jones SK, Clarke SC, Craik CS, Bennett RJ
• In vivo imaging of protease activity by Probody therapeutic activation.
  Biochimie 2015 Wong KR, Menendez E, Craik CS, Kavanaugh WM, Vasiljeva O
• Non-invasive imaging and cellular tracking of pulmonary emboli by near-infrared fluorescence and positron-emission tomography.
  Nature communications 2015 Page MJ, Lourenço AL, David T, LeBeau AM, Cattaruzza F, Castro HC, VanBrocklin HF, Coughlin SR, Craik CS
• Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles.
  Biochimie 2015 Dvorák J, Fajtová P, Ulrychová L, Leontovyc A, Rojo-Arreola L, Suzuki BM, Horn M, Mareš M, Craik CS, Caffrey CR, O'Donoghue AJ
• Destructin-1 is a collagen-degrading endopeptidase secreted by Pseudogymnoascus destructans, the causative agent of white-nose syndrome.
  Proceedings of the National Academy of Sciences of the United States of America 2015 O'Donoghue AJ, Knudsen GM, Beekman C, Perry JA, Johnson AD, DeRisi JL, Craik CS, Bennett RJ
• Ecotin: Exploring a feasible antithrombotic profile.
  International journal of biological macromolecules 2015 Wermelinger LS, Frattani FS, Carneiro-Lobo TC, Craik CS, Castro HC, Zingali RB
• Imaging active urokinase plasminogen activator in prostate cancer.
  Cancer research 2015 LeBeau AM, Sevillano N, Markham K, Winter MB, Murphy ST, Hostetter DR, West J, Lowman H, Craik CS, VanBrocklin HF
• Structural requirements for the collagenase and elastase activity of cathepsin K and its selective inhibition by an exosite inhibitor.
  The Biochemical journal 2015 Sharma V, Panwar P, O'Donoghue AJ, Cui H, Guido RV, Craik CS, Brömme D
• Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter.
  Nature 2014 Kim J, Wu S, Tomasiak TM, Mergel C, Winter MB, Stiller SB, Robles-Colmanares Y, Stroud RM, Tampé R, Craik CS, Cheng Y
• Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity.
  The Journal of biological chemistry 2014 Skala W, Utzschneider DT, Magdolen V, Debela M, Guo S, Craik CS, Brandstetter H, Goettig P
• Cullin E3 ligases and their rewiring by viral factors.
  Biomolecules 2014 Mahon C, Krogan NJ, Craik CS, Pick E
• Current and potential treatments for ubiquitous but neglected herpesvirus infections.
  Chemical reviews 2014 Gable JE, Acker TM, Craik CS
• Sensitive and selective plasmon ruler nanosensors for monitoring the apoptotic drug response in leukemia.
  ACS nano 2014 Tajon CA, Seo D, Asmussen J, Shah N, Jun YW, Craik CS
• The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis.
  Cancer discovery 2014 Lucas JM, Heinlein C, Kim T, Hernandez SA, Malik MS, True LD, Morrissey C, Corey E, Montgomery B, Mostaghel E, Clegg N, Coleman I, Brown CM, Schneider EL, Craik C, Simon JA, Bedalov A, Nelson PS
• Broad-spectrum allosteric inhibition of herpesvirus proteases.
  Biochemistry 2014 Gable JE, Lee GM, Jaishankar P, Hearn BR, Waddling CA, Renslo AR, Craik CS
• Urokinase-type plasminogen activator receptor (uPAR) ligation induces a raft-localized integrin signaling switch that mediates the hypermotile phenotype of fibrotic fibroblasts.
  The Journal of biological chemistry 2014 Grove LM, Southern BD, Jin TH, White KE, Paruchuri S, Harel E, Wei Y, Rahaman SO, Gladson CL, Ding Q, Craik CS, Chapman HA, Olman MA
• Imaging the urokinase plasminongen activator receptor in preclinical breast cancer models of acquired drug resistance.
  Theranostics 2014 LeBeau AM, Sevillano N, King ML, Duriseti S, Murphy ST, Craik CS, Murphy LL, VanBrocklin HF
• Single-molecule sensing of caspase activation in live cells via plasmon coupling nanotechnology.
  Methods in enzymology 2014 Tajon C, Jun YW, Craik CS
• MEK-dependent negative feedback underlies BCR-ABL-mediated oncogene addiction.
  Cancer discovery 2013 Asmussen J, Lasater EA, Tajon C, Oses-Prieto J, Jun YW, Taylor BS, Burlingame A, Craik CS, Shah NP
• Elastin degradation by cathepsin V requires two exosites.
  The Journal of biological chemistry 2013 Du X, Chen NL, Wong A, Craik CS, Brömme D
• Global substrate profiling of proteases in human neutrophil extracellular traps reveals consensus motif predominantly contributed by elastase.
  PloS one 2013 O'Donoghue AJ, Jin Y, Knudsen GM, Perera NC, Jenne DE, Murphy JE, Craik CS, Hermiston TW
• Dissecting the active site of the collagenolytic cathepsin L3 protease of the invasive stage of Fasciola hepatica.
  PLoS neglected tropical diseases 2013 Corvo I, O'Donoghue AJ, Pastro L, Pi-Denis N, Eroy-Reveles A, Roche L, McKerrow JH, Dalton JP, Craik CS, Caffrey CR, Tort JF
• Substrate specificity of MarP, a periplasmic protease required for resistance to acid and oxidative stress in Mycobacterium tuberculosis.
  The Journal of biological chemistry 2013 Small JL, O'Donoghue AJ, Boritsch EC, Tsodikov OV, Knudsen GM, Vandal O, Craik CS, Ehrt S
• Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors.
  The Journal of biological chemistry 2013 Raman K, Trivedi NN, Raymond WW, Ganesan R, Kirchhofer D, Verghese GM, Craik CS, Schneider EL, Nimishakavi S, Caughey GH
• Targeting uPAR with antagonistic recombinant human antibodies in aggressive breast cancer.
  Cancer research 2013 LeBeau AM, Duriseti S, Murphy ST, Pepin F, Hann B, Gray JW, VanBrocklin HF, Craik CS
• Imaging a functional tumorigenic biomarker in the transformed epithelium.
  Proceedings of the National Academy of Sciences of the United States of America 2012 LeBeau AM, Lee M, Murphy ST, Hann BC, Warren RS, Delos Santos R, Kurhanewicz J, Hanash SM, VanBrocklin HF, Craik CS
• Mapping inhibitor binding modes on an active cysteine protease via nuclear magnetic resonance spectroscopy.
  Biochemistry 2012 Lee GM, Balouch E, Goetz DH, Lazic A, McKerrow JH, Craik CS
• Global identification of peptidase specificity by multiplex substrate profiling.
  Nature methods 2012 O'Donoghue AJ, Eroy-Reveles AA, Knudsen GM, Ingram J, Zhou M, Statnekov JB, Greninger AL, Hostetter DR, Qu G, Maltby DA, Anderson MO, Derisi JL, McKerrow JH, Burlingame AL, Craik CS
• Activity and inhibition of prostasin and matriptase on apical and basolateral surfaces of human airway epithelial cells.
  American journal of physiology. Lung cellular and molecular physiology 2012 Nimishakavi S, Besprozvannaya M, Raymond WW, Craik CS, Gruenert DC, Caughey GH
• Characterization of gut-associated cathepsin D hemoglobinase from tick Ixodes ricinus (IrCD1).
  The Journal of biological chemistry 2012 Sojka D, Franta Z, Frantová H, Bartosová P, Horn M, Váchová J, O'Donoghue AJ, Eroy-Reveles AA, Craik CS, Knudsen GM, Caffrey CR, McKerrow JH, Mares M, Kopácek P
• Fabs enable single particle cryoEM studies of small proteins.
  Structure (London, England : 1993) 2012 Wu S, Avila-Sakar A, Kim J, Booth DS, Greenberg CH, Rossi A, Liao M, Li X, Alian A, Griner SL, Juge N, Yu Y, Mergel CM, Chaparro-Riggers J, Strop P, Tampé R, Edwards RH, Stroud RM, Craik CS, Cheng Y
• Investigation of the proteolytic functions of an expanded cercarial elastase gene family in Schistosoma mansoni.
  PLoS neglected tropical diseases 2012 Ingram JR, Rafi SB, Eroy-Reveles AA, Ray M, Lambeth L, Hsieh I, Ruelas D, Lim KC, Sakanari J, Craik CS, Jacobson MP, McKerrow JH
• Analysis of Fasciola cathepsin L5 by S2 subsite substitutions and determination of the P1-P4 specificity reveals an unusual preference.
  Biochimie 2012 Norbury LJ, Hung A, Beckham S, Pike RN, Spithill TW, Craik CS, Choe Y, Fecondo JV, Smooker PM
• A screening strategy for trapping the inactive conformer of a dimeric enzyme with a small molecule inhibitor.
  Methods in molecular biology (Clifton, N.J.) 2012 Craik CS, Shahian T
• Global landscape of HIV-human protein complexes.
  Nature 2011 Jäger S, Cimermancic P, Gulbahce N, Johnson JR, McGovern KE, Clarke SC, Shales M, Mercenne G, Pache L, Li K, Hernandez H, Jang GM, Roth SL, Akiva E, Marlett J, Stephens M, D'Orso I, Fernandes J, Fahey…
• Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection.
  Nature 2011 Jäger S, Kim DY, Hultquist JF, Shindo K, LaRue RS, Kwon E, Li M, Anderson BD, Yen L, Stanley D, Mahon C, Kane J, Franks-Skiba K, Cimermancic P, Burlingame A, Sali A, Craik CS, Harris RS, Gross JD, …
• A reverse binding motif that contributes to specific protease inhibition by antibodies.
  Journal of molecular biology 2011 Schneider EL, Lee MS, Baharuddin A, Goetz DH, Farady CJ, Ward M, Wang CI, Craik CS
• Rapid identification of recombinant Fabs that bind to membrane proteins.
  Methods (San Diego, Calif.) 2011 Kim J, Stroud RM, Craik CS
• Inhibition of Granzyme B by PI-9 protects prostate cancer cells from apoptosis.
  The Prostate 2011 Ray M, Hostetter DR, Loeb CR, Simko J, Craik CS
• Human and mouse granzyme M display divergent and species-specific substrate specificities.
  The Biochemical journal 2011 de Poot SA, Westgeest M, Hostetter DR, Van Damme P, Plasman K, Demeyer K, Broekhuizen R, Gevaert K, Craik CS, Bovenschen N
• Inhibitors of SARS-CoV entry--identification using an internally-controlled dual envelope pseudovirion assay.
  Antiviral research 2011 Zhou Y, Agudelo J, Lu K, Goetz DH, Hansell E, Chen YT, Roush WR, McKerrow J, Craik CS, Amberg SM, Simmons G
• IrCL1 - the haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus.
  International journal for parasitology 2011 Franta Z, Sojka D, Frantova H, Dvorak J, Horn M, Srba J, Talacko P, Mares M, Schneider E, Craik CS, McKerrow JH, Caffrey CR, Kopacek P
• GPS-Prot: a web-based visualization platform for integrating host-pathogen interaction data.
  BMC bioinformatics 2011 Fahey ME, Bennett MJ, Mahon C, Jäger S, Pache L, Kumar D, Shapiro A, Rao K, Chanda SK, Craik CS, Frankel AD, Krogan NJ
• Enzyme inhibition by allosteric capture of an inactive conformation.
  Journal of molecular biology 2011 Lee GM, Shahian T, Baharuddin A, Gable JE, Craik CS
• Proteases as therapeutics.
  The Biochemical journal 2011 Craik CS, Page MJ, Madison EL
• Peptide length and leaving-group sterics influence potency of peptide phosphonate protease inhibitors.
  Chemistry & biology 2011 Brown CM, Ray M, Eroy-Reveles AA, Egea P, Tajon C, Craik CS
• Mechanisms of macromolecular protease inhibitors.
  Chembiochem : a European journal of chemical biology 2010 Farady CJ, Craik CS
• The oligopeptidase B of Leishmania regulates parasite enolase and immune evasion.
  The Journal of biological chemistry 2010 Swenerton RK, Zhang S, Sajid M, Medzihradszky KF, Craik CS, Kelly BL, McKerrow JH
• Biochemical properties of a novel cysteine protease of Plasmodium vivax, vivapain-4.
  PLoS neglected tropical diseases 2010 Na BK, Bae YA, Zo YG, Choe Y, Kim SH, Desai PV, Avery MA, Craik CS, Kim TS, Rosenthal PJ, Kong Y
• How immune peptidases change specificity: cathepsin G gained tryptic function but lost efficiency during primate evolution.
  Journal of immunology (Baltimore, Md. : 1950) 2010 Raymond WW, Trivedi NN, Makarova A, Ray M, Craik CS, Caughey GH
• Characterization of proteinases from the midgut of Rhipicephalus (Boophilus) microplus involved in the generation of antimicrobial peptides.
  Parasites & vectors 2010 Cruz CE, Fogaça AC, Nakayasu ES, Angeli CB, Belmonte R, Almeida IC, Miranda A, Miranda MT, Tanaka AS, Braz GR, Craik CS, Schneider E, Caffrey CR, Daffre S
• Prediction of protease substrates using sequence and structure features.
  Bioinformatics (Oxford, England) 2010 Barkan DT, Hostetter DR, Mahrus S, Pieper U, Wells JA, Craik CS, Sali A
• Antagonistic anti-urokinase plasminogen activator receptor (uPAR) antibodies significantly inhibit uPAR-mediated cellular signaling and migration.
  The Journal of biological chemistry 2010 Duriseti S, Goetz DH, Hostetter DR, LeBeau AM, Wei Y, Craik CS
• A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target.
  The Journal of biological chemistry 2010 He C, Nora GP, Schneider EL, Kerr ID, Hansell E, Hirata K, Gonzalez D, Sajid M, Boyd SE, Hruz P, Cobo ER, Le C, Liu WT, Eckmann L, Dorrestein PC, Houpt ER, Brinen LS, Craik CS, Roush WR, McKerrow J, …
• Analysis of an engineered plasma kallikrein inhibitor and its effect on contact activation.
  Biological chemistry 2010 Stoop AA, Joshi RV, Eggers CT, Craik CS
• Prostate-specific antigen: an overlooked candidate for the targeted treatment and selective imaging of prostate cancer.
  Biological chemistry 2010 LeBeau AM, Kostova M, Craik CS, Denmeade SR
• Mycobacterium tuberculosis MycP1 protease plays a dual role in regulation of ESX-1 secretion and virulence.
  Cell host & microbe 2010 Ohol YM, Goetz DH, Chan K, Shiloh MU, Craik CS, Cox JS
• Time-resolved single-step protease activity quantification using nanoplasmonic resonator sensors.
  ACS nano 2010 Sun C, Su KH, Valentine J, Rosa-Bauza YT, Ellman JA, Elboudwarej O, Mukherjee B, Craik CS, Shuman MA, Chen FF, Zhang X
• Tumor detection by imaging proteolytic activity.
  Cancer research 2010 Darragh MR, Schneider EL, Lou J, Phojanakong PJ, Farady CJ, Marks JD, Hann BC, Craik CS
• Local protease signaling contributes to neural tube closure in the mouse embryo.
  Developmental cell 2010 Camerer E, Barker A, Duong DN, Ganesan R, Kataoka H, Cornelissen I, Darragh MR, Hussain A, Zheng YW, Srinivasan Y, Brown C, Xu SM, Regard JB, Lin CY, Craik CS, Kirchhofer D, Coughlin SR
• Continuous imaging of plasmon rulers in live cells reveals early-stage caspase-3 activation at the single-molecule level.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Jun YW, Sheikholeslami S, Hostetter DR, Tajon C, Craik CS, Alivisatos AP
• Engineering ecotin for identifying proteins with a trypsin fold.
  Applied biochemistry and biotechnology 2009 Sathler PC, Craik CS, Takeuchi T, Zingali RB, Castro HC
• Inhibition of a viral enzyme by a small-molecule dimer disruptor.
  Nature chemical biology 2009 Shahian T, Lee GM, Lazic A, Arnold LA, Velusamy P, Roels CM, Guy RK, Craik CS
• Vinyl sulfones as antiparasitic agents and a structural basis for drug design.
  The Journal of biological chemistry 2009 Kerr ID, Lee JH, Farady CJ, Marion R, Rickert M, Sajid M, Pandey KC, Caffrey CR, Legac J, Hansell E, McKerrow JH, Craik CS, Rosenthal PJ, Brinen LS
• Two approaches to discovering and developing new drugs for Chagas disease.
  Memorias do Instituto Oswaldo Cruz 2009 McKerrow JH, Doyle PS, Engel JC, Podust LM, Robertson SA, Ferreira R, Saxton T, Arkin M, Kerr ID, Brinen LS, Craik CS
• Characterization of a multimeric, eukaryotic prolyl aminopeptidase: an inducible and highly specific intracellular peptidase from the non-pathogenic fungus Talaromyces emersonii.
  Microbiology (Reading, England) 2009 Mahon CS, O'Donoghue AJ, Goetz DH, Murray PG, Craik CS, Tuohy MG
• SmCL3, a gastrodermal cysteine protease of the human blood fluke Schistosoma mansoni.
  PLoS neglected tropical diseases 2009 Dvorák J, Mashiyama ST, Sajid M, Braschi S, Delcroix M, Schneider EL, McKerrow WH, Bahgat M, Hansell E, Babbitt PC, Craik CS, McKerrow JH, Caffrey CR
• Improving the species cross-reactivity of an antibody using computational design.
  Bioorganic & medicinal chemistry letters 2009 Farady CJ, Sellers BD, Jacobson MP, Craik CS
• Substrate specificity of transthyretin: identification of natural substrates in the nervous system.
  The Biochemical journal 2009 Liz MA, Fleming CE, Nunes AF, Almeida MR, Mar FM, Choe Y, Craik CS, Powers JC, Bogyo M, Sousa MM
• Trapping moving targets with small molecules.
  Science (New York, N.Y.) 2009 Lee GM, Craik CS
• Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3.
  PloS one 2009 Subramanian S, Hardt M, Choe Y, Niles RK, Johansen EB, Legac J, Gut J, Kerr ID, Craik CS, Rosenthal PJ
• Active plasma kallikrein localizes to mast cells and regulates epithelial cell apoptosis, adipocyte differentiation, and stromal remodeling during mammary gland involution.
  The Journal of biological chemistry 2009 Lilla JN, Joshi RV, Craik CS, Werb Z
• Positional scanning synthetic combinatorial libraries for substrate profiling.
  Methods in molecular biology (Clifton, N.J.) 2009 Schneider EL, Craik CS
• Quantitative and label-free technique for measuring protease activity and inhibition using a microfluidic cantilever array.
  Nano letters 2008 Raorane DA, Lim MD, Chen FF, Craik CS, Majumdar A
• A parasite cysteine protease is key to host protein degradation and iron acquisition.
  The Journal of biological chemistry 2008 O'Brien TC, Mackey ZB, Fetter RD, Choe Y, O'Donoghue AJ, Zhou M, Craik CS, Caffrey CR, McKerrow JH
• Inhibition of a secreted glutamic peptidase prevents growth of the fungus Talaromyces emersonii.
  The Journal of biological chemistry 2008 O'Donoghue AJ, Mahon CS, Goetz DH, O'Malley JM, Gallagher DM, Zhou M, Murray PG, Craik CS, Tuohy MG
• The functional expression and characterisation of a cysteine peptidase from the invasive stage of the neuropathogenic schistosome Trichobilharzia regenti.
  International journal for parasitology 2008 Dolecková K, Kasný M, Mikes L, Cartwright J, Jedelský P, Schneider EL, Dvorák J, Mountford AP, Craik CS, Horák P
• Characterization of a cysteine protease from Tritrichomonas foetus that induces host-cell apoptosis.
  Archives of biochemistry and biophysics 2008 Lucas JJ, Hayes GR, Kalsi HK, Gilbert RO, Choe Y, Craik CS, Singh BN
• Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7.
  Biological chemistry 2008 Debela M, Beaufort N, Magdolen V, Schechter NM, Craik CS, Schmitt M, Bode W, Goettig P
• Structure of an Fab-protease complex reveals a highly specific non-canonical mechanism of inhibition.
  Journal of molecular biology 2008 Farady CJ, Egea PF, Schneider EL, Darragh MR, Craik CS
• Identification of the major cysteine protease of Giardia and its role in encystation.
  The Journal of biological chemistry 2008 DuBois KN, Abodeely M, Sakanari J, Craik CS, Lee M, McKerrow JH, Sajid M
• Using specificity to strategically target proteases.
  Bioorganic & medicinal chemistry 2008 Lim MD, Craik CS
• MT-SP1 proteolysis and regulation of cell-microenvironment interactions.
  Frontiers in bioscience : a journal and virtual library 2008 Darragh MR, Bhatt AS, Craik CS
• Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica.
  The Journal of biological chemistry 2007 Stack CM, Caffrey CR, Donnelly SM, Seshaadri A, Lowther J, Tort JF, Collins PR, Robinson MW, Xu W, McKerrow JH, Craik CS, Geiger SR, Marion R, Brinen LS, Dalton JP
• Substrate modulation of enzyme activity in the herpesvirus protease family.
  Journal of molecular biology 2007 Lazic A, Goetz DH, Nomura AM, Marnett AB, Craik CS
• Hip is a pro-survival substrate of granzyme B.
  The Journal of biological chemistry 2007 Hostetter DR, Loeb CR, Chu F, Craik CS
• Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus.
  Biochemistry 2007 Goetz DH, Choe Y, Hansell E, Chen YT, McDowell M, Jonsson CB, Roush WR, McKerrow J, Craik CS
• Peptide-nanoparticle hybrid SERS probes for optical detection of protease activity.
  Journal of nanoscience and nanotechnology 2007 Liu GL, Rosa-Bauza YT, Salisbury CM, Craik C, Ellman JA, Chen FF, Lee LP
• Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model.
  Eukaryotic cell 2007 Meléndez-López SG, Herdman S, Hirata K, Choi MH, Choe Y, Craik C, Caffrey CR, Hansell E, Chávez-Munguía B, Chen YT, Roush WR, McKerrow J, Eckmann L, Guo J, Stanley SL, Reed SL
• The mechanism of inhibition of antibody-based inhibitors of membrane-type serine protease 1 (MT-SP1).
  Journal of molecular biology 2007 Farady CJ, Sun J, Darragh MR, Miller SM, Craik CS
• Coordinate expression and functional profiling identify an extracellular proteolytic signaling pathway.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Bhatt AS, Welm A, Farady CJ, Vásquez M, Wilson K, Craik CS
• IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus.
  International journal for parasitology 2007 Sojka D, Hajdusek O, Dvorák J, Sajid M, Franta Z, Schneider EL, Craik CS, Vancová M, Buresová V, Bogyo M, Sexton KB, McKerrow JH, Caffrey CR, Kopácek P
• Isotope-coded and affinity-tagged cross-linking (ICATXL): an efficient strategy to probe protein interaction surfaces.
  Journal of the American Chemical Society 2006 Chu F, Mahrus S, Craik CS, Burlingame AL
• Expression and characterization of constitutively active human caspase-14.
  Biochemical and biophysical research communications 2006 Park K, Kuechle MK, Choe Y, Craik CS, Lawrence OT, Presland RB
• Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis.
  The Journal of biological chemistry 2006 Loeb CR, Harris JL, Craik CS
• Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice.
  The EMBO journal 2006 Lund LR, Green KA, Stoop AA, Ploug M, Almholt K, Lilla J, Nielsen BS, Christensen IJ, Craik CS, Werb Z, Danø K, Rømer J
• Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences.
  The Journal of biological chemistry 2006 Debela M, Magdolen V, Schechter N, Valachova M, Lottspeich F, Craik CS, Choe Y, Bode W, Goettig P
• Ecotin modulates thrombin activity through exosite-2 interactions.
  The international journal of biochemistry & cell biology 2006 Castro HC, Monteiro RQ, Assafim M, Loureiro NI, Craik C, Zingali RB
• Conversion of trypsin to a functional threonine protease.
  Protein science : a publication of the Protein Society 2006 Baird TT, Wright WD, Craik CS
• One functional switch mediates reversible and irreversible inactivation of a herpesvirus protease.
  Biochemistry 2006 Nomura AM, Marnett AB, Shimba N, Dötsch V, Craik CS
• Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities.
  The Journal of biological chemistry 2006 Choe Y, Leonetti F, Greenbaum DC, Lecaille F, Bogyo M, Brömme D, Ellman JA, Craik CS
• Induced structure of a helical switch as a mechanism to regulate enzymatic activity.
  Nature structural & molecular biology 2005 Nomura AM, Marnett AB, Shimba N, Dötsch V, Craik CS
• Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers.
  The Biochemical journal 2005 Herter S, Piper DE, Aaron W, Gabriele T, Cutler G, Cao P, Bhatt AS, Choe Y, Craik CS, Walker N, Meininger D, Hoey T, Austin RJ
• Adhesion signaling by a novel mitotic substrate of src kinases.
  Oncogene 2005 Bhatt AS, Erdjument-Bromage H, Tempst P, Craik CS, Moasser MM
• Selective chemical functional probes of granzymes A and B reveal granzyme B is a major effector of natural killer cell-mediated lysis of target cells.
  Chemistry & biology 2005 Mahrus S, Craik CS
• Development of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease.
  Bioorganic & medicinal chemistry 2005 Choe Y, Brinen LS, Price MS, Engel JC, Lange M, Grisostomi C, Weston SG, Pallai PV, Cheng H, Hardy LW, Hartsough DS, McMakin M, Tilton RF, Baldino CM, Craik CS
• Papa's got a brand new tag: advances in identification of proteases and their substrates.
  Trends in biotechnology 2005 Marnett AB, Craik CS
• Substrates of the prostate-specific serine protease prostase/KLK4 defined by positional-scanning peptide libraries.
  The Prostate 2005 Matsumura M, Bhatt AS, Andress D, Clegg N, Takayama TK, Craik CS, Nelson PS
• Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B.
  The Journal of biological chemistry 2004 Mahrus S, Kisiel W, Craik CS
• Optimization of 13C direct detection NMR methods.
  Journal of biomolecular NMR 2004 Shimba N, Kovacs H, Stern AS, Nomura AM, Shimada I, Hoch JC, Craik CS, Dötsch V
• A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms.
  The Journal of biological chemistry 2004 Williamson AL, Lecchi P, Turk BE, Choe Y, Hotez PJ, McKerrow JH, Cantley LC, Sajid M, Craik CS, Loukas A
• Methyl groups as probes for proteins and complexes in in-cell NMR experiments.
  Journal of the American Chemical Society 2004 Serber Z, Straub W, Corsini L, Nomura AM, Shimba N, Craik CS, Ortiz de Montellano P, Dötsch V
• Characterization of structural determinants of granzyme B reveals potent mediators of extended substrate specificity.
  The Journal of biological chemistry 2004 Ruggles SW, Fletterick RJ, Craik CS
• Communication between the active sites and dimer interface of a herpesvirus protease revealed by a transition-state inhibitor.
  Proceedings of the National Academy of Sciences of the United States of America 2004 Marnett AB, Nomura AM, Shimba N, Ortiz de Montellano PR, Craik CS
• The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase.
  The Biochemical journal 2004 Eggers CT, Murray IA, Delmar VA, Day AG, Craik CS
• Identification and biochemical characterization of vivapains, cysteine proteases of the malaria parasite Plasmodium vivax.
  The Biochemical journal 2004 Na BK, Shenai BR, Sijwali PS, Choe Y, Pandey KC, Singh A, Craik CS, Rosenthal PJ
• Untitled Publication
  2004 Brachyurins. Tsu, C., and Craik, C.S. Handbook of Proteolytic Enzymes
• Untitled Publication
  2004 Shimba, N. Nomura, A.M., Marnett, A.B. and Craik, C.S. Herpesvirus Protease Inhibition by Dimer Disruption. J. Virol
• Engineering of a macromolecular scaffold to develop specific protease inhibitors.
  Nature biotechnology 2003 Stoop AA, Craik CS
• Quantitative identification of the protonation state of histidines in vitro and in vivo.
  Biochemistry 2003 Shimba N, Serber Z, Ledwidge R, Miller SM, Craik CS, Dötsch V
• The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity.
  Nature structural biology 2003 Bell JK, Goetz DH, Mahrus S, Harris JL, Fletterick RJ, Craik CS
• Albumin is a substrate of human chymase. Prediction by combinatorial peptide screening and development of a selective inhibitor based on the albumin cleavage site.
  The Journal of biological chemistry 2003 Raymond WW, Ruggles SW, Craik CS, Caughey GH
• Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII.
  The Biochemical journal 2003 Leiting B, Pryor KD, Wu JK, Marsilio F, Patel RA, Craik CS, Ellman JA, Cummings RT, Thornberry NA
• The CD8+ cell noncytotoxic anti-HIV response can be blocked by protease inhibitors.
  Proceedings of the National Academy of Sciences of the United States of America 2003 Mackewicz CE, Craik CS, Levy JA
• Elimination of 13Calpha splitting in protein NMR spectra by deconvolution with maximum entropy reconstruction.
  Journal of the American Chemical Society 2003 Shimba N, Stern AS, Craik CS, Hoch JC, Dötsch V
• Potent and selective inhibition of membrane-type serine protease 1 by human single-chain antibodies.
  Biochemistry 2003 Sun J, Pons J, Craik CS
• Quantitation of membrane type serine protease 1 (MT-SP1) in transformed and normal cells.
  Biological chemistry 2003 Bhatt AS, Takeuchi T, Ylstra B, Ginzinger D, Albertson D, Shuman MA, Craik CS
• Critical role of amino acid 23 in mediating activity and specificity of vinckepain-2, a papain-family cysteine protease of rodent malaria parasites.
  The Biochemical journal 2002 Singh A, Shenai BR, Choe Y, Gut J, Sijwali PS, Craik CS, Rosenthal PJ
• Design and synthesis of novel inhibitors of gelatinase B.
  Bioorganic & medicinal chemistry letters 2002 Wang X, Choe Y, Craik CS, Ellman JA
• Selective inhibition of the collagenolytic activity of human cathepsin K by altering its S2 subsite specificity.
  Biochemistry 2002 Lecaille F, Choe Y, Brandt W, Li Z, Craik CS, Brömme D
• Cercarial elastase is encoded by a functionally conserved gene family across multiple species of schistosomes.
  The Journal of biological chemistry 2002 Salter JP, Choe Y, Albrecht H, Franklin C, Lim KC, Craik CS, McKerrow JH
• Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries.
  Molecular and biochemical parasitology 2002 Mathieu MA, Bogyo M, Caffrey CR, Choe Y, Lee J, Chapman H, Sajid M, Craik CS, McKerrow JH
• Anisotropic dynamics of the JE-2147-HIV protease complex: drug resistance and thermodynamic binding mode examined in a 1.09 A structure.
  Biochemistry 2002 Reiling KK, Endres NF, Dauber DS, Craik CS, Stroud RM
• Expedient solid-phase synthesis of fluorogenic protease substrates using the 7-amino-4-carbamoylmethylcoumarin (ACC) fluorophore.
  The Journal of organic chemistry 2002 Maly DJ, Leonetti F, Backes BJ, Dauber DS, Harris JL, Craik CS, Ellman JA
• Conformational change coupling the dimerization and activation of KSHV protease.
  Biochemistry 2002 Pray TR, Reiling KK, Demirjian BG, Craik CS
• Altered substrate specificity of drug-resistant human immunodeficiency virus type 1 protease.
  Journal of virology 2002 Dauber DS, Ziermann R, Parkin N, Maly DJ, Mahrus S, Harris JL, Ellman JA, Petropoulos C, Craik CS
• Novel inter-protein cross-link identified in the GGH-ecotin D137Y dimer.
  Protein science : a publication of the Protein Society 2001 Person MD, Brown KC, Mahrus S, Craik CS, Burlingame AL
• Definition of the extended substrate specificity determinants for beta-tryptases I and II.
  The Journal of biological chemistry 2001 Harris JL, Niles A, Burdick K, Maffitt M, Backes BJ, Ellman JA, Kuntz I, Haak-Frendscho M, Craik CS
• Structural features of a snake venom thrombin-like enzyme: thrombin and trypsin on a single catalytic platform?
  Biochimica et biophysica acta 2001 Castro HC, Silva DM, Craik C, Zingali RB
• The role of ecotin dimerization in protease inhibition.
  Journal of molecular biology 2001 Eggers CT, Wang SX, Fletterick RJ, Craik CS
• A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiation.
  Nature cell biology 2001 Selvarajan S, Lund LR, Takeuchi T, Craik CS, Werb Z
• Lytic replication of Kaposi's sarcoma-associated herpesvirus results in the formation of multiple capsid species: isolation and molecular characterization of A, B, and C capsids from a gammaherpesvirus.
  Journal of virology 2001 Nealon K, Newcomb WW, Pray TR, Craik CS, Brown JC, Kedes DH
• Functional consequences of the Kaposi's sarcoma-associated herpesvirus protease structure: regulation of activity and dimerization by conserved structural elements.
  Biochemistry 2000 Reiling KK, Pray TR, Craik CS, Stroud RM
• The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity.
  Nature structural biology 2000 Waugh SM, Harris JL, Fletterick R, Craik CS
• Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates.
  The Journal of biological chemistry 2000 Takeuchi T, Harris JL, Huang W, Yan KW, Coughlin SR, Craik CS
• Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries.
  Proceedings of the National Academy of Sciences of the United States of America 2000 Harris JL, Backes BJ, Leonetti F, Mahrus S, Ellman JA, Craik CS
• Compromise and accommodation in ecotin, a dimeric macromolecular inhibitor of serine proteases.
  Journal of molecular biology 2000 Gillmor SA, Takeuchi T, Yang SQ, Craik CS, Fletterick RJ
• Cathepsin G activates protease-activated receptor-4 in human platelets.
  The Journal of biological chemistry 2000 Sambrano GR, Huang W, Faruqi T, Mahrus S, Craik C, Coughlin SR
• Macromolecular inhibitors of HIV-1 protease. Characterization of designed heterodimers.
  The Journal of biological chemistry 2000 Rozzelle JE, Dauber DS, Todd S, Kelley R, Craik CS
• HIV protease as a target for retrovirus vector-mediated gene therapy.
  Biochimica et biophysica acta 2000 Todd S, Anderson C, Jolly DJ, Craik CS
• Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin.
  Nature biotechnology 2000 Backes BJ, Harris JL, Leonetti F, Craik CS, Ellman JA
• Yeast two-hybrid assay for examining human immunodeficiency virus protease heterodimer formation with dominant-negative inhibitors and multidrug-resistant variants.
  Analytical biochemistry 2000 Todd S, Laboissière MC, Craik CS
• J. Am. Chem. Soc
  Chemically Mediated Site-Specific Cleavage of Proteins 2000 B. Wang, M. Lodder, J. Zhou, T.T. Baird, Jr., K.C. Brown, C.S. Craik, S.M. Hecht
• Untitled Publication
  2000 K.K. Reiling, T.R. Pray, C.S. Craik, R.M. Stroud. Structure: Regulation of Activity and Dimerization by Conserved Structural Elements. Biochemistry
• Untitled Publication
  2000 T.T. Baird Jr., B. Wang, M. Lodder, S.M. Hecht and C.S. Craik. Generation of Active Trypsin by Chemical Cleavage. Tetrahedron Letters
• Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue.
  Proceedings of the National Academy of Sciences of the United States of America 1999 Takeuchi T, Shuman MA, Craik CS
• Auto-inactivation by cleavage within the dimer interface of Kaposi's sarcoma-associated herpesvirus protease.
  Journal of molecular biology 1999 Pray TR, Nomura AM, Pennington MW, Craik CS
• Definition and redesign of the extended substrate specificity of granzyme B.
  The Journal of biological chemistry 1998 Harris JL, Peterson EP, Hudig D, Thornberry NA, Craik CS
• Ecotin: a serine protease inhibitor with two distinct and interacting binding sites.
  Journal of molecular biology 1998 Yang SQ, Wang CI, Gillmor SA, Fletterick RJ, Craik CS
• Engineering bidentate macromolecular inhibitors for trypsin and urokinase-type plasminogen activator.
  Journal of molecular biology 1998 Yang SQ, Craik CS
• Determining protein-protein interactions by oxidative cross-linking of a glycine-glycine-histidine fusion protein.
  Biochemistry 1998 Brown KC, Yu Z, Burlingame AL, Craik CS
• Domain flexibility in retroviral proteases: structural implications for drug resistant mutations.
  Biochemistry 1998 Rose RB, Craik CS, Stroud RM
• Engineering enzyme specificity.
  Current opinion in chemical biology 1998 Harris JL, Craik CS
• Engineering catalytically defective forms of HIV protease to modulate its activity.
  Advances in experimental medicine and biology 1998 Craik CS, Babé LM, Dauber D, McPhee F, Rosé J, Unal A
• Optimization of a macromolecular inhibitor of HIV-1 protease.
  Advances in experimental medicine and biology 1998 Dauber DS, McPhee F, Unal A, Craik CS
• Evolutionary divergence of substrate specificity within the chymotrypsin-like serine protease fold.
  The Journal of biological chemistry 1997 Perona JJ, Craik CS
• Viral proteases: evolution of diverse structural motifs to optimize function.
  Cell 1997 Babé LM, Craik CS
• Alkylation of a catalytic aspartate group of the SIV protease by an epoxide inhibitor.
  Bioorganic & medicinal chemistry 1997 Caldera PS, Yu Z, Knegtel RM, McPhee F, Burlingame AL, Craik CS, Kuntz ID, Ortiz de Montellano PR
• The protease and the assembly protein of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8).
  Journal of virology 1997 Unal A, Pray TR, Lagunoff M, Pennington MW, Ganem D, Craik CS
• Structural determinants of specificity in the cysteine protease cruzain.
  Protein science : a publication of the Protein Society 1997 Gillmor SA, Craik CS, Fletterick RJ
• The discovery, characterization and crystallographically determined binding mode of an FMOC-containing inhibitor of HIV-1 protease.
  Bioorganic & medicinal chemistry 1997 Rutenber EE, De Voss JJ, Hoffman L, Stroud RM, Lee KH, Alvarez J, McPhee F, Craik C, Ortiz de Montellano PR
• P-4 and RNKP-7, new granzyme-like serine proteases expressed in activated rat lymphocytes.
  Journal of immunology (Baltimore, Md. : 1950) 1997 Ewoldt GR, Smyth MJ, Darcy PK, Harris JL, Craik CS, Horowitz B, Woodard SL, Powers JC, Hudig D
• Crystal structure of an ecotin-collagenase complex suggests a model for recognition and cleavage of the collagen triple helix.
  Biochemistry 1997 Perona JJ, Tsu CA, Craik CS, Fletterick RJ
• Structural basis for the broad substrate specificity of fiddler crab collagenolytic serine protease 1.
  Biochemistry 1997 Tsu CA, Perona JJ, Fletterick RJ, Craik CS
• Obstruction of HIV-1 particle release by interferon-alpha occurs before viral protease processing and is independent of envelope glycoprotein.
  Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1997 Babé LM, Unal A, Craik CS
• Use of the intestinal bile acid transporter for the uptake of cholic acid conjugates with HIV-1 protease inhibitory activity.
  Pharmaceutical research 1997 Kågedahl M, Swaan PW, Redemann CT, Tang M, Craik CS, Szoka FC, Oie S
• Untitled Publication
  1997 C.S. Craik & R.J. Fletterick. The Marriage of Protein Structure and Pharmaceutical Discovery. Biotech. & Appl. Biochem. 26
• Bile pigments as HIV-1 protease inhibitors and their effects on HIV-1 viral maturation and infectivity in vitro.
  The Biochemical journal 1996 McPhee F, Caldera PS, Bemis GW, McDonagh AF, Kuntz ID, Craik CS
• Intracellular expression of human immunodeficiency virus type 1 (HIV-1) protease variants inhibits replication of wild-type and protease inhibitor-resistant HIV-1 strains in human T-cell lines.
  Journal of virology 1996 Junker U, Escaich S, Plavec I, Baker J, McPhee F, Rose JR, Craik CS, Böhnlein E
• Engineering human immunodeficiency virus 1 protease heterodimers as macromolecular inhibitors of viral maturation.
  Proceedings of the National Academy of Sciences of the United States of America 1996 McPhee F, Good AC, Kuntz ID, Craik CS
• Three-dimensional structures of HIV-1 and SIV protease product complexes.
  Biochemistry 1996 Rose RB, Craik CS, Douglas NL, Stroud RM
• X-ray structures of a designed binding site in trypsin show metal-dependent geometry.
  Biochemistry 1996 Brinen LS, Willett WS, Craik CS, Fletterick RJ
• Substrate recognition by recombinant serine collagenase 1 from Uca pugilator.
  The Journal of biological chemistry 1996 Tsu CA, Craik CS
• Isolation and characterization of two cDNAs from Atlantic cod encoding two distinct psychrophilic elastases.
  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 1996 Gudmundsdóttir E, Spilliaert R, Yang Q, Craik CS, Bjarnason JB, Gudmundsdóttir A
• Phage display of proteases and macromolecular inhibitors.
  Methods in enzymology 1996 Wang CI, Yang Q, Craik CS
• Untitled Publication
  1996 E.E. Rutenber, F. McPhee, A.P. Kaplan, S.L. Gallion, J.C. Hogan Jr., C.S. Craik & R.M. Stroud. A New Class of HIV1 Protease Inhibitor: The Crystallographic Structure, Inhibition and Chemical Synthesis…
• Untitled Publication
  1996 R. Li, X. Chen, B. Gong, Z. Li, E. Davidson, G. Kurzban, R.E. Miller, E.O. Nuzman, J.H. McKerrow, R.J. Fletterick, S.A. Gillmore, C.S. Craik, I.D. Kuntz, F.E. Cohen & G.L. Kenyon. Structure-based …
• Untitled Publication
  1996 S. Halfon & C.S. Craik. Regulation of Proteolytic Activity by Engineered Tridentate Metal Binding Loops. J. Am. Chem. Soc. 118
• Untitled Publication
  1996 W.S. Willett, L.S. Brinen, R.J. Fletterick & C.S. Craik. Delocalizing Trypsin Specificity with Metal-Activation. Biochem; 35
• Untitled Publication
  1996 Z. Yu, P. Caldera, F. McPhee, J. DeVoss, P.R. Jones, A. Burlingame, I. Kuntz, C.S. Craik & P.R. Ortiz de Montellano. Irreversible Inhibition of the HIV-1 Protease: Targeting Alkylating Agents to the …
• Trans-dominant inhibitory human immunodeficiency virus type 1 protease monomers prevent protease activation and virion maturation.
  Proceedings of the National Academy of Sciences of the United States of America 1995 Babé LM, Rosé J, Craik CS
• Regulation of clathrin assembly and trimerization defined using recombinant triskelion hubs.
  Cell 1995 Liu SH, Wong ML, Craik CS, Brodsky FM
• Trypsin specificity increased through substrate-assisted catalysis.
  Biochemistry 1995 Corey DR, Willett WS, Coombs GS, Craik CS
• Isolation of a high affinity inhibitor of urokinase-type plasminogen activator by phage display of ecotin.
  The Journal of biological chemistry 1995 Wang CI, Yang Q, Craik CS
• Defining the level of human immunodeficiency virus type 1 (HIV-1) protease activity required for HIV-1 particle maturation and infectivity.
  Journal of virology 1995 Rosé JR, Babé LM, Craik CS
• The crystal structure of cruzain: a therapeutic target for Chagas' disease.
  Journal of molecular biology 1995 McGrath ME, Eakin AE, Engel JC, McKerrow JH, Craik CS, Fletterick RJ
• Conversion of human 15-lipoxygenase to an efficient 12-lipoxygenase: the side-chain geometry of amino acids 417 and 418 determine positional specificity.
  Protein engineering 1995 Sloane DL, Leung R, Barnett J, Craik CS, Sigal E
• Structural basis of substrate specificity in the serine proteases.
  Protein science : a publication of the Protein Society 1995 Perona JJ, Craik CS
• Engineered metal regulation of trypsin specificity.
  Biochemistry 1995 Willett WS, Gillmor SA, Perona JJ, Fletterick RJ, Craik CS
• Untitled Publication
  1995 A.E. Eakin, J.H. McKerrow & C.S.Craik. A Cysteine Protease is a Target for the Enzyme Structure-based Design of Antiparasitic Drugs. Drug Information Journal 29
• Structure-assisted design of nonpeptide human immunodeficiency virus-1 protease inhibitors.
  American journal of respiratory and critical care medicine 1994 Rosé JR, Craik CS
• Constitutive production of nonenveloped human immunodeficiency virus type 1 particles by a mammalian cell line and effects of a protease inhibitor on particle maturation.
  Antimicrobial agents and chemotherapy 1994 Babé LM, Craik CS
• Atlantic cod cDNA encoding a psychrophilic chymotrypsinogen.
  Biochimica et biophysica acta 1994 Guthmundsdóttir A, Oskarsson S, Eakin AE, Craik CS, Bjarnason JB
• The substrate specificity of Uca pugilator collagenolytic serine protease 1 correlates with the bovine type I collagen cleavage sites.
  The Journal of biological chemistry 1994 Tsu CA, Perona JJ, Schellenberger V, Turck CW, Craik CS
• Can small cyclic peptides have the activity and specificity of proteolytic enzymes?
  Proceedings of the National Academy of Sciences of the United States of America 1994 Matthews BW, Craik CS, Neurath H
• In vitro characterization of nonpeptide irreversible inhibitors of HIV proteases.
  The Journal of biological chemistry 1994 Salto R, Babé LM, Li J, Rosé JR, Yu Z, Burlingame A, De Voss JJ, Sui Z, Ortiz de Montellano P, Craik CS
• Exogenous acetate reconstitutes the enzymatic activity of trypsin Asp189Ser.
  Biochemistry 1994 Perona JJ, Hedstrom L, Wagner RL, Rutter WJ, Craik CS, Fletterick RJ
• Haloperidol-based irreversible inhibitors of the HIV-1 and HIV-2 proteases.
  Journal of medicinal chemistry 1994 De Voss JJ, Sui Z, DeCamp DL, Salto R, Babé LM, Craik CS, Ortiz de Montellano PR
• Untitled Publication
  1994 K.L. Lee, F. McPhee, J.J. DeVoss, C.S. Craik & P. Ortiz de Montellano. Nonpeptide HIV Protease Inhibitors. Differential Introduction of Alkylamino Groups into the two Aryl Rings of Haloperidol. J. of …
• A genetic selection elucidates structural determinants of arginine versus lysine specificity in trypsin.
  Gene 1993 Perona JJ, Evnin LB, Craik CS
• Structure of the protease from simian immunodeficiency virus: complex with an irreversible nonpeptide inhibitor.
  Biochemistry 1993 Rose RB, Rosé JR, Salto R, Craik CS, Stroud RM
• Isolation and characterization of cDNAs from Atlantic cod encoding two different forms of trypsinogen.
  European journal of biochemistry 1993 Gudmundsdóttir A, Gudmundsdóttir E, Oskarsson S, Bjarnason JB, Eakin AK, Craik CS
• Locating the catalytic water molecule in serine proteases.
  Science (New York, N.Y.) 1993 Perona JJ, Craik CS, Fletterick RJ
• Trypsin display on the surface of bacteriophage.
  Gene 1993 Corey DR, Shiau AK, Yang Q, Janowski BA, Craik CS
• Regulation of autoproteolysis of the HIV-1 and HIV-2 proteases with engineered amino acid substitutions.
  The Journal of biological chemistry 1993 Rosé JR, Salto R, Craik CS
• Crystal structures of rat anionic trypsin complexed with the protein inhibitors APPI and BPTI.
  Journal of molecular biology 1993 Perona JJ, Tsu CA, Craik CS, Fletterick RJ
• Production of crystallizable cruzain, the major cysteine protease from Trypanosoma cruzi.
  The Journal of biological chemistry 1993 Eakin AE, McGrath ME, McKerrow JH, Fletterick RJ, Craik CS
• Structure of an engineered, metal-actuated switch in trypsin.
  Biochemistry 1993 McGrath ME, Haymore BL, Summers NL, Craik CS, Fletterick RJ
• J. Bio. Chem
  Structure of a Non-Peptide Inhibitor Complexed with HIV-1 Protease: Developing a Cycle of Structure-Based Drug Design 1993 E. Rutenber, E.B. Fauman, R.J. Keenan, S. Fong, P.S. Furth, P.R. Ortiz de Montellano, E. Meng, I.D. Kuntz, D.L. DeCamp, R. Salto, J.R. Rosé, C.S. Craik, R.M. Stroud.
• Synthesis
  Synthesis of Haloperidol Ethanedithioketal HIV-1 Protease Inhibitors: Magnesium Chloride Facilitated Addition of Grignard Reagents 1993 Z. Sui, J. DeVoss, D. DeCamp, J. Li, C.S. Craik & P.R. Ortiz de Montellano
• Untitled Publication
  1993 D.L. Decamp, S.B. Kahl & C.S. Craik. Boronated Porphyrins—A New Class of HIV Proteinase Inhibitors. Intl. Antiviral News 1
• Untitled Publication
  1993 J.J. Perona, C.A. Tsu, M.E. McGrath, C.S. Craik & R.J. Fletterick. Relocating a Negative Charge in the Binding Pocket of Trypsin. J. Mol. Bio. 230
• Untitled Publication
  1993 T.K. Sawyer, J.F. Fisher, J.B. Hester, C.W. Smith, A.G. Tomasselli, W.G. Tarpley, P.S. Burton, J.O. Hui T.J. McQuade, R.A. Conradi, V.S. Bradford, L. Liu, J.H. Kinner, J.Tustin,D.L. Alexander, A.W. …
• Untitled Publication
  1993 Z. Sui, R. Salto, C.S. Craik, P. Ortiz de Montellano. Inhibition of the HIV1 and the HIV2 Proteases by Curcumin and Curcumin Boron Complexes. Bioorg. & Med. Chem. Let. 1
• Synthetic "interface" peptides alter dimeric assembly of the HIV 1 and 2 proteases.
  Protein science : a publication of the Protein Society 1992 Babé LM, Rosé J, Craik CS
• Specific inhibition of HIV-1 protease by boronated porphyrins.
  Journal of medicinal chemistry 1992 DeCamp DL, Babé LM, Salto R, Lucich JL, Koo MS, Kahl SB, Craik CS
• The sequence, organization, and expression of the major cysteine protease (cruzain) from Trypanosoma cruzi.
  The Journal of biological chemistry 1992 Eakin AE, Mills AA, Harth G, McKerrow JH, Craik CS
• Perturbing the polar environment of Asp102 in trypsin: consequences of replacing conserved Ser214.
  Biochemistry 1992 McGrath ME, Vásquez JR, Craik CS, Yang AS, Honig B, Fletterick RJ
• Engineered metalloregulation in enzymes.
  Trends in biochemical sciences 1992 Higaki JN, Fletterick RJ, Craik CS
• Physical map location of the new Escherichia coli gene eco, encoding the serine protease inhibitor ecotin.
  Journal of bacteriology 1992 Erpel T, Hwang P, Craik CS, Fletterick RJ, McGrath ME
• Int. J. Pep. Protein Res
  HIV Protease (HIV PR) Inhibitor Structure-Activity-Selectivity and Active Site Molecular Modeling of High Affinity Leu [CH(OH)CH2] Val Modified Viral and Nonviral Substrate Analogs 1992 T.K. Sawyer, D.J. Staples, L. Liu, A.G. Tomasselli, J.O. Hui, K. O’Connell, H. Schostarez, J.B. Hester, J. Moon, W.J. Howe, C.W. Smith, D. L. DeCamp, C.S. Craik, B.M. Dunn,W. T. Lowther, J. Harris, R.…
• Untitled Publication
  1992 D.R. Corey, M.E. McGrath, J.R. Vasquez, R.J. Fletterick & C.S. Craik. An Alternate Geometry for the Catalytic Triad of Serine Proteases. J. Amer. Chem. Soc. 114
• A primary determinant for lipoxygenase positional specificity.
  Nature 1991 Sloane DL, Leung R, Craik CS, Sigal E
• Crystal structure of rat trypsin-S195C at -150 degrees C. Analysis of low activity of recombinant and semisynthetic thiol proteases.
  Journal of molecular biology 1991 Wilke ME, Higaki JN, Craik CS, Fletterick RJ
• Crystallographic analysis of trypsin-G226A. A specificity pocket mutant of rat trypsin with altered binding and catalysis.
  Journal of molecular biology 1991 Wilke ME, Higaki JN, Craik CS, Fletterick RJ
• The sequence and reactive site of ecotin. A general inhibitor of pancreatic serine proteases from Escherichia coli.
  The Journal of biological chemistry 1991 McGrath ME, Hines WM, Sakanari JA, Fletterick RJ, Craik CS
• Inhibition of HIV protease activity by heterodimer formation.
  Biochemistry 1991 Babé LM, Pichuantes S, Craik CS
• 1.59 A structure of trypsin at 120 K: comparison of low temperature and room temperature structures.
  Proteins 1991 Earnest T, Fauman E, Craik CS, Stroud R
• A Primary Determinant for Lipoxygenase Postional Specificity. Nature 354, 149-152
  A Primary Determinant for Lipoxygenase Postional Specificity. Nature 354, 149-152 1991 D.L. Sloane, R. Leung, C.S. Craik & E. Sigal
• Adv. Exptl. Med. Bio
  Structure-based inhibition of HIV-1 protease activity and viral infectivity 1991 D.L. DeCamp, L.M. Babé, P. Furth, P. Ortiz de Montellano, I.D. Kuntz & C.S. Craik
• Calcium-free calmodulin is a substrate of proteases from human immunodeficiency viruses 1 and 2.
  Proteins 1991 Tomasselli AG, Howe WJ, Hui JO, Sawyer TK, Reardon IM, DeCamp DL, Craik CS, Heinrikson RL
• Expression of cloned human 15-lipoxygenase in eukaryotic and prokaryotic systems.
  Advances in prostaglandin, thromboxane, and leukotriene research 1991 Sloane DL, Dixon RA, Craik CS, Sigal E
• Structure-based inhibition of HIV-1 protease activity and viral infectivity.
  Advances in experimental medicine and biology 1991 DeCamp DL, Babé LM, Furth P, Ortiz de Montellano P, Kuntz ID, Craik CS
• Time dependent heterodimer formation leads to inhibition of HIV protease activity.
  Advances in experimental medicine and biology 1991 Babé LM, Craik CS
• Untitled Publication
  1991 C.S.Craik. Modus Operandi. Nature
• Regulation of serine protease activity by an engineered metal switch.
  Biochemistry 1990 Higaki JN, Haymore BL, Chen S, Fletterick RJ, Craik CS
• Characterization of the human immunodeficiency virus type-1 reverse transcriptase enzyme produced in yeast.
  Biochemical and biophysical research communications 1990 Bathurst IC, Moen LK, Lujan MA, Gibson HL, Feucht PH, Pichuantes S, Craik CS, Santi DV, Barr PJ
• Homeodomain of yeast repressor alpha 2 contains a nuclear localization signal.
  Proceedings of the National Academy of Sciences of the United States of America 1990 Hall MN, Craik C, Hiraoka Y
• Structure-based design of nonpeptide inhibitors specific for the human immunodeficiency virus 1 protease.
  Proceedings of the National Academy of Sciences of the United States of America 1990 DesJarlais RL, Seibel GL, Kuntz ID, Furth PS, Alvarez JC, Ortiz de Montellano PR, DeCamp DL, Babé LM, Craik CS
• Recombinant HIV2 protease processes HIV1 Pr53gag and analogous junction peptides in vitro.
  The Journal of biological chemistry 1990 Pichuantes S, Babé LM, Barr PJ, DeCamp DL, Craik CS
• Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family.
  Proceedings of the National Academy of Sciences of the United States of America 1990 Vanderslice P, Ballinger SM, Tam EK, Goldstein SM, Craik CS, Caughey GH
• Human carboxypeptidase A identifies a BglII RFLP and maps to 7q31-qter.
  American journal of human genetics 1990 Stewart EA, Craik CS, Hake L, Bowcock AM
• Expression of cloned human reticulocyte 15-lipoxygenase and immunological evidence that 15-lipoxygenases of different cell types are related.
  The Journal of biological chemistry 1990 Sigal E, Grunberger D, Highland E, Gross C, Dixon RA, Craik CS
• Amplification and sequencing of genomic DNA fragments encoding cysteine proteases from protozoan parasites.
  Molecular and biochemical parasitology 1990 Eakin AE, Bouvier J, Sakanari JA, Craik CS, McKerrow JH
• The expression of active human reticulocyte 15-lipoxygenase in bacteria.
  Biomedica biochimica acta 1990 Sloane DL, Craik CS, Sigal E
• Untitled Publication
  1990 L. Evnin, J. Vasquez & C.S. Craik. Proc. Substrate Specificity of Trypsin Investigated Using a Genetic Selection. Natl. Acad. Sci. USA 87
• Untitled Publication
  1990 A.L. Ferris, A. Hizi, S.D. Showalter, S. Pichuantes, L. Babé & C.S. Craik. Immunologic and Proteolytic Analysis of HIV-2 Reverse Transcriptase Structure. Virology 175
• Untitled Publication
  1990 E. Stewart, C.S. Craik, L. Hake & A. Bowcock. Human CPA Identifies a BglII RFLP and Maps to 7q31-qter. Amer. J. Hum. Gen. 46, 795 -800
• Untitled Publication
  1990 M. Obukowicz, M. Gustafson, K. Junger, R. Leimgruber, A. Wittwer, T-C. Wun, T. Warren, B. Bishop, K. Mathis, D. McPherson, N. Siegel, M. Jennings, B. Brightwell, J. Diaz-Collier, L. Bell, C.S. Craik &…
• Untitled Publication
  1990 S. Pichuantes, L. Babé, P. Barr, D. DeCamp & C.S. Craik. Recombinant HIV 2 Protease Processes HIV 1 Pr53gag and Analogous Junction Peptides In Vitro. J. Bio. Chem. 265, 13890-13898
• Crystal structures of two engineered thiol trypsins.
  Biochemistry 1989 McGrath ME, Wilke ME, Higaki JN, Craik CS, Fletterick RJ
• Serine proteases from nematode and protozoan parasites: isolation of sequence homologs using generic molecular probes.
  Proceedings of the National Academy of Sciences of the United States of America 1989 Sakanari JA, Staunton CE, Eakin AE, Craik CS, McKerrow JH
• Molecular cloning of dog mast cell tryptase and a related protease: structural evidence of a unique mode of serine protease activation.
  Biochemistry 1989 Vanderslice P, Craik CS, Nadel JA, Caughey GH
• An expression system for trypsin.
  Journal of cellular biochemistry 1989 Vasquez JR, Evnin LB, Higaki JN, Craik CS
• Rapid preparation of proteins for crystallization trials.
  BioTechniques 1989 McGrath ME, Fletterick RJ, Craik CS
• [A case of aseptic meningoencephalitis with recurrent abnormal behavior, status epilepticus and aphthous stomatitis, improved by acyclovir].
  Rinsho shinkeigaku = Clinical neurology 1989 Shimada K, Koh CS, Hashimoto T, Shoji S, Yanagisawa N
• Arachidonate 15-lipoxygenase from human leukocytes: purification and structural homology to other mammalian lipoxygenases.
  Advances in prostaglandin, thromboxane, and leukotriene research 1989 Sigal E, Grunberger D, Craik CS, Caughey GH, Nadel JA
• Cloning and expression of human arachidonate 15-lipoxygenase.
  Transactions of the Association of American Physicians 1989 Sigal E, Craik CS, Dixon RA, Nadel JA
• Recombinant HIV1 protease secreted by Saccharomyces cerevisiae correctly processes myristylated gag polyprotein.
  Proteins 1989 Pichuantes S, Babé LM, Barr PJ, Craik CS
• Untitled Publication
  1989 A. Eakin, J.N. Higaki, J.H. McKerrow & C.S. Craik. Cysteine or Serine Proteinase. Nature 342,132
• Untitled Publication
  1989 J. Higaki L.B. Evnin & C.S. Craik. Introduction of a Cysteine Protease Active Site into Trypsin. Biochem. 28, 9256-9263
• Molecular cloning and primary structure of human 15-lipoxygenase.
  Biochemical and biophysical research communications 1988 Sigal E, Craik CS, Highland E, Grunberger D, Costello LL, Dixon RA, Nadel JA
• Structural and functional integrity of specificity and catalytic sites of trypsin.
  International journal of peptide and protein research 1988 Gráf L, Hegyi G, Likó I, Hepp J, Medzihradszky K, Craik CS, Rutter WJ
• A novel rat carboxypeptidase, CPA2: characterization, molecular cloning, and evolutionary implications on substrate specificity in the carboxypeptidase gene family.
  The Journal of biological chemistry 1988 Gardell SJ, Craik CS, Clauser E, Goldsmith EJ, Stewart CB, Graf M, Rutter WJ
• Structural characterization of the rat carboxypeptidase A1 and B genes. Comparative analysis of the rat carboxypeptidase gene family.
  The Journal of biological chemistry 1988 Clauser E, Gardell SJ, Craik CS, MacDonald RJ, Rutter WJ
• Efficient targeting to storage granules of human proinsulins with altered propeptide domain.
  The Journal of cell biology 1988 Powell SK, Orci L, Craik CS, Moore HP
• Arachidonate 15-lipoxygenase (omega-6 lipoxygenase) from human leukocytes. Purification and structural homology to other mammalian lipoxygenases.
  The Journal of biological chemistry 1988 Sigal E, Grunberger D, Craik CS, Caughey GH, Nadel JA
• Arachidonate 15-lipoxygenase from human eosinophil-enriched leukocytes: partial purification and properties.
  Biochemical and biophysical research communications 1988 Sigal E, Grunberger D, Cashman JR, Craik CS, Caughey GH, Nadel JA
• Development of an efficient method for generating and screening active trypsin and trypsin variants.
  Annals of the New York Academy of Sciences 1988 Evnin LB, Craik CS
• Studies of specificity and catalysis in trypsin by structural analysis of site-directed mutants.
  Critical reviews in biotechnology 1988 Sprang SR, Fletterick RJ, Gráf L, Rutter WJ, Craik CS
• The catalytic role of the active site aspartic acid in serine proteases.
  Science (New York, N.Y.) 1987 Craik CS, Roczniak S, Largman C, Rutter WJ
• The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis.
  Science (New York, N.Y.) 1987 Sprang S, Standing T, Fletterick RJ, Stroud RM, Finer-Moore J, Xuong NH, Hamlin R, Rutter WJ, Craik CS
• Isolation and characterization of a cDNA encoding rat cationic trypsinogen.
  Biochemistry 1987 Fletcher TS, Alhadeff M, Craik CS, Largman C
• Selective alteration of substrate specificity by replacement of aspartic acid-189 with lysine in the binding pocket of trypsin.
  Biochemistry 1987 Graf L, Craik CS, Patthy A, Roczniak S, Fletterick RJ, Rutter WJ
• Redesigning trypsin via genetic engineering.
  Journal of cellular biochemistry 1987 Craik CS, Roczniak S, Sprang S, Fletterick R, Rutter W
• Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.
  Proceedings of the National Academy of Sciences of the United States of America 1987 Ebina Y, Araki E, Taira M, Shimada F, Mori M, Craik CS, Siddle K, Pierce SB, Roth RA, Rutter WJ
• Evolution of catalysis in the serine proteases.
  Cold Spring Harbor symposia on quantitative biology 1987 Higaki JN, Gibson BW, Craik CS
• Untitled Publication
  1987 C.S. Craik, S. Roczniak, S. Sprang, R.J. Fletterick & W.J. Rutter. Edited by D. Cunningham and G. Long. New York: Alan R Liss, Inc. Redesigning Trypsin via Genetic Engineering. In: Proteases in …
• Untitled Publication
  1987 C.S. Craik. Edited by D. Oxender. New York: Alan R. Liss, Inc. Expression and Overproduction of Proteins. In: Protein Structure, Folding and Design 2, pp. 467-476.
• Untitled Publication
  1987 T.L. Burgess, C.S. Craik, L. Matsuuchi & R.B. Kelly. In Vitro Mutagenesis of Trypsinogen: The Role of the N-Terminus in Intracellular Protein Targeting to Secretory Granules. J. Cell Bio. 105, 659-668
• Untitled Publication
  1987 W.J. Rutter, S.J. Gardell, S. Roczniak, D. Hilvert, S. Sprang, R.J. Fletterick & C.S. Craik. Edited by D. Oxender and C.F. Fox. New York: Alan R. Liss, Inc. Redesigning Proteins via Genetic …
• Genetic analysis of cystic fibrosis: linkage of DNA and classical markers in multiplex families.
  American journal of human genetics 1986 Bowcock AM, Crandall J, Daneshvar L, Lee GM, Young B, Zunzunegui V, Craik C, Cavalli-Sforza LL, King MC
• Untitled Publication
  1986 S. Gardell, C.S. Craik, D. Hilvert, M. Urdea & W. Rutter. Edited by I. Bertini, C. Luchinat, W. Maret, and M. Zeppezauer. Boston, Massachusetts: Birkhäuser. Probing the Role of Tyrosine 248 in …
• Site-directed mutagenesis shows that tyrosine 248 of carboxypeptidase A does not play a crucial role in catalysis.
  Nature 1985 Gardell SJ, Craik CS, Hilvert D, Urdea MS, Rutter WJ
• The exocrine protein trypsinogen is targeted into the secretory granules of an endocrine cell line: studies by gene transfer.
  The Journal of cell biology 1985 Burgess TL, Craik CS, Kelly RB
• Redesigning trypsin: alteration of substrate specificity.
  Science (New York, N.Y.) 1985 Craik CS, Largman C, Fletcher T, Roczniak S, Barr PJ, Fletterick R, Rutter WJ
• Biotechniques
  Use of Oligonucleotides for Site-Specific Mutagenesis 1985 C.S. Craik
• Isolation and sequence of a rat chymotrypsin B gene.
  The Journal of biological chemistry 1984 Bell GI, Quinto C, Quiroga M, Valenzuela P, Craik CS, Rutter WJ
• Structure of the two related elastase genes expressed in the rat pancreas.
  The Journal of biological chemistry 1984 Swift GH, Craik CS, Stary SJ, Quinto C, Lahaie RG, Rutter WJ, MacDonald RJ
• Structure of two related rat pancreatic trypsin genes.
  The Journal of biological chemistry 1984 Craik CS, Choo QL, Swift GH, Quinto C, MacDonald RJ, Rutter WJ
• Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse.
  Somatic cell and molecular genetics 1984 Honey NK, Sakaguchi AY, Lalley PA, Quinto C, MacDonald RJ, Craik C, Bell GI, Rutter WJ, Naylor SL
• Chromosomal assignments of human genes for serine proteases trypsin, chymotrypsin B, and elastase.
  Somatic cell and molecular genetics 1984 Honey NK, Sakaguchi AY, Quinto C, MacDonald RJ, Bell GI, Craik C, Rutter WJ, Naylor SL
• Splice junctions: association with variation in protein structure.
  Science (New York, N.Y.) 1983 Craik CS, Rutter WJ, Fletterick R
• Intron-exon splice junctions map at protein surfaces.
  Nature 1982 Craik CS, Sprang S, Fletterick R, Rutter WJ
• Untitled Publication
  1982 C.S. Craik & S. Beychok. Edited by C. Ho. In: Interaction Between Iron Proteins in Oxygen and Electron Transport, Elsevier North Holland Biomedical Press
• O2 binding properties of the product of the central exon of beta-globin gene.
  Nature 1981 Craik CS, Buchman SR, Beychok S
• Refolding defects in hemoglobin Rothschild.
  The Journal of biological chemistry 1980 Craik CS, Vallette I, Beychok S, Waks M
• Characterization of globin domains: heme binding to the central exon product.
  Proceedings of the National Academy of Sciences of the United States of America 1980 Craik CS, Buchman SR, Beychok S