Chad Christine, MD
Professor
Neurology
School of Medicine
Awards
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- Elected as Fellow of AAN, American Academy of Neurology (AAN), 2018
- Elected as Fellow of the ANA, American Neurological Association (ANA), 2013
- William Koller Memorial Fund Award, International Movement Disorder Society, 2006
- Innovative Curricular Design and Program Development, UCSF Academy of Medical Educators, 2006
- Kean-Haas Fellowship for International Study, Cornell University Medical College, 1991
- Walton Foundation Scholarship, Stanford University School of Medicine, 1988
Education & Training
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- M.D. School of Medicine Cornell University Medical College 1991
- BA Physics and English Cornell University 1985
Websites
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- Clinical Profile at UCSF Medical Center (ucsfhealth.org)
Grants and Projects
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- PD 1104: An Observational, Long-Term Extension Study for Participants of Prior VY-AADC01 or VY-AADC02 Clinical Studies, Neurocrine Biosciences, Inc, 2018-2029
- Open-Label Safety Study of Glial cell Line derived neurotrophic factor Gene transfer (AAV2-GDNF) in Parkinson’s disease, Brain Neurotherapy Bio, Inc, 2020-2026
- Relationship of B12 status measures with outcomes in SURE-PD2, SURE-PD3 and STEADY-PD III, Michael J Fox Foundation for Parkinson's Research, 2020-2022
- NLY01-PD-1Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of 36 Weeks of Treatment with NLY01 in Early-stage Parkinson’s Disease, Neuraly, Inc, 2020-2021
- PD 1102: An Open-label Safety and Efficacy Study of VY-AADC01 Administered by MRI-Guided Convective Infusion using a Posterior Trajectory into the Putamen of Participants with Parkinson’s Disease with fluctuating Responses to Levodopa., Voyager Therapeutics, 2017-2021
- Relationship of cerebrospinal markers of B12 status to baseline status and outcomes in the DATATOP study, NIH and Michael J Fox Foundation for Parkinson's Research, 2016-2019
- “A Phase 3 double-blind placebo-controlled parallel group study of isradipine as a disease modifying agent in patients with early Parkinson disease.”, NIH, 2014-2015
- Parkinson's Disease Neuroprotection Clinical Trial, NIH, 2002-2015
- The Relationship of Vitamin B12 status and Parkinson’s disease, Michael J Fox Foundation for Parkinson's Research, 2014-2015
- Mechanisms Underlying Homosynaptic Long Term Depression, NIH, 1995-2000
Publications (62)
Top publication keywords:
Subthalamic NucleusAntiparkinson AgentsCarboxy-LyasesPutamenHomocysteineParkinson DiseaseParkinsonian DisordersLevodopaAromatic-L-Amino-Acid DecarboxylasesVitamin B 12Dopamine AgentsNarcolepsyGenetic TherapyAmphetamineDyskinesias
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Relationship of Cerebrospinal Fluid Vitamin B12 Status Markers With Parkinson's Disease Progression.
Movement disorders : official journal of the Movement Disorder Society 2020 Christine CW, Auinger P, Saleh N, Tian M, Bottiglieri T, Arning E, Tran NK, Ueland PM, Green R, Parkinson Study Group-DATATOP Investigators -
Aromatic L-Amino Acid Decarboxylase Gene Therapy Enhances Levodopa Response in Parkinson's Disease.
Movement disorders : official journal of the Movement Disorder Society 2020 Nutt JG, Curtze C, Hiller A, Anderson S, Larson PS, Van Laar AD, Richardson RM, Thompson ME, Sedkov A, Leinonen M, Ravina B, Bankiewicz KS, Christine CW -
Magnetic resonance imaging-guided phase 1 trial of putaminal AADC gene therapy for Parkinson's disease.
Annals of neurology 2019 Christine CW, Bankiewicz KS, Van Laar AD, Richardson RM, Ravina B, Kells AP, Boot B, Martin AJ, Nutt J, Thompson ME, Larson PS -
Vitamin B12 and Homocysteine Levels Predict Different Outcomes in Early Parkinson's Disease.
Movement disorders : official journal of the Movement Disorder Society 2018 Christine CW, Auinger P, Joslin A, Yelpaala Y, Green R, Parkinson Study Group-DATATOP Investigators -
Intraputaminal Delivery of Adeno-Associated Virus Serotype 2-Glial Cell Line-Derived Neurotrophic Factor in Mild or Moderate Parkinson's Disease.
Movement disorders : official journal of the Movement Disorder Society 2025 Van Laar AD, Christine CW, Phielipp N, Larson PS, Elder JB, Merola A, San Sebastian W, Fiandaca MS, Kells AP, Wisniewski ME, Bankiewicz KS
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Relationships of B12 and Homocysteine with Outcomes in the SURE-PD, SURE-PD3, and STEADY-PDIII Trials.
Journal of Parkinson's disease 2024 Christine CW, Auinger P, Forti EAR, Tat L, Cannizzaro N, Mustafa A, Iyer JM, Oakes D, Green R -
NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62.
Nature communications 2023 Furthmann N, Bader V, Angersbach L, Blusch A, Goel S, Sánchez-Vicente A, Krause LJ, Chaban SA, Grover P, Trinkaus VA, van Well EM, Jaugstetter M, Tschulik K, Damgaard RB, Saft C, Ellrichmann G, Gold R… -
Long-Term Intake of Folate, Vitamin B6, and Vitamin B12 and the Incidence of Parkinson's Disease in a Sample of U.S. Women and Men.
Movement disorders : official journal of the Movement Disorder Society 2023 Flores-Torres MH, Christine CW, Bjornevik K, Molsberry SA, Hung AY, Healy BC, Blacker D, Schwarzschild MA, Ascherio A -
Linear ubiquitination induces NEMO phase separation to activate NF-κB signaling.
Life science alliance 2023 Goel S, Oliva R, Jeganathan S, Bader V, Krause LJ, Kriegler S, Stender ID, Christine CW, Nakamura K, Hoffmann JE, Winter R, Tatzelt J, Winklhofer KF -
Author Response: Safety of AADC Gene Therapy for Moderately Advanced Parkinson Disease: Three-Year Outcomes From the PD-1101 Trial.
Neurology 2022 Christine CW, Richardson RM, Fine EM, Khwaja OS, Liang GS, Meier A, Roberts EW, Bankiewicz K, Larson PS -
Author Response: Safety of AADC Gene Therapy for Moderately Advanced Parkinson Disease: Three-Year Outcomes From the PD-1101 Trial.
Neurology 2022 Christine CW, Richardson RM, Van Laar A, Fine EM, Khwaja OS, Liang GS, Bankiewicz K, Larson PS -
Association of elevated blood homocysteine with cognitive decline in early, untreated Parkinson's disease.
Journal of the neurological sciences 2022 Christine CW, Green R -
Safety of AADC Gene Therapy for Moderately Advanced Parkinson Disease: Three-Year Outcomes From the PD-1101 Trial.
Neurology 2021 Christine CW, Richardson RM, Van Laar AD, Thompson ME, Fine EM, Khwaja OS, Li C, Liang GS, Meier A, Roberts EW, Pfau ML, Rodman JR, Bankiewicz KS, Larson PS -
Effect of Urate-Elevating Inosine on Early Parkinson Disease Progression: The SURE-PD3 Randomized Clinical Trial.
JAMA 2021 Parkinson Study Group SURE-PD3 Investigators, Schwarzschild MA, Ascherio A, Casaceli C, Curhan GC, Fitzgerald R, Kamp C, Lungu C, Macklin EA, Marek K, Mozaffarian D, Oakes D, Rudolph A, Shoulson I, … -
Data-driven evolution of neurosurgical gene therapy delivery in Parkinson's disease.
Journal of neurology, neurosurgery, and psychiatry 2020 Richardson RM, Bankiewicz KS, Christine CW, Van Laar AD, Gross RE, Lonser R, Factor SA, Kostyk SK, Kells AP, Ravina B, Larson PS -
Vitamin B12 measurements across neurodegenerative disorders.
Journal of clinical movement disorders 2020 Luthra NS, Marcus AH, Hills NK, Christine CW -
Characterization of Vitamin B12 Supplementation and Correlation with Clinical Outcomes in a Large Longitudinal Study of Early Parkinson's Disease.
Journal of movement disorders 2019 Dietiker C, Kim S, Zhang Y, Christine CW -
Linking vitamin B12 and a trembling disorder.
Cell research 2019 Green R, Christine CW -
Characterization of vitamin D supplementation and clinical outcomes in a large cohort of early Parkinson's disease.
Journal of clinical movement disorders 2018 Luthra NS, Kim S, Zhang Y, Christine CW, NINDS NET-PD Investigators -
Association of metabolic syndrome and change in Unified Parkinson's Disease Rating Scale scores.
Neurology 2017 Leehey M, Luo S, Sharma S, Wills AA, Bainbridge JL, Wong PS, Simon DK, Schneider J, Zhang Y, Pérez A, Dhall R, Christine CW, Singer C, Cambi F, Boyd JT -
Precipitous Deterioration of Motor Function, Cognition, and Behavior.
JAMA neurology 2017 Fernández-Fournier M, Perry DC, Tartaglia MC, de May M, Boxer A, Coppola G, Christine CW, Huang EJ, Seeley WW, Miller BL, DeArmond SJ, Grinberg LT, Geschwind MD -
Factors associated with falling in early, treated Parkinson's disease: The NET-PD LS1 cohort.
Journal of the neurological sciences 2017 Chou KL, Elm JJ, Wielinski CL, Simon DK, Aminoff MJ, Christine CW, Liang GS, Hauser RA, Sudarsky L, Umeh CC, Voss T, Juncos J, Fang JY, Boyd JT, Bodis-Wollner I, Mari Z, Morgan JC, Wills AM, Lee SL, … -
Longer Duration of MAO-B Inhibitor Exposure is Associated with Less Clinical Decline in Parkinson's Disease: An Analysis of NET-PD LS1.
Journal of Parkinson's disease 2017 Hauser RA, Li R, Pérez A, Ren X, Weintraub D, Elm J, Goudreau JL, Morgan JC, Fang JY, Aminoff MJ, Christine CW, Dhall R, Umeh CC, Boyd JT, Stover N, Leehey M, Zweig RM, Nicholas AP, Bodis-Wollner I, … -
Cognitive function in 1736 participants in NINDS Exploratory Trials in PD Long-term Study-1.
Parkinsonism & related disorders 2016 Wills AA, Elm JJ, Ye R, Chou KL, Parashos SA, Hauser RA, Bodis-Wollner I, Hinson VK, Christine CW, Schneider JS, NINDS NET-PD Investigators -
Choice of dopaminergic therapy among early, mild Parkinson disease subjects in North America.
Journal of the neurological sciences 2016 Goudreau JL, Pérez A, Aminoff MJ, Boyd JT, Burau KD, Christine CW, Leehey M, Morgan JC, NET-PD Investigators. -
Impact of Depression on Progression of Impairment and Disability in Early Parkinson's Disease.
Movement disorders clinical practice 2015 Bega D, Luo S, Fernandez H, Chou K, Aminoff M, Parashos S, Walker H, Russell DS, Christine CW, Dhall R, Singer C, Bodis-Wollner I, Hamill R, Truong D, Mari Z, Glazmann S, Huang M, Houston E, Simuni T -
Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a randomized clinical trial.
JAMA 2015 Writing Group for the NINDS Exploratory Trials in Parkinson Disease (NET-PD) Investigators, Kieburtz K, Tilley BC, Elm JJ, Babcock D, Hauser R, Ross GW, Augustine AH, Augustine EU, Aminoff MJ, Bodis-… -
Parkinson's disease severity and use of dopaminergic medications.
Parkinsonism & related disorders 2014 Fang JY, Pérez A, Christine CW, Leehey M, Aminoff MJ, Boyd JT, Morgan JC, Dhall R, Nicholas AP, Bodis-Wollner I, Zweig RM, Goudreau JL, NINDS NET-PD Investigators -
No sex differences in use of dopaminergic medication in early Parkinson disease in the US and Canada - baseline findings of a multicenter trial.
PloS one 2014 Umeh CC, Pérez A, Augustine EF, Dhall R, Dewey RB, Mari Z, Simon DK, Wills AM, Christine CW, Schneider JS, Suchowersky O -
Severity of depression and anxiety are predictors of response to antidepressant treatment in Parkinson's disease.
Parkinsonism & related disorders 2014 Moonen AJ, Wijers A, Leentjens AF, Christine CW, Factor SA, Juncos J, Lyness JM, Marsh L, Panisset M, Pfeiffer R, Rottenberg D, Serrano Ramos C, Shulman L, Singer C, Slevin J, McDonald W, Auinger P, … -
Changes in the thalamus in atypical parkinsonism detected using shape analysis and diffusion tensor imaging.
AJNR. American journal of neuroradiology 2013 Hess CP, Christine CW, Apple AC, Dillon WP, Aminoff MJ -
Development of corticobasal syndrome in a patient with congenital erythropoietic porphyria.
Parkinsonism & related disorders 2013 Sidorsky TI, Christine CW, Epstein JH, Berger TG -
Cerebrospinal fluid-based kinetic biomarkers of axonal transport in monitoring neurodegeneration.
The Journal of clinical investigation 2012 Fanara P, Wong PY, Husted KH, Liu S, Liu VM, Kohlstaedt LA, Riiff T, Protasio JC, Boban D, Killion S, Killian M, Epling L, Sinclair E, Peterson J, Price RW, Cabin DE, Nussbaum RL, Brühmann J, Brandt R… -
A randomized, double-blind, placebo-controlled trial of antidepressants in Parkinson disease.
Neurology 2012 Richard IH, McDermott MP, Kurlan R, Lyness JM, Como PG, Pearson N, Factor SA, Juncos J, Serrano Ramos C, Brodsky M, Manning C, Marsh L, Shulman L, Fernandez HH, Black KJ, Panisset M, Christine CW, … -
Long-term evaluation of a phase 1 study of AADC gene therapy for Parkinson's disease.
Human gene therapy 2012 Mittermeyer G, Christine CW, Rosenbluth KH, Baker SL, Starr P, Larson P, Kaplan PL, Forsayeth J, Aminoff MJ, Bankiewicz KS -
Development of Parkinson's disease in patients with Narcolepsy.
Journal of neural transmission (Vienna, Austria : 1996) 2012 Christine CW, Marks WJ, Ostrem JL -
A case of slow orthostatic tremor, responsive to intravenous immunoglobulin.
Movement disorders : official journal of the Movement Disorder Society 2011 Hegde M, Glass GA, Dalmau J, Christine CW -
Hospitalization in Parkinson disease: a survey of National Parkinson Foundation Centers.
Parkinsonism & related disorders 2011 Chou KL, Zamudio J, Schmidt P, Price CC, Parashos SA, Bloem BR, Lyons KE, Christine CW, Pahwa R, Bodis-Wollner I, Oertel WH, Suchowersky O, Aminoff MJ, Malaty IA, Friedman JH, Okun MS -
Management of the hospitalized patient with Parkinson's disease: current state of the field and need for guidelines.
Parkinsonism & related disorders 2010 Aminoff MJ, Christine CW, Friedman JH, Chou KL, Lyons KE, Pahwa R, Bloem BR, Parashos SA, Price CC, Malaty IA, Iansek R, Bodis-Wollner I, Suchowersky O, Oertel WH, Zamudio J, Oberdorf J, Schmidt P, … -
Qualitative imaging of adeno-associated virus serotype 2-human aromatic L-amino acid decarboxylase gene therapy in a phase I study for the treatment of Parkinson disease.
Neurosurgery 2010 Valles F, Fiandaca MS, Eberling JL, Starr PA, Larson PS, Christine CW, Forsayeth J, Richardson RM, Su X, Aminoff MJ, Bankiewicz KS -
Parkinsonism in patients with a history of amphetamine exposure.
Movement disorders : official journal of the Movement Disorder Society 2010 Christine CW, Garwood ER, Schrock LE, Austin DE, McCulloch CE -
Pedunculopontine nucleus deep brain stimulation in a patient with primary progressive freezing gait disorder.
Stereotactic and functional neurosurgery 2009 Ostrem JL, Christine CW, Glass GA, Schrock LE, Starr PA -
Safety and tolerability of putaminal AADC gene therapy for Parkinson disease.
Neurology 2009 Christine CW, Starr PA, Larson PS, Eberling JL, Jagust WJ, Hawkins RA, VanBrocklin HF, Wright JF, Bankiewicz KS, Aminoff MJ -
Cognitive and neuropsychiatric profile of the synucleinopathies: Parkinson disease, dementia with Lewy bodies, and multiple system atrophy.
Alzheimer disease and associated disorders 2009 Kao AW, Racine CA, Quitania LC, Kramer JH, Christine CW, Miller BL -
The neurophysiology and effect of deep brain stimulation in a patient with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism.
Journal of neurosurgery 2009 Christine CW, Langston JW, Turner RS, Starr PA -
Results from a phase I safety trial of hAADC gene therapy for Parkinson disease.
Neurology 2008 Eberling JL, Jagust WJ, Christine CW, Starr P, Larson P, Bankiewicz KS, Aminoff MJ -
Effects of unilateral subthalamic and pallidal deep brain stimulation on fine motor functions in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2007 Nakamura K, Christine CW, Starr PA, Marks WJ -
Amphetamine exposure is elevated in Parkinson's disease.
Neurotoxicology 2006 Garwood ER, Bekele W, McCulloch CE, Christine CW -
Online support groups for Parkinson's patients: a pilot study of effectiveness.
Social work in health care 2005 Lieberman MA, Winzelberg A, Golant M, Wakahiro M, DiMinno M, Aminoff M, Christine C -
Clinical differentiation of parkinsonian syndromes: prognostic and therapeutic relevance.
The American journal of medicine 2004 Christine CW, Aminoff MJ -
Locations of movement-related cells in the human subthalamic nucleus in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2003 Theodosopoulos PV, Marks WJ, Christine C, Starr PA -
Implantation of deep brain stimulators into the subthalamic nucleus: technical approach and magnetic resonance imaging-verified lead locations.
Journal of neurosurgery 2002 Starr PA, Christine CW, Theodosopoulos PV, Lindsey N, Byrd D, Mosley A, Marks WJ -
Activity differentially regulates the surface expression of synaptic AMPA and NMDA glutamate receptors.
Proceedings of the National Academy of Sciences of the United States of America 1998 Lissin DV, Gomperts SN, Carroll RC, Christine CW, Kalman D, Kitamura M, Hardy S, Nicoll RA, Malenka RC, von Zastrow M -
Magnesium removal induces paroxysmal neuronal firing and NMDA receptor-mediated neuronal degeneration in cortical cultures.
Neuroscience letters 1990 Rose K, Christine CW, Choi DW -
Acidosis reduces NMDA receptor activation, glutamate neurotoxicity, and oxygen-glucose deprivation neuronal injury in cortical cultures.
Brain research 1990 Giffard RG, Monyer H, Christine CW, Choi DW -
Acute brain injury, NMDA receptors, and hydrogen ions: observations in cortical cell cultures.
Advances in experimental medicine and biology 1990 Choi DW, Monyer H, Giffard RG, Goldberg MP, Christine CW -
Cation channels in the apical membrane of collecting duct principal cell epithelium in culture.
Renal physiology and biochemistry 1990 Laskowski FH, Christine CW, Gitter AH, Beyenbach KW, Gross P, Frömter E -
Effect of zinc on NMDA receptor-mediated channel currents in cortical neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1990 Christine CW, Choi DW -
Bicarbonate dependence of glutamate receptor activation by beta-N-methylamino-L-alanine: channel recording and study with related compounds.
Neuron 1989 Weiss JH, Christine CW, Choi DW -
Zinc and LTP.
Nature 1989 Weiss JH, Koh JY, Christine CW, Choi DW -
Glutamate neurotoxicity, calcium, and zinc.
Annals of the New York Academy of Sciences 1989 Choi DW, Weiss JH, Koh JY, Christine CW, Kurth MC -
High-conductance K+ channel in apical membranes of principal cells cultured from rabbit renal cortical collecting duct anlagen.
Pflugers Archiv : European journal of physiology 1987 Gitter AH, Beyenbach KW, Christine CW, Gross P, Minuth WW, Frömter E