Cathy Lomen-Hoerth, MD, PhD
Professor
Neurology
School of Medicine

I trained under Dr. Richard Olney and took over as director of the ALS Center in 2004 when he retired. I am a full professor of neurology at UCSF and have significant experience in ALS clinical trials since joining the faculty after completing my neurology residency and EMG fellowship at UCSF in 1999. I was a site PI for the following ALS clinical research trials: all 3 Avanir studies, the Creatine study, the Co-Q10 study, and the Ceftriaxone study. I am a member of both NEALS and WALS, which are the major ALS clinical trial groups. In addition I have received grants from the NIH and ALS association to study ALS predictors of prognosis, ALS environmental risk factors, imaging abnormalities in PLS and ALS, efficacy of intrathecal baclofen pump treatment for PLS, and also the overlap with ALS and frontotemporal dementia.

• Corrigendum to "Longitudinal Screening Detects Cognitive Stability and Behavioral Deterioration in ALS Patients".
  Behavioural neurology 2019 Woolley S, Goetz R, Factor-Litvak P, Murphy J, Hupf J, Garofalo DC, Lomen-Hoerth C, Andrews H, Heitzman D, Bedlack R, Katz J, Barohn R, Sorenson E, Oskarsson B, Filho AF, Kasarskis E, Mozaffar T, …
• Revised Airlie House consensus guidelines for design and implementation of ALS clinical trials.
  Neurology 2019 van den Berg LH, Sorenson E, Gronseth G, Macklin EA, Andrews J, Baloh RH, Benatar M, Berry JD, Chio A, Corcia P, Genge A, Gubitz AK, Lomen-Hoerth C, McDermott CJ, Pioro EP, Rosenfeld J, Silani V, …
• Primary progressive aphasia and the FTD-MND spectrum disorders: clinical, pathological, and neuroimaging correlates.
  Amyotrophic lateral sclerosis & frontotemporal degeneration 2019 Vinceti G, Olney N, Mandelli ML, Spina S, Hubbard HI, Santos-Santos MA, Watson C, Miller ZA, Lomen-Hoerth C, Nichelli P, Miller BL, Grinberg LT, Seeley WW, Gorno-Tempini ML
• Measurement of spinal cord atrophy using phase sensitive inversion recovery (PSIR) imaging in motor neuron disease.
  PloS one 2018 Olney NT, Bischof A, Rosen H, Caverzasi E, Stern WA, Lomen-Hoerth C, Miller BL, Henry RG, Papinutto N
• Navigating a fine balance in the treatment of amyotrophic lateral sclerosis.
  Muscle & nerve 2018 Greene M, Lomen-Hoerth C
• Longitudinal Screening Detects Cognitive Stability and Behavioral Deterioration in ALS Patients.
  Behavioural neurology 2018 Woolley S, Goetz R, Factor-Litvak P, Murphy J, Hupf J, Garofalo DC, Lomen-Hoerth C, Andrews H, Heitzman D, Bedlack R, Katz J, Barohn R, Sorenson E, Oskarsson B, Filho AF, Kasarskis E, Mozaffar T, …
• Transcriptome analysis in whole blood reveals increased microbial diversity in schizophrenia.
  Translational psychiatry 2018 Olde Loohuis LM, Mangul S, Ori APS, Jospin G, Koslicki D, Yang HT, Wu T, Boks MP, Lomen-Hoerth C, Wiedau-Pazos M, Cantor RM, de Vos WM, Kahn RS, Eskin E, Ophoff RA
• Progression and effect of cognitive-behavioral changes in patients with amyotrophic lateral sclerosis.
  Neurology. Clinical practice 2017 Bock M, Duong YN, Kim A, Allen I, Murphy J, Lomen-Hoerth C
• Serious Bacterial Infections Acquired During Treatment of Patients Given a Diagnosis of Chronic Lyme Disease - United States.
  MMWR. Morbidity and mortality weekly report 2017 Marzec NS, Nelson C, Waldron PR, Blackburn BG, Hosain S, Greenhow T, Green GM, Lomen-Hoerth C, Golden M, Mead PS
• Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis.
  Nature genetics 2016 van Rheenen W, Shatunov A, Dekker AM, McLaughlin RL, Diekstra FP, Pulit SL, van der Spek RA, Võsa U, de Jong S, Robinson MR, Yang J, Fogh I, van Doormaal PT, Tazelaar GH, Koppers M, Blokhuis AM, …
• Cognitive-behavioral changes in amyotrophic lateral sclerosis: Screening prevalence and impact on patients and caregivers.
  Amyotrophic lateral sclerosis & frontotemporal degeneration 2016 Bock M, Duong YN, Kim A, Allen I, Murphy J, Lomen-Hoerth C
• Primary Lateral Sclerosis and Early Upper Motor Neuron Disease: Characteristics of a Cross-Sectional Population.
  Journal of clinical neuromuscular disease 2016 Fournier CN, Murphy A, Loci L, Mitsumoto H, Lomen-Hoerth C, Kisanuki Y, Simmons Z, Maragakis NJ, McVey AL, Al-Lahham T, Heiman-Patterson TD, Andrews J, McDonnell E, Cudkowicz M, Atassi N
• Cognitive-behavioral screening reveals prevalent impairment in a large multicenter ALS cohort.
  Neurology 2016 Murphy J, Factor-Litvak P, Goetz R, Lomen-Hoerth C, Nagy PL, Hupf J, Singleton J, Woolley S, Andrews H, Heitzman D, Bedlack RS, Katz JS, Barohn RJ, Sorenson EJ, Oskarsson B, Fernandes Filho JA, …
• Prospective study of cost of care at multidisciplinary ALS centers adhering to American Academy of Neurology (AAN) ALS practice parameters.
  Amyotrophic lateral sclerosis & frontotemporal degeneration 2015 Boylan K, Levine T, Lomen-Hoerth C, Lyon M, Maginnis K, Callas P, Gaspari C, Tandan R, ALS Center Cost Evaluation W/Standards & Satisfaction (Access) Consortium
• Quantitative ultrasound of denervated hand muscles.
  Muscle & nerve 2015 Simon NG, Ralph JW, Lomen-Hoerth C, Poncelet AN, Vucic S, Kiernan MC, Kliot M
• Amyotrophic lateral sclerosis.
  Seminars in neurology 2014 Malik R, Lui A, Lomen-Hoerth C
• Patterns of clinical and electrodiagnostic abnormalities in early amyotrophic lateral sclerosis.
  Muscle & nerve 2014 Simon NG, Lomen-Hoerth C, Kiernan MC
• The UCSF screening exam effectively screens cognitive and behavioral impairment in patients with ALS.
  Amyotrophic lateral sclerosis & frontotemporal degeneration 2014 Murphy J, Ahmed F, Lomen-Hoerth C
• Quantifying disease progression in amyotrophic lateral sclerosis.
  Annals of neurology 2014 Simon NG, Turner MR, Vucic S, Al-Chalabi A, Shefner J, Lomen-Hoerth C, Kiernan MC
• An open-label multicenter study to assess the safety of dextromethorphan/quinidine in patients with pseudobulbar affect associated with a range of underlying neurological conditions.
  Current medical research and opinion 2014 Pattee GL, Wymer JP, Lomen-Hoerth C, Appel SH, Formella AE, Pope LE
• Japanese and American ALS patient preferences regarding TIV (tracheostomy with invasive ventilation): a cross-national survey.
  Amyotrophic lateral sclerosis & frontotemporal degeneration 2014 Rabkin J, Ogino M, Goetz R, McElhiney M, Hupf J, Heitzman D, Heiman-Patterson T, Miller R, Katz J, Lomen-Hoerth C, Imai T, Atsuta N, Morita M, Tateishi T, Matsumura T, Mitsumoto H
• ALS Multicenter Cohort Study of Oxidative Stress (ALS COSMOS): study methodology, recruitment, and baseline demographic and disease characteristics.
  Amyotrophic lateral sclerosis & frontotemporal degeneration 2014 Mitsumoto H, Factor-Litvak P, Andrews H, Goetz RR, Andrews L, Rabkin JG, McElhiney M, Nieves J, Santella RM, Murphy J, Hupf J, Singleton J, Merle D, Kilty M, Heitzman D, Bedlack RS, Miller RG, Katz JS…
• Is IVIg therapy warranted in progressive lower motor neuron syndromes without conduction block?
  Neurology 2013 Simon NG, Ayer G, Lomen-Hoerth C
• TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease.
  Molecular neurodegeneration 2013 Rayaprolu S, Mullen B, Baker M, Lynch T, Finger E, Seeley WW, Hatanpaa KJ, Lomen-Hoerth C, Kertesz A, Bigio EH, Lippa C, Josephs KA, Knopman DS, White CL, Caselli R, Mackenzie IR, Miller BL, Boczarska…
• Influenza-associated global amnesia and hippocampal imaging abnormality.
  Neurocase 2013 Lopez J, Lomen-Hoerth C, Deutsch GK, Kerchner GA, Koshy A
• ALS Untangled No. 20: the Deanna protocol.
  Amyotrophic lateral sclerosis & frontotemporal degeneration 2013 ALSUntangled Group, Fournier C, Bedlack B, Hardiman O, Heiman-Patterson T, Gutmann L, Bromberg M, Ostrow L, Carter G, Kabashi E, Bertorini T, Mozaffar T, Andersen P, Dietz J, Gamez J, Dimachkie M, …
• Deciphering amyotrophic lateral sclerosis: what phenotype, neuropathology and genetics are telling us about pathogenesis.
  Amyotrophic lateral sclerosis & frontotemporal degeneration 2013 Ravits J, Appel S, Baloh RH, Barohn R, Brooks BR, Elman L, Floeter MK, Henderson C, Lomen-Hoerth C, Macklis JD, McCluskey L, Mitsumoto H, Przedborski S, Rothstein J, Trojanowski JQ, van den Berg LH, …
• Frontotemporal dementia in a Brazilian kindred with the c9orf72 mutation.
  Archives of neurology 2012 Takada LT, Pimentel ML, Dejesus-Hernandez M, Fong JC, Yokoyama JS, Karydas A, Thibodeau MP, Rutherford NJ, Baker MC, Lomen-Hoerth C, Rademakers R, Miller BL
• Length of normal alleles of C9ORF72 GGGGCC repeat do not influence disease phenotype.
  Neurobiology of aging 2012 Rutherford NJ, Heckman MG, Dejesus-Hernandez M, Baker MC, Soto-Ortolaza AI, Rayaprolu S, Stewart H, Finger E, Volkening K, Seeley WW, Hatanpaa KJ, Lomen-Hoerth C, Kertesz A, Bigio EH, Lippa C, Knopman…
• C9ORF72 hexanucleotide repeat expansions in patients with ALS from the Coriell Cell Repository.
  Neurology 2012 Rutherford NJ, DeJesus-Hernandez M, Baker MC, Kryston TB, Brown PE, Lomen-Hoerth C, Boylan K, Wszolek ZK, Rademakers R
• Organ donation after cardiac death in amyotrophic lateral sclerosis.
  Annals of neurology 2012 Toossi S, Lomen-Hoerth C, Josephson SA, Gropper MA, Roberts J, Patton K, Smith WS
• Behaviour, physiology and experience of pathological laughing and crying in amyotrophic lateral sclerosis.
  Brain : a journal of neurology 2011 Olney NT, Goodkind MS, Lomen-Hoerth C, Whalen PK, Williamson CA, Holley DE, Verstaen A, Brown LM, Miller BL, Kornak J, Levenson RW, Rosen HJ
• Clinical phenomenology and neuroimaging correlates in ALS-FTD.
  Journal of molecular neuroscience : MN 2011 Lomen-Hoerth C
• Ataxin-2 repeat-length variation and neurodegeneration.
  Human molecular genetics 2011 Ross OA, Rutherford NJ, Baker M, Soto-Ortolaza AI, Carrasquillo MM, DeJesus-Hernandez M, Adamson J, Li M, Volkening K, Finger E, Seeley WW, Hatanpaa KJ, Lomen-Hoerth C, Kertesz A, Bigio EH, Lippa C, …
• Pathogenicity of exonic indels in fused in sarcoma in amyotrophic lateral sclerosis.
  Neurobiology of aging 2010 Rutherford NJ, Finch NA, DeJesus-Hernandez M, Crook RJ, Lomen-Hoerth C, Wszolek ZK, Uitti RJ, Graff-Radford NR, Rademakers R
• Extensive FUS-immunoreactive pathology in juvenile amyotrophic lateral sclerosis with basophilic inclusions.
  Brain pathology (Zurich, Switzerland) 2010 Huang EJ, Zhang J, Geser F, Trojanowski JQ, Strober JB, Dickson DW, Brown RH, Shapiro BE, Lomen-Hoerth C
• Cognitive and behavioral challenges in caring for patients with frontotemporal dementia and amyotrophic lateral sclerosis.
  Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 2010 Merrilees J, Klapper J, Murphy J, Lomen-Hoerth C, Miller BL
• Phase II trial of CoQ10 for ALS finds insufficient evidence to justify phase III.
  Annals of neurology 2009 Kaufmann P, Thompson JL, Levy G, Buchsbaum R, Shefner J, Krivickas LS, Katz J, Rollins Y, Barohn RJ, Jackson CE, Tiryaki E, Lomen-Hoerth C, Armon C, Tandan R, Rudnicki SA, Rezania K, Sufit R, Pestronk…
• Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis.
  Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 2009 Strong MJ, Grace GM, Freedman M, Lomen-Hoerth C, Woolley S, Goldstein LH, Murphy J, Shoesmith C, Rosenfeld J, Leigh PN, Bruijn L, Ince P, Figlewicz D
• Nouns, verbs, and ALS.
  Neurology 2008 Albert SM, Lomen-Hoerth C
• Amyotrophic lateral sclerosis from bench to bedside.
  Seminars in neurology 2008 Lomen-Hoerth C
• Whole-genome analysis of sporadic amyotrophic lateral sclerosis.
  The New England journal of medicine 2007 Dunckley T, Huentelman MJ, Craig DW, Pearson JV, Szelinger S, Joshipura K, Halperin RF, Stamper C, Jensen KR, Letizia D, Hesterlee SE, Pestronk A, Levine T, Bertorini T, Graves MC, Mozaffar T, Jackson…
• Continuum of frontal lobe impairment in amyotrophic lateral sclerosis.
  Archives of neurology 2007 Murphy JM, Henry RG, Langmore S, Kramer JH, Miller BL, Lomen-Hoerth C
• Establishing subtypes of the continuum of frontal lobe impairment in amyotrophic lateral sclerosis.
  Archives of neurology 2007 Murphy J, Henry R, Lomen-Hoerth C
• Dysphagia in patients with frontotemporal lobar dementia.
  Archives of neurology 2007 Langmore SE, Olney RK, Lomen-Hoerth C, Miller BL
• Comparison of family histories in FTLD subtypes and related tauopathies.
  Neurology 2005 Goldman JS, Farmer JM, Wood EM, Johnson JK, Boxer A, Neuhaus J, Lomen-Hoerth C, Wilhelmsen KC, Lee VM, Grossman M, Miller BL
• The effects of executive and behavioral dysfunction on the course of ALS.
  Neurology 2005 Olney RK, Murphy J, Forshew D, Garwood E, Miller BL, Langmore S, Kohn MA, Lomen-Hoerth C
• A voxel-based morphometry study of patterns of brain atrophy in ALS and ALS/FTLD.
  Neurology 2005 Chang JL, Lomen-Hoerth C, Murphy J, Henry RG, Kramer JH, Miller BL, Gorno-Tempini ML
• Exit strategies in ALS: an influence of depression or despair?
  Neurology 2005 Olney RK, Lomen-Hoerth C
• A clinical trial of creatine in ALS.
  Neurology 2004 Shefner JM, Cudkowicz ME, Schoenfeld D, Conrad T, Taft J, Chilton M, Urbinelli L, Qureshi M, Zhang H, Pestronk A, Caress J, Donofrio P, Sorenson E, Bradley W, Lomen-Hoerth C, Pioro E, Rezania K, Ross …
• 17q-linked frontotemporal dementia-amyotrophic lateral sclerosis without tau mutations with tau and alpha-synuclein inclusions.
  Archives of neurology 2004 Wilhelmsen KC, Forman MS, Rosen HJ, Alving LI, Goldman J, Feiger J, Lee JV, Segall SK, Kramer JH, Lomen-Hoerth C, Rankin KP, Johnson J, Feiler HS, Weiner MW, Lee VM, Trojanowski JQ, Miller BL
• Characterization of amyotrophic lateral sclerosis and frontotemporal dementia.
  Dementia and geriatric cognitive disorders 2004 Lomen-Hoerth C
• Statistical motor unit number estimation: from theory to practice.
  Muscle & nerve 2003 Lomen-Hoerth C, Slawnych MP
• ALS treatment strikes out while trying for a homer: the topiramate trial.
  Neurology 2003 Kaufmann P, Lomen-Hoerth C
• Are amyotrophic lateral sclerosis patients cognitively normal?
  Neurology 2003 Lomen-Hoerth C, Murphy J, Langmore S, Kramer JH, Olney RK, Miller B
• Cognitive impairment, frontotemporal dementia, and the motor neuron diseases.
  Annals of neurology 2003 Strong MJ, Lomen-Hoerth C, Caselli RJ, Bigio EH, Yang W
• The overlap of amyotrophic lateral sclerosis and frontotemporal dementia.
  Neurology 2002 Lomen-Hoerth C, Anderson T, Miller B
• Effect of recording window and stimulation variables on the statistical technique of motor unit number estimation.
  Muscle & nerve 2001 Lomen-Hoerth C, Olney RK
• Comparison of multiple point and statistical motor unit number estimation.
  Muscle & nerve 2000 Lomen-Hoerth C, Olney RK
• Motor unit number estimation (MUNE): how may it contribute to the diagnosis of ALS?
  Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 2000 Olney RK, Lomen-Hoerth C
• Adult-onset nemaline myopathy: Another cause of dropped head.
  Muscle & nerve 1999 Lomen-Hoerth C, Simmons ML, Dearmond SJ, Layzer RB
• Clinical neurophysiologic studies: which test is useful and when?
  Neurologic clinics 1999 Lomen-Hoerth C, Aminoff MJ
• Widespread neurotrophin receptor expression in the immune system and other nonneuronal rat tissues.
  Journal of neurochemistry 1995 Lomen-Hoerth C, Shooter EM
• Tissue-specific alternative splicing generates two isoforms of the trkA receptor.
  The Journal of biological chemistry 1993 Barker PA, Lomen-Hoerth C, Gensch EM, Meakin SO, Glass DJ, Shooter EM