Cathryn Cadwell, MD, PhD
Assistant Professor
Neurological Surgery
School of Medicine

Education & Training

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• Fellowship Neuropathology University of California 06/2021
• Diversity, Equity, and Inclusion Champion Training University of California 2020
• Residency Anatomic Pathology University of California 06/2019
• M.D. Baylor College of Medicine 12/2016
• Ph.D. Neuroscience Baylor College of Medicine 12/2015
• B.S. Neuroscience, Biochemistry Baylor University 05/2007

Websites

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• Neuroscience Program Page (neurograd.ucsf.edu)
• Lab website (cadwelllab.ucsf.edu)

Grants and Projects

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• The role of retinoic acid signaling in patterning the human cerebral cortex, NIH/NINDS, 2022-2027
• NINDS Research Education Programs for Residents and Fellows in Neurology, Neurosurgery, Neuropathology, Neuroradiology and Emergency Medicine (R25), NIH, 2010-2025
• The Role of Cell Lineage in Determining Tuning Preferences in Visual Cortex, NIH, 2013-2015

Publications (35)

Top publication keywords:
Gene Expression ProfilingNeurofibromaNeocortexUltrasonic Surgical ProceduresPatch-Clamp TechniquesUltrasonicsNeurilemmomaSingle-Cell AnalysisMotor CortexSequence Analysis, RNANeuronsAntigens, NeoplasmTranscriptomeNeurogenesisNerve Sheath Neoplasms

• High-Complexity Barcoded Rabies Virus for Scalable Circuit Mapping Using Single-Cell and Single-Nucleus Sequencing.
  bioRxiv : the preprint server for biology 2024 Shin D, Urbanek ME, Larson HH, Moussa AJ, Lee KY, Baker DL, Standen-Bloom E, Ramachandran S, Bogdanoff D, Cadwell CR, Nowakowski TJ
• Implementation and validation of single-cell genomics experiments in neuroscience.
  Nature neuroscience 2024 Colonna M, Konopka G, Liddelow SA, Nowakowski T, Awatramani R, Bateup HS, Cadwell CR, Caglayan E, Chen JL, Gillis J, Kampmann M, Krienen F, Marsh SE, Monje M, O'Dea MR, Patani R, Pollen AA, Quintana …
• Multimodal evaluation of network activity and optogenetic interventions in human hippocampal slices.
  Nature neuroscience 2024 Andrews JP, Geng J, Voitiuk K, Elliott MAT, Shin D, Robbins A, Spaeth A, Wang A, Li L, Solis D, Keefe MG, Sevetson JL, Rivera de Jesús JA, Donohue KC, Larson HH, Ehrlich D, Auguste KI, Salama S, Sohal…
• Prenatal AAV9-GFP administration in fetal lambs results in transduction of female germ cells and maternal exposure to virus.
  Molecular therapy. Methods & clinical development 2024 Borges B, Varthaliti A, Schwab M, Clarke MT, Pivetti C, Gupta N, Cadwell CR, Guibinga G, Phillips S, Del Rio T, Ozsolak F, Imai-Leonard D, Kong L, Laird DJ, Herzeg A, Sumner CJ, MacKenzie TC
• Cell-Type Specificity of Mosaic Chromosome 1q Gain Resolved by snRNA-seq in a Case of Epilepsy With Hyaline Protoplasmic Astrocytopathy.
  Neurology. Genetics 2024 Leng K, Cadwell CR, Devine WP, Tihan T, Qi Z, Singhal NS, Glenn OA, Kamiya S, Wiita AP, Berger AC, Shieh JT, Titus EW, Paredes MF, Upadhyay V

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• Thalamocortical organoids enable in vitro modeling of 22q11.2 microdeletion associated with neuropsychiatric disorders.
  Cell stem cell 2024 Shin D, Kim CN, Ross J, Hennick KM, Wu SR, Paranjape N, Leonard R, Wang JC, Keefe MG, Pavlovic BJ, Donohue KC, Moreau C, Wigdor EM, Larson HH, Allen DE, Cadwell CR, Bhaduri A, Popova G, Bearden CE, …
• Cell type specificity of mosaic chromosome 1q gain resolved by snRNA-seq in a case of epilepsy with hyaline protoplasmic astrocytopathy.
  bioRxiv : the preprint server for biology 2024 Leng K, Cadwell CR, Patrick Devine W, Tihan T, Qi Z, Singhal N, Glenn O, Kamiya S, Wiita A, Berger A, Shieh JT, Titus EW, Paredes MF, Upadhyay V
• Patch-seq: Multimodal Profiling of Single-Cell Morphology, Electrophysiology, and Gene Expression.
  Methods in molecular biology (Clifton, N.J.) 2024 Cadwell CR, Tolias AS
• Dual ankyrinG and subpial autoantibodies in a man with well-controlled HIV infection with steroid-responsive meningoencephalitis: A case report.
  Frontiers in neurology 2023 Bartley CM, Ngo TT, Cadwell CR, Harroud A, Schubert RD, Alvarenga BD, Hawes IA, Zorn KC, Hunyh T, Teliska LH, Kung AF, Shah S, Gelfand JM, Chow FC, Rasband MN, Dubey D, Pittock SJ, DeRisi JL, Wilson …
• Targeted Next-Generation Sequencing Reveals Divergent Clonal Evolution in Components of Composite Pleomorphic Xanthoastrocytoma-Ganglioglioma.
  Journal of neuropathology and experimental neurology 2022 Lucas CG, Davidson CJ, Alashari M, Putnam AR, Whipple NS, Bruggers CS, Mendez JS, Cheshier SH, Walker JB, Ramani B, Cadwell CR, Sullivan DV, Lu R, Mirchia K, Van Ziffle J, Devine P, Goldschmidt E, …
• Fate mapping of neural stem cell niches reveals distinct origins of human cortical astrocytes.
  Science (New York, N.Y.) 2022 Allen DE, Donohue KC, Cadwell CR, Shin D, Keefe MG, Sohal VS, Nowakowski TJ
• Amyloid-β related angiitis presenting as eosinophilic meningitis: a case report.
  BMC neurology 2022 Tanner JA, Richie MB, Cadwell CR, Eliaz A, Kim S, Haq Z, Rasool N, Shah MP, Guterman EL
• A multimodal cell census and atlas of the mammalian primary motor cortex.
  Nature 2021 BRAIN Initiative Cell Census Network (BICCN)
• Preferentially Expressed Antigen in Melanoma (PRAME) Expression in Malignant, but Not Benign, Peripheral Nerve Sheath Tumors.
  Journal of neuropathology and experimental neurology 2021 Cadwell CR, Yuksek GE, Hirbe AC, Srihari D, LeBoit P, Dahiya S, Pekmezci M
• Loss of fidelity in scanned digital images compared to glass slides of brain tumors resected using cavitron ultrasonic surgical aspirator.
  Brain pathology (Zurich, Switzerland) 2021 Cadwell CR, Bowman S, Laszik ZG, Pekmezci M
• Patch-seq: Past, Present, and Future.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Lipovsek M, Bardy C, Cadwell CR, Hadley K, Kobak D, Tripathy SJ
• Phenotypic variation of transcriptomic cell types in mouse motor cortex.
  Nature 2020 Scala F, Kobak D, Bernabucci M, Bernaerts Y, Cadwell CR, Castro JR, Hartmanis L, Jiang X, Laturnus S, Miranda E, Mulherkar S, Tan ZH, Yao Z, Zeng H, Sandberg R, Berens P, Tolias AS
• Comprehensive analysis of diverse low-grade neuroepithelial tumors with FGFR1 alterations reveals a distinct molecular signature of rosette-forming glioneuronal tumor.
  Acta neuropathologica communications 2020 Lucas CG, Gupta R, Doo P, Lee JC, Cadwell CR, Ramani B, Hofmann JW, Sloan EA, Kleinschmidt-DeMasters BK, Lee HS, Wood MD, Grafe M, Born D, Vogel H, Salamat S, Puccetti D, Scharnhorst D, Samuel D, …
• Development of renal cysts in a transplanted kidney.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2020 Freise J, Cadwell C, Park M, Freise C
• Gliomas arising in the setting of Li-Fraumeni syndrome stratify into two molecular subgroups with divergent clinicopathologic features.
  Acta neuropathologica 2020 Sloan EA, Hilz S, Gupta R, Cadwell C, Ramani B, Hofmann J, Kline CN, Banerjee A, Reddy A, Oberheim Bush NA, Chang S, Braunstein S, Chang EF, Raffel C, Gupta N, Sun PP, Kim JYH, Moes G, Alva E, Li R, …
• Cell type composition and circuit organization of clonally related excitatory neurons in the juvenile mouse neocortex.
  eLife 2020 Cadwell CR, Scala F, Fahey PG, Kobak D, Mulherkar S, Sinz FH, Papadopoulos S, Tan ZH, Johnsson P, Hartmanis L, Li S, Cotton RJ, Tolias KF, Sandberg R, Berens P, Jiang X, Tolias AS
• Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma.
  Cell stem cell 2020 Bhaduri A, Di Lullo E, Jung D, Müller S, Crouch EE, Espinosa CS, Ozawa T, Alvarado B, Spatazza J, Cadwell CR, Wilkins G, Velmeshev D, Liu SJ, Malatesta M, Andrews MG, Mostajo-Radji MA, Huang EJ, …
• Author Correction: Layer 4 of mouse neocortex differs in cell types and circuit organization between sensory areas.
  Nature communications 2019 Scala F, Kobak D, Shan S, Bernaerts Y, Laturnus S, Cadwell CR, Hartmanis L, Froudarakis E, Castro JR, Tan ZH, Papadopoulos S, Patel SS, Sandberg R, Berens P, Jiang X, Tolias AS
• Development and Arealization of the Cerebral Cortex.
  Neuron 2019 Cadwell CR, Bhaduri A, Mostajo-Radji MA, Keefe MG, Nowakowski TJ
• Layer 4 of mouse neocortex differs in cell types and circuit organization between sensory areas.
  Nature communications 2019 Scala F, Kobak D, Shan S, Bernaerts Y, Laturnus S, Cadwell CR, Hartmanis L, Froudarakis E, Castro JR, Tan ZH, Papadopoulos S, Patel SS, Sandberg R, Berens P, Jiang X, Tolias AS
• Management of Inverted Papilloma During Holmium Laser Enucleation of the Prostate.
  Urology 2018 Tzou DT, Cadwell C, Simko JP, Chi T, Stoller ML
• Multimodal profiling of single-cell morphology, electrophysiology, and gene expression using Patch-seq.
  Nature protocols 2017 Cadwell CR, Scala F, Li S, Livrizzi G, Shen S, Sandberg R, Jiang X, Tolias AS
• Q&A: using Patch-seq to profile single cells.
  BMC biology 2017 Cadwell CR, Sandberg R, Jiang X, Tolias AS
• Response to Comment on "Principles of connectivity among morphologically defined cell types in adult neocortex".
  Science (New York, N.Y.) 2016 Jiang X, Shen S, Sinz F, Reimer J, Cadwell CR, Berens P, Ecker AS, Patel S, Denfield GH, Froudarakis E, Li S, Walker E, Tolias AS
• Electrophysiological, transcriptomic and morphologic profiling of single neurons using Patch-seq.
  Nature biotechnology 2015 Cadwell CR, Palasantza A, Jiang X, Berens P, Deng Q, Yilmaz M, Reimer J, Shen S, Bethge M, Tolias KF, Sandberg R, Tolias AS
• Principles of connectivity among morphologically defined cell types in adult neocortex.
  Science (New York, N.Y.) 2015 Jiang X, Shen S, Cadwell CR, Berens P, Sinz F, Ecker AS, Patel S, Tolias AS
• Waking State: Rapid Variations Modulate Neural and Behavioral Responses.
  Neuron 2015 McGinley MJ, Vinck M, Reimer J, Batista-Brito R, Zagha E, Cadwell CR, Tolias AS, Cardin JA, McCormick DA
• Pupil fluctuations track fast switching of cortical states during quiet wakefulness.
  Neuron 2014 Reimer J, Froudarakis E, Cadwell CR, Yatsenko D, Denfield GH, Tolias AS
• State dependence of noise correlations in macaque primary visual cortex.
  Neuron 2014 Ecker AS, Berens P, Cotton RJ, Subramaniyan M, Denfield GH, Cadwell CR, Smirnakis SM, Bethge M, Tolias AS
• Phenytoin normalizes exaggerated fear behavior in p-chlorophenylalanine (PCPA)-treated rats.
  Epilepsy & behavior : E&B 2006 Hughes CR, Keele NB