Cathrine Sant
Postdoctoral Scholar
Business Service Ctr
Chancellor/EVC/FAS

Education & Training

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• PhD Neuroscience University of California, San Francisco 12/2024
• BA Molecular and Cellular Biology, Statistics University of California, Berkeley 12/2018

Publications (18)

Top publication keywords:
Brain DiseasesTauopathiesSoftwareCaspase 6Locus CoeruleusSubstantia NigraWakefulnessSingle-Cell AnalysisInduced Pluripotent Stem CellsAutopsytau ProteinsNeuronsNeuropathologyAlzheimer DiseaseNeurofibrillary Tangles

• APOE4-Aβ synergy drives brain network dysfunction and neuronal lysosomal-ER proteostasis dysregulation a preclinical Alzheimer's disease model.
  bioRxiv : the preprint server for biology 2025 Shin J, Brady E, Chen C, Lauderdale K, Agrawal A, Zhang Y, Jiang X, Nambiar P, Herbert J, Mallen DD, Ly KK, Honma PS, Guo Z, Sant C, Thomas R, Miller SR, Cobos I, Palop JJ
• CHOIR improves significance-based detection of cell types and states from single-cell data.
  Nature genetics 2025 Sant C, Mucke L, Corces MR
• Pathways underlying selective neuronal vulnerability in Alzheimer's disease: Contrasting the vulnerable locus coeruleus to the resilient substantia nigra.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2025 Ehrenberg AJ, Sant C, Pereira FL, Li SH, Buxton J, Langlois S, Trinidad M, Oh I, Leite REP, Rodriguez RD, Paes VR, Pasqualucci CA, Seeley WW, Spina S, Suemoto CK, Temple S, Kaufer D, Grinberg LT
• iPSC-induced neurons with the V337M MAPT mutation are selectively vulnerable to caspase-mediated cleavage of tau and apoptotic cell death.
  Molecular and cellular neurosciences 2024 Theofilas P, Wang C, Butler D, Morales DO, Petersen C, Ambrose A, Chin B, Yang T, Khan S, Ng R, Kayed R, Karch CM, Miller BL, Gestwicki JE, Gan L, Temple S, Arkin MR, Grinberg LT
• Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models.
  Neurobiology of disease 2023 Das M, Mao W, Voskobiynyk Y, Necula D, Lew I, Petersen C, Zahn A, Yu GQ, Yu X, Smith N, Sayed FA, Gan L, Paz JT, Mucke L

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• Caspase-6-cleaved tau is relevant in Alzheimer's disease and marginal in four-repeat tauopathies: Diagnostic and therapeutic implications.
  Neuropathology and applied neurobiology 2022 Theofilas P, Piergies AMH, Oh I, Lee YB, Li SH, Pereira FL, Petersen C, Ehrenberg AJ, Eser RA, Ambrose AJ, Chin B, Yang T, Khan S, Ng R, Spina S, Seeley WW, Miller BL, Arkin MR, Grinberg LT
• Subcortical Neuronal Correlates of Sleep in Neurodegenerative Diseases.
  JAMA neurology 2022 Oh JY, Walsh CM, Ranasinghe K, Mladinov M, Pereira FL, Petersen C, Falgàs N, Yack L, Lamore T, Nasar R, Lew C, Li S, Metzler T, Coppola Q, Pandher N, Le M, Heuer HW, Heinsen H, Spina S, Seeley WW, …
• Comorbid neuropathological diagnoses in early versus late-onset Alzheimer's disease.
  Brain : a journal of neurology 2021 Spina S, La Joie R, Petersen C, Nolan AL, Cuevas D, Cosme C, Hepker M, Hwang JH, Miller ZA, Huang EJ, Karydas AM, Grant H, Boxer AL, Gorno-Tempini ML, Rosen HJ, Kramer JH, Miller BL, Seeley WW, …
• Tau-driven degeneration of sleep- and wake-regulating neurons in Alzheimer's disease.
  Sleep medicine reviews 2021 Lew CH, Petersen C, Neylan TC, Grinberg LT
• Reduced synchrony in alpha oscillations during life predicts post mortem neurofibrillary tangle density in early-onset and atypical Alzheimer's disease.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2021 Ranasinghe KG, Petersen C, Kudo K, Mizuiri D, Rankin KP, Rabinovici GD, Gorno-Tempini ML, Seeley WW, Spina S, Miller BL, Vossel K, Grinberg LT, Nagarajan SS
• Tractography-Pathology Correlations in Traumatic Brain Injury: A TRACK-TBI Study.
  Journal of neurotrauma 2021 Nolan AL, Petersen C, Iacono D, Mac Donald CL, Mukherjee P, van der Kouwe A, Jain S, Stevens A, Diamond BR, Wang R, Markowitz AJ, Fischl B, Perl DP, Manley GT, Keene CD, Diaz-Arrastia R, Edlow BL, …
• Language and spatial dysfunction in Alzheimer disease with white matter thorn-shaped astrocytes.
  Neurology 2020 Resende EPF, Nolan AL, Petersen C, Ehrenberg AJ, Spina S, Allen IE, Rosen HJ, Kramer J, Miller BL, Seeley WW, Gorno-Tempini ML, Miller Z, Grinberg LT
• Astrocytic Tau Deposition Is Frequent in Typical and Atypical Alzheimer Disease Presentations.
  Journal of neuropathology and experimental neurology 2019 Nolan A, De Paula Franca Resende E, Petersen C, Neylan K, Spina S, Huang E, Seeley W, Miller Z, Grinberg LT
• Profound degeneration of wake-promoting neurons in Alzheimer's disease.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2019 Oh J, Eser RA, Ehrenberg AJ, Morales D, Petersen C, Kudlacek J, Dunlop SR, Theofilas P, Resende EDPF, Cosme C, Alho EJL, Spina S, Walsh CM, Miller BL, Seeley WW, Bittencourt JC, Neylan TC, Heinsen H, …
• Alzheimer's disease clinical variants show distinct regional patterns of neurofibrillary tangle accumulation.
  Acta neuropathologica 2019 Petersen C, Nolan AL, de Paula França Resende E, Miller Z, Ehrenberg AJ, Gorno-Tempini ML, Rosen HJ, Kramer JH, Spina S, Rabinovici GD, Miller BL, Seeley WW, Heinsen H, Grinberg LT
• The role of co-neurotransmitters in sleep and wake regulation.
  Molecular psychiatry 2018 Oh J, Petersen C, Walsh CM, Bittencourt JC, Neylan TC, Grinberg LT
• Selective Vulnerability of Brainstem Nuclei in Distinct Tauopathies: A Postmortem Study.
  Journal of neuropathology and experimental neurology 2018 Eser RA, Ehrenberg AJ, Petersen C, Dunlop S, Mejia MB, Suemoto CK, Walsh CM, Rajana H, Oh J, Theofilas P, Seeley WW, Miller BL, Neylan TC, Heinsen H, Grinberg LT
• Neuropathologic Correlates of Psychiatric Symptoms in Alzheimer's Disease.
  Journal of Alzheimer's disease : JAD 2018 Ehrenberg AJ, Suemoto CK, França Resende EP, Petersen C, Leite REP, Rodriguez RD, Ferretti-Rebustini REL, You M, Oh J, Nitrini R, Pasqualucci CA, Jacob-Filho W, Kramer JH, Gatchel JR, Grinberg LT