Casper Hoogenraad, PhD
Professor
Biochemistry and Biophysics
School of Medicine

He is Adjunct Professor in Department of Biochemistry and Biophysics at University of California San Francisco (UCSF).

Prior to joining Genentech, he was full Professor of Molecular Neuroscience and served as Chair of the Cell Biology, Neurobiology and Biophysics Division at Utrecht University, The Netherlands. Casper received his Bachelor of Science in Biochemistry and Master of Science in Molecular Biology from Utrecht University, and his doctorate in Cell Biology from the Erasmus University Rotterdam. Casper was a postdoctoral fellow at the Massachusetts Institute of Technology (MIT) in Cambridge, Massachusetts and joined the faculty of the Erasmus Medical Center Rotterdam as an Associate Professor in the Department of Neuroscience.

Casper continues his basic research as a Senior Fellow at Genentech to study the molecular and cellular mechanisms that regulate the development and function of the brain and aims to translate these findings into potential therapies for neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. Throughout his career, he discovered new molecular mechanisms and cell biological processes that control cytoskeleton remodeling and cargo trafficking. Work from his lab has characterized in detail the cytoskeleton and transport events required to 'build' and 'wire' neurons, including the early developmental stages of axon formation and neuronal polarization, assembly of the axon initial segment, dendrite outgrowth and spine plasticity. He has also contributed to the development of new molecular methods and imaging tools to study intracellular dynamics in living cells.

• Sodium channel endocytosis drives axon initial segment plasticity.
  Science advances 2023 Fréal A, Jamann N, Ten Bos J, Jansen J, Petersen N, Ligthart T, Hoogenraad CC, Kole MHP
• Correlating the Structure and Gene Silencing Activity of Oligonucleotide-Loaded Lipid Nanoparticles Using Small-Angle X-ray Scattering.
  ACS nano 2023 Hammel M, Fan Y, Sarode A, Byrnes AE, Zang N, Kou P, Nagapudi K, Leung D, Hoogenraad CC, Chen T, Yen CW, Hura GL
• Lipid nanoparticle delivery limits antisense oligonucleotide activity and cellular distribution in the brain after intracerebroventricular injection.
  Molecular therapy. Nucleic acids 2023 Byrnes AE, Dominguez SL, Yen CW, Laufer BI, Foreman O, Reichelt M, Lin H, Sagolla M, Hötzel K, Ngu H, Soendergaard C, Estevez A, Lin HC, Goyon A, Bian J, Lin J, Hinz FI, Friedman BA, Easton A, …
• PTRN-1 (CAMSAP) and NOCA-2 (NINEIN) are required for microtubule polarity in Caenorhabditis elegans dendrites.
  PLoS biology 2022 He L, van Beem L, Snel B, Hoogenraad CC, Harterink M
• Stress-induced vesicular assemblies of dual leucine zipper kinase are signaling hubs involved in kinase activation and neurodegeneration.
  The EMBO journal 2022 Tortosa E, Sengupta Ghosh A, Li Q, Wong WR, Hinkle T, Sandoval W, Rose CM, Hoogenraad CC
• Predictive high-throughput screening of PEGylated lipids in oligonucleotide-loaded lipid nanoparticles for neuronal gene silencing.
  Nanoscale advances 2022 Sarode A, Fan Y, Byrnes AE, Hammel M, Hura GL, Fu Y, Kou P, Hu C, Hinz FI, Roberts J, Koenig SG, Nagapudi K, Hoogenraad CC, Chen T, Leung D, Yen CW
• Organization and dynamics of the cortical complexes controlling insulin secretion in β-cells.
  Journal of cell science 2022 Noordstra I, van den Berg CM, Boot FWJ, Katrukha EA, Yu KL, Tas RP, Portegies S, Viergever BJ, de Graaff E, Hoogenraad CC, de Koning EJP, Carlotti F, Kapitein LC, Akhmanova A
• Inducible manipulation of motor-cargo interaction using engineered kinesin motors.
  Journal of cell science 2021 Hummel JJA, Hoogenraad CC
• ER - lysosome contacts at a pre-axonal region regulate axonal lysosome availability.
  Nature communications 2021 Özkan N, Koppers M, van Soest I, van Harten A, Jurriens D, Liv N, Klumperman J, Kapitein LC, Hoogenraad CC, Farías GG
• Specific KIF1A-adaptor interactions control selective cargo recognition.
  The Journal of cell biology 2021 Hummel JJA, Hoogenraad CC
• WDR47 protects neuronal microtubule minus ends from katanin-mediated severing.
  Cell reports 2021 Buijs RR, Hummel JJA, Burute M, Pan X, Cao Y, Stucchi R, Altelaar M, Akhmanova A, Kapitein LC, Hoogenraad CC
• Inducible manipulation of motor-cargo interaction using engineered kinesin motors.
  Journal of cell science 2021 Hummel JJA, Hoogenraad CC
• Multiple layers of spatial regulation coordinate axonal cargo transport.
  Current opinion in neurobiology 2021 Zahavi EE, Hoogenraad CC
• Combined kinesin-1 and kinesin-3 activity drives axonal trafficking of TrkB receptors in Rab6 carriers.
  Developmental cell 2021 Zahavi EE, Hummel JJA, Han Y, Bar C, Stucchi R, Altelaar M, Hoogenraad CC
• Centrosome-mediated microtubule remodeling during axon formation in human iPSC-derived neurons.
  The EMBO journal 2021 Lindhout FW, Portegies S, Kooistra R, Herstel LJ, Stucchi R, Hummel JJA, Scheefhals N, Katrukha EA, Altelaar M, MacGillavry HD, Wierenga CJ, Hoogenraad CC
• Combined kinesin-1 and kinesin-3 activity drives axonal trafficking of TrkB receptors in Rab6 carriers.
  Developmental cell 2021 Zahavi EE, Hummel JJA, Han Y, Bar C, Stucchi R, Altelaar M, Hoogenraad CC
• The mechanism of kinesin inhibition by kinesin-binding protein.
  eLife 2020 Atherton J, Hummel JJ, Olieric N, Locke J, Peña A, Rosenfeld SS, Steinmetz MO, Hoogenraad CC, Moores CA
• Quantitative mapping of transcriptome and proteome dynamics during polarization of human iPSC-derived neurons.
  eLife 2020 Lindhout FW, Kooistra R, Portegies S, Herstel LJ, Stucchi R, Snoek BL, Altelaar AM, MacGillavry HD, Wierenga CJ, Hoogenraad CC
• Temporal Quantitative Proteomics of mGluR-induced Protein Translation and Phosphorylation in Neurons.
  Molecular & cellular proteomics : MCP 2020 van Gelder CAGH, Penning R, Veth TS, Catsburg LAE, Hoogenraad CC, MacGillavry HD, Altelaar M
• Deciphering the Proteome Dynamics during Development of Neurons Derived from Induced Pluripotent Stem Cells.
  Journal of proteome research 2020 Varderidou-Minasian S, Verheijen BM, Schätzle P, Hoogenraad CC, Pasterkamp RJ, Altelaar M
• Interleukin-17: A Social Cytokine.
  Cell 2020 Hoogenraad CC, Riol-Blanco L
• Cortical anchoring of the microtubule cytoskeleton is essential for neuron polarity.
  eLife 2020 He L, Kooistra R, Das R, Oudejans E, van Leen E, Ziegler J, Portegies S, de Haan B, van Regteren Altena A, Stucchi R, Altelaar AM, Wieser S, Krieg M, Hoogenraad CC, Harterink M
• Tropomyosin Tpm3.1 Is Required to Maintain the Structure and Function of the Axon Initial Segment.
  iScience 2020 Abouelezz A, Stefen H, Segerstråle M, Micinski D, Minkeviciene R, Lahti L, Hardeman EC, Gunning PW, Hoogenraad CC, Taira T, Fath T, Hotulainen P
• Publisher Correction: Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics.
  Nature structural & molecular biology 2020 Vogl AM, Phu L, Becerra R, Giusti SA, Verschueren E, Hinkle TB, Bordenave MD, Adrian M, Heidersbach A, Yankilevich P, Stefani FD, Wurst W, Hoogenraad CC, Kirkpatrick DS, Refojo D, Sheng M
• Loss of BICD2 in muscle drives motor neuron loss in a developmental form of spinal muscular atrophy.
  Acta neuropathologica communications 2020 Rossor AM, Sleigh JN, Groves M, Muntoni F, Reilly MM, Hoogenraad CC, Schiavo G
• Microtubule Minus-End Binding Protein CAMSAP2 and Kinesin-14 Motor KIFC3 Control Dendritic Microtubule Organization.
  Current biology : CB 2020 Cao Y, Lipka J, Stucchi R, Burute M, Pan X, Portegies S, Tas R, Willems J, Will L, MacGillavry H, Altelaar M, Kapitein LC, Harterink M, Hoogenraad CC
• Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics.
  Nature structural & molecular biology 2020 Vogl AM, Phu L, Becerra R, Giusti SA, Verschueren E, Hinkle TB, Bordenave MD, Adrian M, Heidersbach A, Yankilevich P, Stefani FD, Wurst W, Hoogenraad CC, Kirkpatrick DS, Refojo D, Sheng M
• Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau.
  Nature communications 2020 Ferrari L, Stucchi R, Konstantoulea K, van de Kamp G, Kos R, Geerts WJC, van Bezouwen LS, Förster FG, Altelaar M, Hoogenraad CC, Rüdiger SGD
• Neuronal Cytoskeleton: Presynaptic Boutons as Hotspots for Activity-Dependent Microtubule Nucleation.
  Current biology : CB 2019 Freal A, Hoogenraad CC
• Glucocorticoid and β-adrenergic regulation of hippocampal dendritic spines.
  Journal of neuroendocrinology 2019 Lesuis SL, Timmermans W, Lucassen PJ, Hoogenraad CC, Krugers HJ
• Solving the Mysteries of Dementia: FTD Mutant Tau Impairs Structural Axon Initial Segment Plasticity.
  Neuron 2019 Lipka J, Hoogenraad CC
• Dynein activating adaptor BICD2 controls radial migration of upper-layer cortical neurons in vivo.
  Acta neuropathologica communications 2019 Will L, Portegies S, van Schelt J, van Luyk M, Jaarsma D, Hoogenraad CC
• Shank Proteins Couple the Endocytic Zone to the Postsynaptic Density to Control Trafficking and Signaling of Metabotropic Glutamate Receptor 5.
  Cell reports 2019 Scheefhals N, Catsburg LAE, Westerveld ML, Blanpied TA, Hoogenraad CC, MacGillavry HD
• Cytolinker Gas2L1 regulates axon morphology through microtubule-modulated actin stabilization.
  EMBO reports 2019 van de Willige D, Hummel JJ, Alkemade C, Kahn OI, Au FK, Qi RZ, Dogterom M, Koenderink GH, Hoogenraad CC, Akhmanova A
• Feedback-Driven Assembly of the Axon Initial Segment.
  Neuron 2019 Fréal A, Rai D, Tas RP, Pan X, Katrukha EA, van de Willige D, Stucchi R, Aher A, Yang C, Altelaar AFM, Vocking K, Post JA, Harterink M, Kapitein LC, Akhmanova A, Hoogenraad CC
• VAP-SCRN1 interaction regulates dynamic endoplasmic reticulum remodeling and presynaptic function.
  The EMBO journal 2019 Lindhout FW, Cao Y, Kevenaar JT, Bodzeta A, Stucchi R, Boumpoutsari MM, Katrukha EA, Altelaar M, MacGillavry HD, Hoogenraad CC
• SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse.
  Neuron 2019 Koopmans F, van Nierop P, Andres-Alonso M, Byrnes A, Cijsouw T, Coba MP, Cornelisse LN, Farrell RJ, Goldschmidt HL, Howrigan DP, Hussain NK, Imig C, de Jong APH, Jung H, Kohansalnodehi M, Kramarz B, …
• The expanded clinical spectrum of anti-GABABR encephalitis and added value of KCTD16 autoantibodies.
  Brain : a journal of neurology 2019 van Coevorden-Hameete MH, de Bruijn MAAM, de Graaff E, Bastiaansen DAEM, Schreurs MWJ, Demmers JAA, Ramberger M, Hulsenboom ESP, Nagtzaam MMP, Boukhrissi S, Veldink JH, Verschuuren JJGM, Hoogenraad CC…
• Endocannabinoid Signaling Mediates Local Dendritic Coordination between Excitatory and Inhibitory Synapses.
  Cell reports 2019 Hu HY, Kruijssen DLH, Frias CP, Rózsa B, Hoogenraad CC, Wierenga CJ
• TRIM46 Organizes Microtubule Fasciculation in the Axon Initial Segment.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Harterink M, Vocking K, Pan X, Soriano Jerez EM, Slenders L, Fréal A, Tas RP, van de Wetering WJ, Timmer K, Motshagen J, van Beuningen SFB, Kapitein LC, Geerts WJC, Post JA, Hoogenraad CC
• Semaphorin4D Induces Inhibitory Synapse Formation by Rapid Stabilization of Presynaptic Boutons via MET Coactivation.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Frias CP, Liang J, Bresser T, Scheefhals L, van Kesteren M, van Dorland R, Hu HY, Bodzeta A, van Bergen En Henegouwen PMP, Hoogenraad CC, Wierenga CJ
• Wnt Signaling Directs Neuronal Polarity and Axonal Growth.
  iScience 2019 Stanganello E, Zahavi EE, Burute M, Smits J, Jordens I, Maurice MM, Kapitein LC, Hoogenraad CC
• MAP7D2 Localizes to the Proximal Axon and Locally Promotes Kinesin-1-Mediated Cargo Transport into the Axon.
  Cell reports 2019 Pan X, Cao Y, Stucchi R, Hooikaas PJ, Portegies S, Will L, Martin M, Akhmanova A, Harterink M, Hoogenraad CC
• MAP7 family proteins regulate kinesin-1 recruitment and activation.
  The Journal of cell biology 2019 Hooikaas PJ, Martin M, Mühlethaler T, Kuijntjes GJ, Peeters CAE, Katrukha EA, Ferrari L, Stucchi R, Verhagen DGF, van Riel WE, Grigoriev I, Altelaar AFM, Hoogenraad CC, Rüdiger SGD, Steinmetz MO, …
• Feedback-Driven Mechanisms between Microtubules and the Endoplasmic Reticulum Instruct Neuronal Polarity.
  Neuron 2019 Farías GG, Fréal A, Tortosa E, Stucchi R, Pan X, Portegies S, Will L, Altelaar M, Hoogenraad CC
• More is not always better: hyperglutamylation leads to neurodegeneration.
  The EMBO journal 2018 Akhmanova A, Hoogenraad CC
• Local microtubule organization promotes cargo transport in C. elegans dendrites.
  Journal of cell science 2018 Harterink M, Edwards SL, de Haan B, Yau KW, van den Heuvel S, Kapitein LC, Miller KG, Hoogenraad CC
• Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer's disease.
  Molecular neurodegeneration 2018 Dumbacher M, Van Dooren T, Princen K, De Witte K, Farinelli M, Lievens S, Tavernier J, Dehaen W, Wera S, Winderickx J, Allasia S, Kilonda A, Spieser S, Marchand A, Chaltin P, Hoogenraad CC, Griffioen …
• Membrane trafficking and cytoskeletal dynamics in neuronal function.
  Molecular and cellular neurosciences 2018 MacGillavry HD, Hoogenraad CC
• Polarity of Neuronal Membrane Traffic Requires Sorting of Kinesin Motor Cargo during Entry into Dendrites by a Microtubule-Associated Septin.
  Developmental cell 2018 Karasmanis EP, Phan CT, Angelis D, Kesisova IA, Hoogenraad CC, McKenney RJ, Spiliotis ET
• The HAUS Complex Is a Key Regulator of Non-centrosomal Microtubule Organization during Neuronal Development.
  Cell reports 2018 Cunha-Ferreira I, Chazeau A, Buijs RR, Stucchi R, Will L, Pan X, Adolfs Y, van der Meer C, Wolthuis JC, Kahn OI, Schätzle P, Altelaar M, Pasterkamp RJ, Kapitein LC, Hoogenraad CC
• APC2 controls dendrite development by promoting microtubule dynamics.
  Nature communications 2018 Kahn OI, Schätzle P, van de Willige D, Tas RP, Lindhout FW, Portegies S, Kapitein LC, Hoogenraad CC
• Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca2+/CaM Controls DCV Binding and Liprin-α/TANC2 Recruits DCVs to Postsynaptic Sites.
  Cell reports 2018 Stucchi R, Plucinska G, Hummel JJA, Zahavi EE, Guerra San Juan I, Klykov O, Scheltema RA, Altelaar AFM, Hoogenraad CC
• Polarity of Neuronal Membrane Traffic Requires Sorting of Kinesin Motor Cargo during Entry into Dendrites by a Microtubule-Associated Septin.
  Developmental cell 2018 Karasmanis EP, Phan CT, Angelis D, Kesisova IA, Hoogenraad CC, McKenney RJ, Spiliotis ET
• Activity-Dependent Actin Remodeling at the Base of Dendritic Spines Promotes Microtubule Entry.
  Current biology : CB 2018 Schätzle P, Esteves da Silva M, Tas RP, Katrukha EA, Hu HY, Wierenga CJ, Kapitein LC, Hoogenraad CC
• Local mechanisms regulating selective cargo entry and long-range trafficking in axons.
  Current opinion in neurobiology 2018 Gumy LF, Hoogenraad CC
• Caldendrin Directly Couples Postsynaptic Calcium Signals to Actin Remodeling in Dendritic Spines.
  Neuron 2018 Mikhaylova M, Bär J, van Bommel B, Schätzle P, YuanXiang P, Raman R, Hradsky J, Konietzny A, Loktionov EY, Reddy PP, Lopez-Rojas J, Spilker C, Kobler O, Raza SA, Stork O, Hoogenraad CC, Kreutz MR
• Polarized trafficking: the palmitoylation cycle distributes cytoplasmic proteins to distinct neuronal compartments.
  Current opinion in cell biology 2018 Tortosa E, Hoogenraad CC
• Differentiation between Oppositely Oriented Microtubules Controls Polarized Neuronal Transport.
  Neuron 2017 Tas RP, Chazeau A, Cloin BMC, Lambers MLA, Hoogenraad CC, Kapitein LC
• Myosin-V Induces Cargo Immobilization and Clustering at the Axon Initial Segment.
  Frontiers in cellular neuroscience 2017 Janssen AFJ, Tas RP, van Bergeijk P, Oost R, Hoogenraad CC, Kapitein LC
• Solubilization of human cells by the styrene-maleic acid copolymer: Insights from fluorescence microscopy.
  Biochimica et biophysica acta. Biomembranes 2017 Dörr JM, van Coevorden-Hameete MH, Hoogenraad CC, Killian JA
• Antibodies to TRIM46 are associated with paraneoplastic neurological syndromes.
  Annals of clinical and translational neurology 2017 van Coevorden-Hameete MH, van Beuningen SFB, Perrenoud M, Will LM, Hulsenboom E, Demonet JF, Sabater L, Kros JM, Verschuuren JJGM, Titulaer MJ, de Graaff E, Sillevis Smitt PAE, Hoogenraad CC
• Probing the Interplay between Dendritic Spine Morphology and Membrane-Bound Diffusion.
  Biophysical journal 2017 Adrian M, Kusters R, Storm C, Hoogenraad CC, Kapitein LC
• Efficient switching of mCherry fluorescence using chemical caging.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Cloin BMC, De Zitter E, Salas D, Gielen V, Folkers GE, Mikhaylova M, Bergeler M, Krajnik B, Harvey J, Hoogenraad CC, Van Meervelt L, Dedecker P, Kapitein LC
• Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization.
  Neuron 2017 Tortosa E, Adolfs Y, Fukata M, Pasterkamp RJ, Kapitein LC, Hoogenraad CC
• MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus KIF5-Dependent Cargo Transport in Sensory Neurons.
  Neuron 2017 Gumy LF, Katrukha EA, Grigoriev I, Jaarsma D, Kapitein LC, Akhmanova A, Hoogenraad CC
• DeActs: genetically encoded tools for perturbing the actin cytoskeleton in single cells.
  Nature methods 2017 Harterink M, da Silva ME, Will L, Turan J, Ibrahim A, Lang AE, van Battum EY, Pasterkamp RJ, Kapitein LC, Kudryashov D, Barres BA, Hoogenraad CC, Zuchero JB
• Probing cytoskeletal modulation of passive and active intracellular dynamics using nanobody-functionalized quantum dots.
  Nature communications 2017 Katrukha EA, Mikhaylova M, van Brakel HX, van Bergen En Henegouwen PM, Akhmanova A, Hoogenraad CC, Kapitein LC
• Axonal transport deficits in multiple sclerosis: spiraling into the abyss.
  Acta neuropathologica 2017 van den Berg R, Hoogenraad CC, Hintzen RQ
• Kinesin-4 KIF21B is a potent microtubule pausing factor.
  eLife 2017 van Riel WE, Rai A, Bianchi S, Katrukha EA, Liu Q, Heck AJ, Hoogenraad CC, Steinmetz MO, Kapitein LC, Akhmanova A
• Inducible Control of mRNA Transport Using Reprogrammable RNA-Binding Proteins.
  ACS synthetic biology 2017 Abil Z, Gumy LF, Zhao H, Hoogenraad CC
• Quantitative Map of Proteome Dynamics during Neuronal Differentiation.
  Cell reports 2017 Frese CK, Mikhaylova M, Stucchi R, Gautier V, Liu Q, Mohammed S, Heck AJR, Altelaar AFM, Hoogenraad CC
• Biophysical model of the role of actin remodeling on dendritic spine morphology.
  PloS one 2017 Miermans CA, Kusters RP, Hoogenraad CC, Storm C
• NGF-dependent axon growth and regeneration are altered in sympathetic neurons of dystrophic mdx mice.
  Molecular and cellular neurosciences 2017 Lombardi L, Persiconi I, Gallo A, Hoogenraad CC, De Stefano ME
• Robust, Sensitive, and Automated Phosphopeptide Enrichment Optimized for Low Sample Amounts Applied to Primary Hippocampal Neurons.
  Journal of proteome research 2016 Post H, Penning R, Fitzpatrick MA, Garrigues LB, Wu W, MacGillavry HD, Hoogenraad CC, Heck AJ, Altelaar AF
• Effects of Early Life Stress on Synaptic Plasticity in the Developing Hippocampus of Male and Female Rats.
  PloS one 2016 Derks NA, Krugers HJ, Hoogenraad CC, Joëls M, Sarabdjitsingh RA
• Molecular Pathway of Microtubule Organization at the Golgi Apparatus.
  Developmental cell 2016 Wu J, de Heus C, Liu Q, Bouchet BP, Noordstra I, Jiang K, Hua S, Martin M, Yang C, Grigoriev I, Katrukha EA, Altelaar AFM, Hoogenraad CC, Qi RZ, Klumperman J, Akhmanova A
• A tissue-specific protein purification approach in Caenorhabditis elegans identifies novel interaction partners of DLG-1/Discs large.
  BMC biology 2016 Waaijers S, Muñoz J, Berends C, Ramalho JJ, Goerdayal SS, Low TY, Zoumaro-Djayoon AD, Hoffmann M, Koorman T, Tas RP, Harterink M, Seelk S, Kerver J, Hoogenraad CC, Bossinger O, Tursun B, van den …
• Moving on: mobility for early-career neuroscientists.
  The European journal of neuroscience 2016 Grubb MS, Hoogenraad CC, Schwabe L, López-Bendito G
• Tumour Suppressor Adenomatous Polyposis Coli (APC) localisation is regulated by both Kinesin-1 and Kinesin-2.
  Scientific reports 2016 Ruane PT, Gumy LF, Bola B, Anderson B, Wozniak MJ, Hoogenraad CC, Allan VJ
• Three-Step Model for Polarized Sorting of KIF17 into Dendrites.
  Current biology : CB 2016 Franker MA, Esteves da Silva M, Tas RP, Tortosa E, Cao Y, Frias CP, Janssen AFJ, Wulf PS, Kapitein LC, Hoogenraad CC
• Detection and Characterization of Autoantibodies to Neuronal Cell-Surface Antigens in the Central Nervous System.
  Frontiers in molecular neuroscience 2016 van Coevorden-Hameete MH, Titulaer MJ, Schreurs MW, de Graaff E, Sillevis Smitt PA, Hoogenraad CC
• Cooperative Interactions between 480 kDa Ankyrin-G and EB Proteins Assemble the Axon Initial Segment.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Fréal A, Fassier C, Le Bras B, Bullier E, De Gois S, Hazan J, Hoogenraad CC, Couraud F
• Heterozygous KIDINS220/ARMS nonsense variants cause spastic paraplegia, intellectual disability, nystagmus, and obesity.
  Human molecular genetics 2016 Josifova DJ, Monroe GR, Tessadori F, de Graaff E, van der Zwaag B, Mehta SG, DDD Study, Harakalova M, Duran KJ, Savelberg SM, Nijman IJ, Jungbluth H, Hoogenraad CC, Bakkers J, Knoers NV, Firth HV, …
• KIF5C S176 Phosphorylation Regulates Microtubule Binding and Transport Efficiency in Mammalian Neurons.
  Frontiers in cellular neuroscience 2016 Padzik A, Deshpande P, Hollos P, Franker M, Rannikko EH, Cai D, Prus P, Mågård M, Westerlund N, Verhey KJ, James P, Hoogenraad CC, Coffey ET
• Microtubule plus-end tracking proteins in neuronal development.
  Cellular and molecular life sciences : CMLS 2016 van de Willige D, Hoogenraad CC, Akhmanova A
• Kinesin-Binding Protein Controls Microtubule Dynamics and Cargo Trafficking by Regulating Kinesin Motor Activity.
  Current biology : CB 2016 Kevenaar JT, Bianchi S, van Spronsen M, Olieric N, Lipka J, Frias CP, Mikhaylova M, Harterink M, Keijzer N, Wulf PS, Hilbert M, Kapitein LC, de Graaff E, Ahkmanova A, Steinmetz MO, Hoogenraad CC
• Neuronal polarity: remodeling microtubule organization.
  Current opinion in neurobiology 2016 van Beuningen SF, Hoogenraad CC
• Light-controlled intracellular transport in Caenorhabditis elegans.
  Current biology : CB 2016 Harterink M, van Bergeijk P, Allier C, de Haan B, van den Heuvel S, Hoogenraad CC, Kapitein LC
• Dynein Regulator NDEL1 Controls Polarized Cargo Transport at the Axon Initial Segment.
  Neuron 2016 Kuijpers M, van de Willige D, Freal A, Chazeau A, Franker MA, Hofenk J, Rodrigues RJ, Kapitein LC, Akhmanova A, Jaarsma D, Hoogenraad CC
• Dendrites In Vitro and In Vivo Contain Microtubules of Opposite Polarity and Axon Formation Correlates with Uniform Plus-End-Out Microtubule Orientation.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Yau KW, Schätzle P, Tortosa E, Pagès S, Holtmaat A, Kapitein LC, Hoogenraad CC
• Bicaudal D Family of Motor Adaptors: Linking Dynein Motility to Cargo Binding.
  Trends in cell biology 2016 Hoogenraad CC, Akhmanova A
• Rotarod motor performance and advanced spinal cord lesion image analysis refine assessment of neurodegeneration in experimental autoimmune encephalomyelitis.
  Journal of neuroscience methods 2016 van den Berg R, Laman JD, van Meurs M, Hintzen RQ, Hoogenraad CC
• Microtubule-binding protein doublecortin-like kinase 1 (DCLK1) guides kinesin-3-mediated cargo transport to dendrites.
  The EMBO journal 2016 Lipka J, Kapitein LC, Jaworski J, Hoogenraad CC
• Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
  Developmental cell 2015 van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
• TRIM46 Controls Neuronal Polarity and Axon Specification by Driving the Formation of Parallel Microtubule Arrays.
  Neuron 2015 van Beuningen SFB, Will L, Harterink M, Chazeau A, van Battum EY, Frias CP, Franker MAM, Katrukha EA, Stucchi R, Vocking K, Antunes AT, Slenders L, Doulkeridou S, Sillevis Smitt P, Altelaar AFM, Post …
• Right Time, Right Place: Probing the Functions of Organelle Positioning.
  Trends in cell biology 2015 van Bergeijk P, Hoogenraad CC, Kapitein LC
• Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders.
  Frontiers in neuroscience 2015 Jaarsma D, Hoogenraad CC
• Positioning of AMPA Receptor-Containing Endosomes Regulates Synapse Architecture.
  Cell reports 2015 Esteves da Silva M, Adrian M, Schätzle P, Lipka J, Watanabe T, Cho S, Futai K, Wierenga CJ, Kapitein LC, Hoogenraad CC
• Plasticity-related gene 5: A novel surface autoantigen in paraneoplastic cerebellar degeneration.
  Neurology(R) neuroimmunology & neuroinflammation 2015 van Coevorden-Hameete MH, de Graaff E, Titulaer MJ, Hulsenboom E, Sabater L, Hoogenraad CC, Sillevis Smitt PA
• Live imaging of microtubule dynamics in organotypic hippocampal slice cultures.
  Methods in cell biology 2015 Schätzle P, Kapitein LC, Hoogenraad CC
• Studying neuronal microtubule organization and microtubule-associated proteins using single molecule localization microscopy.
  Methods in cell biology 2015 Chazeau A, Katrukha EA, Hoogenraad CC, Kapitein LC
• The axonal cytoskeleton: from organization to function.
  Frontiers in molecular neuroscience 2015 Kevenaar JT, Hoogenraad CC
• Resolving bundled microtubules using anti-tubulin nanobodies.
  Nature communications 2015 Mikhaylova M, Cloin BM, Finan K, van den Berg R, Teeuw J, Kijanka MM, Sokolowski M, Katrukha EA, Maidorn M, Opazo F, Moutel S, Vantard M, Perez F, van Bergen en Henegouwen PM, Hoogenraad CC, Ewers H, …
• Building the Neuronal Microtubule Cytoskeleton.
  Neuron 2015 Kapitein LC, Hoogenraad CC
• Exclusion of integrins from CNS axons is regulated by Arf6 activation and the AIS.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Franssen EH, Zhao RR, Koseki H, Kanamarlapudi V, Hoogenraad CC, Eva R, Fawcett JW
• The Hitchhiker's Guide to a Neuroscience Career.
  Neuron 2015 Joëls M, Hoogenraad CC, Poirazi P, Di Luca M
• The internal architecture of dendritic spines revealed by super-resolution imaging: What did we learn so far?
  Experimental cell research 2015 MacGillavry HD, Hoogenraad CC
• Microtubule minus-end-targeting proteins.
  Current biology : CB 2015 Akhmanova A, Hoogenraad CC
• Optogenetic control of organelle transport and positioning.
  Nature 2015 van Bergeijk P, Adrian M, Hoogenraad CC, Kapitein LC
• Barriers in the brain: resolving dendritic spine morphology and compartmentalization.
  Frontiers in neuroanatomy 2014 Adrian M, Kusters R, Wierenga CJ, Storm C, Hoogenraad CC, Kapitein LC
• Bicaudal d family adaptor proteins control the velocity of Dynein-based movements.
  Cell reports 2014 Schlager MA, Serra-Marques A, Grigoriev I, Gumy LF, Esteves da Silva M, Wulf PS, Akhmanova A, Hoogenraad CC
• The intracellular redox protein MICAL-1 regulates the development of hippocampal mossy fibre connections.
  Nature communications 2014 Van Battum EY, Gunput RA, Lemstra S, Groen EJ, Yu KL, Adolfs Y, Zhou Y, Hoogenraad CC, Yoshida Y, Schachner M, Akhmanova A, Pasterkamp RJ
• The microtubule destabilizing protein stathmin controls the transition from dividing neuronal precursors to postmitotic neurons during adult hippocampal neurogenesis.
  Developmental neurobiology 2014 Boekhoorn K, van Dis V, Goedknegt E, Sobel A, Lucassen PJ, Hoogenraad CC
• Microtubule minus-end binding protein CAMSAP2 controls axon specification and dendrite development.
  Neuron 2014 Yau KW, van Beuningen SF, Cunha-Ferreira I, Cloin BM, van Battum EY, Will L, Schätzle P, Tas RP, van Krugten J, Katrukha EA, Jiang K, Wulf PS, Mikhaylova M, Harterink M, Pasterkamp RJ, Akhmanova A, …
• Axon and dendritic trafficking.
  Current opinion in neurobiology 2014 Maeder CI, Shen K, Hoogenraad CC
• Golgi fragmentation precedes neuromuscular denervation and is associated with endosome abnormalities in SOD1-ALS mouse motor neurons.
  Acta neuropathologica communications 2014 van Dis V, Kuijpers M, Haasdijk ED, Teuling E, Oakes SA, Hoogenraad CC, Jaarsma D
• Identification of Srp9 as a febrile seizure susceptibility gene.
  Annals of clinical and translational neurology 2014 Hessel EV, de Wit M, Wolterink-Donselaar IG, Karst H, de Graaff E, van Lith HA, de Bruijn E, de Sonnaville S, Verbeek NE, Lindhout D, de Kovel CG, Koeleman BP, van Kempen M, Brilstra E, Cuppen E, Loos…
• A role for Bicaudal-D2 in radial cerebellar granule cell migration.
  Nature communications 2014 Jaarsma D, van den Berg R, Wulf PS, van Erp S, Keijzer N, Schlager MA, de Graaff E, De Zeeuw CI, Pasterkamp RJ, Akhmanova A, Hoogenraad CC
• The GRIP1/14-3-3 pathway coordinates cargo trafficking and dendrite development.
  Developmental cell 2014 Geiger JC, Lipka J, Segura I, Hoyer S, Schlager MA, Wulf PS, Weinges S, Demmers J, Hoogenraad CC, Acker-Palmer A
• Microtubule minus-end stabilization by polymerization-driven CAMSAP deposition.
  Developmental cell 2014 Jiang K, Hua S, Mohan R, Grigoriev I, Yau KW, Liu Q, Katrukha EA, Altelaar AF, Heck AJ, Hoogenraad CC, Akhmanova A
• The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes.
  The EMBO journal 2013 Schwenk BM, Lang CM, Hogl S, Tahirovic S, Orozco D, Rentzsch K, Lichtenthaler SF, Hoogenraad CC, Capell A, Haass C, Edbauer D
• Shape-induced asymmetric diffusion in dendritic spines allows efficient synaptic AMPA receptor trapping.
  Biophysical journal 2013 Kusters R, Kapitein LC, Hoogenraad CC, Storm C
• Mutations in cytoplasmic dynein and its regulators cause malformations of cortical development and neurodegenerative diseases.
  Biochemical Society transactions 2013 Lipka J, Kuijpers M, Jaworski J, Hoogenraad CC
• Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A.
  Nature 2013 Benoit RM, Frey D, Hilbert M, Kevenaar JT, Wieser MM, Stirnimann CU, McMillan D, Ceska T, Lebon F, Jaussi R, Steinmetz MO, Schertler GF, Hoogenraad CC, Capitani G, Kammerer RA
• Molecular and cellular mechanisms underlying anti-neuronal antibody mediated disorders of the central nervous system.
  Autoimmunity reviews 2013 van Coevorden-Hameete MH, de Graaff E, Titulaer MJ, Hoogenraad CC, Sillevis Smitt PA
• CFEOM1-associated kinesin KIF21A is a cortical microtubule growth inhibitor.
  Developmental cell 2013 van der Vaart B, van Riel WE, Doodhi H, Kevenaar JT, Katrukha EA, Gumy L, Bouchet BP, Grigoriev I, Spangler SA, Yu KL, Wulf PS, Wu J, Lansbergen G, van Battum EY, Pasterkamp RJ, Mimori-Kiyosue Y, …
• Developmental and activity-dependent miRNA expression profiling in primary hippocampal neuron cultures.
  PloS one 2013 van Spronsen M, van Battum EY, Kuijpers M, Vangoor VR, Rietman ML, Pothof J, Gumy LF, van Ijcken WF, Akhmanova A, Pasterkamp RJ, Hoogenraad CC
• New insights into mRNA trafficking in axons.
  Developmental neurobiology 2013 Gumy LF, Katrukha EA, Kapitein LC, Hoogenraad CC
• Slide to the left and slide to the right: motor coordination in neurons.
  Developmental cell 2013 Harterink M, Hoogenraad CC
• The kinesin-2 family member KIF3C regulates microtubule dynamics and is required for axon growth and regeneration.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Gumy LF, Chew DJ, Tortosa E, Katrukha EA, Kapitein LC, Tolkovsky AM, Hoogenraad CC, Fawcett JW
• Amyotrophic lateral sclerosis (ALS)-associated VAPB-P56S inclusions represent an ER quality control compartment.
  Acta neuropathologica communications 2013 Kuijpers M, van Dis V, Haasdijk ED, Harterink M, Vocking K, Post JA, Scheper W, Hoogenraad CC, Jaarsma D
• Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission.
  The Journal of cell biology 2013 Spangler SA, Schmitz SK, Kevenaar JT, de Graaff E, de Wit H, Demmers J, Toonen RF, Hoogenraad CC
• The ALS8 protein VAPB interacts with the ER-Golgi recycling protein YIF1A and regulates membrane delivery into dendrites.
  The EMBO journal 2013 Kuijpers M, Yu KL, Teuling E, Akhmanova A, Jaarsma D, Hoogenraad CC
• Psychiatric phenomena as initial manifestation of encephalitis by anti-NMDAR antibodies.
  Acta neuropsychiatrica 2013 Maat P, de Graaff E, van Beveren NM, Hulsenboom E, Verdijk RM, Koorengevel K, van Duijn M, Hooijkaas H, Hoogenraad C, Sillevis Smitt PA
• Microtubule-based transport - basic mechanisms, traffic rules and role in neurological pathogenesis.
  Journal of cell science 2013 Franker MA, Hoogenraad CC
• Stress and excitatory synapses: from health to disease.
  Neuroscience 2013 Timmermans W, Xiong H, Hoogenraad CC, Krugers HJ
• Off the rails: axonal cargoes on the road to nowhere.
  The EMBO journal 2013 Gumy LF, Hoogenraad CC
• Myosin-V opposes microtubule-based cargo transport and drives directional motility on cortical actin.
  Current biology : CB 2013 Kapitein LC, van Bergeijk P, Lipka J, Keijzer N, Wulf PS, Katrukha EA, Akhmanova A, Hoogenraad CC
• Spatio-temporal analysis of molecular determinants of neuronal degeneration in the aging mouse cerebellum.
  Molecular & cellular proteomics : MCP 2013 de Graaf EL, Vermeij WP, de Waard MC, Rijksen Y, van der Pluijm I, Hoogenraad CC, Hoeijmakers JH, Altelaar AF, Heck AJ
• TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites.
  Neuron 2013 van Spronsen M, Mikhaylova M, Lipka J, Schlager MA, van den Heuvel DJ, Kuijpers M, Wulf PS, Keijzer N, Demmers J, Kapitein LC, Jaarsma D, Gerritsen HC, Akhmanova A, Hoogenraad CC
• Structural basis of tubulin tyrosination by tubulin tyrosine ligase.
  The Journal of cell biology 2013 Prota AE, Magiera MM, Kuijpers M, Bargsten K, Frey D, Wieser M, Jaussi R, Hoogenraad CC, Kammerer RA, Janke C, Steinmetz MO
• Microtubule plus-end tracking proteins SLAIN1/2 and ch-TOG promote axonal development.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 van der Vaart B, Franker MA, Kuijpers M, Hua S, Bouchet BP, Jiang K, Grigoriev I, Hoogenraad CC, Akhmanova A
• BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures.
  Molecular biology of the cell 2012 Splinter D, Razafsky DS, Schlager MA, Serra-Marques A, Grigoriev I, Demmers J, Keijzer N, Jiang K, Poser I, Hyman AA, Hoogenraad CC, King SJ, Akhmanova A
• Identification of delta/notch-like epidermal growth factor-related receptor as the Tr antigen in paraneoplastic cerebellar degeneration.
  Annals of neurology 2012 de Graaff E, Maat P, Hulsenboom E, van den Berg R, van den Bent M, Demmers J, Lugtenburg PJ, Hoogenraad CC, Sillevis Smitt P
• Molecular motors in cargo trafficking and synapse assembly.
  Advances in experimental medicine and biology 2012 van den Berg R, Hoogenraad CC
• Differential expression of liprin-α family proteins in the brain suggests functional diversification.
  The Journal of comparative neurology 2011 Spangler SA, Jaarsma D, De Graaff E, Wulf PS, Akhmanova A, Hoogenraad CC
• Combined β-adrenergic and corticosteroid receptor activation regulates AMPA receptor function in hippocampal neurons.
  Journal of psychopharmacology (Oxford, England) 2011 Zhou M, Hoogenraad CC, Joëls M, Krugers HJ
• Maintenance of dendritic spine morphology by partitioning-defective 1b through regulation of microtubule growth.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Hayashi K, Suzuki A, Hirai S, Kurihara Y, Hoogenraad CC, Ohno S
• Liprin-mediated large signaling complex organization revealed by the liprin-α/CASK and liprin-α/liprin-β complex structures.
  Molecular cell 2011 Wei Z, Zheng S, Spangler SA, Yu C, Hoogenraad CC, Zhang M
• New insights in endosomal dynamics and AMPA receptor trafficking.
  Seminars in cell & developmental biology 2011 van der Sluijs P, Hoogenraad CC
• Spinal inhibitory interneuron pathology follows motor neuron degeneration independent of glial mutant superoxide dismutase 1 expression in SOD1-ALS mice.
  Journal of neuropathology and experimental neurology 2011 Hossaini M, Cardona Cano S, van Dis V, Haasdijk ED, Hoogenraad CC, Holstege JC, Jaarsma D
• βCaMKII plays a nonenzymatic role in hippocampal synaptic plasticity and learning by targeting αCaMKII to synapses.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Borgesius NZ, van Woerden GM, Buitendijk GH, Keijzer N, Jaarsma D, Hoogenraad CC, Elgersma Y
• Absence of common somatic alterations in genes on 1p and 19q in oligodendrogliomas.
  PloS one 2011 Bralten LB, Nouwens S, Kockx C, Erdem L, Hoogenraad CC, Kros JM, Moorhouse MJ, Sillevis Smitt PA, van der Spek P, van Ijcken W, Stubbs A, French PJ
• SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase.
  The Journal of cell biology 2011 van der Vaart B, Manatschal C, Grigoriev I, Olieric V, Gouveia SM, Bjelic S, Demmers J, Vorobjev I, Hoogenraad CC, Steinmetz MO, Akhmanova A
• NMDA receptor activation suppresses microtubule growth and spine entry.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Kapitein LC, Yau KW, Gouveia SM, van der Zwan WA, Wulf PS, Keijzer N, Demmers J, Jaworski J, Akhmanova A, Hoogenraad CC
• Centrosomes, microtubules and neuronal development.
  Molecular and cellular neurosciences 2011 Kuijpers M, Hoogenraad CC
• Rab6, Rab8, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers.
  Current biology : CB 2011 Grigoriev I, Yu KL, Martinez-Sanchez E, Serra-Marques A, Smal I, Meijering E, Demmers J, Peränen J, Pasterkamp RJ, van der Sluijs P, Hoogenraad CC, Akhmanova A
• CLIP-170 and IQGAP1 cooperatively regulate dendrite morphology.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Swiech L, Blazejczyk M, Urbanska M, Pietruszka P, Dortland BR, Malik AR, Wulf PS, Hoogenraad CC, Jaworski J
• IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo.
  Annals of neurology 2011 Bralten LB, Kloosterhof NK, Balvers R, Sacchetti A, Lapre L, Lamfers M, Leenstra S, de Jonge H, Kros JM, Jansen EE, Struys EA, Jakobs C, Salomons GS, Diks SH, Peppelenbosch M, Kremer A, Hoogenraad CC,…
• Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury.
  Science (New York, N.Y.) 2011 Hellal F, Hurtado A, Ruschel J, Flynn KC, Laskowski CJ, Umlauf M, Kapitein LC, Strikis D, Lemmon V, Bixby J, Hoogenraad CC, Bradke F
• Isolation of novel +TIPs and their binding partners using affinity purification techniques.
  Methods in molecular biology (Clifton, N.J.) 2011 Yu KL, Keijzer N, Hoogenraad CC, Akhmanova A
• Lentiviral transgenesis.
  Methods in molecular biology (Clifton, N.J.) 2011 Nakagawa T, Hoogenraad CC
• Dendritic spine plasticity: new regulatory roles of dynamic microtubules.
  The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2010 Hoogenraad CC, Akhmanova A
• Probing intracellular motor protein activity using an inducible cargo trafficking assay.
  Biophysical journal 2010 Kapitein LC, Schlager MA, van der Zwan WA, Wulf PS, Keijzer N, Hoogenraad CC
• In vitro reconstitution of the functional interplay between MCAK and EB3 at microtubule plus ends.
  Current biology : CB 2010 Montenegro Gouveia S, Leslie K, Kapitein LC, Buey RM, Grigoriev I, Wagenbach M, Smal I, Meijering E, Hoogenraad CC, Wordeman L, Steinmetz MO, Akhmanova A
• Which way to go? Cytoskeletal organization and polarized transport in neurons.
  Molecular and cellular neurosciences 2010 Kapitein LC, Hoogenraad CC
• Stress hormones and AMPA receptor trafficking in synaptic plasticity and memory.
  Nature reviews. Neuroscience 2010 Krugers HJ, Hoogenraad CC, Groc L
• GRASP-1 regulates endocytic receptor recycling and synaptic plasticity.
  Communicative & integrative biology 2010 Hoogenraad CC, van der Sluijs P
• The CASPR2 cell adhesion molecule functions as a tumor suppressor gene in glioma.
  Oncogene 2010 Bralten LB, Gravendeel AM, Kloosterhof NK, Sacchetti A, Vrijenhoek T, Veltman JA, van den Bent MJ, Kros JM, Hoogenraad CC, Sillevis Smitt PA, French PJ
• Integrated genomic profiling identifies candidate genes implicated in glioma-genesis and a novel LEO1-SLC12A1 fusion gene.
  Genes, chromosomes & cancer 2010 Bralten LB, Kloosterhof NK, Gravendeel LA, Sacchetti A, Duijm EJ, Kros JM, van den Bent MJ, Hoogenraad CC, Sillevis Smitt PA, French PJ
• Actin in dendritic spines: connecting dynamics to function.
  The Journal of cell biology 2010 Hotulainen P, Hoogenraad CC
• Synapse pathology in psychiatric and neurologic disease.
  Current neurology and neuroscience reports 2010 van Spronsen M, Hoogenraad CC
• Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry.
  PLoS biology 2010 Splinter D, Tanenbaum ME, Lindqvist A, Jaarsma D, Flotho A, Yu KL, Grigoriev I, Engelsma D, Haasdijk ED, Keijzer N, Demmers J, Fornerod M, Melchior F, Hoogenraad CC, Medema RH, Akhmanova A
• Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis.
  The EMBO journal 2010 Schlager MA, Kapitein LC, Grigoriev I, Burzynski GM, Wulf PS, Keijzer N, de Graaff E, Fukuda M, Shepherd IT, Akhmanova A, Hoogenraad CC
• Segregation of non-p.R132H mutations in IDH1 in distinct molecular subtypes of glioma.
  Human mutation 2010 Gravendeel LA, Kloosterhof NK, Bralten LB, van Marion R, Dubbink HJ, Dinjens W, Bleeker FE, Hoogenraad CC, Michiels E, Kros JM, van den Bent M, Smitt PA, French PJ
• Mixed microtubules steer dynein-driven cargo transport into dendrites.
  Current biology : CB 2010 Kapitein LC, Schlager MA, Kuijpers M, Wulf PS, van Spronsen M, MacKintosh FC, Hoogenraad CC
• Neuron specific Rab4 effector GRASP-1 coordinates membrane specialization and maturation of recycling endosomes.
  PLoS biology 2010 Hoogenraad CC, Popa I, Futai K, Martinez-Sanchez E, Sanchez-Martinez E, Wulf PS, van Vlijmen T, Dortland BR, Oorschot V, Govers R, Monti M, Heck AJ, Sheng M, Klumperman J, Rehmann H, Jaarsma D, …
• Axon extension occurs independently of centrosomal microtubule nucleation.
  Science (New York, N.Y.) 2010 Stiess M, Maghelli N, Kapitein LC, Gomis-Rüth S, Wilsch-Bräuninger M, Hoogenraad CC, Tolic-Nørrelykke IM, Bradke F
• Microtubule dynamics in dendritic spines.
  Methods in cell biology 2010 Kapitein LC, Yau KW, Hoogenraad CC
• A VAPB mutant linked to amyotrophic lateral sclerosis generates a novel form of organized smooth endoplasmic reticulum.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Fasana E, Fossati M, Ruggiano A, Brambillasca S, Hoogenraad CC, Navone F, Francolini M, Borgese N
• Hormonal regulation of AMPA receptor trafficking and memory formation.
  Frontiers in synaptic neuroscience 2009 Krugers HJ, Hoogenraad CC
• Control of neuronal polarity and plasticity--a renaissance for microtubules?
  Trends in cell biology 2009 Hoogenraad CC, Bradke F
• Basic mechanisms for recognition and transport of synaptic cargos.
  Molecular brain 2009 Schlager MA, Hoogenraad CC
• betaCaMKII controls the direction of plasticity at parallel fiber-Purkinje cell synapses.
  Nature neuroscience 2009 van Woerden GM, Hoebeek FE, Gao Z, Nagaraja RY, Hoogenraad CC, Kushner SA, Hansel C, De Zeeuw CI, Elgersma Y
• Corticosterone alters AMPAR mobility and facilitates bidirectional synaptic plasticity.
  PloS one 2009 Martin S, Henley JM, Holman D, Zhou M, Wiegert O, van Spronsen M, Joëls M, Hoogenraad CC, Krugers HJ
• Mammalian end binding proteins control persistent microtubule growth.
  The Journal of cell biology 2009 Komarova Y, De Groot CO, Grigoriev I, Gouveia SM, Munteanu EL, Schober JM, Honnappa S, Buey RM, Hoogenraad CC, Dogterom M, Borisy GG, Steinmetz MO, Akhmanova A
• Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity.
  Neuron 2009 Jaworski J, Kapitein LC, Gouveia SM, Dortland BR, Wulf PS, Grigoriev I, Camera P, Spangler SA, Di Stefano P, Demmers J, Krugers H, Defilippi P, Akhmanova A, Hoogenraad CC
• Microtubule-driven multimerization recruits ase1p onto overlapping microtubules.
  Current biology : CB 2008 Kapitein LC, Janson ME, van den Wildenberg SM, Hoogenraad CC, Schmidt CF, Peterman EJ
• A unique residue in rab3c determines the interaction with novel binding protein Zwint-1.
  FEBS letters 2008 van Vlijmen T, Vleugel M, Evers M, Mohammed S, Wulf PS, Heck AJ, Hoogenraad CC, van der Sluijs P
• A novel mouse model with impaired dynein/dynactin function develops amyotrophic lateral sclerosis (ALS)-like features in motor neurons and improves lifespan in SOD1-ALS mice.
  Human molecular genetics 2008 Teuling E, van Dis V, Wulf PS, Haasdijk ED, Akhmanova A, Hoogenraad CC, Jaarsma D
• Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Jaarsma D, Teuling E, Haasdijk ED, De Zeeuw CI, Hoogenraad CC
• STIM1 is a MT-plus-end-tracking protein involved in remodeling of the ER.
  Current biology : CB 2008 Grigoriev I, Gouveia SM, van der Vaart B, Demmers J, Smyth JT, Honnappa S, Splinter D, Steinmetz MO, Putney JW, Hoogenraad CC, Akhmanova A
• Liprin-alpha proteins: scaffold molecules for synapse maturation.
  Biochemical Society transactions 2007 Spangler SA, Hoogenraad CC
• Microtubule plus-end tracking proteins in differentiated mammalian cells.
  The international journal of biochemistry & cell biology 2007 Jaworski J, Hoogenraad CC, Akhmanova A
• Motor neuron disease-associated mutant vesicle-associated membrane protein-associated protein (VAP) B recruits wild-type VAPs into endoplasmic reticulum-derived tubular aggregates.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 Teuling E, Ahmed S, Haasdijk E, Demmers J, Steinmetz MO, Akhmanova A, Jaarsma D, Hoogenraad CC
• Rab6 regulates transport and targeting of exocytotic carriers.
  Developmental cell 2007 Grigoriev I, Splinter D, Keijzer N, Wulf PS, Demmers J, Ohtsuka T, Modesti M, Maly IV, Grosveld F, Hoogenraad CC, Akhmanova A
• A role for the Rab6B Bicaudal-D1 interaction in retrograde transport in neuronal cells.
  Experimental cell research 2007 Wanschers BF, van de Vorstenbosch R, Schlager MA, Splinter D, Akhmanova A, Hoogenraad CC, Wieringa B, Fransen JA
• Rab6 is increased in Alzheimer's disease brain and correlates with endoplasmic reticulum stress.
  Neuropathology and applied neurobiology 2007 Scheper W, Hoozemans JJ, Hoogenraad CC, Rozemuller AJ, Eikelenboom P, Baas F
• Liprinalpha1 degradation by calcium/calmodulin-dependent protein kinase II regulates LAR receptor tyrosine phosphatase distribution and dendrite development.
  Developmental cell 2007 Hoogenraad CC, Feliu-Mojer MI, Spangler SA, Milstein AD, Dunah AW, Hung AY, Sheng M
• Formation of microtubule-based traps controls the sorting and concentration of vesicles to restricted sites of regenerating neurons after axotomy.
  The Journal of cell biology 2007 Erez H, Malkinson G, Prager-Khoutorsky M, De Zeeuw CI, Hoogenraad CC, Spira ME
• The postsynaptic architecture of excitatory synapses: a more quantitative view.
  Annual review of biochemistry 2007 Sheng M, Hoogenraad CC
• Contribution of CYLN2 and GTF2IRD1 to neurological and cognitive symptoms in Williams Syndrome.
  Neurobiology of disease 2006 van Hagen JM, van der Geest JN, van der Giessen RS, Lagers-van Haselen GC, Eussen HJ, Gille JJ, Govaerts LC, Wouters CH, de Coo IF, Hoogenraad CC, Koekkoek SK, Frens MA, van Camp N, van der Linden A, …
• GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome.
  The EMBO journal 2006 Fumoto K, Hoogenraad CC, Kikuchi A
• Relative and absolute quantification of postsynaptic density proteome isolated from rat forebrain and cerebellum.
  Molecular & cellular proteomics : MCP 2006 Cheng D, Hoogenraad CC, Rush J, Ramm E, Schlager MA, Duong DM, Xu P, Wijayawardana SR, Hanfelt J, Nakagawa T, Sheng M, Peng J
• Control of dendritic arborization by the phosphoinositide-3'-kinase-Akt-mammalian target of rapamycin pathway.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 Jaworski J, Spangler S, Seeburg DP, Hoogenraad CC, Sheng M
• The microtubule plus-end-tracking protein CLIP-170 associates with the spermatid manchette and is essential for spermatogenesis.
  Genes & development 2005 Akhmanova A, Mausset-Bonnefont AL, van Cappellen W, Keijzer N, Hoogenraad CC, Stepanova T, Drabek K, van der Wees J, Mommaas M, Onderwater J, van der Meulen H, Tanenbaum ME, Medema RH, Hoogerbrugge J,…
• ATF3 expression precedes death of spinal motoneurons in amyotrophic lateral sclerosis-SOD1 transgenic mice and correlates with c-Jun phosphorylation, CHOP expression, somato-dendritic ubiquitination and Golgi fragmentation.
  The European journal of neuroscience 2005 Vlug AS, Teuling E, Haasdijk ED, French P, Hoogenraad CC, Jaarsma D
• Generation of lentiviral transgenic rats expressing glutamate receptor interacting protein 1 (GRIP1) in brain, spinal cord and testis.
  Journal of neuroscience methods 2005 Nakagawa T, Feliu-Mojer MI, Wulf P, Lois C, Sheng M, Hoogenraad CC
• GRIP1 controls dendrite morphogenesis by regulating EphB receptor trafficking.
  Nature neuroscience 2005 Hoogenraad CC, Milstein AD, Ethell IM, Henkemeyer M, Sheng M
• LAR receptor protein tyrosine phosphatases in the development and maintenance of excitatory synapses.
  Nature neuroscience 2005 Dunah AW, Hueske E, Wyszynski M, Hoogenraad CC, Jaworski J, Pak DT, Simonetta A, Liu G, Sheng M
• Microtubule plus-end-tracking proteins: mechanisms and functions.
  Current opinion in cell biology 2005 Akhmanova A, Hoogenraad CC
• Conformational changes in CLIP-170 regulate its binding to microtubules and dynactin localization.
  The Journal of cell biology 2004 Lansbergen G, Komarova Y, Modesti M, Wyman C, Hoogenraad CC, Goodson HV, Lemaitre RP, Drechsel DN, van Munster E, Gadella TW, Grosveld F, Galjart N, Borisy GG, Akhmanova A
• LIMK1 and CLIP-115: linking cytoskeletal defects to Williams syndrome.
  BioEssays : news and reviews in molecular, cellular and developmental biology 2004 Hoogenraad CC, Akhmanova A, Galjart N, De Zeeuw CI
• Bicaudal D induces selective dynein-mediated microtubule minus end-directed transport.
  The EMBO journal 2003 Hoogenraad CC, Wulf P, Schiefermeier N, Stepanova T, Galjart N, Small JV, Grosveld F, de Zeeuw CI, Akhmanova A
• Deformation of network connectivity in the inferior olive of connexin 36-deficient mice is compensated by morphological and electrophysiological changes at the single neuron level.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2003 De Zeeuw CI, Chorev E, Devor A, Manor Y, Van Der Giessen RS, De Jeu MT, Hoogenraad CC, Bijman J, Ruigrok TJ, French P, Jaarsma D, Kistler WM, Meier C, Petrasch-Parwez E, Dermietzel R, Sohl G, …
• The return of the exocyst.
  Nature cell biology 2003 Hoogenraad CC, Sheng M
• Visualization of microtubule growth in cultured neurons via the use of EB3-GFP (end-binding protein 3-green fluorescent protein).
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2003 Stepanova T, Slemmer J, Hoogenraad CC, Lansbergen G, Dortland B, De Zeeuw CI, Grosveld F, van Cappellen G, Akhmanova A, Galjart N
• Analysis of Cx36 knockout does not support tenet that olivary gap junctions are required for complex spike synchronization and normal motor performance.
  Annals of the New York Academy of Sciences 2002 Kistler WM, De Jeu MT, Elgersma Y, Van Der Giessen RS, Hensbroek R, Luo C, Koekkoek SK, Hoogenraad CC, Hamers FP, Gueldenagel M, Sohl G, Willecke K, De Zeeuw CI
• Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex.
  Nature cell biology 2002 Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, Galjart N, Grosveld F, Goud B, De Zeeuw CI, Barnekow A, Hoogenraad CC
• Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice.
  Nature genetics 2002 Hoogenraad CC, Koekkoek B, Akhmanova A, Krugers H, Dortland B, Miedema M, van Alphen A, Kistler WM, Jaegle M, Koutsourakis M, Van Camp N, Verhoye M, van der Linden A, Kaverina I, Grosveld F, De Zeeuw …
• LIS1, CLIP-170's key to the dynein/dynactin pathway.
  Molecular and cellular biology 2002 Coquelle FM, Caspi M, Cordelières FP, Dompierre JP, Dujardin DL, Koifman C, Martin P, Hoogenraad CC, Akhmanova A, Galjart N, De Mey JR, Reiner O
• Hereditary familial vestibular degenerative diseases.
  Annals of the New York Academy of Sciences 2001 Sun JC, Van Alphen AM, Wagenaar M, Huygen P, Hoogenraad CC, Hasson T, Koekkoek SK, Bohne BA, De Zeeuw CI
• Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes.
  The EMBO journal 2001 Hoogenraad CC, Akhmanova A, Howell SA, Dortland BR, De Zeeuw CI, Willemsen R, Visser P, Grosveld F, Galjart N
• Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts.
  Cell 2001 Akhmanova A, Hoogenraad CC, Drabek K, Stepanova T, Dortland B, Verkerk T, Vermeulen W, Burgering BM, De Zeeuw CI, Grosveld F, Galjart N
• Origin of vestibular dysfunction in Usher syndrome type 1B.
  Neurobiology of disease 2001 Sun JC, van Alphen AM, Wagenaar M, Huygen P, Hoogenraad CC, Hasson T, Koekkoek SK, Bohne BA, De Zeeuw CI
• Functional analysis of CLIP-115 and its binding to microtubules.
  Journal of cell science 2000 Hoogenraad CC, Akhmanova A, Grosveld F, De Zeeuw CI, Galjart N
• The murine CYLN2 gene: genomic organization, chromosome localization, and comparison to the human gene that is located within the 7q11.23 Williams syndrome critical region.
  Genomics 1998 Hoogenraad CC, Eussen BH, Langeveld A, van Haperen R, Winterberg S, Wouters CH, Grosveld F, De Zeeuw CI, Galjart N
• Microcircuitry and function of the inferior olive.
  Trends in neurosciences 1998 De Zeeuw CI, Simpson JI, Hoogenraad CC, Galjart N, Koekkoek SK, Ruigrok TJ
• CLIP-115, a novel brain-specific cytoplasmic linker protein, mediates the localization of dendritic lamellar bodies.
  Neuron 1997 De Zeeuw CI, Hoogenraad CC, Goedknegt E, Hertzberg E, Neubauer A, Grosveld F, Galjart N