Carolyn Calfee, MD, MAS
Professor
Medicine
School of Medicine

She came to UCSF for residency in Internal Medicine and stayed to complete her chief residency and Pulmonary/Critical Care Medicine fellowship. She also completed her Masters in Clinical Research at UCSF in 2009. After research training with Drs. Michael Matthay and Mark Eisner, she joined the faculty of the division in 2007. Dr. Calfee is also a member of UCSF’s Center for Tobacco Control Research and Education and an associate member of the Cardiovascular Research Institute (CVRI) and the UCSF Cancer Center.

RESEARCH INTERESTS Dr. Calfee’s primary academic focus is the prevention, diagnosis, prognosis, and treatment of the acute respiratory distress syndrome (ARDS). Current research projects include: (1) molecular phenotyping of ARDS and precision medicine in the ICU; (2) the role of cigarette smoke exposure and exposure to novel tobacco products in acute lung injury; and (3) novel treatments for ARDS.

• Molecular Phenotypes of Acute Respiratory Distress Syndrome in the ROSE Trial Have Differential Outcomes and Gene Expression Patterns That Differ at Baseline and Longitudinally over Time.
  American journal of respiratory and critical care medicine 2024 Sinha P, Neyton L, Sarma A, Wu N, Jones C, Zhuo H, Liu KD, Sanchez Guerrero E, Ghale R, Love C, Mick E, Delucchi KL, Langelier CR, Thompson BT, Matthay MA, Calfee CS
• Smoking Primes the Metabolomic Response in Trauma.
  The journal of trauma and acute care surgery 2024 Gallagher LT, Erickson C, D'Alessandro A, Schaid T, Thielen O, Hallas W, Mitra S, Stafford P, Moore EE, Silliman CC, Calfee CS, Cohen MJ
• Clustering COVID-19 ARDS patients through the first days of ICU admission. An analysis of the CIBERESUCICOVID Cohort.
  Critical care (London, England) 2024 Ceccato A, Forne C, Bos LD, Camprubí-Rimblas M, Areny-Balagueró A, Campaña-Duel E, Quero S, Diaz E, Roca O, De Gonzalo-Calvo D, Fernández-Barat L, Motos A, Ferrer R, Riera J, Lorente JA, Peñuelas O, …
• Critical Care: A Second Special Issue of the Blue Journal.
  American journal of respiratory and critical care medicine 2024 Calfee CS, Harhay MO, Schenck EJ, Ferguson ND, Heunks L, White D, Brochard LJ
• Identification of a hyperinflammatory sepsis phenotype using protein biomarker and clinical data in the ProCESS randomized trial.
  Scientific reports 2024 DeMerle KM, Kennedy JN, Chang CH, Delucchi K, Huang DT, Kravitz MS, Shapiro NI, Yealy DM, Angus DC, Calfee CS, Seymour CW
• Critical Care: A Special Issue of the Blue Journal.
  American journal of respiratory and critical care medicine 2024 Calfee CS, Harhay MO, Schenck EJ, Ferguson ND, Heunks L, White DB, Brochard LJ
• The Translational Value of Rodent Models of Sepsis.
  American journal of respiratory and critical care medicine 2024 Matthay MA, Schmidt EP, Bastarache JA, Calfee CS, Frevert CW, Martin TR
• Biological Effects of Corticosteroids on Pneumococcal Pneumonia in Mice and Humans.
  Research square 2024 Taenaka H, Wick KD, Sarma A, Matsumoto S, Ghale R, Fang X, Maishan M, Gotts JE, Langelier CR, Calfee CS, Matthay MA
• Novel subtypes of severe COVID-19 respiratory failure based on biological heterogeneity: a secondary analysis of a randomized controlled trial.
  Critical care (London, England) 2024 Alipanah-Lechner N, Hurst-Hopf J, Delucchi K, Swigart L, Willmore A, LaCombe B, Dewar R, Lane HC, Lallemand P, Liu KD, Esserman L, Matthay MA, Calfee CS, I-SPY COVID Consortium
• Elevated ferritin, mediated by IL-18 is associated with systemic inflammation and mortality in acute respiratory distress syndrome (ARDS).
  Thorax 2024 Mehta P, Samanta RJ, Wick K, Coll RC, Mawhinney T, McAleavey PG, Boyle AJ, Conlon J, Shankar-Hari M, Rogers A, Calfee CS, Matthay MA, Summers C, Chambers RC, McAuley DF, O'Kane CM
• Host-Microbe Multiomic Profiling Reveals Age-Dependent COVID-19 Immunopathology.
  medRxiv : the preprint server for health sciences 2024 Van Phan H, Tsitsiklis A, Maguire CP, Haddad EK, Becker PM, Kim-Schulze S, Lee B, Chen J, Hoch A, Pickering H, Van Zalm P, Altman MC, Augustine AD, Calfee CS, Bosinger S, Cairns C, Eckalbar W, Guan L,…
• The Plasma Lipidomic Landscape in Patients with Sepsis due to Community-acquired Pneumonia.
  American journal of respiratory and critical care medicine 2024 Chouchane O, Schuurman AR, Reijnders TDY, Peters-Sengers H, Butler JM, Uhel F, Schultz MJ, Bonten MJ, Cremer OL, Calfee CS, Matthay MA, Langley RJ, Alipanah-Lechner N, Kingsmore SF, Rogers A, Weeghel …
• Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study.
  Nature communications 2024 Ozonoff A, Jayavelu ND, Liu S, Melamed E, Milliren CE, Qi J, Geng LN, McComsey GA, Cairns CB, Baden LR, Schaenman J, Shaw AC, Samaha H, Seyfert-Margolis V, Krammer F, Rosen LB, Steen H, Syphurs C, …
• The antibiotic resistance reservoir of the lung microbiome expands with age in a population of critically ill patients.
  Nature communications 2024 Chu VT, Tsitsiklis A, Mick E, Ambroggio L, Kalantar KL, Glascock A, Osborne CM, Wagner BD, Matthay MA, DeRisi JL, Calfee CS, Mourani PM, Langelier CR
• A New Global Definition of Acute Respiratory Distress Syndrome.
  American journal of respiratory and critical care medicine 2024 Matthay MA, Arabi Y, Arroliga AC, Bernard G, Bersten AD, Brochard LJ, Calfee CS, Combes A, Daniel BM, Ferguson ND, Gong MN, Gotts JE, Herridge MS, Laffey JG, Liu KD, Machado FR, Martin TR, McAuley DF,…
• From Berlin to Global: The Need for Syndromic Definitions of Acute Respiratory Distress Syndrome.
  American journal of respiratory and critical care medicine 2024 Alipanah-Lechner N, Cavalcanti AB, Diaz J, Ferguson ND, Myatra SN, Calfee CS
• The Impact of Donor Smoking on Primary Graft Dysfunction and Mortality after Lung Transplantation.
  American journal of respiratory and critical care medicine 2024 Diamond JM, Cantu E, Calfee CS, Anderson MR, Clausen ES, Shashaty MGS, Courtwright AM, Kalman L, Oyster M, Crespo MM, Bermudez CA, Benvenuto L, Palmer SM, Snyder LD, Hartwig MG, Todd JL, Wille K, Hage…
• Functional recovery in a cohort of ECMO and non-ECMO acute respiratory distress syndrome survivors.
  Critical care (London, England) 2023 Snyder M, Njie BY, Grabenstein I, Viola S, Abbas H, Bhatti W, Lee R, Traficante R, Yeung SYA, Chow JH, Tabatabai A, Taylor BS, Dahi S, Scalea T, Rabin J, Grazioli A, Calfee CS, Britton N, Levine AR
• Robust airway microbiome signatures in acute respiratory failure and hospital-acquired pneumonia.
  Nature medicine 2023 Montassier E, Kitsios GD, Radder JE, Le Bastard Q, Kelly BJ, Panzer A, Lynch SV, Calfee CS, Dickson RP, Roquilly A
• Corrigendum to "Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: results from the IMPACC study" [eBioMedicine 83 (2022) 104208].
  EBioMedicine 2023 Ozonoff A, Schaenman J, Jayavelu ND, Milliren CE, Calfee CS, Cairns CB, Kraft M, Baden LR, Shaw AC, Krammer F, van Bakel H, Esserman DA, Liu S, Sesma AF, Simon V, Hafler DA, Montgomery RR, Kleinstein …
• Simvastatin in Critically Ill Patients with Covid-19.
  The New England journal of medicine 2023 REMAP-CAP Investigators, Hills TE, Lorenzi E, Berry LR, Shyamsundar M, Al-Beidh F, Annane D, Arabi Y, Aryal D, Au C, Beane A, Bhimani Z, Bonten M, Bradbury CA, Brunkhorst FM, Burrell A, Buxton M, …
• Acute respiratory distress syndrome phenotypes with distinct clinical outcomes in PHARLAP trial cohort.
  Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 2023 Bihari S, Bersten A, Paul E, McGuinness S, Dixon D, Sinha P, Calfee CS, Nichol A, Hodgson C, PHARLAP Study Investigators
• The antibiotic resistance reservoir of the lung microbiome expands with age.
  Research square 2023 Chu VT, Tsitsiklis A, Mick E, Ambroggio L, Kalantar KL, Glascock A, Osborne CM, Wagner BD, Matthay MA, DeRisi JL, Calfee CS, Mourani PM, Langelier CR
• Elevated Plasma Interleukin-18 Identifies High-Risk Acute Respiratory Distress Syndrome Patients not Distinguished by Prior Latent Class Analyses Using Traditional Inflammatory Cytokines: A Retrospective Analysis of Two Randomized Clinical Trials.
  Critical care medicine 2023 Moore AR, Pienkos SM, Sinha P, Guan J, O'Kane CM, Levitt JE, Wilson JG, Shankar-Hari M, Matthay MA, Calfee CS, Baron RM, McAuley DF, Rogers AJ
• Subphenotypes of Acute Respiratory Distress Syndrome: Advancing Towards Precision Medicine.
  Tuberculosis and respiratory diseases 2023 Levine AR, Calfee CS
• A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling.
  iScience 2023 Hackney JA, Shivram H, Vander Heiden J, Overall C, Orozco L, Gao X, Kim E, West N, Qamra A, Chang D, Chakrabarti A, Choy DF, Combes AJ, Courau T, Fragiadakis GK, Rao AA, Ray A, Tsui J, Hu K, Kuhn NF, …
• Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19.
  Research square 2023 Neyton LPA, Patel RK, Sarma A, UCSF COMET Consortium, Willmore A, Haller SC, Kangelaris KN, Eckalbar WL, Erle DJ, Krummel MF, Hendrickson CM, Woodruff PG, Langelier CR, Calfee CS, Fragiadakis GK
• Subphenotypes Assigned to Pediatric Acute Respiratory Failure Patients Show Differing Outcomes.
  American journal of respiratory and critical care medicine 2023 Flori HR, Zhang M, Xie J, Yang G, Sapru A, Calfee CS, Delucchi KL, Sinha P, Curley MAQ, Dahmer MK
• Estimating the attributable fraction of mortality from acute respiratory distress syndrome to inform enrichment in future randomised clinical trials.
  Thorax 2023 Saha R, Pham T, Sinha P, Maddali MV, Bellani G, Fan E, Summers C, Douiri A, Rubenfeld GD, Calfee CS, Laffey JG, McAuley DF, Shankar-Hari M, LUNG-SAFE investigators
• Exposure to ambient air pollutants and acute respiratory distress syndrome risk in sepsis.
  Intensive care medicine 2023 Reilly JP, Zhao Z, Shashaty MGS, Koyama T, Jones TK, Anderson BJ, Ittner CA, Dunn T, Miano TA, Oniyide O, Balmes JR, Matthay MA, Calfee CS, Christie JD, Meyer NJ, Ware LB
• Clinical and biological heterogeneity of multisystem inflammatory syndrome in adults following SARS-CoV-2 infection: a case series.
  Frontiers in medicine 2023 Barth KE, Spottiswoode N, Hurabielle C, Subbaraj L, COMET Consortium, Calfee CS, Matthay MA, French S, Connolly A, Hewitt SM, Vannella KM, Barnett C, Langelier CR, Patterson S
• ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies.
  Intensive care medicine 2023 Grasselli G, Calfee CS, Camporota L, Poole D, Amato MBP, Antonelli M, Arabi YM, Baroncelli F, Beitler JR, Bellani G, Bellingan G, Blackwood B, Bos LDJ, Brochard L, Brodie D, Burns KEA, Combes A, D'…
• Early plasma angiopoietin-2 is prognostic for ARDS and mortality among critically ill patients with sepsis.
  Critical care (London, England) 2023 Rosenberger CM, Wick KD, Zhuo H, Wu N, Chen Y, Kapadia SB, Guimaraes A, Chang D, Choy DF, Chen H, Peck M, Sullivan KM, Ke S, Jauregui A, Leligdowicz A, Sinha P, Gomez AD, Kangelaris KN, Delucchi K, …
• Metagenomic Sequencing in the ICU for Precision Diagnosis of Critical Infectious Illnesses.
  Critical care (London, England) 2023 Neyton LPA, Langelier CR, Calfee CS
• Aerosolized nicotine from e-cigarettes alters gene expression, increases lung protein permeability, and impairs viral clearance in murine influenza infection.
  Frontiers in immunology 2023 Maishan M, Sarma A, Chun LF, Caldera S, Fang X, Abbott J, Christenson SA, Langelier CR, Calfee CS, Gotts JE, Matthay MA
• Subphenotypes of frailty in lung transplant candidates.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023 Singer JP, Calfee CS, Delucchi K, Diamond JM, Anderson MA, Benvenuto LA, Gao Y, Wang P, Arcasoy SM, Lederer DJ, Hays SR, Kukreja J, Venado A, Kolaitis NA, Leard LE, Shah RJ, Kleinhenz ME, Golden J, …
• Plasma metabolic profiling implicates dysregulated lipid metabolism and glycolytic shift in hyperinflammatory ARDS.
  American journal of physiology. Lung cellular and molecular physiology 2023 Alipanah-Lechner N, Neyton L, Mick E, Willmore A, Leligdowicz A, Contrepois K, Jauregui A, Zhuo H, Hendrickson C, Gomez A, Sinha P, Kangelaris KN, Liu KD, Matthay MA, Rogers AJ, Calfee CS
• NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes.
  JCI insight 2022 Calabrese DR, Tsao T, Magnen M, Valet C, Gao Y, Mallavia B, Tian JJ, Aminian EA, Wang KM, Shemesh A, Punzalan EB, Sarma A, Calfee CS, Christenson SA, Langelier CR, Hays SR, Golden JA, Leard LE, …
• Prevalence of type-1 interferon autoantibodies in adults with non-COVID-19 acute respiratory failure.
  Respiratory research 2022 Ghale R, Spottiswoode N, Anderson MS, Mitchell A, Wang G, Calfee CS, DeRisi JL, Langelier CR
• Biological Phenotyping in Sepsis and Acute Respiratory Distress Syndrome.
  Annual review of medicine 2022 Sinha P, Meyer NJ, Calfee CS
• Immune Modulation in Sepsis, ARDS, and Covid-19 - The Road Traveled and the Road Ahead.
  NEJM evidence 2022 Leligdowicz A, Harhay MO, Calfee CS
• Integrated host-microbe plasma metagenomics for sepsis diagnosis in a prospective cohort of critically ill adults.
  Nature microbiology 2022 Kalantar KL, Neyton L, Abdelghany M, Mick E, Jauregui A, Caldera S, Serpa PH, Ghale R, Albright J, Sarma A, Tsitsiklis A, Leligdowicz A, Christenson SA, Liu K, Kangelaris KN, Hendrickson C, Sinha P, …
• COVID-19-associated Lung Microvascular Endotheliopathy: A "From the Bench" Perspective.
  American journal of respiratory and critical care medicine 2022 Joffre J, Rodriguez L, Matthay ZA, Lloyd E, Fields AT, Bainton RJ, Kurien P, Sil A, Calfee CS, Woodruff PG, Erle DJ, Hendrickson C, Krummel MF, Langelier CR, Matthay MA, Kornblith LZ, Hellman J, COVID…
• Hospital trajectories and early predictors of clinical outcomes differ between SARS-CoV-2 and influenza pneumonia.
  EBioMedicine 2022 Lyons PG, Bhavani SV, Mody A, Bewley A, Dittman K, Doyle A, Windham SL, Patel TM, Raju BN, Keller M, Churpek MM, Calfee CS, Michelson AP, Kannampallil T, Geng EH, Sinha P
• Informed consent process in the ISPY COVID trial is ethically acceptable.
  European journal of internal medicine 2022 Files DC, Esserman L, Liu KD, Calfee CS
• Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19.
  Critical care (London, England) 2022 Wick KD, Leligdowicz A, Willmore A, Carrillo SA, Ghale R, Jauregui A, Chak SS, Nguyen V, Lee D, Jones C, Dewar R, Lane HC, Kangelaris KN, Hendrickson CM, Liu KD, Sinha P, Erle DJ, Langelier CR, …
• The relationship between plasma cystatin C, mortality and acute respiratory distress syndrome subphenotype in the HARP-2 trial.
  Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 2022 McKelvey MC, Bradbury I, McDowell C, Calfee CS, Weldon S, O'Kane CM, McAuley DF, Taggart CC
• New Insights into Clinical and Mechanistic Heterogeneity of the Acute Respiratory Distress Syndrome: Summary of the Aspen Lung Conference 2021.
  American journal of respiratory cell and molecular biology 2022 Martin TR, Zemans RL, Ware LB, Schmidt EP, Riches DWH, Bastarache L, Calfee CS, Desai TJ, Herold S, Hough CL, Looney MR, Matthay MA, Meyer N, Parikh SM, Stevens T, Thompson BT
• Contemporary trends in PGD incidence, outcomes, and therapies.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2022 Cantu E, Diamond JM, Cevasco M, Suzuki Y, Crespo M, Clausen E, Dallara L, Ramon CV, Harmon MT, Bermudez C, Benvenuto L, Anderson M, Wille KM, Weinacker A, Dhillon GS, Orens J, Shah P, Merlo C, Lama V,…
• Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study.
  EBioMedicine 2022 Ozonoff A, Schaenman J, Jayavelu ND, Milliren CE, Calfee CS, Cairns CB, Kraft M, Baden LR, Shaw AC, Krammer F, van Bakel H, Esserman DA, Liu S, Sesma AF, Simon V, Hafler DA, Montgomery RR, Kleinstein …
• Metagenomic prediction of antimicrobial resistance in critically ill patients with lower respiratory tract infections.
  Genome medicine 2022 Serpa PH, Deng X, Abdelghany M, Crawford E, Malcolm K, Caldera S, Fung M, McGeever A, Kalantar KL, Lyden A, Ghale R, Deiss T, Neff N, Miller SA, Doernberg SB, Chiu CY, DeRisi JL, Calfee CS, Langelier …
• Redefining critical illness.
  Nature medicine 2022 Maslove DM, Tang B, Shankar-Hari M, Lawler PR, Angus DC, Baillie JK, Baron RM, Bauer M, Buchman TG, Calfee CS, Dos Santos CC, Giamarellos-Bourboulis EJ, Gordon AC, Kellum JA, Knight JC, Leligdowicz A,…
• Extracorporeal Membrane Oxygenation during Respiratory Pandemics: Past, Present, and Future.
  American journal of respiratory and critical care medicine 2022 Brodie D, Abrams D, MacLaren G, Brown CE, Evans L, Barbaro RP, Calfee CS, Hough CL, Fowles JA, Karagiannidis C, Slutsky AS, Combes A
• Impact of e-cigarette aerosol on primary human alveolar epithelial type 2 cells.
  American journal of physiology. Lung cellular and molecular physiology 2022 Wick KD, Fang X, Maishan M, Matsumoto S, Spottiswoode N, Sarma A, Simoneau C, Khakoo M, Langelier C, Calfee CS, Gotts JE, Matthay MA
• Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients.
  Immunity 2022 Burnett CE, Okholm TLH, Tenvooren I, Marquez DM, Tamaki S, Munoz Sandoval P, Willmore A, UCSF COMET Consortium, Hendrickson CM, Kangelaris KN, Langelier CR, Krummel MF, Woodruff PG, Calfee CS, Erle DJ…
• I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations.
  BMJ open 2022 Files DC, Matthay MA, Calfee CS, Aggarwal NR, Asare AL, Beitler JR, Berger PA, Burnham EL, Cimino G, Coleman MH, Crippa A, Discacciati A, Gandotra S, Gibbs KW, Henderson PT, Ittner CAG, Jauregui A, …
• Ventilatory Ratio Is a Valuable Prognostic Indicator in an Observational Cohort of Patients With ARDS.
  Respiratory care 2022 Siegel ER, Zhuo H, Sinha P, Papolos AI, Ni SA, Vessel K, Belzer A, Minus EB, Calfee CS, Matthay MA, Wick KD
• Immediate myeloid depot for SARS-CoV-2 in the human lung.
  Research square 2022 Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, …
• Immediate myeloid depot for SARS-CoV-2 in the human lung.
  bioRxiv : the preprint server for biology 2022 Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, …
• Cigarette Smoke Exposure and Acute Respiratory Distress Syndrome in Sepsis: Epidemiology, Clinical Features, and Biologic Markers.
  American journal of respiratory and critical care medicine 2022 Moazed F, Hendrickson C, Jauregui A, Gotts J, Conroy A, Delucchi K, Zhuo H, Arambulo M, Vessel K, Ke S, Deiss T, Ni A, Leligdowicz A, Abbott J, Cohen MJ, Sinha P, Gomez A, Kangelaris K, Kornblith L, …
• Prognostic factors for development of acute respiratory distress syndrome following traumatic injury: a systematic review and meta-analysis.
  The European respiratory journal 2022 Tran A, Fernando SM, Brochard LJ, Fan E, Inaba K, Ferguson ND, Calfee CS, Burns KEA, Brodie D, McCredie VA, Kim DY, Kyeremanteng K, Lampron J, Slutsky AS, Combes A, Rochwerg B
• Aerosolized vitamin E acetate causes oxidative injury in mice and in alveolar macrophages.
  American journal of physiology. Lung cellular and molecular physiology 2022 Matsumoto S, Traber MG, Leonard SW, Choi J, Fang X, Maishan M, Wick KD, Jones KD, Calfee CS, Gotts JE, Matthay MA
• A conserved immune trajectory of recovery in hospitalized COVID-19 patients.
  bioRxiv : the preprint server for biology 2022 Burnett CE, Okholm TLH, Tenvooren I, Marquez DM, Tamaki S, Sandoval PM, UCSF COMET Consortium, Calfee CS, Hendrickson CM, Kangelaris KN, Langelier CR, Krummel MF, Woodruff PG, Erle DJ, Ansel KM, …
• Towards a biological definition of ARDS: are treatable traits the solution?
  Intensive care medicine experimental 2022 Bos LDJ, Laffey JG, Ware LB, Heijnen NFL, Sinha P, Patel B, Jabaudon M, Bastarache JA, McAuley DF, Summers C, Calfee CS, Shankar-Hari M
• Pulmonary and Critical Care Considerations for e-Cigarette, or Vaping, Product Use-Associated Lung Injury.
  Chest 2022 Hayes D, Board A, Calfee CS, Ellington S, Pollack LA, Kathuria H, Eakin MN, Weissman DN, Callahan SJ, Esper AM, Crotty Alexander LE, Sharma NS, Meyer NJ, Smith LS, Novosad S, Evans ME, Goodman AB, …
• Single Nucleotide Variant in FAS Associates With Organ Failure and Soluble Fas Cell Surface Death Receptor in Critical Illness.
  Critical care medicine 2022 Mikacenic C, Bhatraju P, Robinson-Cohen C, Kosamo S, Fohner AE, Dmyterko V, Long SA, Cerosaletti K, Calfee CS, Matthay MA, Walley KR, Russell JA, Christie JD, Meyer NJ, Christiani DC, Wurfel MM
• Reply to Kuindersma and Spronk: Time to Tailor the One-Size-Fits-All Approach?
  American journal of respiratory and critical care medicine 2022 Furfaro DM, Sinha P, Calfee CS, Brodie D, O'Donnell MR
• Phenotyping in acute respiratory distress syndrome: state of the art and clinical implications.
  Current opinion in critical care 2022 Alipanah N, Calfee CS
• Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report.
  American journal of respiratory cell and molecular biology 2022 Kulkarni HS, Lee JS, Bastarache JA, Kuebler WM, Downey GP, Albaiceta GM, Altemeier WA, Artigas A, Bates JHT, Calfee CS, Dela Cruz CS, Dickson RP, Englert JA, Everitt JI, Fessler MB, Gelman AE, Gowdy …
• Functional Transcriptomic Studies of Immune Responses and Endotoxin Tolerance in Early Human Sepsis.
  Shock (Augusta, Ga.) 2022 Leligdowicz A, Kamm J, Kalantar K, Jauregui A, Vessel K, Caldera S, Serpa PH, Abbott J, Fang X, Tian X, Prakash A, Kangelaris KN, Liu KD, Calfee CS, Langelier C, Matthay MA
• Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis.
  The Lancet. Respiratory medicine 2022 Maddali MV, Churpek M, Pham T, Rezoagli E, Zhuo H, Zhao W, He J, Delucchi KL, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz …
• Clinical trial design during and beyond the pandemic: the I-SPY COVID trial.
  Nature medicine 2022 I-SPY COVID Consortium
• Identification of phenotypes in paediatric patients with acute respiratory distress syndrome: a latent class analysis.
  The Lancet. Respiratory medicine 2021 Dahmer MK, Yang G, Zhang M, Quasney MW, Sapru A, Weeks HM, Sinha P, Curley MAQ, Delucchi KL, Calfee CS, Flori H, RESTORE and BALI study investigators, Pediatric Acute Lung Injury and Sepsis …
• Comparison of machine learning clustering algorithms for detecting heterogeneity of treatment effect in acute respiratory distress syndrome: A secondary analysis of three randomised controlled trials.
  EBioMedicine 2021 Sinha P, Spicer A, Delucchi KL, McAuley DF, Calfee CS, Churpek MM
• Latent Class Analysis Reveals COVID-19-related Acute Respiratory Distress Syndrome Subgroups with Differential Responses to Corticosteroids.
  American journal of respiratory and critical care medicine 2021 Sinha P, Furfaro D, Cummings MJ, Abrams D, Delucchi K, Maddali MV, He J, Thompson A, Murn M, Fountain J, Rosen A, Robbins-Juarez SY, Adan MA, Satish T, Madhavan M, Gupta A, Lyashchenko AK, Agerstrand …
• Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
  medRxiv : the preprint server for health sciences 2021 Tsitsiklis A, Zha BS, Byrne A, DeVoe C, Rackaityte E, Levan S, Sunshine S, Mick E, Ghale R, Love C, Tarashansky AJ, Pisco A, Albright J, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, …
• Promises and challenges of personalized medicine to guide ARDS therapy.
  Critical care (London, England) 2021 Wick KD, McAuley DF, Levitt JE, Beitler JR, Annane D, Riviello ED, Calfee CS, Matthay MA
• Metabolic signatures of ARDS and ARDS heterogeneity.
  American journal of physiology. Lung cellular and molecular physiology 2021 Neyton L, Calfee CS
• A Research Agenda for Precision Medicine in Sepsis and Acute Respiratory Distress Syndrome: An Official American Thoracic Society Research Statement.
  American journal of respiratory and critical care medicine 2021 Shah FA, Meyer NJ, Angus DC, Awdish R, Azoulay É, Calfee CS, Clermont G, Gordon AC, Kwizera A, Leligdowicz A, Marshall JC, Mikacenic C, Sinha P, Venkatesh B, Wong HR, Zampieri FG, Yende S
• Titrating Oxygen Therapy in Critically Ill Patients.
  JAMA 2021 Urner M, Calfee CS, Fan E
• Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01.
  EClinicalMedicine 2021 Weiner J, Suwalski P, Holtgrewe M, Rakitko A, Thibeault C, Müller M, Patriki D, Quedenau C, Krüger U, Ilinsky V, Popov I, Balnis J, Jaitovich A, Helbig ET, Lippert LJ, Stubbemann P, Real LM, Macías J,…
• Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19.
  Science translational medicine 2021 van der Wijst MGP, Vazquez SE, Hartoularos GC, Bastard P, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Mann SA, Lynch KL, Yun C, Havlir DV, Chamie G, Marquez C, …
• Publisher Correction: Global absence and targeting of protective immune states in severe COVID-19.
  Nature 2021 Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, …
• Plasma Metabolites in Early Sepsis Identify Distinct Clusters Defined by Plasma Lipids.
  Critical care explorations 2021 Rogers AJ, Leligdowicz A, Contrepois K, Jauregui A, Vessel K, Deiss TJ, Belzer A, Liu T, Lippi M, Ke S, Ross E, Zhou H, Hendrickson C, Gomez A, Sinha P, Kangelaris KN, Liu KD, Calfee CS, Matthay MA
• Latent class analysis-derived subphenotypes are generalisable to observational cohorts of acute respiratory distress syndrome: a prospective study.
  Thorax 2021 Sinha P, Delucchi KL, Chen Y, Zhuo H, Abbott J, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Liu KD, Matthay MA, Ware LB…
• Mesenchymal stromal cell extracellular vesicles rescue mitochondrial dysfunction and improve barrier integrity in clinically relevant models of ARDS.
  The European respiratory journal 2021 Dutra Silva J, Su Y, Calfee CS, Delucchi KL, Weiss D, McAuley DF, O'Kane C, Krasnodembskaya AD
• Acute Respiratory Distress Syndrome Subphenotypes beyond the Syndrome: A Step toward Treatable Traits?
  American journal of respiratory and critical care medicine 2021 Reddy K, Calfee CS, McAuley DF
• Six-month and 12-month patient outcomes based on inflammatory subphenotypes in sepsis-associated ARDS: secondary analysis of SAILS-ALTOS trial.
  Thorax 2021 Hashem MD, Hopkins RO, Colantuoni E, Dinglas VD, Sinha P, Aronson Friedman L, Morris PE, Jackson JC, Hough CL, Calfee CS, Needham DM
• Accuracy of the Radiographic Assessment of Lung Edema Score for the Diagnosis of ARDS.
  Frontiers in physiology 2021 Zimatore C, Pisani L, Lippolis V, Warren MA, Calfee CS, Ware LB, Algera AG, Smit MR, Grasso S, Schultz MJ
• Immunotherapy in COVID-19: why, who, and when?
  The Lancet. Respiratory medicine 2021 Sinha P, Calfee CS
• Sepsis Subclasses: A Framework for Development and Interpretation.
  Critical care medicine 2021 DeMerle KM, Angus DC, Baillie JK, Brant E, Calfee CS, Carcillo J, Chang CH, Dickson R, Evans I, Gordon AC, Kennedy J, Knight JC, Lindsell CJ, Liu V, Marshall JC, Randolph AG, Scicluna BP, Shankar-Hari…
• Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
  Research square 2021 Tsitsiklis A, Zha BS, Byrne A, Devoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson…
• Transepithelial nasal potential difference in patients with, and at risk of acute respiratory distress syndrome.
  Thorax 2021 Mac Sweeney R, Reddy K, Davies JC, Parker M, Kelly B, Elborn JS, Conlon J, Verghis RM, Calfee CS, Matthay MA, Alton EWFW, McAuley DF
• Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19: Anti-IFN antibodies in critical COVID-19 correlate with poor ISG response and upregulation of LAIR1 surface protein in PBMCs.
  bioRxiv : the preprint server for biology 2021 van der Wijst MGP, Vazquez SE, Hartoularos GC, Bastard P, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Mann SA, Lynch KL, Yun C, Havlir DV, Chamie G, Marquez C, …
• Precision medicine in acute respiratory distress syndrome: workshop report and recommendations for future research.
  European respiratory review : an official journal of the European Respiratory Society 2021 Bos LDJ, Artigas A, Constantin JM, Hagens LA, Heijnen N, Laffey JG, Meyer N, Papazian L, Pisani L, Schultz MJ, Shankar-Hari M, Smit MR, Summers C, Ware LB, Scala R, Calfee CS
• Global absence and targeting of protective immune states in severe COVID-19.
  Nature 2021 Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, …
• Assessing the importance of interleukin-6 in COVID-19 - Authors' reply.
  The Lancet. Respiratory medicine 2021 Leisman DE, Ronner L, Pinotti R, Taylor MD, Sinha P, Calfee CS, Hirayama AV, Mastroianni F, Turtle CJ, Harhay MO, Legrand M, Deutschman CS
• COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone.
  Research square 2021 Sarma A, Christenson SA, Mick E, DeVoe C, Deiss T, Pisco AO, Ghale R, Jauregui A, Byrne A, Moazed F, Spottiswoode N, Sinha P, Zha BS, Neff N, Tan M, Serpa PH, Ansel KM, Wilson JG, Leligdowicz A, …
• The ABO histo-blood group, endothelial activation, and acute respiratory distress syndrome risk in critical illness.
  The Journal of clinical investigation 2021 Reilly JP, Meyer NJ, Shashaty MG, Anderson BJ, Ittner C, Dunn TG, Lim B, Forker C, Bonk MP, Kotloff E, Feng R, Cantu E, Mangalmurti NS, Calfee CS, Matthay MA, Mikacenic C, Walley KR, Russell J, …
• Practitioner's Guide to Latent Class Analysis: Methodological Considerations and Common Pitfalls.
  Critical care medicine 2021 Sinha P, Calfee CS, Delucchi KL
• Severe COVID-19 Infections-Knowledge Gained and Remaining Questions.
  JAMA internal medicine 2021 Bos LDJ, Brodie D, Calfee CS
• A neutrophil subset defined by intracellular olfactomedin 4 is associated with mortality in sepsis.
  American journal of physiology. Lung cellular and molecular physiology 2020 Kangelaris KN, Clemens R, Fang X, Jauregui A, Liu T, Vessel K, Deiss T, Sinha P, Leligdowicz A, Liu KD, Zhuo H, Alder MN, Wong HR, Calfee CS, Lowell C, Matthay MA
• A manifesto for the future of ICU trials.
  Critical care (London, England) 2020 Goligher EC, Zampieri F, Calfee CS, Seymour CW
• Dose-Dependent Pulmonary Toxicity of Aerosolized Vitamin E Acetate.
  American journal of respiratory cell and molecular biology 2020 Matsumoto S, Fang X, Traber MG, Jones KD, Langelier C, Hayakawa Serpa P, Calfee CS, Matthay MA, Gotts JE
• Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial.
  JAMA 2020 Self WH, Semler MW, Leither LM, Casey JD, Angus DC, Brower RG, Chang SY, Collins SP, Eppensteiner JC, Filbin MR, Files DC, Gibbs KW, Ginde AA, Gong MN, Harrell FE, Hayden DL, Hough CL, Johnson NJ, …
• Alternative Tobacco Product Use in Critically Ill Patients.
  International journal of environmental research and public health 2020 Liu T, Deiss TJ, Lippi MW, Jauregui A, Vessel K, Ke S, Belzer A, Zhuo H, Kangelaris KN, Gomez AD, Matthay MA, Liu KD, Calfee CS
• Twenty-Four-Hour Cardiovascular Effects of Electronic Cigarettes Compared With Cigarette Smoking in Dual Users.
  Journal of the American Heart Association 2020 Benowitz NL, St Helen G, Nardone N, Addo N, Zhang JJ, Harvanko AM, Calfee CS, Jacob P
• Phenotypes and personalized medicine in the acute respiratory distress syndrome.
  Intensive care medicine 2020 Matthay MA, Arabi YM, Siegel ER, Ware LB, Bos LDJ, Sinha P, Beitler JR, Wick KD, Curley MAQ, Constantin JM, Levitt JE, Calfee CS
• Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses.
  Nature communications 2020 Mick E, Kamm J, Pisco AO, Ratnasiri K, Babik JM, Castañeda G, DeRisi JL, Detweiler AM, Hao SL, Kangelaris KN, Kumar GR, Li LM, Mann SA, Neff N, Prasad PA, Serpa PH, Shah SJ, Spottiswoode N, Tan M, …
• Fluid administration and monitoring in ARDS: which management?
  Intensive care medicine 2020 Vignon P, Evrard B, Asfar P, Busana M, Calfee CS, Coppola S, Demiselle J, Geri G, Jozwiak M, Martin GS, Gattinoni L, Chiumello D
• Prone Positioning in Awake, Nonintubated Patients With COVID-19: Necessity Is the Mother of Invention.
  JAMA internal medicine 2020 Sarma A, Calfee CS
• Global Absence and Targeting of Protective Immune States in Severe COVID-19.
  bioRxiv : the preprint server for biology 2020 Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, …
• Global Absence and Targeting of Protective Immune States in Severe COVID-19.
  Research square 2020 Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, …
• Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes.
  The Lancet. Respiratory medicine 2020 Leisman DE, Ronner L, Pinotti R, Taylor MD, Sinha P, Calfee CS, Hirayama AV, Mastroiani F, Turtle CJ, Harhay MO, Legrand M, Deutschman CS
• Using best subset regression to identify clinical characteristics and biomarkers associated with sepsis-associated acute kidney injury.
  American journal of physiology. Renal physiology 2020 Kwong YD, Mehta KM, Miaskowski C, Zhuo H, Yee K, Jauregui A, Ke S, Deiss T, Abbott J, Kangelaris KN, Sinha P, Hendrickson C, Gomez A, Leligdowicz A, Matthay MA, Calfee CS, Liu KD
• Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.
  JAMA 2020 Angus DC, Derde L, Al-Beidh F, Annane D, Arabi Y, Beane A, van Bentum-Puijk W, Berry L, Bhimani Z, Bonten M, Bradbury C, Brunkhorst F, Buxton M, Buzgau A, Cheng AC, de Jong M, Detry M, Estcourt L, …
• Machine Learning Classifier Models Can Identify Acute Respiratory Distress Syndrome Phenotypes Using Readily Available Clinical Data.
  American journal of respiratory and critical care medicine 2020 Sinha P, Churpek MM, Calfee CS
• E-Cigarette or Vaping Product Use-associated Lung Injury: Developing a Research Agenda. An NIH Workshop Report.
  American journal of respiratory and critical care medicine 2020 Crotty Alexander LE, Ware LB, Calfee CS, Callahan SJ, Eissenberg T, Farver C, Goniewicz ML, Jaspers I, Kheradmand F, King TE, Meyer NJ, Mikheev VB, Shields PG, Shihadeh A, Strongin R, Tarran R
• Is a "Cytokine Storm" Relevant to COVID-19?
  JAMA internal medicine 2020 Sinha P, Matthay MA, Calfee CS
• Prevalence of phenotypes of acute respiratory distress syndrome in critically ill patients with COVID-19: a prospective observational study.
  The Lancet. Respiratory medicine 2020 Sinha P, Calfee CS, Cherian S, Brealey D, Cutler S, King C, Killick C, Richards O, Cheema Y, Bailey C, Reddy K, Delucchi KL, Shankar-Hari M, Gordon AC, Shyamsundar M, O'Kane CM, McAuley DF, Szakmany T
• Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care. NHLBI Working Group Report.
  American journal of respiratory and critical care medicine 2020 Semler MW, Bernard GR, Aaron SD, Angus DC, Biros MH, Brower RG, Calfee CS, Colantuoni EA, Ferguson ND, Gong MN, Hopkins RO, Hough CL, Iwashyna TJ, Levy BD, Martin TR, Matthay MA, Mizgerd JP, Moss M, …
• Sonographic B-Lines, Fluid Resuscitation, and Hypoxemia in Malawian Patients with Suspected Sepsis.
  American journal of respiratory and critical care medicine 2020 Wang RJ, Katha G, Phiri M, Delbridge P, Gordon SB, Calfee CS, Huang L, Rylance J
• COVID-19-associated acute respiratory distress syndrome: is a different approach to management warranted?
  The Lancet. Respiratory medicine 2020 Fan E, Beitler JR, Brochard L, Calfee CS, Ferguson ND, Slutsky AS, Brodie D
• Cigarette Smoking and ARDS After Blunt Trauma: The Influence of Changing Smoking Patterns and Resuscitation Practices.
  Chest 2020 Moazed F, Hendrickson C, Conroy A, Kornblith LZ, Benowitz NL, Delucchi K, Cohen MJ, Calfee CS
• Clinician Recognition of the Acute Respiratory Distress Syndrome: Risk Factors for Under-Recognition and Trends Over Time.
  Critical care medicine 2020 Schwede M, Lee RY, Zhuo H, Kangelaris KN, Jauregui A, Vessel K, Belzer A, Deiss T, Matthay MA, Liu KD, Calfee CS
• Subphenotypes in critical care: translation into clinical practice.
  The Lancet. Respiratory medicine 2020 Reddy K, Sinha P, O'Kane CM, Gordon AC, Calfee CS, McAuley DF
• The attributable mortality of acute respiratory distress syndrome.
  Intensive care medicine 2020 Auriemma CL, Delucchi K, Liu KD, Calfee CS
• Upper airway gene expression differentiates COVID-19 from other acute respiratory illnesses and reveals suppression of innate immune responses by SARS-CoV-2.
  medRxiv : the preprint server for health sciences 2020 Mick E, Kamm J, Pisco AO, Ratnasiri K, Babik JM, Calfee CS, Castañeda G, DeRisi JL, Detweiler AM, Hao S, Kangelaris KN, Kumar GR, Li LM, Mann SA, Neff N, Prasad PA, Serpa PH, Shah SJ, Spottiswoode N, …
• Long-term ozone exposure is positively associated with telomere length in critically ill patients.
  Environment international 2020 Wang C, Wolters PJ, Calfee CS, Liu S, Balmes JR, Zhao Z, Koyama T, Ware LB
• Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis.
  Respiratory research 2020 Carla A, Pereira B, Boukail H, Audard J, Pinol-Domenech N, De Carvalho M, Blondonnet R, Zhai R, Morand D, Lambert C, Sapin V, Ware LB, Calfee CS, Bastarache JA, Laffey JG, Juffermans NP, Bos LD, …
• Gender Differences in Authorship of Critical Care Literature.
  American journal of respiratory and critical care medicine 2020 Vranas KC, Ouyang D, Lin AL, Slatore CG, Sullivan DR, Kerlin MP, Liu KD, Baron RM, Calfee CS, Ware LB, Halpern SD, Matthay MA, Herridge MS, Mehta S, Rogers AJ
• ARDS Subphenotypes: Understanding a Heterogeneous Syndrome.
  Critical care (London, England) 2020 Wilson JG, Calfee CS
• Acute respiratory distress syndrome-attributable mortality in critically ill patients with sepsis.
  Intensive care medicine 2020 Auriemma CL, Zhuo H, Delucchi K, Deiss T, Liu T, Jauregui A, Ke S, Vessel K, Lippi M, Seeley E, Kangelaris KN, Gomez A, Hendrickson C, Liu KD, Matthay MA, Ware LB, Calfee CS
• Lack of Clinical Benefit of Interferon β-1a Among Patients With Severe Acute Respiratory Distress Syndrome: Time to Overhaul Drug Trials in ARDS?
  JAMA 2020 Shankar-Hari M, Calfee CS
• Detection of Pneumonia Pathogens from Plasma Cell-Free DNA.
  American journal of respiratory and critical care medicine 2020 Langelier C, Fung M, Caldera S, Deiss T, Lyden A, Prince BC, Serpa PH, Moazed F, Chin-Hong P, DeRisi JL, Calfee CS
• Time to Recognition of Sepsis in the Emergency Department Using Electronic Health Record Data: A Comparative Analysis of Systemic Inflammatory Response Syndrome, Sequential Organ Failure Assessment, and Quick Sequential Organ Failure Assessment.
  Critical care medicine 2020 Prasad PA, Fang MC, Abe-Jones Y, Calfee CS, Matthay MA, Kangelaris KN
• Peripheral blood leukocyte telomere length is associated with survival of sepsis patients.
  The European respiratory journal 2020 Liu S, Wang C, Green G, Zhuo H, Liu KD, Kangelaris KN, Gomez A, Jauregui A, Vessel K, Ke S, Hendrickson C, Matthay MA, Calfee CS, Ware LB, Wolters PJ
• Development and validation of parsimonious algorithms to classify acute respiratory distress syndrome phenotypes: a secondary analysis of randomised controlled trials.
  The Lancet. Respiratory medicine 2020 Sinha P, Delucchi KL, McAuley DF, O'Kane CM, Matthay MA, Calfee CS
• Plasma sRAGE Acts as a Genetically Regulated Causal Intermediate in Sepsis-associated Acute Respiratory Distress Syndrome.
  American journal of respiratory and critical care medicine 2020 Jones TK, Feng R, Kerchberger VE, Reilly JP, Anderson BJ, Shashaty MGS, Wang F, Dunn TG, Riley TR, Abbott J, Ittner CAG, Christiani DC, Mikacenic C, Wurfel MM, Ware LB, Calfee CS, Matthay MA, Christie…
• Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study.
  Critical care (London, England) 2019 Anderson BJ, Calfee CS, Liu KD, Reilly JP, Kangelaris KN, Shashaty MGS, Lazaar AL, Bayliffe AI, Gallop RJ, Miano TA, Dunn TG, Johansson E, Abbott J, Jauregui A, Deiss T, Vessel K, Belzer A, Zhuo H, …
• Estimated dead space fraction and the ventilatory ratio are associated with mortality in early ARDS.
  Annals of intensive care 2019 Morales-Quinteros L, Schultz MJ, Bringué J, Calfee CS, Camprubí M, Cremer OL, Horn J, van der Poll T, Sinha P, Artigas A, Bos LD, MARS Consortium
• Biomarkers and Precision Medicine: State of the Art.
  Critical care clinics 2019 Sarma A, Calfee CS, Ware LB
• Clinically relevant model of pneumococcal pneumonia, ARDS, and nonpulmonary organ dysfunction in mice.
  American journal of physiology. Lung cellular and molecular physiology 2019 Gotts JE, Bernard O, Chun L, Croze RH, Ross JT, Nesseler N, Wu X, Abbott J, Fang X, Calfee CS, Matthay MA
• FLASH: a next-generation CRISPR diagnostic for multiplexed detection of antimicrobial resistance sequences.
  Nucleic acids research 2019 Quan J, Langelier C, Kuchta A, Batson J, Teyssier N, Lyden A, Caldera S, McGeever A, Dimitrov B, King R, Wilheim J, Murphy M, Ares LP, Travisano KA, Sit R, Amato R, Mumbengegwi DR, Smith JL, Bennett A…
• A new frontier in ARDS trials: phenotyping before randomisation.
  The Lancet. Respiratory medicine 2019 Hendrickson CM, Calfee CS
• Inflammasomes Assemble: Cytoplasmic Guardians or Fallen Heroes?
  Critical care medicine 2019 Sinha P, Calfee CS
• Predictors of postinjury acute respiratory distress syndrome: Lung injury persists in the era of hemostatic resuscitation.
  The journal of trauma and acute care surgery 2019 Kornblith LZ, Robles AJ, Conroy AS, Redick BJ, Howard BM, Hendrickson CM, Moore S, Nelson MF, Moazed F, Callcut RA, Calfee CS, Cohen MJ
• Peeking under the Hood of Acute Respiratory Distress Syndrome Phenotypes: Deeper Insights into Biological Heterogeneity.
  American journal of respiratory and critical care medicine 2019 Sinha P, Calfee CS
• Pulmonary Dead Space Monitoring: Identifying Subjects With ARDS at Risk of Developing Right Ventricular Dysfunction.
  Respiratory care 2019 Papolos AI, Schiller NB, Belzer A, Zhuo H, Gotts JE, Bibby D, Calfee CS, Matthay MA
• Acute Respiratory Distress Syndrome Phenotypes.
  Seminars in respiratory and critical care medicine 2019 Reilly JP, Calfee CS, Christie JD
• Identification of Acute Kidney Injury Subphenotypes with Differing Molecular Signatures and Responses to Vasopressin Therapy.
  American journal of respiratory and critical care medicine 2019 Bhatraju PK, Zelnick LR, Herting J, Katz R, Mikacenic C, Kosamo S, Morrell ED, Robinson-Cohen C, Calfee CS, Christie JD, Liu KD, Matthay MA, Hahn WO, Dmyterko V, Slivinski NSJ, Russell JA, Walley KR, …
• Positive Cumulative Fluid Balance Is Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome in the Setting of Acute Kidney Injury.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2019 Zinter MS, Spicer AC, Liu KD, Orwoll BE, Alkhouli MF, Brakeman PR, Calfee CS, Matthay MA, Sapru A
• Precision medicine for cell therapy in acute respiratory distress syndrome - Authors' reply.
  The Lancet. Respiratory medicine 2019 Matthay MA, Zhuo H, Gotts JE, Liu KD, Calfee CS
• The authors reply.
  Critical care medicine 2019 Fielding-Singh V, Matthay MA, Calfee CS
• The authors reply.
  Critical care medicine 2019 Fielding-Singh V, Matthay MA, Calfee CS
• Acute respiratory distress syndrome.
  Nature reviews. Disease primers 2019 Matthay MA, Zemans RL, Zimmerman GA, Arabi YM, Beitler JR, Mercat A, Herridge M, Randolph AG, Calfee CS
• Prospective Assessment of the Feasibility of a Trial of Low-Tidal Volume Ventilation for Patients with Acute Respiratory Failure.
  Annals of the American Thoracic Society 2019 Lanspa MJ, Gong MN, Schoenfeld DA, Lee KT, Grissom CK, Hou PC, Serpa-Neto A, Brown SM, Iwashyna TJ, Yealy DM, Hough CL, Brower RG, Calfee CS, Hyzy RC, Matthay MA, Miller RR, Steingrub JS, Thompson BT,…
• Phenotypes in acute respiratory distress syndrome: moving towards precision medicine.
  Current opinion in critical care 2019 Sinha P, Calfee CS
• Physiologic Analysis and Clinical Performance of the Ventilatory Ratio in Acute Respiratory Distress Syndrome.
  American journal of respiratory and critical care medicine 2019 Sinha P, Calfee CS, Beitler JR, Soni N, Ho K, Matthay MA, Kallet RH
• Metagenomic comparison of tracheal aspirate and mini-bronchial alveolar lavage for assessment of respiratory microbiota.
  American journal of physiology. Lung cellular and molecular physiology 2019 Kalantar KL, Moazed F, Christenson SC, Wilson J, Deiss T, Belzer A, Vessel K, Caldera S, Jauregui A, Bolourchi S, DeRisi JL, Calfee CS, Langelier C
• Early Plasma Matrix Metalloproteinase Profiles. A Novel Pathway in Pediatric Acute Respiratory Distress Syndrome.
  American journal of respiratory and critical care medicine 2019 Zinter MS, Delucchi KL, Kong MY, Orwoll BE, Spicer AS, Lim MJ, Alkhouli MF, Ratiu AE, McKenzie AV, McQuillen PS, Dvorak CC, Calfee CS, Matthay MA, Sapru A
• Low to Moderate Air Pollutant Exposure and Acute Respiratory Distress Syndrome after Severe Trauma.
  American journal of respiratory and critical care medicine 2019 Reilly JP, Zhao Z, Shashaty MGS, Koyama T, Christie JD, Lanken PN, Wang C, Balmes JR, Matthay MA, Calfee CS, Ware LB
• Integrating host response and unbiased microbe detection for lower respiratory tract infection diagnosis in critically ill adults.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Langelier C, Kalantar KL, Moazed F, Wilson MR, Crawford ED, Deiss T, Belzer A, Bolourchi S, Caldera S, Fung M, Jauregui A, Malcolm K, Lyden A, Khan L, Vessel K, Quan J, Zinter M, Chiu CY, Chow ED, …
• Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial.
  The Lancet. Respiratory medicine 2018 Matthay MA, Calfee CS, Zhuo H, Thompson BT, Wilson JG, Levitt JE, Rogers AJ, Gotts JE, Wiener-Kronish JP, Bajwa EK, Donahoe MP, McVerry BJ, Ortiz LA, Exline M, Christman JW, Abbott J, Delucchi KL, …
• Beyond Low Tidal Volume Ventilation: Treatment Adjuncts for Severe Respiratory Failure in Acute Respiratory Distress Syndrome.
  Critical care medicine 2018 Fielding-Singh V, Matthay MA, Calfee CS
• Perhaps it's not the platelet: Ristocetin uncovers the potential role of von Willebrand factor in impaired platelet aggregation following traumatic brain injury.
  The journal of trauma and acute care surgery 2018 Kornblith LZ, Robles AJ, Conroy AS, Hendrickson CM, Calfee CS, Fields AT, Callcut RA, Cohen MJ
• Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis.
  Intensive care medicine 2018 Reilly JP, Wang F, Jones TK, Palakshappa JA, Anderson BJ, Shashaty MGS, Dunn TG, Johansson ED, Riley TR, Lim B, Abbott J, Ittner CAG, Cantu E, Lin X, Mikacenic C, Wurfel MM, Christiani DC, Calfee CS, …
• Latent class analysis of ARDS subphenotypes: a secondary analysis of the statins for acutely injured lungs from sepsis (SAILS) study.
  Intensive care medicine 2018 Sinha P, Delucchi KL, Thompson BT, McAuley DF, Matthay MA, Calfee CS, NHLBI ARDS Network
• Association between pre-operative biological phenotypes and postoperative pulmonary complications: An unbiased cluster analysis.
  European journal of anaesthesiology 2018 Serpa Neto A, Bos LD, Campos PPZA, Hemmes SNT, Bluth T, Calfee CS, Ferner M, Güldner A, Hollmann MW, India I, Kiss T, Laufenberg-Feldmann R, Sprung J, Sulemanji D, Unzueta C, Vidal Melo MF, Weingarten…
• Assessment of industry data on pulmonary and immunosuppressive effects of IQOS.
  Tobacco control 2018 Moazed F, Chun L, Matthay MA, Calfee CS, Gotts J
• Possible hepatotoxicity of IQOS.
  Tobacco control 2018 Chun L, Moazed F, Matthay M, Calfee C, Gotts J
• Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data.
  Intensive care medicine 2018 Jabaudon M, Blondonnet R, Pereira B, Cartin-Ceba R, Lichtenstern C, Mauri T, Determann RM, Drabek T, Hubmayr RD, Gajic O, Uhle F, Coppadoro A, Pesenti A, Schultz MJ, Ranieri MV, Brodska H, Mrozek S, …
• Human pulmonary endothelial cell permeability after exposure to LPS-stimulated leukocyte supernatants derived from patients with early sepsis.
  American journal of physiology. Lung cellular and molecular physiology 2018 Leligdowicz A, Chun LF, Jauregui A, Vessel K, Liu KD, Calfee CS, Matthay MA
• Health care utilization and the cost of posttraumatic acute respiratory distress syndrome care.
  The journal of trauma and acute care surgery 2018 Robles AJ, Kornblith LZ, Hendrickson CM, Howard BM, Conroy AS, Moazed F, Calfee CS, Cohen MJ, Callcut RA
• Elevated plasma levels of TIMP-3 are associated with a higher risk of acute respiratory distress syndrome and death following severe isolated traumatic brain injury.
  Trauma surgery & acute care open 2018 Hendrickson CM, Gibb SL, Miyazawa BY, Keating SM, Ross E, Conroy AS, Calfee CS, Pati S, Cohen MJ
• Severity scoring of lung oedema on the chest radiograph is associated with clinical outcomes in ARDS.
  Thorax 2018 Warren MA, Zhao Z, Koyama T, Bastarache JA, Shaver CM, Semler MW, Rice TW, Matthay MA, Calfee CS, Ware LB
• Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice.
  American journal of physiology. Lung cellular and molecular physiology 2018 Gotts JE, Chun L, Abbott J, Fang X, Takasaka N, Nishimura SL, Springer ML, Schick SF, Calfee CS, Matthay MA
• Lung Microbiota Is Related to Smoking Status and to Development of Acute Respiratory Distress Syndrome in Critically Ill Trauma Patients.
  American journal of respiratory and critical care medicine 2018 Panzer AR, Lynch SV, Langelier C, Christie JD, McCauley K, Nelson M, Cheung CK, Benowitz NL, Cohen MJ, Calfee CS
• Stability of ARDS subphenotypes over time in two randomised controlled trials.
  Thorax 2018 Delucchi K, Famous KR, Ware LB, Parsons PE, Thompson BT, Calfee CS, ARDS Network
• Maladaptive role of neutrophil extracellular traps in pathogen-induced lung injury.
  JCI insight 2018 Lefrançais E, Mallavia B, Zhuo H, Calfee CS, Looney MR
• Platelet aggregation after blunt trauma is associated with the acute respiratory distress syndrome and altered by cigarette smoke exposure.
  The journal of trauma and acute care surgery 2018 Moazed F, Hendrickson C, Nelson M, Conroy A, Cohen MJ, Calfee CS
• Exposing the bidirectional effects of alcohol on coagulation in trauma: Impaired clot formation and decreased fibrinolysis in rotational thromboelastometry.
  The journal of trauma and acute care surgery 2018 Howard BM, Kornblith LZ, Redick BJ, Conroy AS, Nelson MF, Calfee CS, Callcut RA, Cohen MJ
• Reply to "Letter to the Editor: Pulmonary toxicity of electronic cigarettes: more doubts than certainties".
  American journal of physiology. Lung cellular and molecular physiology 2017 Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE
• Characterizing the gut microbiome in trauma: significant changes in microbial diversity occur early after severe injury.
  Trauma surgery & acute care open 2017 Howard BM, Kornblith LZ, Christie SA, Conroy AS, Nelson MF, Campion EM, Callcut RA, Calfee CS, Lamere BJ, Fadrosh DW, Lynch S, Cohen MJ
• Reply: Next Step to Understanding Subphenotypes of Acute Respiratory Distress Syndrome.
  American journal of respiratory and critical care medicine 2017 Calfee CS, Delucchi K, Famous KR
• Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice.
  Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2017 Gotts JE, Abbott J, Fang X, Yanagisawa H, Takasaka N, Nishimura SL, Calfee CS, Matthay MA
• Derivation and validation of a two-biomarker panel for diagnosis of ARDS in patients with severe traumatic injuries.
  Trauma surgery & acute care open 2017 Ware LB, Zhao Z, Koyama T, Brown RM, Semler MW, Janz DR, May AK, Fremont RD, Matthay MA, Cohen MJ, Calfee CS
• Gender Parity in Critical Care Medicine.
  American journal of respiratory and critical care medicine 2017 Mehta S, Burns KEA, Machado FR, Fox-Robichaud AE, Cook DJ, Calfee CS, Ware LB, Burnham EL, Kissoon N, Marshall JC, Mancebo J, Finfer S, Hartog C, Reinhart K, Maitland K, Stapleton RD, Kwizera A, Amin …
• External validation of a biomarker and clinical prediction model for hospital mortality in acute respiratory distress syndrome.
  Intensive care medicine 2017 Zhao Z, Wickersham N, Kangelaris KN, May AK, Bernard GR, Matthay MA, Calfee CS, Koyama T, Ware LB
• Characterization of distinct coagulopathic phenotypes in injury: Pathway-specific drivers and implications for individualized treatment.
  The journal of trauma and acute care surgery 2017 Christie SA, Kornblith LZ, Howard BM, Conroy AS, Kunitake RC, Nelson MF, Hendrickson CM, Calfee CS, Callcut RA, Cohen MJ
• Novel translational approaches to the search for precision therapies for acute respiratory distress syndrome.
  The Lancet. Respiratory medicine 2017 Meyer NJ, Calfee CS
• Pulmonary toxicity of e-cigarettes.
  American journal of physiology. Lung cellular and molecular physiology 2017 Chun LF, Moazed F, Calfee CS, Matthay MA, Gotts JE
• Incorporating Inflammation into Mortality Risk in Pediatric Acute Respiratory Distress Syndrome.
  Critical care medicine 2017 Zinter MS, Orwoll BE, Spicer AC, Alkhouli MF, Calfee CS, Matthay MA, Sapru A
• Identification and validation of distinct biological phenotypes in patients with acute respiratory distress syndrome by cluster analysis.
  Thorax 2017 Bos LD, Schouten LR, van Vught LA, Wiewel MA, Ong DSY, Cremer O, Artigas A, Martin-Loeches I, Hoogendijk AJ, van der Poll T, Horn J, Juffermans N, Calfee CS, Schultz MJ, MARS consortium
• The Canary in the Coal Mine Is Coughing: Electronic Cigarettes and Respiratory Symptoms in Adolescents.
  American journal of respiratory and critical care medicine 2017 Moazed F, Calfee CS
• Higher mini-BAL total protein concentration in early ARDS predicts faster resolution of lung injury measured by more ventilator-free days.
  American journal of physiology. Lung cellular and molecular physiology 2017 Hendrickson CM, Abbott J, Zhuo H, Liu KD, Calfee CS, Matthay MA, NHLBI ARDS Network
• Acute Respiratory Distress Syndrome Subphenotypes Respond Differently to Randomized Fluid Management Strategy.
  American journal of respiratory and critical care medicine 2017 Famous KR, Delucchi K, Ware LB, Kangelaris KN, Liu KD, Thompson BT, Calfee CS, ARDS Network
• Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death.
  Critical care (London, England) 2016 Bhatraju PK, Mukherjee P, Robinson-Cohen C, O'Keefe GE, Frank AJ, Christie JD, Meyer NJ, Liu KD, Matthay MA, Calfee CS, Christiani DC, Himmelfarb J, Wurfel MM
• A Simple and Robust Bedside Model for Mortality Risk in Pediatric Patients With Acute Respiratory Distress Syndrome.
  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2016 Spicer AC, Calfee CS, Zinter MS, Khemani RG, Lo VP, Alkhouli MF, Orwoll BE, Graciano AL, Boriosi JP, Howard JP, Flori HR, Matthay MA, Sapru A
• Clinical Predictors of Hospital Mortality Differ Between Direct and Indirect ARDS.
  Chest 2016 Luo L, Shaver CM, Zhao Z, Koyama T, Calfee CS, Bastarache JA, Ware LB
• The authors reply.
  Critical care medicine 2016 Kangelaris KN, Ware LB, Matthay MA, Calfee CS
• The authors reply.
  Critical care medicine 2016 Kangelaris KN, Ware LB, Matthay MA, Calfee CS
• Opening the Debate on the New Sepsis Definition. Precision Medicine: An Opportunity to Improve Outcomes of Patients with Sepsis.
  American journal of respiratory and critical care medicine 2016 Calfee CS
• Toward Smarter Lumping and Smarter Splitting: Rethinking Strategies for Sepsis and Acute Respiratory Distress Syndrome Clinical Trial Design.
  American journal of respiratory and critical care medicine 2016 Prescott HC, Calfee CS, Thompson BT, Angus DC, Liu VX
• The acute respiratory distress syndrome following isolated severe traumatic brain injury.
  The journal of trauma and acute care surgery 2016 Hendrickson CM, Howard BM, Kornblith LZ, Conroy AS, Nelson MF, Zhuo H, Liu KD, Manley GT, Matthay MA, Calfee CS, Cohen MJ
• Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome.
  Critical care (London, England) 2016 Sapru A, Liu KD, Wiemels J, Hansen H, Pawlikowska L, Poon A, Jorgenson E, Witte JS, Calfee CS, Ware LB, Matthay MA, NHLBI ARDS Network
• Long-Term Ozone Exposure Increases the Risk of Developing the Acute Respiratory Distress Syndrome.
  American journal of respiratory and critical care medicine 2016 Ware LB, Zhao Z, Koyama T, May AK, Matthay MA, Lurmann FW, Balmes JR, Calfee CS
• Personalized medicine for ARDS: the 2035 research agenda.
  Intensive care medicine 2016 Beitler JR, Goligher EC, Schmidt M, Spieth PM, Zanella A, Martin-Loeches I, Calfee CS, Cavalcanti AB, ARDSne(x)t Investigators
• Diagnostic workup for ARDS patients.
  Intensive care medicine 2016 Papazian L, Calfee CS, Chiumello D, Luyt CE, Meyer NJ, Sekiguchi H, Matthay MA, Meduri GU
• Focusing on the alveolar epithelium: Alveolar fluid clearance in diffuse versus focal acute respiratory distress syndrome.
  Anaesthesia, critical care & pain medicine 2016 Monsel A, Calfee CS
• Cigarette smokers have exaggerated alveolar barrier disruption in response to lipopolysaccharide inhalation.
  Thorax 2016 Moazed F, Burnham EL, Vandivier RW, O'Kane CM, Shyamsundar M, Hamid U, Abbott J, Thickett DR, Matthay MA, McAuley DF, Calfee CS
• The relationship between plasma lipid peroxidation products and primary graft dysfunction after lung transplantation is modified by donor smoking and reperfusion hyperoxia.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2016 Diamond JM, Porteous MK, Roberts LJ, Wickersham N, Rushefski M, Kawut SM, Shah RJ, Cantu E, Lederer DJ, Chatterjee S, Lama VN, Bhorade S, Crespo M, McDyer J, Wille K, Orens J, Weinacker A, Arcasoy S, …
• Timing of Intubation and Clinical Outcomes in Adults With Acute Respiratory Distress Syndrome.
  Critical care medicine 2016 Kangelaris KN, Ware LB, Wang CY, Janz DR, Zhuo H, Matthay MA, Calfee CS
• Elevated soluble thrombomodulin is associated with organ failure and mortality in children with acute respiratory distress syndrome (ARDS): a prospective observational cohort study.
  Critical care (London, England) 2015 Orwoll BE, Spicer AC, Zinter MS, Alkhouli MF, Khemani RG, Flori HR, Neuhaus JM, Calfee CS, Matthay MA, Sapru A
• Plasma angiopoietin-2 outperforms other markers of endothelial injury in prognosticating pediatric ARDS mortality.
  American journal of physiology. Lung cellular and molecular physiology 2015 Zinter MS, Spicer A, Orwoll BO, Alkhouli M, Dvorak CC, Calfee CS, Matthay MA, Sapru A
• ARDS in 2015: new clinical directions, new biological insights.
  The Lancet. Respiratory medicine 2015 Calfee CS
• Interstitial lung diseases in the hospitalized patient.
  BMC medicine 2015 Disayabutr S, Calfee CS, Collard HR, Wolters PJ
• Cigarette Smoke Exposure and the Acute Respiratory Distress Syndrome.
  Critical care medicine 2015 Calfee CS, Matthay MA, Kangelaris KN, Siew ED, Janz DR, Bernard GR, May AK, Jacob P, Havel C, Benowitz NL, Ware LB
• Misclassification of acute respiratory distress syndrome after traumatic injury: The cost of less rigorous approaches.
  The journal of trauma and acute care surgery 2015 Hendrickson CM, Dobbins S, Redick BJ, Greenberg MD, Calfee CS, Cohen MJ
• Biomarkers of ARDS: what's new?
  Intensive care medicine 2015 Ware LB, Calfee CS
• Distinct molecular phenotypes of direct vs indirect ARDS in single-center and multicenter studies.
  Chest 2015 Calfee CS, Janz DR, Bernard GR, May AK, Kangelaris KN, Matthay MA, Ware LB
• Differences in degree, differences in kind: characterizing lung injury in trauma.
  The journal of trauma and acute care surgery 2015 Howard BM, Kornblith LZ, Hendrickson CM, Redick BJ, Conroy AS, Nelson MF, Callcut RA, Calfee CS, Cohen MJ
• Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS.
  American journal of physiology. Lung cellular and molecular physiology 2015 Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS
• Erratum to: plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome.
  Intensive care medicine 2015 Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Matthay MA, NHLBI ARDS Network
• Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome.
  Intensive care medicine 2015 Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Abbot J, Matthay MA, NHLBI ARDS Network
• Clearing the air. Smoking and incident asthma in adults.
  American journal of respiratory and critical care medicine 2015 Moazed F, Calfee CS
• Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial.
  The Lancet. Respiratory medicine 2014 Wilson JG, Liu KD, Zhuo H, Caballero L, McMillan M, Fang X, Cosgrove K, Vojnik R, Calfee CS, Lee JW, Rogers AJ, Levitt J, Wiener-Kronish J, Bajwa EK, Leavitt A, McKenna D, Thompson BT, Matthay MA
• ARDS: new mechanistic insights, new therapeutic directions.
  Clinics in chest medicine 2014 Ware LB, Bastarache JA, Calfee CS
• Environmental risk factors for acute respiratory distress syndrome.
  Clinics in chest medicine 2014 Moazed F, Calfee CS
• Prevalence and impact of active and passive cigarette smoking in acute respiratory distress syndrome.
  Critical care medicine 2014 Hsieh SJ, Zhuo H, Benowitz NL, Thompson BT, Liu KD, Matthay MA, Calfee CS, National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network, National Heart Lung and Blood …
• Donor smoking is associated with pulmonary edema, inflammation and epithelial dysfunction in ex vivo human donor lungs.
  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2014 Ware LB, Lee JW, Wickersham N, Nguyen J, Matthay MA, Calfee CS, California Transplant Donor Network
• Silencing Bruton's tyrosine kinase in alveolar neutrophils protects mice from LPS/immune complex-induced acute lung injury.
  American journal of physiology. Lung cellular and molecular physiology 2014 Krupa A, Fol M, Rahman M, Stokes KY, Florence JM, Leskov IL, Khoretonenko MV, Matthay MA, Liu KD, Calfee CS, Tvinnereim A, Rosenfield GR, Kurdowska AK
• Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome.
  Annals of intensive care 2014 Liu KD, Wilson JG, Zhuo H, Caballero L, McMillan ML, Fang X, Cosgrove K, Calfee CS, Lee JW, Kangelaris KN, Gotts JE, Rogers AJ, Levitt JE, Wiener-Kronish JP, Delucchi KL, Leavitt AD, McKenna DH, …
• Intensive care unit scoring systems outperform emergency department scoring systems for mortality prediction in critically ill patients: a prospective cohort study.
  Journal of intensive care 2014 Moseson EM, Zhuo H, Chu J, Stein JC, Matthay MA, Kangelaris KN, Liu KD, Calfee CS
• Keratinocyte growth factor promotes epithelial survival and resolution in a human model of lung injury.
  American journal of respiratory and critical care medicine 2014 Shyamsundar M, McAuley DF, Ingram RJ, Gibson DS, O'Kane D, McKeown ST, Edwards A, Taggart C, Elborn JS, Calfee CS, Matthay MA, O'Kane CM
• Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials.
  The Lancet. Respiratory medicine 2014 Calfee CS, Delucchi K, Parsons PE, Thompson BT, Ware LB, Matthay MA, NHLBI ARDS Network
• Performance of interleukin-27 as a sepsis diagnostic biomarker in critically ill adults.
  Journal of critical care 2014 Wong HR, Liu KD, Kangelaris KN, Lahni P, Calfee CS
• Is there still a role for the lung injury score in the era of the Berlin definition ARDS?
  Annals of intensive care 2014 Kangelaris KN, Calfee CS, May AK, Zhuo H, Matthay MA, Ware LB
• Fibrinogen and platelet contributions to clot formation: implications for trauma resuscitation and thromboprophylaxis.
  The journal of trauma and acute care surgery 2014 Kornblith LZ, Kutcher ME, Redick BJ, Calfee CS, Vilardi RF, Cohen MJ
• One-year mortality and predictors of death among hospital survivors of acute respiratory distress syndrome.
  Intensive care medicine 2014 Wang CY, Calfee CS, Paul DW, Janz DR, May AK, Zhuo H, Bernard GR, Matthay MA, Ware LB, Kangelaris KN
• Effect of simvastatin on physiological and biological outcomes in patients undergoing esophagectomy: a randomized placebo-controlled trial.
  Annals of surgery 2014 Shyamsundar M, McAuley DF, Shields MO, MacSweeney R, Duffy MJ, Johnston JR, McGuigan J, Backman JT, Calfee CS, Matthay MM, Griffiths MJ, McDowell C, Elborn SJ, O'Kane CM
• The association between physiologic dead-space fraction and mortality in subjects with ARDS enrolled in a prospective multi-center clinical trial.
  Respiratory care 2013 Kallet RH, Zhuo H, Liu KD, Calfee CS, Matthay MA, National Heart Lung and Blood Institute ARDS Network Investigators
• Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome.
  Critical care (London, England) 2013 Ware LB, Koyama T, Zhao Z, Janz DR, Wickersham N, Bernard GR, May AK, Calfee CS, Matthay MA
• Comparison of thermodilution measured extravascular lung water with chest radiographic assessment of pulmonary oedema in patients with acute lung injury.
  Annals of intensive care 2013 Brown LM, Calfee CS, Howard JP, Craig TR, Matthay MA, McAuley DF
• Early acute lung injury: criteria for identifying lung injury prior to the need for positive pressure ventilation*.
  Critical care medicine 2013 Levitt JE, Calfee CS, Goldstein BA, Vojnik R, Matthay MA
• Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients.
  American journal of respiratory and critical care medicine 2013 Agrawal A, Matthay MA, Kangelaris KN, Stein J, Chu JC, Imp BM, Cortez A, Abbott J, Liu KD, Calfee CS
• Fixing the leak: targeting the vascular endothelium in sepsis.
  Critical care (London, England) 2012 Spicer A, Calfee CS
• The search for diagnostic markers in sepsis: many miles yet to go.
  American journal of respiratory and critical care medicine 2012 Calfee CS, Pugin J
• Clinical evidence of early acute lung injury often precedes the diagnosis of ALI.
  Journal of intensive care medicine 2012 Rackley CR, Levitt JE, Zhuo H, Matthay MA, Calfee CS
• Plasma angiopoietin-2 in clinical acute lung injury: prognostic and pathogenetic significance.
  Critical care medicine 2012 Calfee CS, Gallagher D, Abbott J, Thompson BT, Matthay MA, NHLBI ARDS Network
• Comparison of chest radiograph scoring to lung weight as a quantitative index of pulmonary edema in organ donors.
  Clinical transplantation 2012 Ware LB, Neyrinck A, O'Neal HR, Lee JW, Landeck M, Johnson E, Calfee CS, Matthay MA, California Transplant Donor Network
• Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patients.
  Annals of surgery 2012 Cohen MJ, Call M, Nelson M, Calfee CS, Esmon CT, Brohi K, Pittet JF
• Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma.
  PloS one 2012 Christie JD, Wurfel MM, Feng R, O'Keefe GE, Bradfield J, Ware LB, Christiani DC, Calfee CS, Cohen MJ, Matthay M, Meyer NJ, Kim C, Li M, Akey J, Barnes KC, Sevransky J, Lanken PN, May AK, Aplenc R, …
• The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury.
  Chest 2011 Kangelaris KN, Sapru A, Calfee CS, Liu KD, Pawlikowska L, Witte JS, Vittinghoff E, Zhuo H, Auerbach AD, Ziv E, Matthay MA, National Heart, Lung, and Blood Institute ARDS Network
• A simple classification model for hospital mortality in patients with acute lung injury managed with lung protective ventilation.
  Critical care medicine 2011 Brown LM, Calfee CS, Matthay MA, Brower RG, Thompson BT, Checkley W, National Institutes of Health Acute Respiratory Distress Syndrome Network Investigators
• FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study.
  Annals of intensive care 2011 Zhang M, Hsu R, Hsu CY, Kordesch K, Nicasio E, Cortez A, McAlpine I, Brady S, Zhuo H, Kangelaris KN, Stein J, Calfee CS, Liu KD
• Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury.
  Critical care medicine 2011 Calfee CS, Ware LB, Glidden DV, Eisner MD, Parsons PE, Thompson BT, Matthay MA, National Heart, Blood, and Lung Institute Acute Respiratory Distress Syndrome Network
• Active and passive cigarette smoking and acute lung injury after severe blunt trauma.
  American journal of respiratory and critical care medicine 2011 Calfee CS, Matthay MA, Eisner MD, Benowitz N, Call M, Pittet JF, Cohen MJ
• ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio.
  American journal of respiratory and critical care medicine 2011 Meyer NJ, Li M, Feng R, Bradfield J, Gallop R, Bellamy S, Fuchs BD, Lanken PN, Albelda SM, Rushefski M, Aplenc R, Abramova H, Atochina-Vasserman EN, Beers MF, Calfee CS, Cohen MJ, Pittet JF, …
• Biomarkers increase detection of active smoking and secondhand smoke exposure in critically ill patients.
  Critical care medicine 2011 Hsieh SJ, Ware LB, Eisner MD, Yu L, Jacob P, Havel C, Goniewicz ML, Matthay MA, Benowitz NL, Calfee CS
• Therapeutic potential of mesenchymal stem cells for severe acute lung injury.
  Chest 2010 Matthay MA, Thompson BT, Read EJ, McKenna DH, Liu KD, Calfee CS, Lee JW
• Therapeutic strategies for severe acute lung injury.
  Critical care medicine 2010 Diaz JV, Brower R, Calfee CS, Matthay MA
• Early release of soluble receptor for advanced glycation endproducts after severe trauma in humans.
  The Journal of trauma 2010 Cohen MJ, Carles M, Brohi K, Calfee CS, Rahn P, Call MS, Chesebro BB, West MA, Pittet JF
• Plasma interleukin-8 is not an effective risk stratification tool for adults with vasopressor-dependent septic shock.
  Critical care medicine 2010 Calfee CS, Thompson BT, Parsons PE, Ware LB, Matthay MA, Wong HR
• Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis.
  The Journal of trauma 2010 Fremont RD, Koyama T, Calfee CS, Wu W, Dossett LA, Bossert FR, Mitchell D, Wickersham N, Bernard GR, Matthay MA, May AK, Ware LB
• Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis.
  American journal of physiology. Lung cellular and molecular physiology 2010 Collard HR, Calfee CS, Wolters PJ, Song JW, Hong SB, Brady S, Ishizaka A, Jones KD, King TE, Matthay MA, Kim DS
• Clinical immunology: Culprits with evolutionary ties.
  Nature 2010 Calfee CS, Matthay MA
• Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion.
  Critical care (London, England) 2009 Cohen MJ, Brohi K, Calfee CS, Rahn P, Chesebro BB, Christiaans SC, Carles M, Howard M, Pittet JF
• Determining the aetiology of pulmonary oedema by the oedema fluid-to-plasma protein ratio.
  The European respiratory journal 2009 Ware LB, Fremont RD, Bastarache JA, Calfee CS, Matthay MA
• Plasma granulocyte colony-stimulating factor levels correlate with clinical outcomes in patients with acute lung injury.
  Critical care medicine 2009 Suratt BT, Eisner MD, Calfee CS, Allard JB, Whittaker LA, Engelken DT, Petty JM, Trimarchi T, Gauthier L, Parsons PE, NHLBI Acute Respiratory Distress Syndrome Network
• Clara cell protein (CC16), a marker of lung epithelial injury, is decreased in plasma and pulmonary edema fluid from patients with acute lung injury.
  Chest 2009 Kropski JA, Fremont RD, Calfee CS, Ware LB
• Identification of early acute lung injury at initial evaluation in an acute care setting prior to the onset of respiratory failure.
  Chest 2009 Levitt JE, Bedi H, Calfee CS, Gould MK, Matthay MA
• Elevated levels of the receptor for advanced glycation end products, a marker of alveolar epithelial type I cell injury, predict impaired alveolar fluid clearance in isolated perfused human lungs.
  Chest 2008 Briot R, Frank JA, Uchida T, Lee JW, Calfee CS, Matthay MA
• Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury.
  Intensive care medicine 2008 Calfee CS, Eisner MD, Parsons PE, Thompson BT, Conner ER, Matthay MA, Ware LB, NHLBI Acute Respiratory Distress Syndrome Clinical Trials Network
• Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury.
  Thorax 2008 Calfee CS, Ware LB, Eisner MD, Parsons PE, Thompson BT, Wickersham N, Matthay MA, NHLBI ARDS Network
• Aerosolized beta-adrenergic agonist therapy reduces pulmonary edema following lung surgery.
  Chest 2008 Matthay MA, Calfee CS
• Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders.
  Critical care medicine 2007 Calfee CS, Eisner MD, Ware LB, Thompson BT, Parsons PE, Wheeler AP, Korpak A, Matthay MA, Acute Respiratory Distress Syndrome Network, National Heart, Lung, and Blood Institute
• Biomarkers of lung injury in primary graft dysfunction following lung transplantation.
  Biomarkers in medicine 2007 Calfee CS, Ware LB
• Plasma receptor for advanced glycation end-products predicts duration of ICU stay and mechanical ventilation in patients after lung transplantation.
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2007 Calfee CS, Budev MM, Matthay MA, Church G, Brady S, Uchida T, Ishizaka A, Lara A, Ranes JL, deCamp MM, Arroliga AC
• Nonventilatory treatments for acute lung injury and ARDS.
  Chest 2007 Calfee CS, Matthay MA
• Clinical problem-solving. Anchors away.
  The New England journal of medicine 2007 Calfee CS, Shah SJ, Wolters PJ, Saint S, King TE
• The influence of perceived control of asthma on health outcomes.
  Chest 2006 Calfee CS, Katz PP, Yelin EH, Iribarren C, Eisner MD
• Therapeutic value of a lung protective ventilation strategy in acute lung injury.
  Chest 2005 Matthay MA, Calfee CS
• Recent advances in mechanical ventilation.
  The American journal of medicine 2005 Calfee CS, Matthay MA