Caroline Guglielmetti, PhD
Affiliate
Physical Therapy
School of Medicine
Awards
Show all (9) Hide
- K99/R00: Pathway to Independence Award, NIH/NIAID, 2022
- ISMRM Junior Fellow, International Society for Magnetic Resonance in Medicine (ISMRM), 2021
- Women in Molecular Imaging Network (WIMIN) Scholar Award, World Molecular Imaging Congress (WMIC), 2021
- Young Investigator Award – 3rd place, World Molecular Imaging Congress (WMIC), 2021
- Young Investigator Award, Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) (USA), 2017
- Annual Recipient of the Bruce Hasegawa Award for Excellence in Biomedical Imaging, UCSF Department of Radiology and Biological Imaging (USA), 2017
- Postdoctoral Research Fellowship, National Multiple Sclerosis Society (NMSS) (USA), 2016-2018
- Travel Grant for Long Research Stay Abroad, Research Foundation – Flanders (FWO) (Belgium), 2014-2016
- Ph.D. Student Fellowship, Science and Technology in Flanders (Belgium), 2012-2016
Education & Training
Show all (6) Hide
- Postdoctoral Fellowship Biomedical Sciences | Biomedical Imaging University of California San Francisco 2021
- Diversity, Equity, and Inclusion Champion Training University of California San Francisco 2021
- Ph.D. Biomedical Sciences | Biomedical Imaging University of Antwerp | University of California San Francisco 2016
- M.S. Neurosciences | Biomedical Imaging University of Antwerp | Université Toulouse III 2010
- M.S. Biology | Neurosciences University of Wisconsin-Madison | Université Toulouse III 2009
- B.S Biology | Physiology Université Toulouse III 2008
Websites
Show all (1) Hide
- Chaumeil Lab (chaumeillab.ucsf.edu)
Grants and Projects
Show all (12) Hide
- Understanding the Role of Astrocytes and Glutamate Dynamics in Promoting Neuroprotection and Remyelination Using PET and Metabolic MR Imaging, Department of Defense MSRP - Exploration - Hypothesis Development Award New Investigator, 2022-2024
- Real time imaging of immune cells and glutamate dynamics by PET and metabolic MRI, NIH/NIAID, 2022-2024
- Imaging oxidative stress in multiple sclerosis using HP 13C MRSI, UCSF Radiology and Biomedical Imaging Seed Grant, 2021-2022
- Deciphering the function of astrocytes in multiple sclerosis using PET and MR imaging, UCSF Resource Allocation Program, 2020-2021
- Monitoring of immune cells, lesion stage and response to therapy in a multiple sclerosis model using [18F]F-AraG PET imaging and hyperpolarized 13C MRSI, UCSF Resource Allocation Program, 2019-2021
- MR Metabolic Imaging of Multiple Sclerosis, National Multiple Sclerosis Society, 2017-2021
- In vivo imaging of astroglial glutamate transporter in multiple sclerosis using PET and MR imaging, UCSF Physical Therapy and Rehabilitation Science Seed Grant, 2020-2021
- Imaging innate and adaptive immune response in MS using using [18F]F-AraG PET and hyperpolarized 13C MRSI, NIH/NIAID, 2020-2021
- Metabolic Imaging of Oxidative Stress in Multiple Sclerosis, Conrad Hilton Foundation, 2017-2020
- MR imaging of oxidative stress in multiple sclerosis, The National Multiple Sclerosis Society, 2016-2018
- Modulation of neuroinflammation during de- and re-myelination processes: an in-vivo study, Agency for Innovation by Science and Technology in Flanders (Belgium), 2012-2015
- Studying the metabolic changes following acute inflammation in the cuprizone mouse model for multiple sclerosis using hyperpolarized 13C magnetic resonance spectroscopy, Research Foundation - Flanders (FWO) Belgium, 2014-2015
Publications (33)
Top publication keywords:
Monoamine Oxidase InhibitorsRemyelinationWhite MatterDemyelinating DiseasesGray MatterMagnetic Resonance ImagingCorpus CallosumInterleukin-13Lactic AcidMyelin SheathCuprizoneCarbon IsotopesNeuroimagingOlfactory BulbMultiple Sclerosis
-
Longitudinal Imaging of T Cells and Inflammatory Demyelination in a Preclinical Model of Multiple Sclerosis Using 18F-FAraG PET and MRI.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2021 Guglielmetti C, Levi J, Huynh TL, Tiret B, Blecha J, Tang R, VanBrocklin H, Chaumeil MM -
Imaging Brain Metabolism Using Hyperpolarized 13C Magnetic Resonance Spectroscopy.
Trends in neurosciences 2020 Le Page LM, Guglielmetti C, Taglang C, Chaumeil MM -
Longitudinal evaluation of demyelinated lesions in a multiple sclerosis model using ultrashort echo time magnetization transfer (UTE-MT) imaging.
NeuroImage 2019 Guglielmetti C, Boucneau T, Cao P, Van der Linden A, Larson PEZ, Chaumeil MM -
In vivo metabolic imaging of Traumatic Brain Injury.
Scientific reports 2017 Guglielmetti C, Chou A, Krukowski K, Najac C, Feng X, Riparip LK, Rosi S, Chaumeil MM -
Hyperpolarized 13C MR metabolic imaging can detect neuroinflammation in vivo in a multiple sclerosis murine model.
Proceedings of the National Academy of Sciences of the United States of America 2017 Guglielmetti C, Najac C, Didonna A, Van der Linden A, Ronen SM, Chaumeil MM -
Interleukin-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages.
Glia 2016 Guglielmetti C, Le Blon D, Santermans E, Salas-Perdomo A, Daans J, De Vocht N, Shah D, Hoornaert C, Praet J, Peerlings J, Kara F, Bigot C, Mai Z, Goossens H, Hens N, Hendrix S, Verhoye M, Planas AM, … -
Diffusion kurtosis imaging probes cortical alterations and white matter pathology following cuprizone induced demyelination and spontaneous remyelination.
NeuroImage 2015 Guglielmetti C, Veraart J, Roelant E, Mai Z, Daans J, Van Audekerke J, Naeyaert M, Vanhoutte G, Delgado Y Palacios R, Praet J, Fieremans E, Ponsaerts P, Sijbers J, Van der Linden A, Verhoye M -
Cellular and molecular neuropathology of the cuprizone mouse model: clinical relevance for multiple sclerosis.
Neuroscience and biobehavioral reviews 2014 Praet J, Guglielmetti C, Berneman Z, Van der Linden A, Ponsaerts P -
Multimodal imaging of subventricular zone neural stem/progenitor cells in the cuprizone mouse model reveals increased neurogenic potential for the olfactory bulb pathway, but no contribution to remyelination of the corpus callosum.
NeuroImage 2013 Guglielmetti C, Praet J, Rangarajan JR, Vreys R, De Vocht N, Maes F, Verhoye M, Ponsaerts P, Van der Linden A
Show all (24 more) Hide
-
New Horizons in Hyperpolarized 13C MRI.
Molecular imaging and biology 2023 Chaumeil MM, Bankson JA, Brindle KM, Epstein S, Gallagher FA, Grashei M, Guglielmetti C, Kaggie JD, Keshari KR, Knecht S, Laustsen C, Schmidt AB, Vigneron D, Yen YF, Schilling F -
Hyperpolarized 13C metabolic imaging detects long-lasting metabolic alterations following mild repetitive traumatic brain injury.
Research square 2023 Chaumeil M, Guglielmetti C, Qiao K, Tiret B, Ozen M, Krukowski K, Nolan A, Paladini MS, Lopez C, Rosi S -
Imaging immunomodulatory treatment responses in a multiple sclerosis mouse model using hyperpolarized 13C metabolic MRI.
Communications medicine 2023 Guglielmetti C, Cordano C, Najac C, Green AJ, Chaumeil MM -
Neurons require glucose uptake and glycolysis in vivo.
Cell reports 2023 Li H, Guglielmetti C, Sei YJ, Zilberter M, Le Page LM, Shields L, Yang J, Nguyen K, Tiret B, Gao X, Bennett N, Lo I, Dayton TL, Kampmann M, Huang Y, Rathmell JC, Vander Heiden M, Chaumeil MM, Nakamura… -
Validating visual evoked potentials as a preclinical, quantitative biomarker for remyelination efficacy.
Brain : a journal of neurology 2022 Cordano C, Sin JH, Timmons G, Yiu HH, Stebbins K, Guglielmetti C, Cruz-Herranz A, Xin W, Lorrain D, Chan JR, Green AJ -
Empowering Data Sharing and Analytics through the Open Data Commons for Traumatic Brain Injury Research.
Neurotrauma reports 2022 Chou A, Torres-Espín A, Huie JR, Krukowski K, Lee S, Nolan A, Guglielmetti C, Hawkins BE, Chaumeil MM, Manley GT, Beattie MS, Bresnahan JC, Martone ME, Grethe JS, Rosi S, Ferguson AR -
Long-term ovarian hormone deprivation alters functional connectivity, brain neurochemical profile and white matter integrity in the Tg2576 amyloid mouse model of Alzheimer's disease.
Neurobiology of aging 2021 Kara F, Belloy ME, Voncken R, Sarwari Z, Garima Y, Anckaerts C, Langbeen A, Leysen V, Shah D, Jacobs J, Hamaide J, Bols P, Van Audekerke J, Daans J, Guglielmetti C, Kantarci K, Prevot V, Roßner S, … -
Long-term deprivation of ovarian hormones via ovariectomy alters functional connectivity, brain neurochemistry and white matter integrity in a mouse model of Alzheimer's disease.
Alzheimer's & Dementia 2020 Firat Kara, Michael E Belloy, Rick Voncken, Zahra Sarwari, Garima Yadav, Cynthia Anckaerts, An Langbeen, Valérie Leysen, Disha Shah, Jules Jacobs, Julie Hamaide, Peter Bols, Johan Van Audekerke, … -
Hyperpolarized 13 C magnetic resonance spectroscopy detects toxin-induced neuroinflammation in mice.
NMR in biomedicine 2019 Le Page LM, Guglielmetti C, Najac CF, Tiret B, Chaumeil MM -
Imaging toxin-induced neuroinflammation in mice using hyperpolarized 13C magnetic resonance spectroscopy.
bioRxiv 2019 Lydia M Le Page, Caroline Guglielmetti, Chloe F Najac, Brice Tiret, Myriam M Chaumeil -
Molecular Imaging of Immune Cell Dynamics During De- and Remyelination in the Cuprizone Model of Multiple Sclerosis by [18F]DPA-714 PET and MRI.
Theranostics 2019 Zinnhardt B, Belloy M, Fricke IB, Orije J, Guglielmetti C, Hermann S, Wagner S, Schäfers M, Van der Linden A, Jacobs AH -
Repeated Mild Head Injury Leads to Wide-Ranging Deficits in Higher-Order Cognitive Functions Associated with the Prefrontal Cortex.
Journal of neurotrauma 2018 Nolan A, Hennessy E, Krukowski K, Guglielmetti C, Chaumeil MM, Sohal VS, Rosi S -
Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model.
Journal of neuroinflammation 2016 Le Blon D, Guglielmetti C, Hoornaert C, Quarta A, Daans J, Dooley D, Lemmens E, Praet J, De Vocht N, Reekmans K, Santermans E, Hens N, Goossens H, Verhoye M, Van der Linden A, Berneman Z, Hendrix S, … -
IMST-04. IMAGING INFLAMMATORY CELL FUNCTION USING 13C MAGNETIC RESONANCE SPECTROSCOPY OF HYPERPOLARIZED 6-13C-LABELED ARGININE.
Neuro-Oncology 2016 Chloe Najac, Myriam M. Chaumeil, Gary Kohanbash, Caroline Guglielmetti, Jeremy Gordon, Hideho Okada, Sabrina M. Ronen -
Monitoring Blood-Brain Barrier Integrity Following Amyloid-β Immunotherapy Using Gadolinium-Enhanced MRI in a PDAPP Mouse Model.
Journal of Alzheimer's disease : JAD 2016 Blockx I, Einstein S, Guns PJ, Van Audekerke J, Guglielmetti C, Zago W, Roose D, Verhoye M, Van der Linden A, Bard F -
Detection of inflammatory cell function using (13)C magnetic resonance spectroscopy of hyperpolarized [6-(13)C]-arginine.
Scientific reports 2016 Najac C, Chaumeil MM, Kohanbash G, Guglielmetti C, Gordon JW, Okada H, Ronen SM -
In Vivo Interleukin-13-Primed Macrophages Contribute to Reduced Alloantigen-Specific T Cell Activation and Prolong Immunological Survival of Allogeneic Mesenchymal Stem Cell Implants.
Stem cells (Dayton, Ohio) 2016 Hoornaert CJ, Luyckx E, Reekmans K, Dhainaut M, Guglielmetti C, Le Blon D, Dooley D, Fransen E, Daans J, Verbeeck L, Quarta A, De Vocht N, Lemmens E, Goossens H, Van der Linden A, Roobrouck VD, … -
Longitudinal monitoring of metabolic alterations in cuprizone mouse model of multiple sclerosis using 1H-magnetic resonance spectroscopy.
NeuroImage 2015 Orije J, Kara F, Guglielmetti C, Praet J, Van der Linden A, Ponsaerts P, Verhoye M -
Cuprizone-induced demyelination and demyelination-associated inflammation result in different proton magnetic resonance metabolite spectra.
NMR in biomedicine 2015 Praet J, Orije J, Kara F, Guglielmetti C, Santermans E, Daans J, Hens N, Verhoye M, Berneman Z, Ponsaerts P, Van der Linden A -
Different anesthesia regimes modulate the functional connectivity outcome in mice.
Magnetic Resonance in Medicine 2014 Elisabeth Jonckers, Rafael Delgado y Palacios, Disha Shah, Caroline Guglielmetti, Marleen Verhoye, Annemie Linden -
Multimodal imaging of micron-sized iron oxide particles following in vitro and in vivo uptake by stem cells: down to the nanometer scale.
Contrast media & molecular imaging 2014 Roose D, Leroux F, De Vocht N, Guglielmetti C, Pintelon I, Adriaensen D, Ponsaerts P, Van der Linden A, Bals S -
Oral Presentations.
Regenerative Medicine 2013 Andreeva, S Korovin, A Shubenkov, V Pustovoy, L Buravkova, M Buyukoz, E Erdal, S Alsoy Altinkaya, A Costa, P Aprile, P Aulino, D Rossi, B Perniconi, S Adamo, D Coletti, L Teodori, D Dupin, P Casuso, A… -
Different anesthesia regimes modulate the functional connectivity outcome in mice.
Magnetic resonance in medicine 2013 Jonckers E, Delgado y Palacios R, Shah D, Guglielmetti C, Verhoye M, Van der Linden A -
Quantitative evaluation of MRI-based tracking of ferritin-labeled endogenous neural stem cell progeny in rodent brain.
NeuroImage 2012 Vande Velde G, Raman Rangarajan J, Vreys R, Guglielmetti C, Dresselaers T, Verhoye M, Van der Linden A, Debyser Z, Baekelandt V, Maes F, Himmelreich U