Carlos Corvera, MD
Professor
Surgery
School of Medicine

He specializes in complex conventional surgical procedures yet has also developed innovations in laparoscopic (minimally invasive) surgical techniques for the liver and pancreas.

In his research, Corvera focuses on the mechanisms that underlie inflammation, thickening and scarring in the biliary tract.

Corvera graduated from the University of California, San Diego School of Medicine. He completed a residency in general surgery at UCSF. At Memorial Sloan Kettering Cancer Center in New York City, he completed a clinical fellowship in surgical oncology as well as a fellowship in hepatobiliary surgery.

• ASO Visual Abstract: National Practice Patterns in Malignant Peritoneal Mesothelioma-Updates in Management and Survival.
  Annals of surgical oncology 2023 Calthorpe L, Romero-Hernandez F, Casey M, Nunez M, Conroy PC, Hirose K, Kim A, Kirkwood K, Maker AV, Corvera C, Nakakura E, Alseidi A, Adam MA
• National Practice Patterns in Malignant Peritoneal Mesothelioma: Updates in Management and Survival.
  Annals of surgical oncology 2023 Calthorpe L, Romero-Hernandez F, Casey M, Nunez M, Conroy PC, Hirose K, Kim A, Kirkwood K, Maker AV, Corvera C, Nakakura E, Alseidi A, Adam MA
• Metastatic colorectal adenocarcinoma tumor purity assessment from whole exome sequencing data.
  PloS one 2023 Tbeileh N, Timmerman L, Mattis AN, Toriguchi K, Kasai Y, Corvera C, Nakakura E, Hirose K, Donner DB, Warren RS, Karelehto E
• Minimally Invasive Versus Open Liver Resections for Hepatocellular Carcinoma in Patients With Metabolic Syndrome.
  Annals of surgery 2023 Berardi G, Ivanics T, Sapisochin G, Ratti F, Sposito C, Nebbia M, D'Souza DM, Pascual F, Tohme S, D'Amico FE, Alessandris R, Panetta V, Simonelli I, Del Basso C, Russolillo N, Fiorentini G, Serenari M…
• Conditional Survival After Hepatectomy for Colorectal Liver Metastasis: Results from the Colorectal Liver Operative Metastasis International Collaborative (COLOMIC).
  Annals of surgical oncology 2023 Valenzuela CD, Moaven O, Solsky IB, Stauffer JA, Del Piccolo NR, Cheung T, Corvera CU, Wisneski AD, Cha CH, Pourhabibi Zarandi N, Dourado J, Perry KC, Russell G, Shen P
• Machine Learning Models for Predicting the Outcomes of Surgical Treatment of Colorectal Liver Metastases.
  Journal of the American College of Surgeons 2023 Moaven O, Tavolara TE, Valenzuela CD, Cheung TT, Corvera CU, Cha CH, Stauffer JA, Niazi MKK, Gurcan MN, Shen P
• Hypertension Requiring Medication Use: a Silent Predictor of Poor Outcomes After Pancreaticoduodenectomy.
  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2023 Lin JJ, Conroy PC, Romero-Hernandez F, Yilma M, Feng J, Hirose K, Nakakura E, Maker AV, Corvera C, Kirkwood K, Alseidi A, Adam MA
• Model to predict major complications following liver resection for HCC in patients with metabolic syndrome.
  Hepatology (Baltimore, Md.) 2023 Berardi G, Ratti F, Sposito C, Nebbia M, D'Souza DM, Pascual F, Dogeas E, Tohme S, D'Amico FE, Alessandris R, Simonelli I, Del Basso C, Russolillo N, Moro A, Fiorentini G, Serenari M, Rotellar F, …
• Contemporary Trends in Malignant Peritoneal Mesothelioma: Incidence and Survival in the United States.
  Cancers 2022 Calthorpe L, Romero-Hernandez F, Miller P, Conroy PC, Hirose K, Kim A, Kirkwood K, Nakakura E, Corvera C, Maker AV, Alseidi A, Adam MA
• Hand-Assisted Versus Pure Minimally-Invasive Distal Pancreatectomy: Is There a Downside to Lending a Hand?
  World journal of surgery 2022 Miller PN, Romero-Hernandez F, Conroy P, Calthorpe L, Yilma M, Mohamedaly S, Kelly YM, Feng J, Hirose K, Kirkwood K, Maker AV, Corvera C, Nakakura E, Alseidi A, Adam MA
• Minimally Invasive Distal Pancreatectomy Techniques: A Contemporary Analysis Exploring Trends, Similarities, and Differences to Open Surgery.
  Cancers 2022 Romero-Hernandez F, Mohamedaly S, Miller P, Rodriguez N, Calthorpe L, Conroy PC, Ganjouei AA, Hirose K, Maker AV, Nakakura E, Corvera C, Kirkwood KS, Alseidi A, Adam MA
• Outcomes after repeat hepatectomy for colorectal liver metastases from the colorectal liver operative metastasis international collaborative (COLOMIC).
  Journal of surgical oncology 2022 Valenzuela CD, Moaven O, Gawdi R, Stauffer JA, Del Piccolo NR, Cheung TT, Corvera CU, Wisneski AD, Cha C, Pourhabibi Zarandi N, Dourado J, Perry KC, Russell G, Shen P
• Primary Cutaneous Malignant Perivascular Epithelioid Cell Tumor Mimicking Undifferentiated Pleomorphic Sarcoma: A Report of a Rare Entity.
  The American Journal of dermatopathology 2022 Neumann NM, Cornelia Ding CK, Borgen A, Corvera CU, North JP, Qorbani A, Horvai AE
• Association of primary tumor laterality with surgical outcomes for colorectal liver metastases: results from the Colorectal Liver Operative Metastasis International Collaborative (COLOMIC).
  HPB : the official journal of the International Hepato Pancreato Biliary Association 2022 Valenzuela CD, Moaven O, Gawdi R, Stauffer JA, Del Piccolo NR, Cheung TT, Corvera CU, Wisneski AD, Cha C, Mangieri CW, Zarandi NP, Dourado J, Perry KC, Russell G, Shen P
• ASO Visual Abstract: Determining Hospital Volume Threshold for the Safety of Minimally Invasive Pancreaticoduodenectomy: A Contemporary Cutpoint Analysis.
  Annals of surgical oncology 2022 Conroy PC, Calthorpe L, Lin JA, Mohamedaly S, Kim A, Hirose K, Nakakura E, Corvera C, Sosa JA, Sarin A, Kirkwood KS, Alseidi A, Adam MA
• Determining Hospital Volume Threshold for Safety of Minimally Invasive Pancreaticoduodenectomy: A Contemporary Cutpoint Analysis.
  Annals of surgical oncology 2021 Conroy PC, Calthorpe L, Lin JA, Mohamedaly S, Kim A, Hirose K, Nakakura E, Corvera C, Sosa JA, Sarin A, Kirkwood KS, Alseidi A, Adam MA
• Multifocal pancreatic PPoma in the setting of MEN1: Case report and review of literature.
  International journal of surgery case reports 2021 Mosenia A, Ward C, Yee A, Qorbani A, Corvera C
• Burden of Ionizing Radiation in the Diagnosis and Management of Necrotizing Pancreatitis.
  Clinical and translational gastroenterology 2021 Thiruvengadam NR, Miranda J, Kim C, Behr S, Corvera C, Dai SC, Kirkwood K, Harris HW, Hirose K, Nakakura E, Ostroff JW, Kochman ML, Arain MA
• Minimally Invasive Surgery for Ileal Neuroendocrine Tumors.
  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2021 Mahuron KM, Kasai Y, Javeed ZA, Bergsland EK, Hirose K, Corvera CU, Nakakura EK
• Contemporary Management of Hepatic Cyst Disease: Techniques and Outcomes at a Tertiary Hepatobiliary Center.
  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2020 Gomez A, Wisneski AD, Luu HY, Hirose K, Roberts JP, Hirose R, Freise CE, Nakakura EK, Corvera CU
• Synchronous Versus Metachronous Colorectal Liver Metastasis Yields Similar Survival in Modern Era.
  The Journal of surgical research 2020 Wisneski AD, Jin C, Huang CY, Warren R, Hirose K, Nakakura EK, Corvera CU
• A rare presentation of hepatolithiasis in an adolescent patient: A case report.
  International journal of surgery case reports 2020 Freise J, Mena J, Wen KW, Stoller M, Ho S, Corvera C
• Ampullary stenosis and choledocholithiasis post Roux-En-Y gastric bypass: challenges of biliary access and intervention.
  HPB : the official journal of the International Hepato Pancreato Biliary Association 2020 Wisneski AD, Carter J, Nakakura EK, Posselt A, Rogers SJ, Cello JP, Arain M, Kirkwood KS, Hirose K, Stewart L, Corvera CU
• A novel stratification of mesenteric mass involvement as a predictor of challenging mesenteric lymph node dissection by minimally invasive approach for ileal neuroendocrine tumors.
  Journal of surgical oncology 2020 Kasai Y, Mahuron K, Hirose K, Corvera CU, Kim GE, Hope TA, Shih BE, Warren RS, Bergsland EK, Nakakura EK
• Residual tumor volume discriminates prognosis after surgery for neuroendocrine liver metastasis.
  Journal of surgical oncology 2019 Kasai Y, Hirose K, Corvera CU, Kim GE, Hope TA, Shih BE, Harun N, Kim MO, Warren RS, Bergsland EK, Nakakura EK
• Prognostic impact of a large mesenteric mass >2 cm in ileal neuroendocrine tumors.
  Journal of surgical oncology 2019 Kasai Y, Mahuron K, Hirose K, Corvera CU, Kim GE, Hope TA, Shih BE, Warren RS, Bergsland EK, Nakakura EK
• Esophageal and Esophagogastric Junction Cancers, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology.
  Journal of the National Comprehensive Cancer Network : JNCCN 2019 Ajani JA, D'Amico TA, Bentrem DJ, Chao J, Corvera C, Das P, Denlinger CS, Enzinger PC, Fanta P, Farjah F, Gerdes H, Gibson M, Glasgow RE, Hayman JA, Hochwald S, Hofstetter WL, Ilson DH, Jaroszewski D,…
• Comparison of Tumor Regression Grading of Residual Pancreatic Ductal Adenocarcinoma Following Neoadjuvant Chemotherapy Without Radiation: Would Fewer Tier-Stratification Be Favorable Toward Standardization?
  The American journal of surgical pathology 2019 Kim SS, Ko AH, Nakakura EK, Wang ZJ, Corvera CU, Harris HW, Kirkwood KS, Hirose R, Tempero MA, Kim GE
• Evaluation of an abbreviated screening MRI protocol for patients at risk for hepatocellular carcinoma.
  Abdominal radiology (New York) 2018 Lee JY, Huo EJ, Weinstein S, Santos C, Monto A, Corvera CU, Yee J, Hope TA
• Change in Liver Imaging Reporting and Data System Characterization of Focal Liver Lesions Using Gadoxetate Disodium Magnetic Resonance Imaging Compared With Contrast-Enhanced Computed Tomography.
  Journal of computer assisted tomography 2017 Hope TA, Aslam R, Weinstein S, Yeh BM, Corvera CU, Monto A, Yee J
• Multiple arterial phase MRI of arterial hypervascular hepatic lesions: improved arterial phase capture and lesion enhancement.
  Abdominal radiology (New York) 2017 Ikram NS, Yee J, Weinstein S, Yeh BM, Corvera CU, Monto A, Hope TA
• Imaging Hepatocellular Carcinoma With 68Ga-Citrate PET: First Clinical Experience.
  Molecular imaging 2017 Mari Aparici C, Behr SC, Seo Y, Kelley RK, Corvera C, Gao KT, Aggarwal R, Evans MJ
• Preoperative FOLFIRINOX for borderline resectable pancreatic cancer: Is radiation necessary in the modern era of chemotherapy?
  Journal of surgical oncology 2016 Kim SS, Nakakura EK, Wang ZJ, Kim GE, Corvera CU, Harris HW, Kirkwood KS, Hirose R, Tempero MA, Ko AH
• In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis.
  Cell stem cell 2016 Rezvani M, Español-Suñer R, Malato Y, Dumont L, Grimm AA, Kienle E, Bindman JG, Wiedtke E, Hsu BY, Naqvi SJ, Schwabe RF, Corvera CU, Grimm D, Willenbring H
• Management of Postoperative Hepatic Failure.
  Journal of the American College of Surgeons 2015 Qadan M, Garden OJ, Corvera CU, Visser BC
• Correcting for respiratory motion in liver PET/MRI: preliminary evaluation of the utility of bellows and navigated hepatobiliary phase imaging.
  EJNMMI physics 2015 Hope TA, Verdin EF, Bergsland EK, Ohliger MA, Corvera CU, Nakakura EK
• The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice.
  Gastroenterology 2014 Lieu T, Jayaweera G, Zhao P, Poole DP, Jensen D, Grace M, McIntyre P, Bron R, Wilson YM, Krappitz M, Haerteis S, Korbmacher C, Steinhoff MS, Nassini R, Materazzi S, Geppetti P, Corvera CU, Bunnett NW
• Impact of pre-operative positron emission tomography in gallbladder cancer.
  HPB : the official journal of the International Hepato Pancreato Biliary Association 2014 Leung U, Pandit-Taskar N, Corvera CU, D'Angelica MI, Allen PJ, Kingham TP, DeMatteo RP, Jarnagin WR, Fong Y
• Expanded use of aggressive therapies improves survival in early and intermediate hepatocellular carcinoma.
  HPB : the official journal of the International Hepato Pancreato Biliary Association 2014 Ho EY, Cozen ML, Shen H, Lerrigo R, Trimble E, Ryan JC, Corvera CU, Monto A, HOVAS Group (Hepatocellular Carcinoma Treatment Outcome at VA San Francisco)
• The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts.
  The Journal of biological chemistry 2013 Jensen DD, Godfrey CB, Niklas C, Canals M, Kocan M, Poole DP, Murphy JE, Alemi F, Cottrell GS, Korbmacher C, Lambert NA, Bunnett NW, Corvera CU
• The TGR5 receptor mediates bile acid-induced itch and analgesia.
  The Journal of clinical investigation 2013 Alemi F, Kwon E, Poole DP, Lieu T, Lyo V, Cattaruzza F, Cevikbas F, Steinhoff M, Nassini R, Materazzi S, Guerrero-Alba R, Valdez-Morales E, Cottrell GS, Schoonjans K, Geppetti P, Vanner SJ, Bunnett NW…
• Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway.
  American journal of physiology. Gastrointestinal and liver physiology 2012 Rajagopal S, Kumar DP, Mahavadi S, Bhattacharya S, Zhou R, Corvera CU, Bunnett NW, Grider JR, Murthy KS
• The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice.
  Gastroenterology 2012 Alemi F, Poole DP, Chiu J, Schoonjans K, Cattaruzza F, Grider JR, Bunnett NW, Corvera CU
• Localization of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) in human gastrointestinal tract.
  Peptides 2012 Cottrell GS, Alemi F, Kirkland JG, Grady EF, Corvera CU, Bhargava A
• Impairment of central leptin-mediated PI3K signaling manifested as hepatic steatosis independent of hyperphagia and obesity.
  Cell metabolism 2011 Warne JP, Alemi F, Reed AS, Varonin JM, Chan H, Piper ML, Mullin ME, Myers MG, Corvera CU, Xu AW
• Visual vignette. What is the diagnosis? Insulin-secreting tumor.
  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2011 Thompson M, Hiniker A, Duh QY, Corvera CU
• Laparoscopic treatment of liver tumours using a two-needle probe bipolar radiofrequency ablation device.
  HPB : the official journal of the International Hepato Pancreato Biliary Association 2011 Alemi F, Kwon E, Chiu J, Aoki H, Stewart L, Corvera CU
• Hepatic surgery at a VA tertiary medical center: lessons learned.
  American journal of surgery 2010 Alemi F, Kwon E, Freise C, Kang SM, Hirose R, Stewart L, Corvera CU
• Periprocedural complications by Child-Pugh class in patients undergoing transcatheter arterial embolization or chemoembolization to treat unresectable hepatocellular carcinoma at a VA medical center.
  American journal of surgery 2010 Russell JS, Sawhney R, Monto A, Nanavati S, Davoren JB, Aslam R, Corvera CU
• Hydrophobic bile salts inhibit gallbladder smooth muscle function via stimulation of GPBAR1 receptors and activation of KATP channels.
  The Journal of physiology 2010 Lavoie B, Balemba OB, Godfrey C, Watson CA, Vassileva G, Corvera CU, Nelson MT, Mawe GM
• Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system.
  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2010 Poole DP, Godfrey C, Cattaruzza F, Cottrell GS, Kirkland JG, Pelayo JC, Bunnett NW, Corvera CU
• Hemorrhagic cholecystitis.
  Archives of surgery (Chicago, Ill. : 1960) 2010 Parekh J, Corvera CU
• Giant mesenteric cystic lymphangioma presenting with abdominal pain and masquerading as a gynecologic malignancy.
  Rare tumors 2009 Maa J, Wa C, Jaigirdir A, Cho SJ, Corvera CU
• Reversible surgical model of biliary inflammation and obstructive jaundice in mice.
  The Journal of surgical research 2009 Kirkland JG, Godfrey CB, Garrett R, Kakar S, Yeh BM, Corvera CU
• Abdominal actinomycosis after laparoscopic cholecystectomy: a rare complication of bile spillage.
  Surgical infections 2009 Ozgediz D, Zheng J, Smith EB, Corvera CU
• Perforated ulcer mimicking a spontaneous pneumothorax in a patient with congenital diaphragmatic hernia.
  The American surgeon 2009 Maa J, Lubbock C, Harrison M, Corvera C
• Caudate split for open and laparoscopic liver resections.
  Journal of the American College of Surgeons 2008 Chang TT, Corvera CU
• Basal cell carcinoma does metastasize.
  Dermatology online journal 2008 Ozgediz D, Smith EB, Zheng J, Otero J, Tabatabai ZL, Corvera CU
• Implementation of a multidisciplinary treatment team for hepatocellular cancer at a Veterans Affairs Medical Center improves survival.
  HPB : the official journal of the International Hepato Pancreato Biliary Association 2008 Chang TT, Sawhney R, Monto A, Davoren JB, Kirkland JG, Stewart L, Corvera CU
• 18F-fluorodeoxyglucose positron emission tomography influences management decisions in patients with biliary cancer.
  Journal of the American College of Surgeons 2007 Corvera CU, Blumgart LH, Akhurst T, DeMatteo RP, D'Angelica M, Fong Y, Jarnagin WR
• Agonists of protease-activated receptors 1 and 2 stimulate electrolyte secretion from mouse gallbladder.
  American journal of physiology. Gastrointestinal and liver physiology 2007 Kirkland JG, Cottrell GS, Bunnett NW, Corvera CU
• Role of calcitonin receptor-like receptor in colonic motility and inflammation.
  American journal of physiology. Gastrointestinal and liver physiology 2007 Clifton MS, Hoy JJ, Chang J, Idumalla PS, Fakhruddin H, Grady EF, Dada S, Corvera CU, Bhargava A
• Bipolar pulse coagulation for resection of the cirrhotic liver.
  The Journal of surgical research 2006 Corvera CU, Dada SA, Kirkland JG, Garrett RD, Way LW, Stewart L
• Recurrent invasive intraductal papillary mucinous carcinoma of the pancreas mimicking pott disease: review of the literature.
  Pancreas 2006 Corvera CU, Dunnican WJ, Blumgart LH, D'Angelica M
• Clinical and pathologic features of proximal biliary strictures masquerading as hilar cholangiocarcinoma.
  Journal of the American College of Surgeons 2005 Corvera CU, Blumgart LH, Darvishian F, Klimstra DS, DeMatteo R, Fong Y, D'Angelica M, Jarnagin WR
• The missing thyroid.
  Journal of the American College of Surgeons 2005 Sturgeon C, Corvera C, Clark OH
• Retrocardiac parathyroid tumor: a rare mediastinal site.
  Surgery 2004 Corvera CU, Jablons D, Morita E, Clark OH
• Improvement in perioperative outcome after hepatic resection: analysis of 1,803 consecutive cases over the past decade.
  Annals of surgery 2002 Jarnagin WR, Gonen M, Fong Y, DeMatteo RP, Ben-Porat L, Little S, Corvera C, Weber S, Blumgart LH
• Role of laparoscopy in the evaluation of biliary tract cancer.
  Surgical oncology clinics of North America 2002 Corvera CU, Weber SM, Jarnagin WR
• Proteinase-activated receptor-2 in human skin: tissue distribution and activation of keratinocytes by mast cell tryptase.
  Experimental dermatology 1999 Steinhoff M, Corvera CU, Thoma MS, Kong W, McAlpine BE, Caughey GH, Ansel JC, Bunnett NW
• Thrombin and mast cell tryptase regulate guinea-pig myenteric neurons through proteinase-activated receptors-1 and -2.
  The Journal of physiology 1999 Corvera CU, Déry O, McConalogue K, Gamp P, Thoma M, Al-Ani B, Caughey GH, Hollenberg MD, Bunnett NW
• The relationship between hospital volume and outcomes of hepatic resection for hepatocellular carcinoma.
  Archives of surgery (Chicago, Ill. : 1960) 1999 Glasgow RE, Showstack JA, Katz PP, Corvera CU, Warren RS, Mulvihill SJ
• Desensitization of the neurokinin-1 receptor (NK1-R) in neurons: effects of substance P on the distribution of NK1-R, Galphaq/11, G-protein receptor kinase-2/3, and beta-arrestin-1/2.
  Molecular biology of the cell 1998 McConalogue K, Corvera CU, Gamp PD, Grady EF, Bunnett NW
• Proteinase-activated receptors: novel mechanisms of signaling by serine proteases.
  The American journal of physiology 1998 Déry O, Corvera CU, Steinhoff M, Bunnett NW
• A hospital's annual rate of esophagectomy influences the operative mortality rate.
  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 1998 Patti MG, Corvera CU, Glasgow RE, Way LW
• Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2.
  The Journal of clinical investigation 1997 Corvera CU, Déry O, McConalogue K, Böhm SK, Khitin LM, Caughey GH, Payan DG, Bunnett NW
• Recent advances. General surgery.
  BMJ (Clinical research ed.) 1997 Corvera CU, Kirkwood KS
• Heterogeneity of P2u- and P2y-purinergic receptor regulation of phospholipases in MDCK cells.
  The American journal of physiology 1996 Firestein BL, Xing M, Hughes RJ, Corvera CU, Insel PA