Carlo Condello, PhD
Associate Professor
Institute for Neurodegenerative Diseases
School of Medicine

Neuroscientist with interests in the cell and molecular biology of neurodegenerative diseases, innate immunity, neuron-glial interactions, protein misfolding/prion mechanisms, in vivo/in vitro optical imaging techniques and developing animal models for preclinical studies.

Awards

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• Thome Memorial Foundation; Alzheimer's Disease Drug Discovery Award, UCSF, 2022-2024
• Sandler Foundation; Program for Breakthrough Biomedical Research, New Frontier Award, UCSF, 2022-2023
• John A. Watson Faculty Scholar, UCSF, 2021-2024
• Ludwig Family Foundation; Early Career Award, UCSF, 2021-2023

Education & Training

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• Postdoctoral Insitute for Neurodegenerative Diseases UCSF 2015
• Postdoctoral Neurology Yale University 2012
• Ph.D. Neuroscience Northwestern University 2011

Websites

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• Condello Lab (condellolab.ucsf.edu)

Grants and Projects

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• Structural characterization of tau aggregation variability and maturity in isolated cell types of the brain, NIH/NINDS, 2023-2028
• Identification of regulatory mechanisms operating in rare pathogenic astrocyte subsets in multiple sclerosis with a novel genomic technology, NIH/NINDS, 2023-2028
• Molecular mechanisms of selective vulnerability of neurons to tauopathy, NIH/NIA, 2023-2028
• Relationships between conformational strains of tau and amyloid-beta, TREM2 and APOE variants, and phenotypic variations of Alzheimer's Disease, NIH, 2018-2023

Publications (42)

Top publication keywords:
Receptors, Granulocyte-Macrophage Colony-Stimulating FactorPrion DiseasesAmyloid beta-PeptidesParkinsonian DisordersTauopathiestau ProteinsAmyloidPick Disease of the BrainMicrogliaPlaque, AmyloidReceptors, ImmunologicAlzheimer DiseaseCryoelectron MicroscopyPrionsDown Syndrome

• CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.
  bioRxiv : the preprint server for biology 2024 Samelson AJ, Ariqat N, McKetney J, Rohanitazangi G, Bravo CP, Bose R, Travaglini KJ, Lam VL, Goodness D, Dixon G, Marzette E, Jin J, Tian R, Tse E, Abskharon R, Pan H, Carroll EC, Lawrence RE, …
• Expanding the Prion Paradigm to Include Alzheimer and Parkinson Diseases.
  JAMA neurology 2024 Condello C, Westaway D, Prusiner SB
• Methods for high throughput discovery of fluoroprobes that recognize tau fibril polymorphs.
  bioRxiv : the preprint server for biology 2024 Carroll EC, Yang H, Jones JG, Oehler A, Charvat AF, Montgomery KM, Yung A, Millbern Z, Vinueza NR, DeGrado WF, Mordes DA, Condello C, Gestwicki JE
• Severe neurodegeneration in brains of transgenic rats producing human tau prions.
  Acta neuropathologica 2024 Ayers J, Lopez TP, Steele IT, Oehler A, Roman-Albarran R, Cleveland E, Chong A, Carlson GA, Condello C, Prusiner SB
• Cryo-EM structures reveal tau filaments from Down syndrome adopt Alzheimer's disease fold.
  Acta neuropathologica communications 2024 Ghosh U, Tse E, Yang H, Shi M, Caro CD, Wang F, Merz GE, Prusiner SB, Southworth DR, Condello C

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• Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer's Disease Fold.
  bioRxiv : the preprint server for biology 2024 Ghosh U, Tse E, Yang H, Shi M, Carlo CD, Wang F, Merz GE, Prusiner SB, Southworth DR, Condello C
• De novo design of peptides that bind specific conformers of α-synuclein.
  Chemical science 2024 Wallace HM, Yang H, Tan S, Pan HS, Yang R, Xu J, Jo H, Condello C, Polizzi NF, DeGrado WF
• Type-I-interferon-responsive microglia shape cortical development and behavior.
  Cell 2024 Escoubas CC, Dorman LC, Nguyen PT, Lagares-Linares C, Nakajo H, Anderson SR, Barron JJ, Wade SD, Cuevas B, Vainchtein ID, Silva NJ, Guajardo R, Xiao Y, Lidsky PV, Wang EY, Rivera BM, Taloma SE, Kim DK…
• De novo Design of Peptides that Bind Specific Conformers of α-Synuclein.
  bioRxiv : the preprint server for biology 2023 Wallace HM, Yang H, Tan S, Pan HS, Yang R, Xu J, Jo H, Condello C, Polizzi NF, DeGrado WF
• Amyloid β Proteoforms Elucidated by Quantitative LC/MS in the 5xFAD Mouse Model of Alzheimer's Disease.
  Journal of proteome research 2023 Kandi S, Cline EN, Rivera BM, Viola KL, Zhu J, Condello C, LeDuc RD, Klein WL, Kelleher NL, Patrie SM
• Total Chemical Synthesis of Glycosylated TREM2 Ectodomain.
  ACS chemical neuroscience 2023 Wijegunawardena G, Castillo E, Henrickson B, Davis R, Condello C, Wu H
• Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Aβ prions.
  Proceedings of the National Academy of Sciences of the United States of America 2023 Condello C, Ayers JI, Dalgard CL, Garcia Garcia MM, Rivera BM, Seeley WW, Perl DP, Prusiner SB
• Type I interferon responsive microglia shape cortical development and behavior.
  bioRxiv : the preprint server for biology 2023 Escoubas CC, Dorman LC, Nguyen PT, Lagares-Linares C, Nakajo H, Anderson SR, Cuevas B, Vainchtein ID, Silva NJ, Xiao Y, Lidsky PV, Wang EY, Taloma SE, Nakao-Inoue H, Schwer B, Andino R, Nowakowski TJ,…
• EMBER multidimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains.
  Proceedings of the National Academy of Sciences of the United States of America 2023 Yang H, Yuan P, Wu Y, Shi M, Caro CD, Tengeiji A, Yamanoi S, Inoue M, DeGrado WF, Condello C
• CSF1R inhibitors induce a sex-specific resilient microglial phenotype and functional rescue in a tauopathy mouse model.
  Nature communications 2023 Johnson NR, Yuan P, Castillo E, Lopez TP, Yue W, Bond A, Rivera BM, Sullivan MC, Hirouchi M, Giles K, Aoyagi A, Condello C
• Aβ and Tau Prions Causing Alzheimer's Disease.
  Methods in molecular biology (Clifton, N.J.) 2023 Condello C, Merz GE, Aoyagi A, DeGrado WF, Prusiner SB
• Aβ and tau prions feature in the neuropathogenesis of Down syndrome.
  Proceedings of the National Academy of Sciences of the United States of America 2022 Condello C, Maxwell AM, Castillo E, Aoyagi A, Graff C, Ingelsson M, Lannfelt L, Bird TD, Keene CD, Seeley WW, Perl DP, Head E, Prusiner SB
• Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy.
  Nature communications 2022 Wang C, Fan L, Khawaja RR, Liu B, Zhan L, Kodama L, Chin M, Li Y, Le D, Zhou Y, Condello C, Grinberg LT, Seeley WW, Miller BL, Mok SA, Gestwicki JE, Cuervo AM, Luo W, Gan L
• Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy.
  Proceedings of the National Academy of Sciences of the United States of America 2022 Ayers JI, Lee J, Monteiro O, Woerman AL, Lazar AA, Condello C, Paras NA, Prusiner SB
• Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ.
  Proceedings of the National Academy of Sciences of the United States of America 2022 Belsare KD, Wu H, Mondal D, Bond A, Castillo E, Jin J, Jo H, Roush AE, Pilla KB, Sali A, Condello C, DeGrado WF
• Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer's disease pathology in Down syndrome.
  Acta neuropathologica communications 2021 Maxwell AM, Yuan P, Rivera BM, Schaaf W, Mladinov M, Prasher VP, Robinson AC, DeGrado WF, Condello C
• Prion biology: implications for Alzheimer's disease therapeutics.
  The Lancet. Neurology 2020 Condello C, DeGrado WF, Prusiner SB
• Aβ and tau prion-like activities decline with longevity in the Alzheimer's disease human brain.
  Science translational medicine 2019 Aoyagi A, Condello C, Stöhr J, Yue W, Rivera BM, Lee JC, Woerman AL, Halliday G, van Duinen S, Ingelsson M, Lannfelt L, Graff C, Bird TD, Keene CD, Seeley WW, DeGrado WF, Prusiner SB
• Sex-specific Tau methylation patterns and synaptic transcriptional alterations are associated with neural vulnerability during chronic neuroinflammation.
  Journal of autoimmunity 2019 Didonna A, Cantó E, Shams H, Isobe N, Zhao C, Caillier SJ, Condello C, Yamate-Morgan H, Tiwari-Woodruff SK, Mofrad MRK, Hauser SL, Oksenberg JR
• Mapping interactions with the chaperone network reveals factors that protect against tau aggregation.
  Nature structural & molecular biology 2018 Mok SA, Condello C, Freilich R, Gillies A, Arhar T, Oroz J, Kadavath H, Julien O, Assimon VA, Rauch JN, Dunyak BM, Lee J, Tsai FTF, Wilson MR, Zweckstetter M, Dickey CA, Gestwicki JE
• Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer's disease.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Condello C, Lemmin T, Stöhr J, Nick M, Wu Y, Maxwell AM, Watts JC, Caro CD, Oehler A, Keene CD, Bird TD, van Duinen SG, Lannfelt L, Ingelsson M, Graff C, Giles K, DeGrado WF, Prusiner SB
• Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Johnson NR, Condello C, Guan S, Oehler A, Becker J, Gavidia M, Carlson GA, Giles K, Prusiner SB
• A novel vector for transgenesis in the rat CNS.
  Acta neuropathologica communications 2017 Lopez TP, Giles K, Dugger BN, Oehler A, Condello C, Krejciova Z, Castaneda JA, Carlson GA, Prusiner SB
• Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging.
  Biological psychiatry 2017 Condello C, Yuan P, Grutzendler J
• A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells.
  Nature chemistry 2017 Stöhr J, Wu H, Nick M, Wu Y, Bhate M, Condello C, Johnson N, Rodgers J, Lemmin T, Acharya S, Becker J, Robinson K, Kelly MJS, Gai F, Stubbs G, Prusiner SB, DeGrado WF
• Aβ propagation and strains: Implications for the phenotypic diversity in Alzheimer's disease.
  Neurobiology of disease 2017 Condello C, Stöehr J
• TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.
  Neuron 2016 Yuan P, Condello C, Keene CD, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J
• Optimization of Aryl Amides that Extend Survival in Prion-Infected Mice.
  The Journal of pharmacology and experimental therapeutics 2016 Giles K, Berry DB, Condello C, Dugger BN, Li Z, Oehler A, Bhardwaj S, Elepano M, Guan S, Silber BM, Olson SH, Prusiner SB
• TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy.
  Neuron 2016 Yuan P, Condello C, Keene CD, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J
• Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains.
  The Journal of pharmacology and experimental therapeutics 2015 Giles K, Berry DB, Condello C, Hawley RC, Gallardo-Godoy A, Bryant C, Oehler A, Elepano M, Bhardwaj S, Patel S, Silber BM, Guan S, DeArmond SJ, Renslo AR, Prusiner SB
• Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques.
  Nature communications 2015 Condello C, Yuan P, Schain A, Grutzendler J
• Distinct synthetic Aβ prion strains producing different amyloid deposits in bigenic mice.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Stöhr J, Condello C, Watts JC, Bloch L, Oehler A, Nick M, DeArmond SJ, Giles K, DeGrado WF, Prusiner SB
• Serial propagation of distinct strains of Aβ prions from Alzheimer's disease patients.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Watts JC, Condello C, Stöhr J, Oehler A, Lee J, DeArmond SJ, Lannfelt L, Ingelsson M, Giles K, Prusiner SB
• Minocycline attenuates microglia activation and blocks the long-term epileptogenic effects of early-life seizures.
  Neurobiology of disease 2012 Abraham J, Fox PD, Condello C, Bartolini A, Koh S
• Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition.
  Scientific reports 2011 Condello C, Schain A, Grutzendler J
• CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-β phagocytosis.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Liu Z, Condello C, Schain A, Harb R, Grutzendler J
• Chemokines in the MPTP model of Parkinson's disease: absence of CCL2 and its receptor CCR2 does not protect against striatal neurodegeneration.
  Brain research 2006 Kalkonde YV, Morgan WW, Sigala J, Maffi SK, Condello C, Kuziel W, Ahuja SS, Ahuja SK