Caitlin Roake, MD
Resident Physician
Emergency Medicine - Fresno
School of Medicine

Education & Training

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• PhD Cancer Biology Stanford University 06/2020
• MD Medicine Stanford University 06/2020

Publications (15)

Top publication keywords:
ExoribonucleasesTelomereTelomere HomeostasisDyskeratosis CongenitaDNA HelicasesRNA, UntranslatedTumor Suppressor Protein p53TelomeraseCellular SenescenceRNA NucleotidyltransferasesHomeostasisRNAGene Expression RegulationRecombination, GeneticMethyltransferases

• TGS1 impacts snRNA 3'-end processing, ameliorates survival motor neuron-dependent neurological phenotypes in vivo and prevents neurodegeneration.
  Nucleic acids research 2022 Chen L, Roake CM, Maccallini P, Bavasso F, Dehghannasiri R, Santonicola P, Mendoza-Ferreira N, Scatolini L, Rizzuti L, Esposito A, Gallotta I, Francia S, Cacchione S, Galati A, Palumbo V, Kobin MA, …
• The S-adenosylmethionine analog sinefungin inhibits the trimethylguanosine synthase TGS1 to promote telomerase activity and telomere lengthening.
  FEBS letters 2021 Galati A, Scatolini L, Micheli E, Bavasso F, Cicconi A, Maccallini P, Chen L, Roake CM, Schoeftner S, Artandi SE, Gatti M, Cacchione S, Raffa GD
• Acinar cell clonal expansion in pancreas homeostasis and carcinogenesis.
  Nature 2021 Neuhöfer P, Roake CM, Kim SJ, Lu RJ, West RB, Charville GW, Artandi SE
• Tissue-specific telomere shortening and degenerative changes in a patient with TINF2 mutation and dyskeratosis congenita.
  Human pathology (New York) 2021 Roake CM, Juntilla M, Agarwal-Hashmi R, Artandi S, Kuo CS
• Regulation of human telomerase in homeostasis and disease.
  Nature reviews. Molecular cell biology 2020 Roake CM, Artandi SE

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• Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation.
  Cell reports 2020 Chen L, Roake CM, Galati A, Bavasso F, Micheli E, Saggio I, Schoeftner S, Cacchione S, Gatti M, Artandi SE, Raffa GD
• HiChIRP reveals RNA-associated chromosome conformation.
  Nature methods 2019 Mumbach MR, Granja JM, Flynn RA, Roake CM, Satpathy AT, Rubin AJ, Qi Y, Jiang Z, Shams S, Louie BH, Guo JK, Gennert DG, Corces MR, Khavari PA, Atianand MK, Artandi SE, Fitzgerald KA, Greenleaf WJ, …
• Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease.
  Molecular cell 2019 Roake CM, Chen L, Chakravarthy AL, Ferrell JE, Raffa GD, Artandi SE
• An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1.
  Cell 2018 Chen L, Roake CM, Freund A, Batista PJ, Tian S, Yin YA, Gajera CR, Lin S, Lee B, Pech MF, Venteicher AS, Das R, Chang HY, Artandi SE
• Approaching TERRA Firma: Genomic Functions of Telomeric Noncoding RNA.
  Cell 2017 Roake CM, Artandi SE
• Control of Cellular Aging, Tissue Function, and Cancer by p53 Downstream of Telomeres.
  Cold Spring Harbor perspectives in medicine 2017 Roake CM, Artandi SE
• DNA repair: Telomere-lengthening mechanism revealed.
  Nature 2016 Roake CM, Artandi SE
• Keeping It in the Family: ATRX Loss Promotes Persistent Sister Telomere Cohesion in ALT Cancer Cells.
  Cancer cell 2015 Roake CM, Artandi SE
• Characterization of the cell of origin for small cell lung cancer.
  Cell cycle (Georgetown, Tex.) 2011 Park KS, Liang MC, Raiser DM, Zamponi R, Roach RR, Curtis SJ, Walton Z, Schaffer BE, Roake CM, Zmoos AF, Kriegel C, Wong KK, Sage J, Kim CF
• Regulation of RB transcription in vivo by RB family members.
  Molecular and cellular biology 2010 Burkhart DL, Ngai LK, Roake CM, Viatour P, Thangavel C, Ho VM, Knudsen ES, Sage J