Buck Strewler, MD
Professor Emeritus
Medicine
School of Medicine

He is an expert in calcium and bone metabolism; With Robert Nissenson, PhD,his laboratory identified, sequenced and cloned the parathyroid hormone-related protein, PTHrP, developed an assay to detect PTHrP in patients with hypercalcemia, and led the way to the understanding of its role in disease. He was Chief of the Endocrine Unit at the SFVAMC and also directed the UCSF Endocrinology Fellowship Program. Dr. Strewler returned to Boston in 1996. He was Chief of Medicine at the West Roxbury VA Medical Center (now part of the VA Boston Healthcare System) until 2001, when he became Master of the Walter Bradford Cannon Society, one of five learning communities in which Harvard medical students spend their academic lives. He subsequently became Director of the Scholars in Medicine program at HMS and Vice Chair for Education in the department of medicine at Beth Israel Deaconess Medical Center. He returned to UCSF in September, 2015 to join the Inquiry leadership team.

• Untangling klotho's role in calcium homeostasis.
  Cell metabolism 2007 Strewler GJ
• Incidence of osteonecrosis of the jaw in patients with multiple myeloma and breast or prostate cancer on intravenous bisphosphonate therapy.
  Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 2007 Wang EP, Kaban LB, Strewler GJ, Raje N, Troulis MJ
• A 64-year-old woman with primary hyperparathyroidism.
  JAMA 2005 Strewler GJ
• Physiology: do neural signals remodel bone?
  Nature 2005 Elmquist JK, Strewler GJ
• Decimal point--osteoporosis therapy at the 10-year mark.
  The New England journal of medicine 2004 Strewler GJ
• FGF23, hypophosphatemia, and rickets: has phosphatonin been found?
  Proceedings of the National Academy of Sciences of the United States of America 2001 Strewler GJ
• Local and systemic control of the osteoblast.
  The Journal of clinical investigation 2001 Strewler GJ
• Medical approaches to primary hyperparathyroidism.
  Endocrinology and metabolism clinics of North America 2000 Strewler GJ
• The parathyroid hormone-related protein.
  Endocrinology and metabolism clinics of North America 2000 Strewler GJ
• The physiology of parathyroid hormone-related protein.
  The New England journal of medicine 2000 Strewler GJ
• Calcium sensing in cultured chondrogenic RCJ3.1C5.18 cells.
  Endocrinology 1999 Chang W, Tu C, Bajra R, Komuves L, Miller S, Strewler G, Shoback D
• Bone-selective analogs of human PTH(1-34) increase bone formation in an ovariectomized rat model.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1996 Lane NE, Kimmel DB, Nilsson MH, Cohen FE, Newton S, Nissenson RA, Strewler GJ
• Parathyroid hormone-related protein is induced during lethal endotoxemia and contributes to endotoxin-induced mortality in rodents.
  Molecular medicine (Cambridge, Mass.) 1996 Funk JL, Moser AH, Strewler GJ, Feingold KR, Grünfeld C
• Intermittent treatment with human parathyroid hormone (hPTH[1-34]) increased trabecular bone volume but not connectivity in osteopenic rats.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1995 Lane NE, Thompson JM, Strewler GJ, Kinney JH
• Endotoxin induces parathyroid hormone-related protein gene expression in splenic stromal and smooth muscle cells, not in splenic lymphocytes.
  Endocrinology 1995 Funk JL, Lausier J, Moser AH, Shigenaga JK, Huling S, Nissenson RA, Strewler GJ, Grunfeld C, Feingold KR
• Indications for surgery in patients with minimally symptomatic primary hyperparathyroidism.
  The Surgical clinics of North America 1995 Strewler GJ
• Cytokine regulation of parathyroid hormone-related protein messenger ribonucleic acid levels in mouse spleen: paradoxical effects of interferon-gamma and interleukin-4.
  Endocrinology 1994 Funk JL, Shigenaga JK, Moser AH, Krul EJ, Strewler GJ, Feingold KR, Grunfeld C
• Functional properties of a synthetic chicken parathyroid hormone-related protein 1-36 fragment.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1994 Schermer DT, Bradley MS, Bambino TH, Nissenson RA, Strewler GJ
• Familial benign hypocalciuric hypercalcemia--from the clinic to the calcium sensor.
  The Western journal of medicine 1994 Strewler GJ
• Endotoxin increases parathyroid hormone-related protein mRNA levels in mouse spleen. Mediation by tumor necrosis factor.
  The Journal of clinical investigation 1993 Funk JL, Krul EJ, Moser AH, Shigenaga JK, Strewler GJ, Grunfeld C, Feingold KR
• Production of parathyroid hormone by a malignant nonparathyroid tumor in a hypercalcemic patient.
  The Journal of clinical endocrinology and metabolism 1993 Strewler GJ, Budayr AA, Clark OH, Nissenson RA
• Hypercalcaemia and elevated levels of parathyroid hormone-related protein in cutaneous squamous/basal cell carcinoma.
  Journal of internal medicine 1993 Marino MT, Asp AA, Budayer AA, Marsden JS, Strewler GJ
• Two homologs of the Drosophila polarity gene frizzled (fz) are widely expressed in mammalian tissues.
  The Journal of biological chemistry 1992 Chan SD, Karpf DB, Fowlkes ME, Hooks M, Bradley MS, Vuong V, Bambino T, Liu MY, Arnaud CD, Strewler GJ
• Actions of parathyroid hormone-related protein as an embryonic differentiation factor.
  Journal of endocrinological investigation 1992 Strewler GJ, Chan SD, Globus RK, Schermer DT, Nissenson RA
• Pertussis toxin inhibits hormonal stimulation of bone resorption in fetal rat limb bones.
  The Journal of pharmacology and experimental therapeutics 1991 Klein RF, Nissenson RA, Strewler GJ
• Chicken parathyroid hormone-related protein and its expression during embryologic development.
  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1991 Schermer DT, Chan SD, Bruce R, Nissenson RA, Wood WI, Strewler GJ
• Analogues of parathyroid hormone modified at positions 3 and 6. Effects on receptor binding and activation of adenylyl cyclase in kidney and bone.
  The Journal of biological chemistry 1991 Cohen FE, Strewler GJ, Bradley MS, Carlquist M, Nilsson M, Ericsson M, Ciardelli TL, Nissenson RA
• Hypercalcemia in malignancy.
  The Western journal of medicine 1990 Strewler GJ, Nissenson RA
• Transcriptional activation of Gs alpha expression by retinoic acid and parathyroid hormone-related protein in F9 teratocarcinoma cells.
  The Journal of biological chemistry 1990 Chan SD, Strewler GJ, Nissenson RA
• Expression of a parathyroid hormone-like protein and its receptor during differentiation of embryonal carcinoma cells.
  Molecular endocrinology (Baltimore, Md.) 1990 Chan SD, Strewler GJ, King KL, Nissenson RA
• Peptide mediators of hypercalcemia in malignancy.
  Annual review of medicine 1990 Strewler GJ, Nissenson RA
• Increased serum levels of a parathyroid hormone-like protein in malignancy-associated hypercalcemia.
  Annals of internal medicine 1989 Budayr AA, Nissenson RA, Klein RF, Pun KK, Clark OH, Diep D, Arnaud CD, Strewler GJ
• High levels of a parathyroid hormone-like protein in milk.
  Proceedings of the National Academy of Sciences of the United States of America 1989 Budayr AA, Halloran BP, King JC, Diep D, Nissenson RA, Strewler GJ
• Synthetic peptides comprising the amino-terminal sequence of a parathyroid hormone-like protein from human malignancies. Binding to parathyroid hormone receptors and activation of adenylate cyclase in bone cells and kidney.
  The Journal of biological chemistry 1988 Nissenson RA, Diep D, Strewler GJ
• Forskolin mimics the effects of calcitonin but not parathyroid hormone on bone resorption in vitro.
  Bone and mineral 1988 Klein RF, Nissenson RA, Strewler GJ
• Human renal carcinoma expresses two messages encoding a parathyroid hormone-like peptide: evidence for the alternative splicing of a single-copy gene.
  Proceedings of the National Academy of Sciences of the United States of America 1988 Thiede MA, Strewler GJ, Nissenson RA, Rosenblatt M, Rodan GA
• Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone.
  The Journal of clinical investigation 1987 Strewler GJ, Stern PH, Jacobs JW, Eveloff J, Klein RF, Leung SC, Rosenblatt M, Nissenson RA
• Parathyroid hormone-like adenylate cyclase-stimulating activity from a human carcinoma is associated with bone-resorbing activity.
  Endocrinology 1987 Klein RF, Strewler GJ, Leung SC, Nissenson RA
• Nonparathyroid hypercalcemia.
  Advances in internal medicine 1987 Strewler GJ, Nissenson RA
• Pathogenesis of hypercalcemia in nude mice bearing a human renal carcinoma.
  Endocrinology 1986 Strewler GJ, Wronski TJ, Halloran BP, Miller SC, Leung SC, Williams RD, Nissenson RA
• Parathyroid hormone inhibition of Na+-H+ antiporter activity in a cultured renal cell line.
  The American journal of physiology 1986 Pollock AS, Warnock DG, Strewler GJ
• Activation of the parathyroid hormone receptor-adenylate cyclase system in osteosarcoma cells by a human renal carcinoma factor.
  Cancer research 1985 Nissenson RA, Strewler GJ, Williams RD, Leung SC
• Human transforming growth factor-alpha stimulates bone resorption in vitro.
  The Journal of clinical investigation 1985 Stern PH, Krieger NS, Nissenson RA, Williams RD, Winkler ME, Derynck R, Strewler GJ
• Bone disease in alcohol abuse.
  Annals of internal medicine 1985 Bikle DD, Genant HK, Cann C, Recker RR, Halloran BP, Strewler GJ
• Biologic regulation of Na/H antiporter activity in a cultured kidney cell line: effects of parathyroid hormone (PTH).
  Annals of the New York Academy of Sciences 1985 Pollock AS, Strewler GJ, Miller RT, Lawlor D, Horowitz DD, Warnock DG
• Paget's disease of bone.
  The Western journal of medicine 1984 Strewler GJ
• Parathyroid hormone receptors coupled to cyclic adenosine monophosphate formation in an established renal cell line.
  Endocrinology 1984 Teitelbaum AP, Strewler GJ
• Release of cAMP from a renal epithelial cell line.
  The American journal of physiology 1984 Strewler GJ
• Probenecid inhibits the secretion of nephrogenous adenosine 3',5'-monophosphate in normal man.
  The Journal of clinical endocrinology and metabolism 1983 Gogel E, Halloran BP, Strewler GJ
• Ca2+-independent cyclic GMP phosphodiesterases from rat liver and HTC hepatoma cells.
  The Biochemical journal 1983 Strewler GJ, Danello MA, Manganiello VC, Vaughan M
• Human renal carcinoma cells produce hypercalcemia in the nude mouse and a novel protein recognized by parathyroid hormone receptors.
  The Journal of clinical investigation 1983 Strewler GJ, Williams RD, Nissenson RA
• Defective protein phosphorylation in renal medulla of vasopressin-resistant mice.
  Biochemical and biophysical research communications 1981 Strewler GJ, Fallon BG, Orloff J
• Regulation of cyclic nucleotide phosphodiesterase activity.
  Advances in cyclic nucleotide research 1981 Vaughan M, Danello MA, Manganiello VC, Strewler GJ
• Purification and characterization of phosphodiesterase activator from kidney. A lysosomal protease.
  The Journal of biological chemistry 1979 Strewler GJ, Manganiello VC
• Stimulation of adenylate cyclase activity by a protease which activates cyclic nucleotide phosphodiesterase.
  Biochemical and biophysical research communications 1979 Pinkett MO, Strewler GJ, Anderson WB
• Phosphodiesterase activator from rat kidney cortex.
  The Journal of biological chemistry 1978 Strewler GJ, Manganiello VC, Vaughan M
• Adriamycin therapy for advanced insulinoma.
  The Journal of clinical endocrinology and metabolism 1977 Eastman RC, Come SE, Strewler GJ, Gorden P, Kahn CR
• Role of cyclic nucleotides in the transport of water and electrolytes.
  Advances in cyclic nucleotide research 1977 Strewler GJ, Orloff J
• Delayed overt hemolytic transfusion reaction due to anti-U antibody.
  Transfusion 1976 Rothman IK, Alter HJ, Strewler GJ
• Pseudo-vitamin D deficiency rickets (PDR) and relative hypoparathyroidism: a report of a family.
  The Journal of clinical endocrinology and metabolism 1973 Strewler GJ, Bernstein DS, Pletka P
• Sodium intake and vascular smooth muscle responsiveness to norepinephrine and angiotensin in the rabbit.
  Circulation research 1972 Strewler GJ, Hinrichs KJ, Guiod LR, Hollenberg NK
• Hemiparesis occurring six hours after intravenous heroin injection.
  Neurology 1972 Woods BT, Strewler GJ
• Excretion and distribution of iophenoxic acid.
  The Journal of pharmacology and experimental therapeutics 1971 Mudge GH, Strewler GJ, Desbiens N, Berndt WO, Wade DN
• Metabolism of iophenoxic acid in the dog.
  The Journal of pharmacology and experimental therapeutics 1971 Wade DN, Desbiens N, Strewler GJ, Berndt WO, Mudge GH