Bryan Ryder, PhD
Postdoctoral Scholar
Institute for Neurodegenerative Diseases
School of Medicine

Education & Training

Show all (2) Hide

• PhD Molecular Biophysics UT Southwestern Medical Center 08/2022
• BS Biochemistry Rutgers University 05/2015

Publications (12)

Top publication keywords:
Protein Aggregation, PathologicalAlzheimer DiseaseCentrosomeMolecular ChaperonesAmyloidtau ProteinsNerve Tissue ProteinsHSP70 Heat-Shock ProteinsHSP40 Heat-Shock ProteinsSubstrate SpecificityProteostasisProtein AggregatesHEK293 CellsProtein Conformation, beta-StrandTauopathies

• DNAJB8 oligomerization is mediated by an aromatic-rich motif that is dispensable for substrate activity.
  Structure (London, England : 1993) 2024 Ryder BD, Ustyantseva E, Boyer DR, Mendoza-Oliva A, Kuska MI, Wydorski PM, Macierzynska P, Morgan N, Sawaya MR, Diamond MI, Kampinga HH, Joachimiak LA
• Multivalent coiled-coil interactions enable full-scale centrosome assembly and strength.
  The Journal of cell biology 2024 Rios MU, Bagnucka MA, Ryder BD, Ferreira Gomes B, Familiari NE, Yaguchi K, Amato M, Stachera WE, Joachimiak LA, Woodruff JB
• DNAJB8 oligomerization is mediated by an aromatic-rich motif that is dispensable for substrate activity.
  bioRxiv : the preprint server for biology 2024 Ryder BD, Ustyantseva E, Boyer DR, Mendoza-Oliva A, Kuska M, Wydorski PM, Macierzynska P, Morgan N, Sawaya MR, Diamond MI, Kampinga HH, Joachimiak L
• De novo designed Hsp70 activator dissolves intracellular condensates.
  bioRxiv : the preprint server for biology 2023 Zhang JZ, Greenwood N, Hernandez J, Cuperus JT, Huang B, Ryder BD, Queitsch C, Gestwicki JE, Baker D
• A central helical hairpin in SPD-5 enables centrosome strength and assembly.
  bioRxiv : the preprint server for biology 2023 Rios MU, Ryder BD, Familiari N, Joachimiak LA, Woodruff JB

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• Multivalent coiled-coil interactions enable full-scale centrosome assembly and strength.
  bioRxiv : the preprint server for biology 2023 Rios MU, Bagnucka MA, Ryder BD, Gomes BF, Familiari N, Yaguchi K, Amato M, Joachimiak LA, Woodruff JB
• Network of hotspot interactions cluster tau amyloid folds.
  Nature communications 2023 Mullapudi V, Vaquer-Alicea J, Bommareddy V, Vega AR, Ryder BD, White CL, Diamond MI, Joachimiak LA
• Chaperoning shape-shifting tau in disease.
  Trends in biochemical sciences 2022 Ryder BD, Wydorski PM, Hou Z, Joachimiak LA
• DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation.
  Nature communications 2021 Hou Z, Wydorski PM, Perez VA, Mendoza-Oliva A, Ryder BD, Mirbaha H, Kashmer O, Joachimiak LA
• Biophysical properties of a tau seed.
  Scientific reports 2021 Hou Z, Chen D, Ryder BD, Joachimiak LA
• Regulatory inter-domain interactions influence Hsp70 recruitment to the DnaJB8 chaperone.
  Nature communications 2021 Ryder BD, Matlahov I, Bali S, Vaquer-Alicea J, van der Wel PCA, Joachimiak LA
• Tau local structure shields an amyloid-forming motif and controls aggregation propensity.
  Nature communications 2019 Chen D, Drombosky KW, Hou Z, Sari L, Kashmer OM, Ryder BD, Perez VA, Woodard DR, Lin MM, Diamond MI, Joachimiak LA