Bryan Pavlovic, PhD, MS
Assistant Researcher
Neurology
School of Medicine

Education & Training

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• PhD Human Genetics University of Chicago 03/2018
• BS Biochemistry and Molecular Biology University of California, Santa Cruz 05/2007

Publications (25)

Top publication keywords:
Primitive StreakBiological EvolutionEndodermPan troglodytesHominidaeMyocardiumDiGeorge SyndromeCell DifferentiationSequence DeletionMyocytes, CardiacPluripotent Stem CellsCardiovascular SystemSpecies SpecificityCell FusionInduced Pluripotent Stem Cells

• Dissecting gene regulatory networks governing human cortical cell fate.
  Nature 2026 Ding JW, Kim CN, Ostrowski MS, Abeykoon Y, Pavlovic BJ, Wallace JL, Schaefer NK, Nowakowski TJ, Pollen AA
• NPEPPS segmental duplication drives position effect expression of TBC1D3 in the human brain.
  bioRxiv : the preprint server for biology 2026 Guitart X, Brunner JW, Ren L, Jeong H, Yoo D, Porubsky D, Hoekzema K, Munson KM, Sun KA, Ayllon M, Hoglin K, McMullen R, Pavlovic B, Vollger MR, Pollen AA, Eichler EE
• Mapping cis- and trans-regulatory target genes of human-specific deletions.
  Nature communications 2025 Fair T, Pavlovic BJ, Swope D, Castillo OE, Schaefer NK, Pollen AA
• Interrogating the Regulatory Function of HAQERs during Human Cortical Development.
  bioRxiv : the preprint server for biology 2025 Abeykoon Y, Dzikowski N, Luo Y, Sinniah E, Weaver S, Pavlovic BJ, Wallace JL, Mangan RJ, Lowe CB, Pollen AA
• Dissecting Gene Regulatory Networks Governing Human Cortical Cell Fate
  Dissecting Gene Regulatory Networks Governing Human Cortical Cell Fate 2025 Jingwen W. Ding, Chang N. Kim, Megan S. Ostrowski, Yashodara Abeykoon, Bryan J. Pavlovic, Jenelle L. Wallace, Tomasz J. Nowakowski, Alex A. Pollen

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• ANTIPODE Provides a Global View of Cell Type Homology and Transcriptomic Divergence in the Developing Mammalian Brain
  ANTIPODE Provides a Global View of Cell Type Homology and Transcriptomic Divergence in the Developing Mammalian Brain 2025 Matthew T. Schmitz, Jingwen W. Ding, Sara Nolbrant, Reed McMullen, Chang N. Kim, Bryan J. Pavlovic, Tomasz J. Nowakowski, Trygve E. Bakken, Chun Jimmie Ye, Alex A. Pollen
• Dissecting Gene Regulatory Networks Governing Human Cortical Cell Fate.
  bioRxiv : the preprint server for biology 2025 Ding JW, Kim CN, Ostrowski MS, Abeykoon Y, Pavlovic BJ, Wallace JL, Nowakowski TJ, Pollen AA
• Interspecies Organoids Reveal Human-Specific Molecular Features of Dopaminergic Neuron Development and Vulnerability.
  bioRxiv : the preprint server for biology 2025 Nolbrant S, Wallace JL, Ding JW, Zhu T, Sevetson JL, Kajtez J, Baldacci IA, Corrigan EK, Hoglin K, McMullen R, Ostrowski MS, Schmitz MT, Breevoort A, Swope D, Wu F, Pavlovic BJ, Salama SR, Kirkeby A, …
• CellBouncer, A Unified Toolkit for Single-Cell Demultiplexing and Ambient RNA Analysis, Reveals Hominid Mitochondrial Incompatibilities.
  bioRxiv : the preprint server for biology 2025 Schaefer NK, Pavlovic BJ, Pollen AA
• Mapping cis- and trans-regulatory target genes of human-specific deletions.
  bioRxiv : the preprint server for biology 2024 Fair T, Pavlovic BJ, Swope D, Castillo OE, Schaefer NK, Pollen AA
• Thalamocortical organoids enable in vitro modeling of 22q11.2 microdeletion associated with neuropsychiatric disorders.
  Cell stem cell 2024 Shin D, Kim CN, Ross J, Hennick KM, Wu SR, Paranjape N, Leonard R, Wang JC, Keefe MG, Pavlovic BJ, Donohue KC, Moreau C, Wigdor EM, Larson HH, Allen DE, Cadwell CR, Bhaduri A, Popova G, Bearden CE, …
• Comparative landscape of genetic dependencies in human and chimpanzee stem cells.
  Cell 2023 She R, Fair T, Schaefer NK, Saunders RA, Pavlovic BJ, Weissman JS, Pollen AA
• Comparative landscape of genetic dependencies in human and chimpanzee stem cells.
  bioRxiv : the preprint server for biology 2023 She R, Fair T, Schaefer NK, Saunders RA, Pavlovic BJ, Weissman JS, Pollen AA
• Rethinking nomenclature for interspecies cell fusions.
  Nature reviews. Genetics 2022 Pavlovic BJ, Fox D, Schaefer NK, Pollen AA
• Gene expression variability in human and chimpanzee populations share common determinants.
  eLife 2020 Fair BJ, Blake LE, Sarkar A, Pavlovic BJ, Cuevas C, Gilad Y
• Getting to the heart of cardiovascular evolution in humans.
  eLife 2019 Pollen A, Pavlovic BJ
• Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution.
  Cell 2019 Pollen AA, Bhaduri A, Andrews MG, Nowakowski TJ, Meyerson OS, Mostajo-Radji MA, Di Lullo E, Alvarado B, Bedolli M, Dougherty ML, Fiddes IT, Kronenberg ZN, Shuga J, Leyrat AA, West JA, Bershteyn M, …
• A Comparative Assessment of Human and Chimpanzee iPSC-derived Cardiomyocytes with Primary Heart Tissues.
  Scientific reports 2018 Pavlovic BJ, Blake LE, Roux J, Chavarria C, Gilad Y
• A comparative study of endoderm differentiation in humans and chimpanzees.
  Genome biology 2018 Blake LE, Thomas SM, Blischak JD, Hsiao CJ, Chavarria C, Myrthil M, Gilad Y, Pavlovic BJ
• Silencing of transposable elements may not be a major driver of regulatory evolution in primate iPSCs.
  eLife 2018 Ward MC, Zhao S, Luo K, Pavlovic BJ, Karimi MM, Stephens M, Gilad Y
• Impact of regulatory variation across human iPSCs and differentiated cells.
  Genome research 2017 Banovich NE, Li YI, Raj A, Ward MC, Greenside P, Calderon D, Tung PY, Burnett JE, Myrthil M, Thomas SM, Burrows CK, Romero IG, Pavlovic BJ, Kundaje A, Pritchard JK, Gilad Y
• Genetic Variation, Not Cell Type of Origin, Underlies the Majority of Identifiable Regulatory Differences in iPSCs.
  PLoS genetics 2016 Burrows CK, Banovich NE, Pavlovic BJ, Patterson K, Gallego Romero I, Pritchard JK, Gilad Y
• A panel of induced pluripotent stem cells from chimpanzees: a resource for comparative functional genomics.
  eLife 2015 Gallego Romero I, Pavlovic BJ, Hernando-Herraez I, Zhou X, Ward MC, Banovich NE, Kagan CL, Burnett JE, Huang CH, Mitrano A, Chavarria CI, Friedrich Ben-Nun I, Li Y, Sabatini K, Leonardo TR, Parast M, …
• Reprogramming LCLs to iPSCs Results in Recovery of Donor-Specific Gene Expression Signature.
  PLoS genetics 2015 Thomas SM, Kagan C, Pavlovic BJ, Burnett J, Patterson K, Pritchard JK, Gilad Y
• The functional consequences of variation in transcription factor binding.
  PLoS genetics 2014 Cusanovich DA, Pavlovic B, Pritchard JK, Gilad Y