Bruce Wang, MD
Associate Professor
Medicine
School of Medicine

Currently, we have two major research focuses: 1) understanding the biology of adult hepatocyte stem cells and 2) developing a liver cell atlas. We take innovative and integrated approaches to address these two areas using the tools of stem cell biology, developmental biology, genomics and tissue engineering.

I also study the porphyrias, a group of inherited diseases related to defects in heme synthesis pathway. I am a member of the Porphyrias Consortium, a NIH sponsored Rare Disease Clinical Research Consortium. The purpose of the network is to integrate translational studies of the porphyrias with clinical trials testing new therapeutics.

• Reducing diagnostic delays in Acute Hepatic Porphyria using electronic health records data and machine learning: a multicenter development and validation study.
  medRxiv : the preprint server for health sciences 2023 Bhasuran B, Schmolly K, Kapoor Y, Jayakumar NL, Doan R, Amin J, Meninger S, Cheng N, Deering R, Anderson K, Beaven SW, Wang B, Rudrapatna VA
• Evidence-based consensus guidelines for the diagnosis and management of protoporphyria-related liver dysfunction in erythropoietic protoporphyria and X-linked protoporphyria.
  Hepatology (Baltimore, Md.) 2023 Levy C, Dickey AK, Wang B, Thapar M, Naik H, Keel SB, Saberi B, Beaven SW, Rudnick SR, Elmariah SB, Erwin AL, Goddu RJ, Hedstrom K, Leaf RK, Kazamel M, Mazepa M, Philpotts LL, Quigley J, Raef H, Ungar…
• AGA Clinical Practice Update on Diagnosis and Management of Acute Hepatic Porphyrias: Expert Review.
  Gastroenterology 2023 Wang B, Bonkovsky HL, Lim JK, Balwani M
• Concordance of MERFISH spatial transcriptomics with bulk and single-cell RNA sequencing.
  Life science alliance 2022 Liu J, Tran V, Vemuri VNP, Byrne A, Borja M, Kim YJ, Agarwal S, Wang R, Awayan K, Murti A, Taychameekiatchai A, Wang B, Emanuel G, He J, Haliburton J, Oliveira Pisco A, Neff NF
• A pilot study of oral iron therapy in erythropoietic protoporphyria and X-linked protoporphyria.
  Molecular genetics and metabolism reports 2022 Balwani M, Naik H, Overbey JR, Bonkovsky HL, Bissell DM, Wang B, Phillips JD, Desnick RJ, Anderson KE
• Rare, Overlooked, or Underappreciated Causes of Recurrent Abdominal Pain: A Primer for Gastroenterologists.
  Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2022 Brenner DM, Brandt LJ, Fenster M, Hamilton MJ, Kamboj AK, Oxentenko AS, Wang B, Chey WD
• Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data.
  Nature genetics 2022 Zhang MJ, Hou K, Dey KK, Sakaue S, Jagadeesh KA, Weinand K, Taychameekiatchai A, Rao P, Pisco AO, Zou J, Wang B, Gandal M, Raychaudhuri S, Pasaniuc B, Price AL
• Evidence-based consensus guidelines for the diagnosis and management of erythropoietic protoporphyria and X-linked protoporphyria.
  Journal of the American Academy of Dermatology 2022 Dickey AK, Naik H, Keel SB, Levy C, Beaven SW, Elmariah SB, Erwin AL, Goddu RJ, Hedstrom K, Leaf RK, Kazamel M, Mazepa M, Philpotts LL, Quigley J, Raef H, Rudnick SR, Saberi B, Thapar M, Ungar J, Wang…
• Disease burden in patients with acute hepatic porphyria: experience from the phase 3 ENVISION study.
  Orphanet journal of rare diseases 2022 Wang B, Ventura P, Takase KI, Thapar M, Cassiman D, Kubisch I, Liu S, Sweetser MT, Balwani M
• Single-cell analysis of hepatoblastoma identifies tumor signatures that predict chemotherapy susceptibility using patient-specific tumor spheroids.
  Nature communications 2022 Song H, Bucher S, Rosenberg K, Tsui M, Burhan D, Hoffman D, Cho SJ, Rangaswami A, Breese M, Leung S, Ventura MVP, Sweet-Cordero EA, Huang FW, Nijagal A, Wang B
• The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans.
  Science (New York, N.Y.) 2022 Tabula Sapiens Consortium*, Jones RC, Karkanias J, Krasnow MA, Pisco AO, Quake SR, Salzman J, Yosef N, Bulthaup B, Brown P, Harper W, Hemenez M, Ponnusamy R, Salehi A, Sanagavarapu BA, Spallino E, …
• Molecular hallmarks of heterochronic parabiosis at single-cell resolution.
  Nature 2022 Pálovics R, Keller A, Schaum N, Tan W, Fehlmann T, Borja M, Kern F, Bonanno L, Calcuttawala K, Webber J, McGeever A, Tabula Muris Consortium, Luo J, Pisco AO, Karkanias J, Neff NF, Darmanis S, Quake …
• Cell types of origin of the cell-free transcriptome.
  Nature biotechnology 2022 Vorperian SK, Moufarrej MN, Tabula Sapiens Consortium, Quake SR
• Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states.
  Nature communications 2022 Song H, Weinstein HNW, Allegakoen P, Wadsworth MH, Xie J, Yang H, Castro EA, Lu KL, Stohr BA, Feng FY, Carroll PR, Wang B, Cooperberg MR, Shalek AK, Huang FW
• Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells.
  Nature cell biology 2021 Kathiriya JJ, Wang C, Zhou M, Brumwell A, Cassandras M, Le Saux CJ, Cohen M, Alysandratos KD, Wang B, Wolters P, Matthay M, Kotton DN, Chapman HA, Peng T
• RNA splicing programs define tissue compartments and cell types at single-cell resolution.
  eLife 2021 Olivieri JE, Dehghannasiri R, Wang PL, Jang S, de Morree A, Tan SY, Ming J, Ruohao Wu A, Tabula Sapiens Consortium, Quake SR, Krasnow MA, Salzman J
• Novel treatment options for acute hepatic porphyrias.
  Current opinion in gastroenterology 2021 Wang B
• The acute hepatic porphyrias.
  Translational gastroenterology and hepatology 2021 Wang B
• TBX3 functions as a tumor suppressor downstream of activated CTNNB1 mutants during hepatocarcinogenesis.
  Journal of hepatology 2021 Liang B, Zhou Y, Qian M, Xu M, Wang J, Zhang Y, Song X, Wang H, Lin S, Ren C, Monga SP, Wang B, Evert M, Chen Y, Chen X, Huang Z, Calvisi DF, Chen X
• Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells.
  eLife 2021 Russell JP, Lim X, Santambrogio A, Yianni V, Kemkem Y, Wang B, Fish M, Haston S, Grabek A, Hallang S, Lodge EJ, Patist AL, Schedl A, Mollard P, Nusse R, Andoniadou CL
• Hepatocellular Carcinoma in Acute Hepatic Porphyrias: Results from the Longitudinal Study of the U.S. Porphyrias Consortium.
  Hepatology (Baltimore, Md.) 2020 Saberi B, Naik H, Overbey JR, Erwin AL, Anderson KE, Bissell DM, Bonkovsky HL, Phillips JD, Wang B, K Singal A, M McGuire B, Desnick RJ, Balwani M
• Evidence in the UK Biobank for the underdiagnosis of erythropoietic protoporphyria.
  Genetics in medicine : official journal of the American College of Medical Genetics 2020 Dickey AK, Quick C, Ducamp S, Zhu Z, Feng YA, Naik H, Balwani M, Anderson KE, Lin X, Phillips JE, Rebeiz L, Bonkovsky HL, McGuire BM, Wang B, Chasman DI, Smoller JW, Fleming MD, Christiani DC
• Ageing hallmarks exhibit organ-specific temporal signatures.
  Nature 2020 Schaum N, Lehallier B, Hahn O, Pálovics R, Hosseinzadeh S, Lee SE, Sit R, Lee DP, Losada PM, Zardeneta ME, Fehlmann T, Webber JT, McGeever A, Calcuttawala K, Zhang H, Berdnik D, Mathur V, Tan W, Zee A…
• Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria.
  The New England journal of medicine 2020 Balwani M, Sardh E, Ventura P, Peiró PA, Rees DC, Stölzel U, Bissell DM, Bonkovsky HL, Windyga J, Anderson KE, Parker C, Silver SM, Keel SB, Wang JD, Stein PE, Harper P, Vassiliou D, Wang B, Phillips …
• Ly6cLo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation.
  Scientific reports 2020 Alkhani A, Levy CS, Tsui M, Rosenberg KA, Polovina K, Mattis AN, Mack M, Van Dyken S, Wang BM, Maher JJ, Nijagal A
• mTORC2 Signaling Is Necessary for Timely Liver Regeneration after Partial Hepatectomy.
  The American journal of pathology 2020 Xu M, Wang H, Wang J, Burhan D, Shang R, Wang P, Zhou Y, Li R, Liang B, Evert K, Utpatel K, Xu Z, Song X, Che L, Calvisi DF, Wang B, Chen X, Zeng Y, Chen X
• Evaluating the Patient-Reported Outcomes Measurement Information System scales in acute intermittent porphyria.
  Genetics in medicine : official journal of the American College of Medical Genetics 2019 Naik H, Overbey JR, Montgomery GH, Winkel G, Balwani M, Anderson KE, Bissell DM, Bonkovsky HL, Phillips JD, Wang B, McGuire B, Keel S, Levy C, Erwin A, Desnick RJ
• Evaluating quality of life tools in North American patients with erythropoietic protoporphyria and X-linked protoporphyria.
  JIMD reports 2019 Naik H, Overbey JR, Desnick RJ, Anderson KE, Bissell DM, Bloomer J, Bonkovsky HL, Phillips JD, Wang B, Singal A, Balwani M
• Axis inhibition protein 1 (Axin1) Deletion-Induced Hepatocarcinogenesis Requires Intact β-Catenin but Not Notch Cascade in Mice.
  Hepatology (Baltimore, Md.) 2019 Qiao Y, Wang J, Karagoz E, Liang B, Song X, Shang R, Evert K, Xu M, Che L, Evert M, Calvisi DF, Tao J, Wang B, Monga SP, Chen X
• Tissue Repair in the Mouse Liver Following Acute Carbon Tetrachloride Depends on Injury-Induced Wnt/β-Catenin Signaling.
  Hepatology (Baltimore, Md.) 2019 Zhao L, Jin Y, Donahue K, Tsui M, Fish M, Logan CY, Wang B, Nusse R
• Acute Hepatic Porphyrias: Review and Recent Progress.
  Hepatology communications 2018 Wang B, Rudnick S, Cengia B, Bonkovsky HL
• Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture.
  Cell 2018 Peng WC, Logan CY, Fish M, Anbarchian T, Aguisanda F, Álvarez-Varela A, Wu P, Jin Y, Zhu J, Li B, Grompe M, Wang B, Nusse R
• Acute hepatic porphyrias: Recommendations for evaluation and long-term management.
  Hepatology (Baltimore, Md.) 2017 Balwani M, Wang B, Anderson KE, Bloomer JR, Bissell DM, Bonkovsky HL, Phillips JD, Desnick RJ, Porphyrias Consortium of the Rare Diseases Clinical Research Network
• Clinical, Biochemical, and Genetic Characterization of North American Patients With Erythropoietic Protoporphyria and X-linked Protoporphyria.
  JAMA dermatology 2017 Balwani M, Naik H, Anderson KE, Bissell DM, Bloomer J, Bonkovsky HL, Phillips JD, Overbey JR, Wang B, Singal AK, Liu LU, Desnick RJ
• Pitfalls in Erythrocyte Protoporphyrin Measurement for Diagnosis and Monitoring of Protoporphyrias.
  Clinical chemistry 2015 Gou EW, Balwani M, Bissell DM, Bloomer JR, Bonkovsky HL, Desnick RJ, Naik H, Phillips JD, Singal AK, Wang B, Keel S, Anderson KE
• Self-renewing diploid Axin2(+) cells fuel homeostatic renewal of the liver.
  Nature 2015 Wang B, Zhao L, Fish M, Logan CY, Nusse R
• Acute Hepatic Porphyria.
  Journal of clinical and translational hepatology 2015 Bissell DM, Wang B
• Acute liver failure with thyrotoxicosis treated with liver transplantation.
  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2013 Cascino MD, McNabb B, Gardner DG, Woeber KA, Fox AN, Wang B, Fix OK
• Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration.
  The Journal of clinical investigation 2011 Malato Y, Naqvi S, Schürmann N, Ng R, Wang B, Zape J, Kay MA, Grimm D, Willenbring H
• Role of alphavbeta6 integrin in acute biliary fibrosis.
  Hepatology (Baltimore, Md.) 2007 Wang B, Dolinski BM, Kikuchi N, Leone DR, Peters MG, Weinreb PH, Violette SM, Bissell DM
• Six decades of progress and change in hospital medicine, 1947-2007.
  The Pharos of Alpha Omega Alpha-Honor Medical Society. Alpha Omega Alpha 2007 Wang B, Dhaliwal G, Sleisenger MH
• TWEAK induces liver progenitor cell proliferation.
  The Journal of clinical investigation 2005 Jakubowski A, Ambrose C, Parr M, Lincecum JM, Wang MZ, Zheng TS, Browning B, Michaelson JS, Baetscher M, Baestcher M, Wang B, Bissell DM, Burkly LC
• Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton.
  Cell 2001 Winter CG, Wang B, Ballew A, Royou A, Karess R, Axelrod JD, Luo L
• Hereditary Coproporphyria
  GeneReviews® 1993 Wang B, Bissell DM