Bruce Cree, MD, PhD, MAS
Professor
Neurology
School of Medicine

He returned to UCSF for a Sylvia Lawry National Multiple Sclerosis Society fellowship and received a Masters in Advanced Studies in Clinical Research. He is the Clinical Research Director at the UCSF MS Center. He divides his time between patient care, clinical research and teaching. His research focuses on the genetic epidemiology of multiple sclerosis, understanding factors that contribute to disease progression and developing novel therapies for MS through clinical trials. In addition to multiple sclerosis, Dr. Cree specializes in research and care of patients with neuromyelitis optica and transverse myelitis.

• Safety and efficacy of MD1003 (high-dose biotin) in patients with progressive multiple sclerosis (SPI2): a randomised, double-blind, placebo-controlled, phase 3 trial.
  The Lancet. Neurology 2020 Cree BAC, Cutter G, Wolinsky JS, Freedman MS, Comi G, Giovannoni G, Hartung HP, Arnold D, Kuhle J, Block V, Munschauer FE, Sedel F, Lublin FD, SPI2 investigative teams
• Inebilizumab for the treatment of neuromyelitis optica spectrum disorder (N-MOmentum): a double-blind, randomised placebo-controlled phase 2/3 trial.
  Lancet (London, England) 2019 Cree BAC, Bennett JL, Kim HJ, Weinshenker BG, Pittock SJ, Wingerchuk DM, Fujihara K, Paul F, Cutter GR, Marignier R, Green AJ, Aktas O, Hartung HP, Lublin FD, Drappa J, Barron G, Madani S, Ratchford …
• Genome sequencing uncovers phenocopies in primary progressive multiple sclerosis.
  Annals of neurology 2018 Jia X, Madireddy L, Caillier S, Santaniello A, Esposito F, Comi G, Stuve O, Zhou Y, Taylor B, Kilpatrick T, Martinelli-Boneschi F, Cree BAC, Oksenberg JR, Hauser SL, Baranzini SE
• Multiple Sclerosis Therapy: Are We Ready for a One-Size-Fits-All Approach?
  Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2018 Cree BAC
• Phase IV study of retention on fingolimod versus injectable multiple sclerosis therapies: a randomized clinical trial.
  Therapeutic advances in neurological disorders 2018 Cree BAC, Arnold DL, Cascione M, Fox EJ, Williams IM, Meng X, Schofield L, Tenenbaum N
• Comprehensive systematic review summary: Disease-modifying therapies for adults with multiple sclerosis: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology.
  Neurology 2018 Rae-Grant A, Day GS, Marrie RA, Rabinstein A, Cree BAC, Gronseth GS, Haboubi M, Halper J, Hosey JP, Jones DE, Lisak R, Pelletier D, Potrebic S, Sitcov C, Sommers R, Stachowiak J, Getchius TSD, …
• Practice guideline recommendations summary: Disease-modifying therapies for adults with multiple sclerosis: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology.
  Neurology 2018 Rae-Grant A, Day GS, Marrie RA, Rabinstein A, Cree BAC, Gronseth GS, Haboubi M, Halper J, Hosey JP, Jones DE, Lisak R, Pelletier D, Potrebic S, Sitcov C, Sommers R, Stachowiak J, Getchius TSD, …
• Progressive multifocal leukoencephalopathy after fingolimod treatment.
  Neurology 2018 Berger JR, Cree BA, Greenberg B, Hemmer B, Ward BJ, Dong VM, Merschhemke M
• Placebo-controlled study in neuromyelitis optica-Ethical and design considerations.
  Multiple sclerosis (Houndmills, Basingstoke, England) 2015 Cree BA, Bennett JL, Sheehan M, Cohen J, Hartung HP, Aktas O, Kim HJ, Paul F, Pittock S, Weinshenker B, Wingerchuk D, Fujihara K, Cutter G, Patra K, Flor A, Barron G, Madani S, Ratchford JN, Katz E
• Placebo controlled trials in neuromyelitis optica are needed and ethical.
  Multiple sclerosis and related disorders 2015 Cree BA
• Acute inflammatory myelopathies.
  Handbook of clinical neurology 2014 Cree BA
• Genetics of primary progressive multiple sclerosis.
  Handbook of clinical neurology 2014 Cree BA
• Multiple sclerosis genetics.
  Handbook of clinical neurology 2014 Cree BA
• Update on reproductive safety of current and emerging disease-modifying therapies for multiple sclerosis.
  Multiple sclerosis (Houndmills, Basingstoke, England) 2013 Cree BA
• Efficacy of natalizumab therapy in patients of African descent with relapsing multiple sclerosis: analysis of AFFIRM and SENTINEL data.
  Archives of neurology 2011 Cree BA, Stuart WH, Tornatore CS, Jeffery DR, Pace AL, Cha CH
• Pilot trial of low-dose naltrexone and quality of life in multiple sclerosis.
  Annals of neurology 2010 Cree BA, Kornyeyeva E, Goodin DS
• A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01.
  PloS one 2010 Cree BA, Rioux JD, McCauley JL, Gourraud PA, Goyette P, McElroy J, De Jager P, Santaniello A, Vyse TJ, Gregersen PK, Mirel D, Hafler DA, Haines JL, Pericak-Vance MA, Compston A, Sawcer SJ, Oksenberg …
• Multiple sclerosis susceptibility alleles in African Americans.
  Genes and immunity 2009 Johnson BA, Wang J, Taylor EM, Caillier SJ, Herbert J, Khan OA, Cross AH, De Jager PL, Gourraud PA, Cree BC, Hauser SL, Oksenberg JR
• Modification of Multiple Sclerosis Phenotypes by African Ancestry at HLA.
  Archives of neurology 2009 Cree BA, Reich DE, Khan O, De Jager PL, Nakashima I, Takahashi T, Bar-Or A, Tong C, Hauser SL, Oksenberg JR
• Neuromyelitis optica: diagnosis, pathogenesis, and treatment.
  Current neurology and neuroscience reports 2008 Cree B
• Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis.
  Human molecular genetics 2006 Barcellos LF, Sawcer S, Ramsay PP, Baranzini SE, Thomson G, Briggs F, Cree BC, Begovich AB, Villoslada P, Montalban X, Uccelli A, Savettieri G, Lincoln RR, DeLoa C, Haines JL, Pericak-Vance MA, …
• A fatal case of coxsackievirus B4 meningoencephalitis.
  Archives of neurology 2003 Cree BC, Bernardini GL, Hays AP, Lowe G
• Approved and future pharmacotherapy for multiple sclerosis.
  The neurologist 2002 Stüve O, Cree BC, von Büdingen HC, Yousef S, Bowen JD, Genain CP, Hauser SL, Steinman L, Zamvil SS