Brian Orr, PhD
Specialist
Biochemistry and Biophysics
School of Medicine

Publications (6)

Top publication keywords:
Epithelial Sodium ChannelsNerve Tissue ProteinsTalinPresynaptic TerminalsNerve Growth FactorsNeuromuscular JunctionHomeostasisNeuronal PlasticityDrosophila melanogasterDrosophila ProteinsReceptors, Cell SurfaceSemaphorinsNeuroprotectionTumor Suppressor ProteinsAminobutyrates

• Activation and expansion of presynaptic signaling foci drives presynaptic homeostatic plasticity.
  Neuron 2022 Orr BO, Fetter RD, Davis GW
• SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan.
  Nature communications 2021 Johnson AE, Orr BO, Fetter RD, Moughamian AJ, Primeaux LA, Geier EG, Yokoyama JS, Miller BL, Davis GW
• Presynaptic Homeostasis Opposes Disease Progression in Mouse Models of ALS-Like Degeneration: Evidence for Homeostatic Neuroprotection.
  Neuron 2020 Orr BO, Hauswirth AG, Celona B, Fetter RD, Zunino G, Kvon EZ, Zhu Y, Pennacchio LA, Black BL, Davis GW
• Retrograde semaphorin-plexin signalling drives homeostatic synaptic plasticity.
  Nature 2017 Orr BO, Fetter RD, Davis GW
• Composition and Control of a Deg/ENaC Channel during Presynaptic Homeostatic Plasticity.
  Cell reports 2017 Orr BO, Gorczyca D, Younger MA, Jan LY, Jan YN, Davis GW
• Netrin and Frazzled regulate presynaptic gap junctions at a Drosophila giant synapse.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Orr BO, Borgen MA, Caruccio PM, Murphey RK