Brian Feldman, MD, PhD
Professor
Pediatrics
School of Medicine

Walter L. Miller Distinguished Professor University of California, San Francisco Department of Pediatrics Division of Pediatric Endocrinology

A major focus of the Feldman Laboratory is to elucidate previously unrecognized paracrine and endocrine signaling pathways that regulate stem cell fate and differentiation decisions. We are particularly interested in identifying novel pathways that modulate body composition and metabolism. We apply molecular, cellular and in vivo approaches to define these physiological signals as well as examine how perturbations in these pathways can lead to diseases such as diabetes.

• Repurposing mebendazole against triple-negative breast cancer CNS metastasis.
  Journal of neuro-oncology 2024 Rodrigues AJ, Chernikova SB, Wang Y, Trinh TTH, Solow-Cordero DE, Alexandrova L, Casey KM, Alli E, Aggarwal A, Quill T, Koegel AK, Feldman BJ, Ford JM, Hayden-Gephart M
• Repurposing mebendazole against triple-negative breast cancer leptomeningeal disease.
  Research square 2024 Rodrigues A, Chernikova SB, Wang Y, Trinh TTH, Solow-Cordero DE, Alexandrova L, Casey KM, Alli E, Aggarwal A, Quill T, Koegel A, Feldman BJ, Ford JM, Hayden-Gephart M
• Glucocorticoid signaling and the impact of high-fat diet on adipogenesis in vivo.
  Steroids 2023 Babel NK, Feldman BJ
• Quantification of cell energetics in human subcutaneous adipose progenitor cells after target gene knockdown.
  STAR protocols 2023 Li L, Gunewardena AM, Nyima T, Feldman BJ
• A Novel Radioligand Reveals Tissue Specific Pharmacological Modulation of Glucocorticoid Receptor Expression with Positron Emission Tomography.
  ACS chemical biology 2020 Huang Y, Zhao N, Wang YH, Truillet C, Wei J, Blecha JE, VanBrocklin HF, Seo Y, Sayeed M, Feldman BJ, Aggarwal R, Behr SC, Shao H, Wilson DM, Villanueva-Meyer JE, Gestwicki JE, Evans MJ
• A novel platform for isotype-specific testing of autoantibodies.
  PloS one 2019 Carter KL, Treurnicht A, Davis KL, Kumar RB, Feldman BJ
• A context-specific circadian clock in adipocyte precursor cells modulates adipogenesis.
  Adipocyte 2018 Jung Y, Feldman BJ
• The Circadian Clock Regulates Adipogenesis by a Per3 Crosstalk Pathway to Klf15.
  Cell reports 2017 Aggarwal A, Costa MJ, Rivero-Gutiérrez B, Ji L, Morgan SL, Feldman BJ
• Adamts1 responds to systemic cues and gates adipogenesis.
  Adipocyte 2017 Wong JC, Feldman BJ
• Identification of tumor-autonomous and indirect effects of vitamin D action that inhibit breast cancer growth and tumor progression.
  The Journal of steroid biochemistry and molecular biology 2017 Aggarwal A, Feldman D, Feldman BJ
• Amphetamines promote mitochondrial dysfunction and DNA damage in pulmonary hypertension.
  JCI insight 2017 Chen PI, Cao A, Miyagawa K, Tojais NF, Hennigs JK, Li CG, Sweeney NM, Inglis AS, Wang L, Li D, Ye M, Feldman BJ, Rabinovitch M
• Tumor Autonomous Effects of Vitamin D Deficiency Promote Breast Cancer Metastasis.
  Endocrinology 2016 Williams JD, Aggarwal A, Swami S, Krishnan AV, Ji L, Albertelli MA, Feldman BJ
• Vitamin D mitigates the adverse effects of obesity on breast cancer in mice.
  Endocrine-related cancer 2016 Swami S, Krishnan AV, Williams J, Aggarwal A, Albertelli MA, Horst RL, Feldman BJ, Feldman D
• Vitamin D Regulates Fatty Acid Composition in Subcutaneous Adipose Tissue Through Elovl3.
  Endocrinology 2015 Ji L, Gupta M, Feldman BJ
• Mifepristone Treatment of Cushing's Syndrome in a Pediatric Patient.
  Pediatrics 2015 Banerjee RR, Marina N, Katznelson L, Feldman BJ
• Inhibition of Mouse Breast Tumor-Initiating Cells by Calcitriol and Dietary Vitamin D.
  Molecular cancer therapeutics 2015 Jeong Y, Swami S, Krishnan AV, Williams JD, Martin S, Horst RL, Albertelli MA, Feldman BJ, Feldman D, Diehn M
• BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension.
  Cell metabolism 2015 Diebold I, Hennigs JK, Miyagawa K, Li CG, Nickel NP, Kaschwich M, Cao A, Wang L, Reddy S, Chen PI, Nakahira K, Alcazar MA, Hopper RK, Ji L, Feldman BJ, Rabinovitch M
• Using SRM-MS to quantify nuclear protein abundance differences between adipose tissue depots of insulin-resistant mice.
  Journal of lipid research 2015 Ota A, Kovary KM, Wu OH, Ahrends R, Shen WJ, Costa MJ, Feldman BJ, Kraemer FB, Teruel MN
• Novel GATA6 mutations in patients with pancreatic agenesis and congenital heart malformations.
  PloS one 2015 Chao CS, McKnight KD, Cox KL, Chang AL, Kim SK, Feldman BJ
• The development of next-generation screening and diagnostic platforms will change diabetes care.
  Expert review of molecular diagnostics 2015 Kumar RB, Gupta M, Feldman BJ
• Characterization of Cre recombinase activity for in vivo targeting of adipocyte precursor cells.
  Stem cell reports 2014 Krueger KC, Costa MJ, Du H, Feldman BJ
• The role of vitamin D in reducing cancer risk and progression.
  Nature reviews. Cancer 2014 Feldman D, Krishnan AV, Swami S, Giovannucci E, Feldman BJ
• Adipose circadian clocks: coordination of metabolic rhythms by clock genes, steroid hormones, and PPARs.
  Hormone molecular biology and clinical investigation 2013 Krueger KC, Feldman BJ
• Cell-autonomous regulation of brown fat identity gene UCP1 by unliganded vitamin D receptor.
  Molecular endocrinology (Baltimore, Md.) 2013 Malloy PJ, Feldman BJ
• Characterization of three vasopressin receptor 2 variants: an apparent polymorphism (V266A) and two loss-of-function mutations (R181C and M311V).
  PloS one 2013 Armstrong SP, Seeber RM, Ayoub MA, Feldman BJ, Pfleger KD
• Enhanced BRET Technology for the Monitoring of Agonist-Induced and Agonist-Independent Interactions between GPCRs and β-Arrestins.
  Frontiers in endocrinology 2011 Kocan M, Dalrymple MB, Seeber RM, Feldman BJ, Pfleger KD
• Circadian rhythm gene period 3 is an inhibitor of the adipocyte cell fate.
  The Journal of biological chemistry 2011 Costa MJ, So AY, Kaasik K, Krueger KC, Pillsbury ML, Fu YH, Ptacek LJ, Yamamoto KR, Feldman BJ
• Glucocorticoid regulation of the circadian clock modulates glucose homeostasis.
  Proceedings of the National Academy of Sciences of the United States of America 2009 So AY, Bernal TU, Pillsbury ML, Yamamoto KR, Feldman BJ
• Glucocorticoids influence on mesenchymal stem cells and implications for metabolic disease.
  Pediatric research 2009 Feldman BJ
• Agonist-independent interactions between beta-arrestins and mutant vasopressin type II receptors associated with nephrogenic syndrome of inappropriate antidiuresis.
  Molecular endocrinology (Baltimore, Md.) 2009 Kocan M, See HB, Sampaio NG, Eidne KA, Feldman BJ, Pfleger KD
• Conservation analysis predicts in vivo occupancy of glucocorticoid receptor-binding sequences at glucocorticoid-induced genes.
  Proceedings of the National Academy of Sciences of the United States of America 2008 So AY, Cooper SB, Feldman BJ, Manuchehri M, Yamamoto KR
• Is your metabolism determined by (cell) fate?
  Pediatric research 2007 Feldman BJ
• Report of a hürthle cell neoplasm in a peripubertal girl.
  Thyroid : official journal of the American Thyroid Association 2007 Bremer AA, Feldman BJ, Iezza G, Clark OH, Rosenthal SM
• Cardiac troponin increases among runners in the Boston Marathon.
  Annals of emergency medicine 2006 Fortescue EB, Shin AY, Greenes DS, Mannix RC, Agarwal S, Feldman BJ, Shah MI, Rifai N, Landzberg MJ, Newburger JW, Almond CS
• Nephrogenic syndrome of inappropriate antidiuresis (NSIAD): a paradigm for activating mutations causing endocrine dysfunction.
  Pediatric endocrinology reviews : PER 2006 Rosenthal SM, Feldman BJ, Vargas GA, Gitelman SE
• Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Feldman BJ, Streeper RS, Farese RV, Yamamoto KR
• Nephrogenic syndrome of inappropriate antidiuresis: a novel disorder in water balance in pediatric patients.
  The American journal of medicine 2006 Gitelman SE, Feldman BJ, Rosenthal SM
• Oral urea for the treatment of chronic syndrome of inappropriate antidiuresis in children.
  The Journal of pediatrics 2006 Huang EA, Feldman BJ, Schwartz ID, Geller DH, Rosenthal SM, Gitelman SE
• Nephrogenic syndrome of inappropriate antidiuresis.
  The New England journal of medicine 2005 Feldman BJ, Rosenthal SM, Vargas GA, Fenwick RG, Huang EA, Matsuda-Abedini M, Lustig RH, Mathias RS, Portale AA, Miller WL, Gitelman SE
• Carbohydrate-deficient glycoprotein syndrome-associated pericardial effusion treated with corticosteroids and salicylic acid.
  Pediatric cardiology 2002 Feldman BJ, Rosenthal D
• The development of androgen-independent prostate cancer.
  Nature reviews. Cancer 2001 Feldman BJ, Feldman D
• A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice.
  Blood 2000 Feldman BJ, Hampton T, Cleary ML
• Pim1 cooperates with E2a-Pbx1 to facilitate the progression of thymic lymphomas in transgenic mice.
  Oncogene 1997 Feldman BJ, Reid TR, Cleary ML
• The chimeric oncoproteins E2A-PBX1 and E2A-HLF are concentrated within spherical nuclear domains.
  Oncogene 1997 LeBrun DP, Matthews BP, Feldman BJ, Cleary ML
• A novel role for DNA photolyase: binding to DNA damaged by drugs is associated with enhanced cytotoxicity in Saccharomyces cerevisiae.
  Molecular and cellular biology 1994 Fox ME, Feldman BJ, Chu G
• Concanavalin A and the in vitro induction in macrophages of vacuolation and lysosomal enzyme synthesis.
  Experimental cell research 1975 Goldman R, Raz A
• Seasonal variations in the composition of urine in relation to calcium stone-formation.
  Clinical science and molecular medicine 1975 Robertson WG, Peacock M, Marshall RW, Speed R, Nordin BE
• Digitoxin metabolism by rat liver microsomes.
  Biochemical pharmacology 1975 Schmoldt A, Benthe HF, Haberland G