Brian Black, PhD
Professor
Cardiovascular Research Inst
School of Medicine

Our major goal is to define pathways controlling organ formation to understand normal development, the molecular basis for congenital and other genetic defects, and potential mechanisms for organ regeneration and repair. Our focus is primarily on the cardiovascular system, but the development of other organs and tissues is also being investigated in our laboratory.

We use a combination of gene knockouts, transgenic reporter assays, biochemical, computational, and genomic approaches to investigate basic developmental mechanisms. We primarily use the mouse as a model system, but several current projects also use cultured cells, zebrafish, and Drosophila as models to understand developmental gene regulation. Current work in the lab is focused primarily on cell autonomous mechanisms underlying gene regulation, tissue specification, organ formation during cardiovascular, craniofacial, neural crest, and skeletal muscle development and function.

• An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair.
  Cell stem cell 2022 Yan R, Cigliola V, Oonk KA, Petrover Z, DeLuca S, Wolfson DW, Vekstein A, Mendiola MA, Devlin G, Bishawi M, Gemberling MP, Sinha T, Sargent MA, York AJ, Shakked A, DeBenedittis P, Wendell DC, Ou J, …
• Cold shock domain-containing protein E1 is a posttranscriptional regulator of the LDL receptor.
  Science translational medicine 2022 Smith GA, Padmanabhan A, Lau BH, Pampana A, Li L, Lee CY, Pelonero A, Nishino T, Sadagopan N, Xia VQ, Jain R, Natarajan P, Wu RS, Black BL, Srivastava D, Shokat KM, Chorba JS
• Transcription Factor GATA4 Regulates Cell Type-Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitors.
  Circulation 2022 Zhu L, Choudhary K, Gonzalez-Teran B, Ang YS, Thomas R, Stone NR, Liu L, Zhou P, Zhu C, Ruan H, Huang Y, Jin S, Pelonero A, Koback F, Padmanabhan A, Sadagopan N, Hsu A, Costa MW, Gifford CA, van …
• Transcriptional regulation of vascular smooth muscle cell proliferation, differentiation and senescence: Novel targets for therapy.
  Vascular pharmacology 2022 Khachigian LM, Black BL, Ferdinandy P, De Caterina R, Madonna R, Geng YJ
• Differential Etv2 threshold requirement for endothelial and erythropoietic development.
  Cell reports 2022 Sinha T, Lammerts van Bueren K, Dickel DE, Zlatanova I, Thomas R, Lizama CO, Xu SM, Zovein AC, Ikegami K, Moskowitz IP, Pollard KS, Pennacchio LA, Black BL
• Transcription factor protein interactomes reveal genetic determinants in heart disease.
  Cell 2022 Gonzalez-Teran B, Pittman M, Felix F, Thomas R, Richmond-Buccola D, Hüttenhain R, Choudhary K, Moroni E, Costa MW, Huang Y, Padmanabhan A, Alexanian M, Lee CY, Maven BEJ, Samse-Knapp K, Morton SU, …
• Abstract 11332: Integration of Protein Interactome Networks with Congenital Heart Disease Variants Reveals Candidate Disease Genes.
  Circulation 2021 Barbara Gonzalez Teran, Maureen Pittman, Reuben Thomas, Franco Felix, Desmond Richmond-Buccola, Krishna Choudhary, Elisabetta Moroni, Colombo Giorgio, Arun Padmanabhan, Mauro Costa, Yu Huang, Michael …
• Comprehensive cell type decomposition of circulating cell-free DNA with CelFiE.
  Nature communications 2021 Caggiano C, Celona B, Garton F, Mefford J, Black BL, Henderson R, Lomen-Hoerth C, Dahl A, Zaitlen N
• Control of ribosomal protein synthesis by the Microprocessor complex.
  Science signaling 2021 Jiang X, Prabhakar A, Van der Voorn SM, Ghatpande P, Celona B, Venkataramanan S, Calviello L, Lin C, Wang W, Black BL, Floor SN, Lagna G, Hata A
• ATAC-Seq Reveals an Isl1 Enhancer That Regulates Sinoatrial Node Development and Function.
  Circulation research 2020 Galang G, Mandla R, Ruan H, Jung C, Sinha T, Stone NR, Wu RS, Mannion BJ, Allu PKR, Chang K, Rammohan A, Shi MB, Pennacchio LA, Black BL, Vedantham V
• Genome-Wide Analysis Identifies an Essential Human TBX3 Pacemaker Enhancer.
  Circulation research 2020 van Eif VWW, Protze SI, Bosada FM, Yuan X, Sinha T, van Duijvenboden K, Ernault AC, Mohan RA, Wakker V, de Gier-de Vries C, Hooijkaas IB, Wilson MD, Verkerk AO, Bakkers J, Boukens BJ, Black BL, Scott …
• Presynaptic Homeostasis Opposes Disease Progression in Mouse Models of ALS-Like Degeneration: Evidence for Homeostatic Neuroprotection.
  Neuron 2020 Orr BO, Hauswirth AG, Celona B, Fetter RD, Zunino G, Kvon EZ, Zhu Y, Pennacchio LA, Black BL, Davis GW
• Estimating the Rate of Cell Type Degeneration from Epigenetic Sequencing of Cell-Free DNA.
  2020 Christa Caggiano, Barbara Celona, Fleur Garton, Joel Mefford, Brian Black, Catherine Lomen-Hoerth, Andrew Dahl, Noah Zaitlen
• Loss-of-function variants in myocardin cause congenital megabladder in humans and mice.
  The Journal of clinical investigation 2019 Houweling AC, Beaman GM, Postma AV, Gainous TB, Lichtenbelt KD, Brancati F, Lopes FM, van der Made I, Polstra AM, Robinson ML, Wright KD, Ellingford JM, Jackson AR, Overwater E, Genesio R, Romano S, …
• Noncoding deletions reveal a gene that is critical for intestinal function.
  Nature 2019 Oz-Levi D, Olender T, Bar-Joseph I, Zhu Y, Marek-Yagel D, Barozzi I, Osterwalder M, Alkelai A, Ruzzo EK, Han Y, Vos ESM, Reznik-Wolf H, Hartman C, Shamir R, Weiss B, Shapiro R, Pode-Shakked B, …
• Venous endothelin modulates responsiveness of cardiac sympathetic axons to arterial semaphorin.
  eLife 2019 Poltavski DM, Colombier P, Hu J, Duron A, Black BL, Makita T
• Cardiovascular development and survival require Mef2c function in the myocardial but not the endothelial lineage.
  Developmental biology 2018 Materna SC, Sinha T, Barnes RM, Lammerts van Bueren K, Black BL
• Genomic analysis of transcriptional networks directing progression of cell states during MGE development.
  Neural development 2018 Sandberg M, Taher L, Hu J, Black BL, Nord AS, Rubenstein JLR
• Cooperative activation of cardiac transcription through myocardin bridging of paired MEF2 sites.
  Development (Cambridge, England) 2017 Anderson CM, Hu J, Thomas R, Gainous TB, Celona B, Sinha T, Dickel DE, Heidt AB, Xu SM, Bruneau BG, Pollard KS, Pennacchio LA, Black BL
• Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice.
  eLife 2017 Overman J, Fontaine F, Moustaqil M, Mittal D, Sierecki E, Sacilotto N, Zuegg J, Robertson AAB, Holmes K, Salim AA, Mamidyala S, Butler MS, Robinson AS, Lesieur E, Johnston W, Alexandrov K, Black BL, …
• Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106.
  eLife 2017 Celona B, Dollen JV, Vatsavayai SC, Kashima R, Johnson JR, Tang AA, Hata A, Miller BL, Huang EJ, Krogan NJ, Seeley WW, Black BL
• Fast revascularization of the injured area is essential to support zebrafish heart regeneration.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Marín-Juez R, Marass M, Gauvrit S, Rossi A, Lai SL, Materna SC, Black BL, Stainier DY
• Modulation of tissue repair by regeneration enhancer elements.
  Nature 2016 Kang J, Hu J, Karra R, Dickson AL, Tornini VA, Nachtrab G, Gemberling M, Goldman JA, Black BL, Poss KD
• MEF2C regulates outflow tract alignment and transcriptional control of Tdgf1.
  Development (Cambridge, England) 2016 Barnes RM, Harris IS, Jaehnig EJ, Sauls K, Sinha T, Rojas A, Schachterle W, McCulley DJ, Norris RA, Black BL
• Nodal Signaling and Congenital Heart Defects.
  Etiology and Morphogenesis of Congenital Heart Disease 2016 Ralston M. Barnes, Brian L. Black
• Endothelin signaling activates Mef2c expression in the neural crest through a MEF2C-dependent positive-feedback transcriptional pathway.
  Development (Cambridge, England) 2015 Hu J, Verzi MP, Robinson AS, Tang PL, Hua LL, Xu SM, Kwok PY, Black BL
• Identification of novel Fgf enhancers and their role in dental evolution.
  Evolution & development 2015 Tapaltsyan V, Charles C, Hu J, Mindell D, Ahituv N, Wilson GM, Black BL, Viriot L, Klein OD
• Developmental biology: Diversity in the lymphatic vasculature.
  Nature 2015 Hogan BM, Black BL
• Mef2c-F10N enhancer driven β-galactosidase (LacZ) and Cre recombinase mice facilitate analyses of gene function and lineage fate in neural crest cells.
  Developmental biology 2015 Aoto K, Sandell LL, Butler Tjaden NE, Yuen KC, Watt KE, Black BL, Durnin M, Trainor PA
• Myocyte enhancer factor 2C function in skeletal muscle is required for normal growth and glucose metabolism in mice.
  Skeletal muscle 2015 Anderson CM, Hu J, Barnes RM, Heidt AB, Cornelissen I, Black BL
• NFATc1 controls skeletal muscle fiber type and is a negative regulator of MyoD activity.
  Cell reports 2014 Ehlers ML, Celona B, Black BL
• An arterial-specific enhancer of the human endothelin converting enzyme 1 (ECE1) gene is synergistically activated by Sox17, FoxC2, and Etv2.
  Developmental biology 2014 Robinson AS, Materna SC, Barnes RM, De Val S, Xu SM, Black BL
• Specification of the mouse cardiac conduction system in the absence of Endothelin signaling.
  Developmental biology 2014 Hua LL, Vedantham V, Barnes RM, Hu J, Robinson AS, Bressan M, Srivastava D, Black BL
• Abstract 327: ETS Factors Regulate the VEGF-Dependent, Arterial-Specific Expression of Dll4.
  Arteriosclerosis Thrombosis and Vascular Biology 2014 Lan T Dang, Joshua D Wythe, Patrick W Devine, Emilie Boudreau, Stanley T Artap, Daniel He, William Schachterle, Didier Y Stainier, Peter Oettgen, Brian L Black, Benoit G Bruneau, Jason E Fish
• Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Parker SC, Stitzel ML, Taylor DL, Orozco JM, Erdos MR, Akiyama JA, van Bueren KL, Chines PS, Narisu N, NISC Comparative Sequencing Program, Black BL, Visel A, Pennacchio LA, Collins FS, National …
• ETS factors regulate Vegf-dependent arterial specification.
  Developmental cell 2013 Wythe JD, Dang LT, Devine WP, Boudreau E, Artap ST, He D, Schachterle W, Stainier DY, Oettgen P, Black BL, Bruneau BG, Fish JE
• Regulation of endothelial and hematopoietic development by the ETS transcription factor Etv2.
  Current opinion in hematology 2012 Lammerts van Bueren K, Black BL
• Chapter 3 Cardiac Myocyte Specification and Differentiation.
  Muscle 2012 Benoit G. Bruneau, Brian L. Black
• Transcription factor pathways and congenital heart disease.
  Current topics in developmental biology 2012 McCulley DJ, Black BL
• Large-scale discovery of enhancers from human heart tissue.
  Nature genetics 2011 May D, Blow MJ, Kaplan T, McCulley DJ, Jensen BC, Akiyama JA, Holt A, Plajzer-Frick I, Shoukry M, Wright C, Afzal V, Simpson PC, Rubin EM, Black BL, Bristow J, Pennacchio LA, Visel A
• Vascular endothelial and endocardial progenitors differentiate as cardiomyocytes in the absence of Etsrp/Etv2 function.
  Development (Cambridge, England) 2011 Palencia-Desai S, Kohli V, Kang J, Chi NC, Black BL, Sumanas S
• ETS-dependent regulation of a distal Gata4 cardiac enhancer.
  Developmental biology 2011 Schachterle W, Rojas A, Xu SM, Black BL
• Etsrp/Etv2 initiates endothelial/endocardial and inhibits myocardial differentiation by two distinct mechanisms in zebrafish embryos.
  Developmental Biology 2011 Sharina Palencia-Desai, Vikram Kohli, Jione Kang, Neil C. Chi, Brian L. Black, Saulius Sumanas
• FGF-dependent regulation of VEGF receptor 2 expression in mice.
  The Journal of clinical investigation 2011 Murakami M, Nguyen LT, Hatanaka K, Schachterle W, Chen PY, Zhuang ZW, Black BL, Simons M
• The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10.
  Development (Cambridge, England) 2011 Agarwal P, Verzi MP, Nguyen T, Hu J, Ehlers ML, McCulley DJ, Xu SM, Dodou E, Anderson JP, Wei ML, Black BL
• Hand2 function in second heart field progenitors is essential for cardiogenesis.
  Developmental biology 2010 Tsuchihashi T, Maeda J, Shin CH, Ivey KN, Black BL, Olson EN, Yamagishi H, Srivastava D
• Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism.
  Developmental cell 2010 Wang J, Greene SB, Bonilla-Claudio M, Tao Y, Zhang J, Bai Y, Huang Z, Black BL, Wang F, Martin JF
• ChIP-Seq identification of weakly conserved heart enhancers.
  Nature genetics 2010 Blow MJ, McCulley DJ, Li Z, Zhang T, Akiyama JA, Holt A, Plajzer-Frick I, Shoukry M, Wright C, Chen F, Afzal V, Bristow J, Ren B, Black BL, Rubin EM, Visel A, Pennacchio LA
• Direct transcriptional regulation of Gata4 during early endoderm specification is controlled by FoxA2 binding to an intronic enhancer.
  Developmental biology 2010 Rojas A, Schachterle W, Xu SM, Martín F, Black BL
• Development of the endocardium.
  Pediatric cardiology 2010 Harris IS, Black BL
• Chapter 9.5 Myocyte Enhancer Factor 2 Transcription Factors in Heart Development and Disease.
  Heart Development and Regeneration 2010 Brian L. Black, Richard M. Cripps
• An endoderm-specific transcriptional enhancer from the mouse Gata4 gene requires GATA and homeodomain protein-binding sites for function in vivo.
  Developmental dynamics : an official publication of the American Association of Anatomists 2009 Rojas A, Schachterle W, Xu SM, Black BL
• Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1.
  Pharmacogenetics and genomics 2009 Ha Choi J, Wah Yee S, Kim MJ, Nguyen L, Ho Lee J, Kang JO, Hesselson S, Castro RA, Stryke D, Johns SJ, Kwok PY, Ferrin TE, Goo Lee M, Black BL, Ahituv N, Giacomini KM
• Reptilian heart development and the molecular basis of cardiac chamber evolution.
  Nature 2009 Koshiba-Takeuchi K, Mori AD, Kaynak BL, Cebra-Thomas J, Sukonnik T, Georges RO, Latham S, Beck L, Beck L, Henkelman RM, Black BL, Olson EN, Wade J, Takeuchi JK, Nemer M, Gilbert SF, Bruneau BG
• Erratum: Reptilian heart development and the molecular basis of cardiac chamber evolution.
  Nature 2009 Kazuko Koshiba-Takeuchi, Alessandro D. Mori, Bogac L. Kaynak, Judith Cebra-Thomas, Tatyana Sukonnik, Romain O. Georges, Stephany Latham, Laurel Beck, R. Mark Henkelman, Brian L. Black, Eric N. Olson, …
• Isl1 is a direct transcriptional target of Forkhead transcription factors in second-heart-field-derived mesoderm.
  Developmental biology 2009 Kang J, Nathan E, Xu SM, Tzahor E, Black BL
• Maintenance of blastemal proliferation by functionally diverse epidermis in regenerating zebrafish fins.
  Developmental biology 2009 Lee Y, Hami D, De Val S, Kagermeier-Schenk B, Wills AA, Black BL, Weidinger G, Poss KD
• Transcriptional control of endothelial cell development.
  Developmental cell 2009 De Val S, Black BL
• Identification and characterization of proximal promoter polymorphisms in the human concentrative nucleoside transporter 2 (SLC28A2).
  The Journal of pharmacology and experimental therapeutics 2008 Yee SW, Shima JE, Hesselson S, Nguyen L, De Val S, Lafond RJ, Kawamoto M, Johns SJ, Stryke D, Kwok PY, Ferrin TE, Black BL, Gurwitz D, Ahituv N, Giacomini KM
• Combinatorial regulation of endothelial gene expression by ets and forkhead transcription factors.
  Cell 2008 De Val S, Chi NC, Meadows SM, Minovitsky S, Anderson JP, Harris IS, Ehlers ML, Agarwal P, Visel A, Xu SM, Pennacchio LA, Dubchak I, Krieg PA, Stainier DY, Black BL
• BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development.
  Developmental dynamics : an official publication of the American Association of Anatomists 2008 McCulley DJ, Kang JO, Martin JF, Black BL
• A p38 MAPK-MEF2C pathway regulates B-cell proliferation.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Khiem D, Cyster JG, Schwarz JJ, Black BL
• Genetic and functional interaction between transcription factors MEF2C and Dlx5/6 is required for craniofacial development.
  Developmental Biology 2008 Pooja Agarwal, Michael P. Verzi, Brian L. Black
• GATA4 is a direct transcriptional activator of cyclin D2 and Cdk4 and is required for cardiomyocyte proliferation in anterior heart field-derived myocardium.
  Molecular and cellular biology 2008 Rojas A, Kong SW, Agarwal P, Gilliss B, Pu WT, Black BL
• Foxn4 directly regulates tbx2b expression and atrioventricular canal formation.
  Genes & development 2008 Chi NC, Shaw RM, De Val S, Kang G, Jan LY, Black BL, Stainier DY
• Transcriptional pathways in heart development.
  The FASEB Journal 2008 Brian L Black, Jione Kang, Ian S Harris, William Schachterle
• Determinants of myogenic specificity within MyoD are required for noncanonical E box binding.
  Molecular and cellular biology 2007 Heidt AB, Rojas A, Harris IS, Black BL
• Transcriptional control of second heart field development.
  Developmental Biology 2007 Brian L. Black, Jione Kang, Ian S. Harris, Will Schachterle, Anabel Rojas
• The transcription factor MEF2C is required for craniofacial development.
  Developmental cell 2007 Verzi MP, Agarwal P, Brown C, McCulley DJ, Schwarz JJ, Black BL
• The heart's Da Vinci code: a Renaissance at Keystone.
  Development (Cambridge, England) 2007 Bruneau BG, Black BL
• An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.
  Cell 2007 Prall OW, Menon MK, Solloway MJ, Watanabe Y, Zaffran S, Bajolle F, Biben C, McBride JJ, Robertson BR, Chaulet H, Stennard FA, Wise N, Schaft D, Wolstein O, Furtado MB, Shiratori H, Chien KR, Hamada H,…
• Model systems for the study of heart development and disease.
  Seminars in Cell and Developmental Biology 2007 Robert A. Schulz, Brian L. Black
• Transcriptional pathways in second heart field development.
  Seminars in cell & developmental biology 2007 Black BL
• Transcriptional Control of Cardiac Boundary Formation.
  Cardiovascular Development 2007 Anabel Rojas, Brian L. Black
• In vivo enhancer analysis of human conserved non-coding sequences.
  Nature 2006 Pennacchio LA, Ahituv N, Moses AM, Prabhakar S, Nobrega MA, Shoukry M, Minovitsky S, Dubchak I, Holt A, Lewis KD, Plajzer-Frick I, Akiyama J, De Val S, Afzal V, Black BL, Couronne O, Eisen MB, Visel A…
• Increased susceptibility to isoproterenol-induced cardiac hypertrophy and impaired weight gain in mice lacking the histidine-rich calcium-binding protein.
  Molecular and cellular biology 2006 Jaehnig EJ, Heidt AB, Greene SB, Cornelissen I, Black BL
• Pitx2 regulates cardiac left-right asymmetry by patterning second cardiac lineage-derived myocardium.
  Developmental biology 2006 Ai D, Liu W, Ma L, Dong F, Lu MF, Wang D, Verzi MP, Cai C, Gage PJ, Evans S, Black BL, Brown NA, Martin JF
• Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling.
  Development (Cambridge, England) 2006 Park EJ, Ogden LA, Talbot A, Evans S, Cai CL, Black BL, Frank DU, Moon AM
• A single mutation causes a spectrum of cardiovascular defects: the potential role of genetic modifiers, epigenetic influences, and stochastic events in phenotypic variability.
  Journal of molecular and cellular cardiology 2005 Black BL
• The right ventricle, outflow tract, and ventricular septum comprise a restricted expression domain within the secondary/anterior heart field.
  Developmental biology 2005 Verzi MP, McCulley DJ, De Val S, Dodou E, Black BL
• Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element.
  Development (Cambridge, England) 2005 Rojas A, De Val S, Heidt AB, Xu SM, Bristow J, Black BL
• Transgenic mice that express Cre recombinase under control of a skeletal muscle-specific promoter from mef2c.
  Genesis (New York, N.Y. : 2000) 2005 Heidt AB, Black BL
• Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation.
  Development (Cambridge, England) 2005 Stennard FA, Costa MW, Lai D, Biben C, Furtado MB, Solloway MJ, McCulley DJ, Leimena C, Preis JI, Dunwoodie SL, Elliott DE, Prall OW, Black BL, Fatkin D, Harvey RP
• Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development.
  Development (Cambridge, England) 2005 Takeuchi JK, Mileikovskaia M, Koshiba-Takeuchi K, Heidt AB, Mori AD, Arruda EP, Gertsenstein M, Georges R, Davidson L, Mo R, Hui CC, Henkelman RM, Nemer M, Black BL, Nagy A, Bruneau BG
• Mef2c is activated directly by Ets transcription factors through an evolutionarily conserved endothelial cell-specific enhancer.
  Developmental biology 2004 De Val S, Anderson JP, Heidt AB, Khiem D, Xu SM, Black BL
• Mef2c is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development.
  Development (Cambridge, England) 2004 Dodou E, Verzi MP, Anderson JP, Xu SM, Black BL
• HRC is a direct transcriptional target of MEF2 during cardiac, skeletal, and arterial smooth muscle development in vivo.
  Molecular and cellular biology 2004 Anderson JP, Dodou E, Heidt AB, De Val SJ, Jaehnig EJ, Greene SB, Olson EN, Black BL
• mef2c is activated directly by myogenic basic helix-loop-helix proteins during skeletal muscle development in vivo.
  Mechanisms of development 2003 Dodou E, Xu SM, Black BL
• N-twist, an evolutionarily conserved bHLH protein expressed in the developing CNS, functions as a transcriptional inhibitor.
  Developmental biology 2002 Verzi MP, Anderson JP, Dodou E, Kelly KK, Greene SB, North BJ, Cripps RM, Black BL
• TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3.
  Genes & development 2001 Liu D, Black BL, Derynck R
• Activated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C.
  Molecular and cellular biology 1999 Wilson-Rawls J, Molkentin JD, Black BL, Olson EN
• 8 Control of Cardiac Development by the MEF2 Family of Transcription Factors.
  Heart Development 1999 Brian L. Black, Eric N. Olson
• The myogenic regulatory gene Mef2 is a direct target for transcriptional activation by Twist during Drosophila myogenesis.
  Genes & development 1998 Cripps RM, Black BL, Zhao B, Lien CL, Schulz RA, Olson EN
• Multiple roles for the MyoD basic region in transmission of transcriptional activation signals and interaction with MEF2.
  Molecular and cellular biology 1998 Black BL, Molkentin JD, Olson EN
• Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins.
  Annual review of cell and developmental biology 1998 Black BL, Olson EN
• The MEF2A 3' untranslated region functions as a cis-acting translational repressor.
  Molecular and cellular biology 1997 Black BL, Lu J, Olson EN
• Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family.
  The Journal of biological chemistry 1996 Black BL, Ligon KL, Zhang Y, Olson EN
• MEF2B is a potent transactivator expressed in early myogenic lineages.
  Molecular and cellular biology 1996 Molkentin JD, Firulli AB, Black BL, Martin JF, Hustad CM, Copeland N, Jenkins N, Lyons G, Olson EN
• Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2C.
  Molecular and cellular biology 1996 Molkentin JD, Black BL, Martin JF, Olson EN
• Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins.
  Cell 1995 Molkentin JD, Black BL, Martin JF, Olson EN
• The mouse MRF4 promoter is trans-activated directly and indirectly by muscle-specific transcription factors.
  The Journal of biological chemistry 1995 Black BL, Martin JF, Olson EN
• Effect of vesicular stomatitis virus matrix protein on host-directed translation in vivo.
  Journal of virology 1994 Black BL, Brewer G, Lyles DS
• The role of vesicular stomatitis virus matrix protein in inhibition of host-directed gene expression is genetically separable from its function in virus assembly.
  Journal of virology 1993 Black BL, Rhodes RB, McKenzie M, Lyles DS
• Vesicular stomatitis virus matrix protein inhibits host cell-directed transcription of target genes in vivo.
  Journal of virology 1992 Black BL, Lyles DS
• Focal toxicity of oxysterols in vascular smooth muscle cell culture. A model of the atherosclerotic core region.
  The American journal of pathology 1990 Guyton JR, Black BL, Seidel CL