Brandon Holmes, MD, PhD
Assistant Professor
Neurology
School of Medicine
Awards
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- Weill Award for Clinician-Scientists in the Neurosciences, UCSF, 2023
Education & Training
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- Behavioral Neurology UCSF 06/2023
- Neurology Residency UCSF 06/2021
- MD Medicine Washington University in Saint Louis 05/2017
- PhD Neuroscience Washington University in Saint Louis 05/2017
- BA Neuroscience Oberlin College 05/2007
- Postdoctoral Scholar, Wells Lab UCSF
Interests
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- microglia
- aging
- prion
- protein engineering
- proteomics
- neuroinflammation
- cellular engineering
- neurodegeneration
Websites
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- The Holmes Lab (holmeslab.ucsf.edu)
Grants and Projects
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- Interrogating and Targeting Microglia Phagocytosis in Alzheimer’s Disease, NIH, 2023-2028
- Interrogating and Targeting the Microglia Cell-Surface in Alzheimer’s Disease, BrightFocus Foundation, 2022-2024
- Neuroinflammation in Neurodegeneration: A Microglia Perspective, UCSF ADRC, 2022-2024
- R25 Postdoctoral Research Fellowship: Elucidating the Microglia Surfaceome, NIH, 2020-2023
- Tracking the Propagation of Misfolded Tau: A Study of Cellular Uptake and Traffic, NIH, 2012-2015
Publications (27)
Top publication keywords:
Lipid Metabolism, Inborn Errorstau ProteinsHeart ArrestTauopathiesOptic TractCarnitine O-PalmitoyltransferaseProtein Aggregation, PathologicalHypoglycemiaVertebrobasilar InsufficiencyGlossopharyngeal Nerve DiseasesPrion DiseasesPinocytosisHeparan Sulfate ProteoglycansPrionsHemianopsia
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Jugular Foramen Syndrome Caused by Varicella Zoster Virus Infection.
The Neurohospitalist 2022 Adjepong KO, LaHue SC, Ha D, Holmes BB -
A striking dichotomy.
Journal of hospital medicine 2022 Thomas NJ, Shekarchian S, Bock MA, Holmes BB, Geha RM, Shah MP -
Amnestic Syndrome and Bilateral Hippocampal Diffusion Abnormalities From Opioid Use.
Neurology. Clinical practice 2021 Ahlbach C, Holmes BB, Narvid J, Rosendale N -
Author Response: Amnestic Syndrome and Bilateral Hippocampal Diffusion Abnormalities From Opioid Use.
Neurology. Clinical practice 2021 Holmes BB, Ahlbach C, Narvid J, Rosendale N -
Clinical Reasoning: A 2-Day-Old Boy With Sudden Cardiac Arrest and Encephalopathy.
Neurology 2021 Holmes BB, Russ JB, Wu YW, Gallagher RC, Gano D
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Hyper-Acute Necrotizing Encephalopathy-Like Syndrome in Early Pregnancy.
The Neurohospitalist 2021 Holmes BB, Nolan A, Wong C, Sun CH -
An isolated ruptured spinal aneurysm presents with a thalamic Infarct: case report.
BMC neurology 2021 Tenorio A, Holmes BB, Abla AA, Amans M, Meisel K -
A synthetic heparinoid blocks Tau aggregate cell uptake and amplification.
The Journal of biological chemistry 2020 Stopschinski BE, Thomas TL, Nadji S, Darvish E, Fan L, Holmes BB, Modi AR, Finnell JG, Kashmer OM, Estill-Terpack S, Mirbaha H, Luu HS, Diamond MI -
Adult-Onset Subacute Sclerosing Panencephalitis With a 30-Year Latent Period.
The Neurohospitalist 2019 Holmes BB, Conell-Price J, Kreple CJ, Ashraf D, Betjemann J, Rosendale N -
Parkinson's disease and multiple system atrophy have distinct α-synuclein seed characteristics.
The Journal of biological chemistry 2018 Yamasaki TR, Holmes BB, Furman JL, Dhavale DD, Su BW, Song ES, Cairns NJ, Kotzbauer PT, Diamond MI -
Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus α-synuclein and β-amyloid aggregates.
The Journal of biological chemistry 2018 Stopschinski BE, Holmes BB, Miller GM, Manon VA, Vaquer-Alicea J, Prueitt WL, Hsieh-Wilson LC, Diamond MI -
Vertebrobasilar Dolichoectasia Causing An Optic Tract Syndrome.
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2017 Holmes BB, Green WC, Kung NH, Goebel JA, Van Stavern GP -
Cellular Models for the Study of Prions.
Cold Spring Harbor perspectives in medicine 2017 Holmes BB, Diamond MI -
Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy.
Science translational medicine 2017 DeVos SL, Miller RL, Schoch KM, Holmes BB, Kebodeaux CS, Wegener AJ, Chen G, Shen T, Tran H, Nichols B, Zanardi TA, Kordasiewicz HB, Swayze EE, Bennett CF, Diamond MI, Miller TM -
Prions and Protein Assemblies that Convey Biological Information in Health and Disease.
Neuron 2016 Sanders DW, Kaufman SK, Holmes BB, Diamond MI -
Heparan sulfate proteoglycans mediate Aβ-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells.
Molecular neurodegeneration 2016 Reynolds MR, Singh I, Azad TD, Holmes BB, Verghese PB, Dietrich HH, Diamond M, Bu G, Han BH, Zipfel GJ -
Sensitive Detection of Proteopathic Seeding Activity with FRET Flow Cytometry.
Journal of visualized experiments : JoVE 2015 Furman JL, Holmes BB, Diamond MI -
Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation.
The Journal of biological chemistry 2015 Mirbaha H, Holmes BB, Sanders DW, Bieschke J, Diamond MI -
Proteopathic tau seeding predicts tauopathy in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2014 Holmes BB, Furman JL, Mahan TE, Yamasaki TR, Mirbaha H, Eades WC, Belaygorod L, Cairns NJ, Holtzman DM, Diamond MI -
Prion-like properties of Tau protein: the importance of extracellular Tau as a therapeutic target.
The Journal of biological chemistry 2014 Holmes BB, Diamond MI -
Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds.
Proceedings of the National Academy of Sciences of the United States of America 2013 Holmes BB, DeVos SL, Kfoury N, Li M, Jacks R, Yanamandra K, Ouidja MO, Brodsky FM, Marasa J, Bagchi DP, Kotzbauer PT, Miller TM, Papy-Garcia D, Diamond MI -
An N-terminal nuclear export signal regulates trafficking and aggregation of Huntingtin (Htt) protein exon 1.
The Journal of biological chemistry 2013 Zheng Z, Li A, Holmes BB, Marasa JC, Diamond MI -
Amyotrophic lateral sclerosis and organ donation: is there risk of disease transmission?
Annals of neurology 2012 Holmes BB, Diamond MI -
Cellular mechanisms of protein aggregate propagation.
Current opinion in neurology 2012 Holmes BB, Diamond MI -
Macrophage migration inhibitory factor acts as a neurotrophin in the developing inner ear.
Development (Cambridge, England) 2012 Bank LM, Bianchi LM, Ebisu F, Lerman-Sinkoff D, Smiley EC, Shen YC, Ramamurthy P, Thompson DL, Roth TM, Beck CR, Flynn M, Teller RS, Feng L, Llewellyn GN, Holmes B, Sharples C, Coutinho-Budd J, Linn … -
Trans-cellular propagation of Tau aggregation by fibrillar species.
The Journal of biological chemistry 2012 Kfoury N, Holmes BB, Jiang H, Holtzman DM, Diamond MI -
In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Yamada K, Cirrito JR, Stewart FR, Jiang H, Finn MB, Holmes BB, Binder LI, Mandelkow EM, Diamond MI, Lee VM, Holtzman DM