Boris Bastian, MD, PhD
Professor
Dermatology
School of Medicine

Awards

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• Lila and Murray Gruber Memorial Cancer Research Award, American Academy of Dermatology, 2017
• NCI Outstanding Investigatory Award, National Cancer Institute, 2017
• Research Achievement Award, American Skin Association, 2016
• Lifetime Achievement Award, Society of Melanoma Research, 2014
• Helwig Award, American Society of Dermatopathology, 2012
• Elected Member, German National Academy of Science Leopoldina, 2012
• Scientific Leadership Award, Melanoma Research Foundation, 2012
• President, Society of Melanoma Research, 2010-2013
• Honorary Member, European Association of Dermatologic Oncology, 2010
• Abby S. and Howard P. Milstein Innovation Award for Skin Cancer Research, American Skin Association, 2008
• Hermann Pinkus Lectureship and Award, American Society of Dermatopathology, 2005

Grants and Projects

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• Molecular and immunologic evolution of melanomas from pre-neoplastic lesions, NIH, 2017-2024
• The GNAQ pathway as a therapeutic target in uveal melanoma, NIH, 2009-2021
• Molecular Pathology of Cancer, NIH, 2013-2018
• Human Melanoma: Etiology, Progression and Therapy, NIH, 1980-2016
• Biomarker Discovery for the Classification of Melanoma, NIH, 2008-2013
• Program Project Grant, NIH, 2003-2010
• Classification of ambiguous melanocytic tumors, NIH, 2002-2006

Publications (234)

Top publication keywords:
MutationOncogene Proteins, FusionMelanocytesProto-Oncogene Proteins c-kitGTP-Binding Protein alpha SubunitsDNA, NeoplasmNevus, PigmentedMelanomaMAP Kinase Signaling SystemUveal NeoplasmsProto-Oncogene Proteins B-rafNevus, Epithelioid and Spindle CellIn Situ Hybridization, FluorescenceNevus, BlueSkin Neoplasms

• Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism.
  Science (New York, N.Y.) 2017 Chiba K, Lorbeer FK, Shain AH, McSwiggen DT, Schruf E, Oh A, Ryu J, Darzacq X, Bastian BC, Hockemeyer D
• RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma.
  Cancer cell 2017 Chen X, Wu Q, Depeille P, Chen P, Thornton S, Kalirai H, Coupland SE, Roose JP, Bastian BC
• NTRK3 kinase fusions in Spitz tumours.
  The Journal of pathology 2016 Yeh I, Tee MK, Botton T, Shain AH, Sparatta AJ, Gagnon A, Vemula SS, Garrido MC, Nakamaru K, Isoyama T, McCalmont TH, LeBoit PE, Bastian BC
• From melanocytes to melanomas.
  Nature reviews. Cancer 2016 Shain AH, Bastian BC
• CNVkit: Genome-Wide Copy Number Detection and Visualization from Targeted DNA Sequencing.
  PLoS computational biology 2016 Talevich E, Shain AH, Botton T, Bastian BC
• The Genetic Evolution of Melanoma from Precursor Lesions.
  The New England journal of medicine 2015 Shain AH, Yeh I, Kovalyshyn I, Sriharan A, Talevich E, Gagnon A, Dummer R, North J, Pincus L, Ruben B, Rickaby W, D'Arrigo C, Robson A, Bastian BC
• Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway.
  Nature genetics 2015 Shain AH, Garrido M, Botton T, Talevich E, Yeh I, Sanborn JZ, Chung J, Wang NJ, Kakavand H, Mann GJ, Thompson JF, Wiesner T, Roy R, Olshen AB, Gagnon A, Gray JW, Huh N, Hur JS, Busam KJ, Scolyer RA, …
• Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Sanborn JZ, Chung J, Purdom E, Wang NJ, Kakavand H, Wilmott JS, Butler T, Thompson JF, Mann GJ, Haydu LE, Saw RP, Busam KJ, Lo RS, Collisson EA, Hur JS, Spellman PT, Cleaver JE, Gray JW, Huh N, Murali…
• Activating MET kinase rearrangements in melanoma and Spitz tumours.
  Nature communications 2015 Yeh I, Botton T, Talevich E, Shain AH, Sparatta AJ, de la Fouchardiere A, Mully TW, North JP, Garrido MC, Gagnon A, Vemula SS, McCalmont TH, LeBoit PE, Bastian BC
• Clinical, histopathologic, and genomic features of Spitz tumors with ALK fusions.
  The American journal of surgical pathology 2015 Yeh I, de la Fouchardiere A, Pissaloux D, Mully TW, Garrido MC, Vemula SS, Busam KJ, LeBoit PE, McCalmont TH, Bastian BC
• Phase II Study of Nilotinib in Melanoma Harboring KIT Alterations Following Progression to Prior KIT Inhibition.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2015 Carvajal RD, Lawrence DP, Weber JS, Gajewski TF, Gonzalez R, Lutzky J, O'Day SJ, Hamid O, Wolchok JD, Chapman PB, Sullivan RJ, Teitcher JB, Ramaiya N, Giobbie-Hurder A, Antonescu CR, Heinrich MC, …
• Fluorescence in situ hybridization as an ancillary tool in the diagnosis of ambiguous melanocytic neoplasms: a review of 804 cases.
  The American journal of surgical pathology 2014 North JP, Garrido MC, Kolaitis NA, LeBoit PE, McCalmont TH, Bastian BC
• The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia.
  Annual review of pathology 2014 Bastian BC
• Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations.
  Oncogene 2013 Chen X, Wu Q, Tan L, Porter D, Jager MJ, Emery C, Bastian BC
• Recurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapy.
  Pigment cell & melanoma research 2013 Botton T, Yeh I, Nelson T, Vemula SS, Sparatta A, Garrido MC, Allegra M, Rocchi S, Bahadoran P, McCalmont TH, LeBoit PE, Burton EA, Bollag G, Ballotti R, Bastian BC
• Targeting activated KIT signaling for melanoma therapy.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2013 Bastian BC, Esteve-Puig R
• MC1R and cAMP signaling inhibit cdc25B activity and delay cell cycle progression in melanoma cells.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Lyons J, Bastian BC, McCormick F
• Clonal BRAF mutations in melanocytic nevi and initiating role of BRAF in melanocytic neoplasia.
  Journal of the National Cancer Institute 2013 Yeh I, von Deimling A, Bastian BC
• A distinct subset of atypical Spitz tumors is characterized by BRAF mutation and loss of BAP1 expression.
  The American journal of surgical pathology 2012 Wiesner T, Murali R, Fried I, Cerroni L, Busam K, Kutzner H, Bastian BC
• GNAQ and GNA11 mutations in melanocytomas of the central nervous system.
  Acta neuropathologica 2012 Murali R, Wiesner T, Rosenblum MK, Bastian BC
• Sunitinib therapy for melanoma patients with KIT mutations.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2012 Minor DR, Kashani-Sabet M, Garrido M, O'Day SJ, Hamid O, Bastian BC
• The melanomas: a synthesis of epidemiological, clinical, histopathological, genetic, and biological aspects, supporting distinct subtypes, causal pathways, and cells of origin.
  Pigment cell & melanoma research 2011 Whiteman DC, Pavan WJ, Bastian BC
• Assessment of copy number status of chromosomes 6 and 11 by FISH provides independent prognostic information in primary melanoma.
  The American journal of surgical pathology 2011 North JP, Vetto JT, Murali R, White KP, White CR, Bastian BC
• KIT as a therapeutic target in metastatic melanoma.
  JAMA 2011 Carvajal RD, Antonescu CR, Wolchok JD, Chapman PB, Roman RA, Teitcher J, Panageas KS, Busam KJ, Chmielowski B, Lutzky J, Pavlick AC, Fusco A, Cane L, Takebe N, Vemula S, Bouvier N, Bastian BC, …
• Genetic and morphologic features for melanoma classification.
  Pigment cell & melanoma research 2010 Broekaert SM, Roy R, Okamoto I, van den Oord J, Bauer J, Garbe C, Barnhill RL, Busam KJ, Cochran AJ, Cook MG, Elder DE, McCarthy SW, Mihm MC, Schadendorf D, Scolyer RA, Spatz A, Bastian BC
• Mutations in GNA11 in uveal melanoma.
  The New England journal of medicine 2010 Van Raamsdonk CD, Griewank KG, Crosby MB, Garrido MC, Vemula S, Wiesner T, Obenauf AC, Wackernagel W, Green G, Bouvier N, Sozen MM, Baimukanova G, Roy R, Heguy A, Dolgalev I, Khanin R, Busam K, …
• Use of fluorescence in situ hybridization (FISH) to distinguish intranodal nevus from metastatic melanoma.
  The American journal of surgical pathology 2010 Dalton SR, Gerami P, Kolaitis NA, Charzan S, Werling R, LeBoit PE, Bastian BC
• Somatic mutation of epidermal growth factor receptor in a small subset of cutaneous squamous cell carcinoma.
  The Journal of investigative dermatology 2009 Ridd K, Bastian BC
• Fluorescence in situ hybridization (FISH) as an ancillary diagnostic tool in the diagnosis of melanoma.
  The American journal of surgical pathology 2009 Gerami P, Jewell SS, Morrison LE, Blondin B, Schulz J, Ruffalo T, Matushek P, Legator M, Jacobson K, Dalton SR, Charzan S, Kolaitis NA, Guitart J, Lertsbarapa T, Boone S, LeBoit PE, Bastian BC
• Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi.
  Nature 2008 Van Raamsdonk CD, Bezrookove V, Green G, Bauer J, Gaugler L, O'Brien JM, Simpson EM, Barsh GS, Bastian BC
• Improving melanoma classification by integrating genetic and morphologic features.
  PLoS medicine 2008 Viros A, Fridlyand J, Bauer J, Lasithiotakis K, Garbe C, Pinkel D, Bastian BC
• Distribution and significance of occult intraepidermal tumor cells surrounding primary melanoma.
  The Journal of investigative dermatology 2008 North JP, Kageshita T, Pinkel D, LeBoit PE, Bastian BC
• The prevalence and prognostic value of BRAF mutation in thyroid cancer.
  Annals of surgery 2007 Kebebew E, Weng J, Bauer J, Ranvier G, Clark OH, Duh QY, Shibru D, Bastian B, Griffin A
• Somatic activation of KIT in distinct subtypes of melanoma.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006 Curtin JA, Busam K, Pinkel D, Bastian BC
• Congenital melanocytic nevi frequently harbor NRAS mutations but no BRAF mutations.
  The Journal of investigative dermatology 2006 Bauer J, Curtin JA, Pinkel D, Bastian BC
• MC1R germline variants confer risk for BRAF-mutant melanoma.
  Science (New York, N.Y.) 2006 Landi MT, Bauer J, Pfeiffer RM, Elder DE, Hulley B, Minghetti P, Calista D, Kanetsky PA, Pinkel D, Bastian BC
• Mechanisms of cell-cycle arrest in Spitz nevi with constitutive activation of the MAP-kinase pathway.
  The American journal of pathology 2004 Maldonado JL, Timmerman L, Fridlyand J, Bastian BC
• Determinants of BRAF mutations in primary melanomas.
  Journal of the National Cancer Institute 2003 Maldonado JL, Fridlyand J, Patel H, Jain AN, Busam K, Kageshita T, Ono T, Albertson DG, Pinkel D, Bastian BC
• Cyclin D1 is a candidate oncogene in cutaneous melanoma.
  Cancer research 2002 Sauter ER, Yeo UC, von Stemm A, Zhu W, Litwin S, Tichansky DS, Pistritto G, Nesbit M, Pinkel D, Herlyn M, Bastian BC
• Mutations and copy number increase of HRAS in Spitz nevi with distinctive histopathological features.
  The American journal of pathology 2000 Bastian BC, LeBoit PE, Pinkel D

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• Congenital melanocytic naevi initiated by BRAF fusion oncogene with firmness, pruritus and desmoplastic stroma.
  The British journal of dermatology 2025 Roy SF, Agim NG, Mir A, Couts KL, Vandergriff T, Robinson WA, Bastian BC, Frieden IJ, Yeh I
• Genetic evolution of keratinocytes to cutaneous squamous cell carcinoma.
  bioRxiv : the preprint server for biology 2024 Tandukar B, Deivendran D, Chen L, Cruz-Pacheco N, Sharma H, Xu A, Bandari AK, Chen DB, George C, Marty A, Cho RJ, Cheng J, Saylor D, Gerami P, Arron ST, Bastian BC, Shain AH
• Primary Melanoma of the Urinary Bladder: Clinical, Histopathologic, and Comprehensive Molecular Analysis of a Rare Tumor.
  International journal of surgical pathology 2024 Kayraklioglu N, Chan E, Bastian B, Long SR
• The genetic evolution of acral melanoma.
  Nature communications 2024 Wang M, Fukushima S, Sheen YS, Ramelyte E, Cruz-Pacheco N, Shi C, Liu S, Banik I, Aquino JD, Sangueza Acosta M, Levesque M, Dummer R, Liau JY, Chu CY, Shain AH, Yeh I, Bastian BC
• Observation of Interatomic Coulombic Decay Induced by Double Excitation of Helium in Nanodroplets.
  Physical review letters 2024 Bastian B, Asmussen JD, Ltaief LB, Pedersen HB, Sishodia K, De S, Krishnan SR, Medina C, Pal N, Richter R, Sisourat N, Mudrich M
• Amplification of Mutant NRAS in Melanocytic Tumors With Features of Spitz Tumors.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2024 Cloutier JM, Wang M, Vemula SS, Mirza S, Weier J, Aquino JD, McCalmont TH, LeBoit PE, Bastian BC, Yeh I
• Distinct senescence mechanisms restrain progression of dysplastic nevi.
  PNAS nexus 2024 Lorbeer FK, Rieser G, Goel A, Wang M, Oh A, Yeh I, Bastian BC, Hockemeyer D
• STmut: a framework for visualizing somatic alterations in spatial transcriptomics data of cancer.
  Genome biology 2023 Chen L, Chang D, Tandukar B, Deivendran D, Pozniak J, Cruz-Pacheco N, Cho RJ, Cheng J, Yeh I, Marine C, Bastian BC, Ji AL, Shain AH
• Tracing cancer evolution and heterogeneity using Hi-C.
  Nature communications 2023 Erdmann-Pham DD, Batra SS, Turkalo TK, Durbin J, Blanchette M, Yeh I, Shain H, Bastian BC, Song YS, Rokhsar DS, Hockemeyer D
• The genetic evolution of acral melanoma.
  bioRxiv : the preprint server for biology 2023 Wang M, Fukushima S, Sheen YS, Ramelyte E, Pacheco NC, Shi C, Liu S, Banik I, Aquino JD, Acosta MS, Levesque M, Dummer R, Liau JY, Chu CY, Shain AH, Yeh I, Bastian BC
• Melanoma in infants, caused by a gene fusion involving the anaplastic lymphoma kinase (ALK).
  Pigment cell & melanoma research 2023 Perkins IU, Tan SY, McCalmont TH, Chou PM, Mully TW, Gerami P, Pomerantz JH, Reyes-Múgica M, Balkin DM, Kruse LL, Huang B, Reichek JL, Gangopadhyay N, Chiosea S, Green JR, Chamlin SL, Frieden IJ, …
• Histologic and Genetic Features of 51 Melanocytic Neoplasms With Protein Kinase C Fusion Genes.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2023 de la Fouchardière A, Pissaloux D, Houlier A, Paindavoine S, Tirode F, LeBoit PE, Bastian BC, Yeh I
• Distinct senescence mechanisms restrain progression of dysplastic nevi.
  bioRxiv : the preprint server for biology 2023 Lorbeer FK, Rieser G, Goel A, Wang M, Oh A, Yeh I, Bastian BC, Hockemeyer D
• Spectrum of Melanocytic Tumors Harboring BRAF Gene Fusions: 58 Cases With Histomorphologic and Genetic Correlations.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2023 Roy SF, Milante R, Pissaloux D, Tirode F, Bastian BC, Fouchardière A, Yeh I
• Revision of the Melanocytic Pathology Assessment Tool and Hierarchy for Diagnosis Classification Schema for Melanocytic Lesions: A Consensus Statement.
  JAMA network open 2023 Barnhill RL, Elder DE, Piepkorn MW, Knezevich SR, Reisch LM, Eguchi MM, Bastian BC, Blokx W, Bosenberg M, Busam KJ, Carr R, Cochran A, Cook MG, Duncan LM, Elenitsas R, de la Fouchardière A, Gerami P, …
• Relaxation dynamics in excited helium nanodroplets probed with high resolution, time-resolved photoelectron spectroscopy.
  Physical chemistry chemical physics : PCCP 2022 LaForge AC, Asmussen JD, Bastian B, Bonanomi M, Callegari C, De S, Di Fraia M, Gorman L, Hartweg S, Krishnan SR, Kling MF, Mishra D, Mandal S, Ngai A, Pal N, Plekan O, Prince KC, Rosenberger P, …
• Evidence for neutrino emission from the nearby active galaxy NGC 1068.
  Science (New York, N.Y.) 2022 IceCube Collaboration*†, Abbasi R, Ackermann M, Adams J, Aguilar JA, Ahlers M, Ahrens M, Alameddine JM, Alispach C, Alves AA, Amin NM, Andeen K, Anderson T, Anton G, Argüelles C, Ashida Y, Axani S, …
• Search for Unstable Sterile Neutrinos with the IceCube Neutrino Observatory.
  Physical review letters 2022 Abbasi R, Ackermann M, Adams J, Aguilar JA, Ahlers M, Ahrens M, Alameddine JM, Alves AA, Amin NM, Andeen K, Anderson T, Anton G, Argüelles C, Ashida Y, Axani S, Bai X, Balagopal V A, Barwick SW, …
• Iris and Ciliary Body Melanocytomas Are Defined by Solitary GNAQ Mutation Without Additional Oncogenic Alterations.
  Ophthalmology 2022 Solomon DA, Ramani B, Eiger-Moscovich M, Milman T, Uludag G, Crawford JB, Phan I, Char DH, Shields CL, Eagle RC, Bastian BC, Bloomer MM, Pekmezci M
• Strong Constraints on Neutrino Nonstandard Interactions from TeV-Scale ν_{μ} Disappearance at IceCube.
  Physical review letters 2022 Abbasi R, Ackermann M, Adams J, Aguilar JA, Ahlers M, Ahrens M, Alameddine JM, Alispach C, Alves AA, Amin NM, Andeen K, Anderson T, Anton G, Argüelles C, Ashida Y, Axani S, Bai X, Balagopal A, Barbano…
• Integrated genomic analyses of acral and mucosal melanomas nominate novel driver genes.
  Genome medicine 2022 Wang M, Banik I, Shain AH, Yeh I, Bastian BC
• Search for Relativistic Magnetic Monopoles with Eight Years of IceCube Data.
  Physical review letters 2022 Abbasi R, Ackermann M, Adams J, Aguilar JA, Ahlers M, Ahrens M, Alispach C, Alves AA, Amin NM, An R, Andeen K, Anderson T, Anton G, Argüelles C, Ashida Y, Axani S, Bai X, Balagopal V A, Barbano A, …
• Genetic polymorphism in Methylenetetrahydrofolate Reductase chloride transport protein 6 (MTHFR CLCN6) gene is associated with keratinocyte skin cancer in a cohort of renal transplant recipients.
  Skin health and disease 2022 Griffin L, Ho L, Akhurst RJ, Arron ST, Boggs JME, Conlon P, O'Kelly P, Toland AE, Epstein EH, Balmain A, Bastian BC, Moloney FJ, Murphy GM, Laing ME
• Evaluation of Crizotinib Treatment in a Patient With Unresectable GOPC-ROS1 Fusion Agminated Spitz Nevi.
  JAMA dermatology 2021 Robertson SJ, Orme L, Teixeira R, Shamassi M, Newell F, Patch AM, Yeh I, Gard G, Wilmott J, Jackett L, LeBoit P, Fellowes A, MacArthur G, Fox S, Hayward NK, Bastian B, Scolyer R, Waddell N, Penington …
• Melanoma pathology: new approaches and classification.
  The British journal of dermatology 2021 Yeh I, Bastian BC
• Multiple desmoplastic Spitz nevi with BRAF fusions in a patient with ring chromosome 7 syndrome.
  Pigment cell & melanoma research 2021 Roy SF, Bastian BC, Maguiness S, Giubellino A, Vemula SS, McCalmont TH, Yeh I
• Publisher Correction: The genomic landscapes of individual melanocytes from human skin.
  Nature 2021 Tang J, Fewings E, Chang D, Zeng H, Liu S, Jorapur A, Belote RL, McNeal AS, Tan TM, Yeh I, Arron ST, Judson-Torres RL, Bastian BC, Shain AH
• Functional characterization of uveal melanoma oncogenes.
  Oncogene 2020 Ma J, Weng L, Bastian BC, Chen X
• The genomic landscapes of individual melanocytes from human skin.
  Nature 2020 Tang J, Fewings E, Chang D, Zeng H, Liu S, Jorapur A, Belote RL, McNeal AS, Tan TM, Yeh I, Arron ST, Judson-Torres RL, Bastian BC, Shain AH
• eV-Scale Sterile Neutrino Search Using Eight Years of Atmospheric Muon Neutrino Data from the IceCube Neutrino Observatory.
  Physical review letters 2020 Aartsen MG, Abbasi R, Ackermann M, Adams J, Aguilar JA, Ahlers M, Ahrens M, Alispach C, Amin NM, Andeen K, Anderson T, Ansseau I, Anton G, Argüelles C, Auffenberg J, Axani S, Bagherpour H, Bai X, …
• Eruptive Spitz nevus, a striking example of benign metastasis.
  Scientific reports 2020 Raghavan SS, Kapler ES, Dinges MM, Bastian BC, Yeh I
• Fusion partners of NTRK3 affect subcellular localization of the fusion kinase and cytomorphology of melanocytes.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2020 de la Fouchardière A, Tee MK, Peternel S, Valdebran M, Pissaloux D, Tirode F, Busam KJ, LeBoit PE, McCalmont TH, Bastian BC, Yeh I
• Characteristics of the Diffuse Astrophysical Electron and Tau Neutrino Flux with Six Years of IceCube High Energy Cascade Data.
  Physical review letters 2020 Aartsen MG, Ackermann M, Adams J, Aguilar JA, Ahlers M, Ahrens M, Alispach C, Andeen K, Anderson T, Ansseau I, Anton G, Argüelles C, Auffenberg J, Axani S, Backes P, Bagherpour H, Bai X, Balagopal V A…
• Pervasive chromosomal instability and karyotype order in tumour evolution.
  Nature 2020 Watkins TBK, Lim EL, Petkovic M, Elizalde S, Birkbak NJ, Wilson GA, Moore DA, Grönroos E, Rowan A, Dewhurst SM, Demeulemeester J, Dentro SC, Horswell S, Au L, Haase K, Escudero M, Rosenthal R, Bakir …
• Author Correction: From melanocytes to melanomas.
  Nature reviews. Cancer 2020 Shain AH, Bastian BC
• The 2018 World Health Organization Classification of Cutaneous, Mucosal, and Uveal Melanoma: Detailed Analysis of 9 Distinct Subtypes Defined by Their Evolutionary Pathway.
  Archives of pathology & laboratory medicine 2020 Elder DE, Bastian BC, Cree IA, Massi D, Scolyer RA
• Time-Integrated Neutrino Source Searches with 10 Years of IceCube Data.
  Physical review letters 2020 Aartsen MG, Ackermann M, Adams J, Aguilar JA, Ahlers M, Ahrens M, Alispach C, Andeen K, Anderson T, Ansseau I, Anton G, Argüelles C, Auffenberg J, Axani S, Backes P, Bagherpour H, Bai X, Balagopal A, …
• The Tumor Suppressor BAP1 Regulates the Hippo Pathway in Pancreatic Ductal Adenocarcinoma.
  Cancer research 2020 Lee HJ, Pham T, Chang MT, Barnes D, Cai AG, Noubade R, Totpal K, Chen X, Tran C, Hagenbeek T, Wu X, Eastham-Anderson J, Tao J, Lee W, Bastian BC, Carbone M, Webster JD, Dey A
• Spitz melanoma is a distinct subset of spitzoid melanoma.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2020 Raghavan SS, Peternel S, Mully TW, North JP, Pincus LB, LeBoit PE, McCalmont TH, Bastian BC, Yeh I
• Next-Generation Sequencing of Retinoblastoma Identifies Pathogenic Alterations beyond RB1 Inactivation That Correlate with Aggressive Histopathologic Features.
  Ophthalmology 2019 Afshar AR, Pekmezci M, Bloomer MM, Cadenas NJ, Stevers M, Banerjee A, Roy R, Olshen AB, Van Ziffle J, Onodera C, Devine WP, Grenert JP, Bastian BC, Solomon DA, Damato BE
• Melanocytic tumors with MAP3K8 fusions: report of 33 cases with morphological-genetic correlations.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2019 Houlier A, Pissaloux D, Masse I, Tirode F, Karanian M, Pincus LB, McCalmont TH, LeBoit PE, Bastian BC, Yeh I, de la Fouchardière A
• Association of Indoor Tanning Exposure With Age at Melanoma Diagnosis and BRAF V600E Mutations.
  Journal of the National Cancer Institute 2019 Burbidge TE, Bastian BC, Guo D, Li H, Morris DG, Monzon JG, Leung G, Yang H, Cheng T
• Ewing sarcoma in a child with neurofibromatosis type 1.
  Cold Spring Harbor molecular case studies 2019 Fernandez KS, Turski ML, Shah AT, Bastian BC, Horvai A, Hardee S, Sweet-Cordero EA
• Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses.
  Cell reports 2019 Botton T, Talevich E, Mishra VK, Zhang T, Shain AH, Berquet C, Gagnon A, Judson RL, Ballotti R, Ribas A, Herlyn M, Rocchi S, Brown KM, Hayward NK, Yeh I, Bastian BC
• Targeted Genomic Profiling of Acral Melanoma.
  Journal of the National Cancer Institute 2019 Yeh I, Jorgenson E, Shen L, Xu M, North JP, Shain AH, Reuss D, Wu H, Robinson WA, Olshen A, von Deimling A, Kwok PY, Bastian BC, Asgari MM
• MicroRNA Ratios Distinguish Melanomas from Nevi.
  The Journal of investigative dermatology 2019 Torres R, Lang UE, Hejna M, Shelton SJ, Joseph NM, Shain AH, Yeh I, Wei ML, Oldham MC, Bastian BC, Judson-Torres RL
• Co-occurring Alterations in the RAS-MAPK Pathway Limit Response to MET Inhibitor Treatment in MET Exon 14 Skipping Mutation-Positive Lung Cancer.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Rotow JK, Gui P, Wu W, Raymond VM, Lanman RB, Kaye FJ, Peled N, Fece de la Cruz F, Nadres B, Corcoran RB, Yeh I, Bastian BC, Starostik P, Newsom K, Olivas VR, Wolff AM, Fraser JS, Collisson EA, …
• Melanoma to Vitiligo: The Melanocyte in Biology & Medicine-Joint Montagna Symposium on the Biology of Skin/PanAmerican Society for Pigment Cell Research Annual Meeting.
  The Journal of investigative dermatology 2019 Leachman SA, Hornyak TJ, Barsh G, Bastian BC, Brash DE, Cleaver JE, Cooper CD, D'Orazio JA, Fujita M, Holmen SL, Indra AK, Kraemer KH, Le Poole IC, Lo RS, Lund AW, Manga P, Pavan WJ, Setaluri V, …
• Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets.
  Nature communications 2019 Newell F, Kong Y, Wilmott JS, Johansson PA, Ferguson PM, Cui C, Li Z, Kazakoff SH, Burke H, Dodds TJ, Patch AM, Nones K, Tembe V, Shang P, van der Weyden L, Wong K, Holmes O, Lo S, Leonard C, Wood S, …
• PTCH1 Mutation in a Patient With Metastatic Undifferentiated Carcinoma With Clear Cell Change.
  Journal of the National Comprehensive Cancer Network : JNCCN 2019 Tsai KK, Khurana N, McCalmont T, Daud A, Bastian B, Yeh I
• The genetic evolution of metastatic uveal melanoma.
  Nature genetics 2019 Shain AH, Bagger MM, Yu R, Chang D, Liu S, Vemula S, Weier JF, Wadt K, Heegaard S, Bastian BC, Kiilgaard JF
• Filigree-like Rete Ridges, Lobulated Nests, Rosette-like Structures, and Exaggerated Maturation Characterize Spitz Tumors With NTRK1 Fusion.
  The American journal of surgical pathology 2019 Yeh I, Busam KJ, McCalmont TH, LeBoit PE, Pissaloux D, Alberti L, de la Fouchardière A, Bastian BC
• Next-Generation Sequencing of Uveal Melanoma for Detection of Genetic Alterations Predicting Metastasis.
  Translational vision science & technology 2019 Afshar AR, Damato BE, Stewart JM, Zablotska LB, Roy R, Olshen AB, Joseph NM, Bastian BC
• Cross-species genomic landscape comparison of human mucosal melanoma with canine oral and equine melanoma.
  Nature communications 2019 Wong K, van der Weyden L, Schott CR, Foote A, Constantino-Casas F, Smith S, Dobson JM, Murchison EP, Wu H, Yeh I, Fullen DR, Joseph N, Bastian BC, Patel RM, Martincorena I, Robles-Espinoza CD, Iyer V,…
• The genetic landscape of anaplastic pleomorphic xanthoastrocytoma.
  Brain pathology (Zurich, Switzerland) 2018 Phillips JJ, Gong H, Chen K, Joseph NM, van Ziffle J, Bastian BC, Grenert JP, Kline CN, Mueller S, Banerjee A, Nicolaides T, Gupta N, Berger MS, Lee HS, Pekmezci M, Tihan T, Bollen AW, Perry A, Shieh …
• Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma.
  Science (New York, N.Y.) 2018 Ablain J, Xu M, Rothschild H, Jordan RC, Mito JK, Daniels BH, Bell CF, Joseph NM, Wu H, Bastian BC, Zon LI, Yeh I
• The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma.
  Pigment cell & melanoma research 2018 Webster JD, Pham TH, Wu X, Hughes NW, Li Z, Totpal K, Lee HJ, Calses PC, Chaurushiya MS, Stawiski EW, Modrusan Z, Chang MT, Tran C, Lee WP, Chalasani S, Hung J, Sharma N, Chan S, Hotzel K, Talevich E,…
• Oligodendrogliomas, IDH-mutant and 1p/19q-codeleted, arising during teenage years often lack TERT promoter mutation that is typical of their adult counterparts.
  Acta neuropathologica communications 2018 Lee J, Putnam AR, Chesier SH, Banerjee A, Raffel C, Van Ziffle J, Onodera C, Grenert JP, Bastian BC, Perry A, Solomon DA
• The genetic landscape of gliomas arising after therapeutic radiation.
  Acta neuropathologica 2018 López GY, Van Ziffle J, Onodera C, Grenert JP, Yeh I, Bastian BC, Clarke J, Oberheim Bush NA, Taylor J, Chang S, Butowski N, Banerjee A, Mueller S, Kline C, Torkildson J, Samuel D, Siongco A, Raffel C…
• Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2018 Stevers M, Rabban JT, Garg K, Van Ziffle J, Onodera C, Grenert JP, Yeh I, Bastian BC, Zaloudek C, Solomon DA
• Myxoid glioneuronal tumor of the septum pellucidum and lateral ventricle is defined by a recurrent PDGFRA p.K385 mutation and DNT-like methylation profile.
  Acta neuropathologica 2018 Solomon DA, Korshunov A, Sill M, Jones DTW, Kool M, Pfister SM, Fan X, Bannykh S, Hu J, Danielpour M, Li R, Johnston J, Cham E, Cooney T, Sun PP, Oberheim Bush NA, McDermott M, Van Ziffle J, Onodera C…
• Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation.
  Cancer cell 2018 Zeng H, Jorapur A, Shain AH, Lang UE, Torres R, Zhang Y, McNeal AS, Botton T, Lin J, Donne M, Bastian IN, Yu R, North JP, Pincus L, Ruben BS, Joseph NM, Yeh I, Bastian BC, Judson RL
• Genomic and Transcriptomic Analysis Reveals Incremental Disruption of Key Signaling Pathways during Melanoma Evolution.
  Cancer cell 2018 Shain AH, Joseph NM, Yu R, Benhamida J, Liu S, Prow T, Ruben B, North J, Pincus L, Yeh I, Judson R, Bastian BC
• The genetic landscape of ganglioglioma.
  Acta neuropathologica communications 2018 Pekmezci M, Villanueva-Meyer JE, Goode B, Van Ziffle J, Onodera C, Grenert JP, Bastian BC, Chamyan G, Maher OM, Khatib Z, Kleinschmidt-DeMasters BK, Samuel D, Mueller S, Banerjee A, Clarke JL, Cooney …
• A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle.
  Nature communications 2018 Goode B, Mondal G, Hyun M, Ruiz DG, Lin YH, Van Ziffle J, Joseph NM, Onodera C, Talevich E, Grenert JP, Hewedi IH, Snuderl M, Brat DJ, Kleinschmidt-DeMasters BK, Rodriguez FJ, Louis DN, Yong WH, Lopes…
• Deep sequencing of WNT-activated medulloblastomas reveals secondary SHH pathway activation.
  Acta neuropathologica 2018 Iorgulescu JB, Van Ziffle J, Stevers M, Grenert JP, Bastian BC, Chavez L, Stichel D, Buchhalter I, Samuel D, Nicolaides T, Banerjee A, Mueller S, Gupta N, Tihan T, Bollen AW, Northcott PA, Kool M, …
• Multinodular and vacuolating neuronal tumor of the cerebrum is a clonal neoplasm defined by genetic alterations that activate the MAP kinase signaling pathway.
  Acta neuropathologica 2018 Pekmezci M, Stevers M, Phillips JJ, Van Ziffle J, Bastian BC, Tsankova NM, Kleinschmidt-DeMasters BK, Rosenblum MK, Tihan T, Perry A, Solomon DA
• Adenomatoid tumors of the male and female genital tract are defined by TRAF7 mutations that drive aberrant NF-kB pathway activation.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2017 Goode B, Joseph NM, Stevers M, Van Ziffle J, Onodera C, Talevich E, Grenert JP, Yeh I, Bastian BC, Phillips JJ, Garg K, Rabban JT, Zaloudek C, Solomon DA
• Filling the gaps in the genomic catalogue of melanoma subtypes.
  Pigment cell & melanoma research 2017 Shain AH, Bastian BC
• Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi.
  Nature communications 2017 Yeh I, Lang UE, Durieux E, Tee MK, Jorapur A, Shain AH, Haddad V, Pissaloux D, Chen X, Cerroni L, Judson RL, LeBoit PE, McCalmont TH, Bastian BC, de la Fouchardière A
• Acute myeloid leukemia with t(14;21) involving RUNX1 and SYNE2: A novel favorable-risk translocation?
  Cancer genetics 2017 Foley N, Van Ziffle J, Yu J, Qi Z, Grenert JP, Yeh I, Bastian B, Kogan S, Mannis GN
• Efficacy and safety of nilotinib in patients with KIT-mutated metastatic or inoperable melanoma: final results from the global, single-arm, phase II TEAM trial.
  Annals of oncology : official journal of the European Society for Medical Oncology 2017 Guo J, Carvajal RD, Dummer R, Hauschild A, Daud A, Bastian BC, Markovic SN, Queirolo P, Arance A, Berking C, Camargo V, Herchenhorn D, Petrella TM, Schadendorf D, Sharfman W, Testori A, Novick S, …
• Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy.
  Neuro-oncology 2017 Kline CN, Joseph NM, Grenert JP, van Ziffle J, Talevich E, Onodera C, Aboian M, Cha S, Raleigh DR, Braunstein S, Torkildson J, Samuel D, Bloomer M, Campomanes AGA, Banerjee A, Butowski N, Raffel C, …
• Multiple Merkel cell carcinomas: Late metastasis or multiple primary tumors? A molecular study.
  JAAD case reports 2017 Eluri M, Feneran A, Bordeaux JS, Ruben B, Ostrowski S, Bastian BC, Honda K
• Novel computational method for predicting polytherapy switching strategies to overcome tumor heterogeneity and evolution.
  Scientific reports 2017 Jonsson VD, Blakely CM, Lin L, Asthana S, Matni N, Olivas V, Pazarentzos E, Gubens MA, Bastian BC, Taylor BS, Doyle JC, Bivona TG
• Genomic profiling of malignant peritoneal mesothelioma reveals recurrent alterations in epigenetic regulatory genes BAP1, SETD2, and DDX3X.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2016 Joseph NM, Chen YY, Nasr A, Yeh I, Talevich E, Onodera C, Bastian BC, Rabban JT, Garg K, Zaloudek C, Solomon DA
• Activating NRF1-BRAF and ATG7-RAF1 fusions in anaplastic pleomorphic xanthoastrocytoma without BRAF p.V600E mutation.
  Acta neuropathologica 2016 Phillips JJ, Gong H, Chen K, Joseph NM, van Ziffle J, Jin LW, Bastian BC, Bollen AW, Perry A, Nicolaides T, Solomon DA, Shieh JT
• Genomic profiling of malignant phyllodes tumors reveals aberrations in FGFR1 and PI-3 kinase/RAS signaling pathways and provides insights into intratumoral heterogeneity.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2016 Liu SY, Joseph NM, Ravindranathan A, Stohr BA, Greenland NY, Vohra P, Hosfield E, Yeh I, Talevich E, Onodera C, Van Ziffle JA, Grenert JP, Bastian BC, Chen YY, Krings G
• SAPHIRE: Stress and Pulmonary Hypertension in Rheumatoid Evaluation-A Prevalence Study.
  International journal of rheumatology 2016 Reeves GE, Collins N, Hayes P, Knapp J, Squance M, Tran H, Bastian B
• The state of melanoma: challenges and opportunities.
  Pigment cell & melanoma research 2016 Merlino G, Herlyn M, Fisher DE, Bastian BC, Flaherty KT, Davies MA, Wargo JA, Curiel-Lewandrowski C, Weber MJ, Leachman SA, Soengas MS, McMahon M, Harbour JW, Swetter SM, Aplin AE, Atkins MB, …
• The Genetic Evolution of Melanoma.
  The New England journal of medicine 2016 Shain AH, Bastian BC
• Inactivating MUTYH germline mutations in pediatric patients with high-grade midline gliomas.
  Neuro-oncology 2016 Kline CN, Joseph NM, Grenert JP, van Ziffle J, Yeh I, Bastian BC, Mueller S, Solomon DA
• A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity.
  Nature communications 2015 Conde-Perez A, Gros G, Longvert C, Pedersen M, Petit V, Aktary Z, Viros A, Gesbert F, Delmas V, Rambow F, Bastian BC, Campbell AD, Colombo S, Puig I, Bellacosa A, Sansom O, Marais R, Van Kempen LC, …
• Congenital uveal melanoma?
  Survey of ophthalmology 2015 Singh AD, Schoenfield LA, Bastian BC, Aziz HA, Marino MJ, Biscotti CV
• Clinical activity of the MEK inhibitor trametinib in metastatic melanoma containing BRAF kinase fusion.
  Pigment cell & melanoma research 2015 Menzies AM, Yeh I, Botton T, Bastian BC, Scolyer RA, Long GV
• Metastatic melanoma in association with a giant congenital melanocytic nevus in an adult: controversial CGH findings.
  The American Journal of dermatopathology 2015 Machan S, Molina-Ruiz AM, Fernández-Aceñero MJ, Encabo B, LeBoit P, Bastian BC, Requena L
• The combination of axitinib followed by paclitaxel/carboplatin yields extended survival in advanced BRAF wild-type melanoma: results of a clinical/correlative prospective phase II clinical trial.
  British journal of cancer 2015 Algazi AP, Cha E, Ortiz-Urda SM, McCalmont T, Bastian BC, Hwang J, Pampaloni MH, Behr S, Chong K, Cortez B, Quiroz A, Coakley F, Liu S, Daud AI
• Melanoma BRAF fusions--letter.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Botton T, Yeh I, Bastian BC
• Regulatory network decoded from epigenomes of surface ectoderm-derived cell types.
  Nature communications 2014 Lowdon RF, Zhang B, Bilenky M, Mauro T, Li D, Gascard P, Sigaroudinia M, Farnham PJ, Bastian BC, Tlsty TD, Marra MA, Hirst M, Costello JF, Wang T, Cheng JB
• A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation.
  PLoS genetics 2014 Esteve-Puig R, Gil R, González-Sánchez E, Bech-Serra JJ, Grueso J, Hernández-Losa J, Moliné T, Canals F, Ferrer B, Cortés J, Bastian B, Ramón Y Cajal S, Martín-Caballero J, Flores JM, Vivancos A, …
• Biology of advanced uveal melanoma and next steps for clinical therapeutics.
  Pigment cell & melanoma research 2014 Luke JJ, Triozzi PL, McKenna KC, Van Meir EG, Gershenwald JE, Bastian BC, Gutkind JS, Bowcock AM, Streicher HZ, Patel PM, Sato T, Sossman JA, Sznol M, Welch J, Thurin M, Selig S, Flaherty KT, Carvajal…
• Ambiguous melanocytic tumors with loss of 3p21.
  The American journal of surgical pathology 2014 Yeh I, Mully TW, Wiesner T, Vemula SS, Mirza SA, Sparatta AJ, McCalmont TH, Bastian BC, LeBoit PE
• Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP.
  Cancer cell 2014 Yu FX, Luo J, Mo JS, Liu G, Kim YC, Meng Z, Zhao L, Peyman G, Ouyang H, Jiang W, Zhao J, Chen X, Zhang L, Wang CY, Bastian BC, Zhang K, Guan KL
• In melanoma, Hippo signaling is affected by copy number alterations and YAP1 overexpression impairs patient survival.
  Pigment cell & melanoma research 2014 Menzel M, Meckbach D, Weide B, Toussaint NC, Schilbach K, Noor S, Eigentler T, Ikenberg K, Busch C, Quintanilla-Martinez L, Kohlhofer U, Göke A, Göke F, Handgretinger R, Ottmann C, Bastian BC, Garbe C…
• How does pain affect eating and food pleasure?
  Pain 2014 Leknes S, Bastian B
• Chromosomal copy number analysis in melanoma diagnostics.
  Methods in molecular biology (Clifton, N.J.) 2014 North JP, Vemula SS, Bastian BC
• Kinase fusions are frequent in Spitz tumours and spitzoid melanomas.
  Nature communications 2014 Wiesner T, He J, Yelensky R, Esteve-Puig R, Botton T, Yeh I, Lipson D, Otto G, Brennan K, Murali R, Garrido M, Miller VA, Ross JS, Berger MF, Sparatta A, Palmedo G, Cerroni L, Busam KJ, Kutzner H, …
• Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma.
  Pigment cell & melanoma research 2013 Simpson RM, Bastian BC, Michael HT, Webster JD, Prasad ML, Conway CM, Prieto VM, Gary JM, Goldschmidt MH, Esplin DG, Smedley RC, Piris A, Meuten DJ, Kiupel M, Lee CC, Ward JM, Dwyer JE, Davis BJ, …
• SOX10 ablation arrests cell cycle, induces senescence, and suppresses melanomagenesis.
  Cancer research 2013 Cronin JC, Watkins-Chow DE, Incao A, Hasskamp JH, Schönewolf N, Aoude LG, Hayward NK, Bastian BC, Dummer R, Loftus SK, Pavan WJ
• Allele-specific imbalance mapping identifies HDAC9 as a candidate gene for cutaneous squamous cell carcinoma.
  International journal of cancer 2013 Fleming JL, Dworkin AM, Allain DC, Fernandez S, Wei L, Peters SB, Iwenofu OH, Ridd K, Bastian BC, Toland AE
• Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cells.
  Cancer cell 2013 Roesch A, Vultur A, Bogeski I, Wang H, Zimmermann KM, Speicher D, Körbel C, Laschke MW, Gimotty PA, Philipp SE, Krause E, Pätzold S, Villanueva J, Krepler C, Fukunaga-Kalabis M, Hoth M, Bastian BC, …
• Audit of the aetiology and prevalence of pulmonary hypertension in a tertiary hospital setting.
  Internal medicine journal 2013 Suri P, Bull N, Worthington A, Gunawaran P, Reeves G, Bastian B, Collins N
• Genetic and molecular characterization of uveal melanoma cell lines.
  Pigment cell & melanoma research 2012 Griewank KG, Yu X, Khalili J, Sozen MM, Stempke-Hale K, Bernatchez C, Wardell S, Bastian BC, Woodman SE
• An unconventional deep penetrating melanocytic nevus with microscopic involvement of regional lymph nodes.
  Journal of cutaneous pathology 2012 McCalmont TH, Bastian BC
• Beyond BRAF in melanoma.
  Current topics in microbiology and immunology 2012 Daud A, Bastian BC
• Nodular lesions arising in a large congenital melanocytic naevus in a newborn with eruptive disseminated Spitz naevi.
  The British journal of dermatology 2011 Feito-Rodríguez M, de Lucas-Laguna R, Bastian BC, Leboit P, González-Beato MJ, López-Gutiérrez JC, Requena L, Pizarro A
• Metastatic melanoma with striking adenocarcinomatous differentiation illustrating phenotypic plasticity in melanoma.
  The American journal of surgical pathology 2011 Jalas JR, Vemula S, Bezrookove V, Leboit PE, Simko JP, Bastian BC
• Germline mutations in BAP1 predispose to melanocytic tumors.
  Nature genetics 2011 Wiesner T, Obenauf AC, Murali R, Fried I, Griewank KG, Ulz P, Windpassinger C, Wackernagel W, Loy S, Wolf I, Viale A, Lash AE, Pirun M, Socci ND, Rütten A, Palmedo G, Abramson D, Offit K, Ott A, …
• An isolated Merkel cell carcinoma metastasis at a distant cutaneous site presenting as a second 'primary' tumor.
  Journal of cutaneous pathology 2011 Ahronowitz IZ, Daud AI, Leong SP, Shue EH, Bastian BC, McCalmont TH, Yu SS
• Erythropoietin receptor contributes to melanoma cell survival in vivo.
  Oncogene 2011 Kumar SM, Zhang G, Bastian BC, Arcasoy MO, Karande P, Pushparajan A, Acs G, Xu X
• BRAF mutations in cutaneous melanoma are independently associated with age, anatomic site of the primary tumor, and the degree of solar elastosis at the primary tumor site.
  Pigment cell & melanoma research 2011 Bauer J, Büttner P, Murali R, Okamoto I, Kolaitis NA, Landi MT, Scolyer RA, Bastian BC
• Molecular-microscopical correlation in dermatopathology.
  Journal of cutaneous pathology 2011 McCalmont TH, Vemula S, Sands P, Bastian BC
• Loss of the p53/p63 regulated desmosomal protein Perp promotes tumorigenesis.
  PLoS genetics 2010 Beaudry VG, Jiang D, Dusek RL, Park EJ, Knezevich S, Ridd K, Vogel H, Bastian BC, Attardi LD
• Germline variation controls the architecture of somatic alterations in tumors.
  PLoS genetics 2010 Dworkin AM, Ridd K, Bautista D, Allain DC, Iwenofu OH, Roy R, Bastian BC, Toland AE
• Comment on "Cutaneous melanoma in childhood and adolescence shows frequent loss of INK4A and gain of KIT".
  The Journal of investigative dermatology 2010 Griewank KG, Bastian BC
• Molecular analysis of a case of nevus of ota showing progressive evolution to melanoma with intermediate stages resembling cellular blue nevus.
  The American Journal of dermatopathology 2010 Gerami P, Pouryazdanparast P, Vemula S, Bastian BC
• Mutation-driven drug development in melanoma.
  Current opinion in oncology 2010 Flaherty KT, Hodi FS, Bastian BC
• KIT as a therapeutic target in melanoma.
  The Journal of investigative dermatology 2010 Garrido MC, Bastian BC
• Melanoma from bench to bedside: meeting report from the 6th international melanoma congress.
  Pigment cell & melanoma research 2009 Fisher DE, Barnhill R, Hodi FS, Herlyn M, Merlino G, Medrano E, Bastian B, Landi MT, Landi TM, Sosman J
• Genome-wide associations studies for melanoma and nevi.
  Pigment cell & melanoma research 2009 Yeh I, Bastian BC
• Elevated cutaneous Smad activation associates with enhanced skin tumor susceptibility in organ transplant recipients.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Harradine KA, Ridd K, Saunier EF, Clermont FF, Perez-Losada J, Moore DH, Epstein EH, Bastian BC, Akhurst RJ
• Oncogenic GNAQ mutations are not correlated with disease-free survival in uveal melanoma.
  British journal of cancer 2009 Bauer J, Kilic E, Vaarwater J, Bastian BC, Garbe C, de Klein A
• Germline variation of the melanocortin-1 receptor does not explain shared risk for melanoma and thyroid cancer.
  Experimental dermatology 2009 Bauer J, Weng J, Kebebew E, Soares P, Trovisco V, Bastian BC
• Absence of somatic mutations of NEMO in keratoacanthoma.
  The Journal of investigative dermatology 2009 Ridd K, Vemula S, Bastian BC
• Frequent mutations in the MITF pathway in melanoma.
  Pigment cell & melanoma research 2009 Cronin JC, Wunderlich J, Loftus SK, Prickett TD, Wei X, Ridd K, Vemula S, Burrell AS, Agrawal NS, Lin JC, Banister CE, Buckhaults P, Rosenberg SA, Bastian BC, Pavan WJ, Samuels Y
• Loss-of-function fibroblast growth factor receptor-2 mutations in melanoma.
  Molecular cancer research : MCR 2009 Gartside MG, Chen H, Ibrahimi OA, Byron SA, Curtis AV, Wellens CL, Bengston A, Yudt LM, Eliseenkova AV, Ma J, Curtin JA, Hyder P, Harper UL, Riedesel E, Mann GJ, Trent JM, Bastian BC, Meltzer PS, …
• The presence of polyomavirus in non-melanoma skin cancer in organ transplant recipients is rare.
  The Journal of investigative dermatology 2008 Ridd K, Yu S, Bastian BC
• Dose-dependent, complete response to imatinib of a metastatic mucosal melanoma with a K642E KIT mutation.
  Pigment cell & melanoma research 2008 Lutzky J, Bauer J, Bastian BC
• Frequent p16-independent inactivation of p14ARF in human melanoma.
  Journal of the National Cancer Institute 2008 Freedberg DE, Rigas SH, Russak J, Gai W, Kaplow M, Osman I, Turner F, Randerson-Moor JA, Houghton A, Busam K, Timothy Bishop D, Bastian BC, Newton-Bishop JA, Polsky D
• MC1R variants increase risk of melanomas harboring BRAF mutations.
  The Journal of investigative dermatology 2008 Fargnoli MC, Fargnoli MC, Pike K, Pfeiffer RM, Tsang S, Rozenblum E, Munroe DJ, Golubeva Y, Calista D, Seidenari S, Massi D, Carli P, Bauer J, Elder DE, Bastian BC, Peris K, Landi MT
• Beta-catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development.
  Genes & development 2007 Delmas V, Beermann F, Martinozzi S, Carreira S, Ackermann J, Kumasaka M, Denat L, Goodall J, Luciani F, Viros A, Demirkan N, Bastian BC, Goding CR, Larue L
• Constitutive activation of the phosphatidyl inositol 3 kinase signalling pathway in acral lentiginous melanoma.
  The British journal of dermatology 2007 Muchemwa FC, Ma D, Inoue Y, Curtin JA, Bastian BC, Ihn H, Kageshita T
• [DNA copy number changes in the diagnosis of melanocytic tumors].
  Der Pathologe 2007 Bauer J, Bastian BC
• Absence of PDGFRA mutations in primary melanoma.
  The Journal of investigative dermatology 2007 Curtin JA, Pinkel D, Bastian BC
• Expanding the genetic spectrum of pigmentation.
  Pigment cell & melanoma research 2007 Bastian BC, Pinkel D
• Lack of somatic alterations of MC1R in primary melanoma.
  Pigment cell & melanoma research 2007 Kim RD, Curtin JA, Bastian BC
• Establishment of a novel melanoma cell line SMYM-PRGP showing cytogenetic and biological characteristics of the radial growth phase of acral melanomas.
  Cancer science 2007 Murata H, Ashida A, Takata M, Yamaura M, Bastian BC, Saida T
• Chromosomal aberrations in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma unspecified: A matrix-based CGH approach.
  Genes, chromosomes & cancer 2007 Thorns C, Bastian B, Pinkel D, Roydasgupta R, Fridlyand J, Merz H, Krokowski M, Bernd HW, Feller AC
• In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling.
  Cancer research 2006 Dumaz N, Hayward R, Martin J, Ogilvie L, Hedley D, Curtin JA, Bastian BC, Springer C, Marais R
• Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway.
  Nature cell biology 2006 Denoyelle C, Abou-Rjaily G, Bezrookove V, Verhaegen M, Johnson TM, Fullen DR, Pointer JN, Gruber SB, Su LD, Nikiforov MA, Kaufman RJ, Bastian BC, Soengas MS
• PI3-kinase subunits are infrequent somatic targets in melanoma.
  The Journal of investigative dermatology 2006 Curtin JA, Stark MS, Pinkel D, Hayward NK, Bastian BC
• Distinguishing melanocytic nevi from melanoma by DNA copy number changes: comparative genomic hybridization as a research and diagnostic tool.
  Dermatologic therapy 2006 Bauer J, Bastian BC
• Distinct sets of genetic alterations in melanoma.
  The New England journal of medicine 2005 Curtin JA, Fridlyand J, Kageshita T, Patel HN, Busam KJ, Kutzner H, Cho KH, Aiba S, Bröcker EB, LeBoit PE, Pinkel D, Bastian BC
• Genomic analysis of blue nevi and related dermal melanocytic proliferations.
  The American journal of surgical pathology 2005 Maize JC, McCalmont TH, Carlson JA, Busam KJ, Kutzner H, Bastian BC
• Coalescing, nevoid papules in an infant.
  Archives of dermatology 2005 Sahara LY, Bastian BC, Bruckner AL
• Dermal absorption of permethrin following topical administration.
  European journal of clinical pharmacology 2005 Tomalik-Scharte D, Lazar A, Meins J, Bastian B, Ihrig M, Wachall B, Jetter A, Tantcheva-Poór I, Mahrle G, Fuhr U
• Genomic analysis of melanocytic neoplasia.
  Advances in dermatology 2005 Bauer J, Bastian B
• Consumption of the epidermis: a diagnostic criterion for the differential diagnosis of melanoma and Spitz nevus.
  The American journal of surgical pathology 2004 Hantschke M, Bastian BC, LeBoit PE
• Molecular genetics of melanocytic neoplasia: practical applications for diagnosis.
  Pathology 2004 Bastian BC
• Atrial septal aneurysm: MRI and echocardiography correlation.
  Australasian radiology 2003 Puvaneswary M, Singham T, Bastian B
• Classifying melanocytic tumors based on DNA copy number changes.
  The American journal of pathology 2003 Bastian BC, Olshen AB, LeBoit PE, Pinkel D
• Atypical junctional melanocytic proliferations in benign lichenoid keratosis.
  Human pathology 2003 Dalton SR, Fillman EP, Altman CE, Gardner TL, Davis TL, Bastian BC, Libow LF, Elston DM
• Understanding the progression of melanocytic neoplasia using genomic analysis: from fields to cancer.
  Oncogene 2003 Bastian BC
• Hypothesis: a role for telomere crisis in spontaneous regression of melanoma.
  Archives of dermatology 2003 Bastian BC
• The longer your telomeres, the larger your nevus?
  The American Journal of dermatopathology 2003 Bastian BC
• Two cases of unusual acral melanocytic tumors: illustration of molecular cytogenetics as a diagnostic tool.
  Human pathology 2003 Takata M, Maruo K, Kageshita T, Ikeda S, Ono T, Shirasaki F, Takehara K, Bastian BC
• A full-coverage, high-resolution human chromosome 22 genomic microarray for clinical and research applications.
  Human molecular genetics 2002 Buckley PG, Mantripragada KK, Benetkiewicz M, Tapia-Páez I, Diaz De Ståhl T, Rosenquist M, Ali H, Jarbo C, De Bustos C, Hirvelä C, Sinder Wilén B, Fransson I, Thyr C, Johnsson BI, Bruder CE, Menzel U,…
• Genetic changes in neoplasms arising in congenital melanocytic nevi: differences between nodular proliferations and melanomas.
  The American journal of pathology 2002 Bastian BC, Xiong J, Frieden IJ, Williams ML, Chou P, Busam K, Pinkel D, LeBoit PE
• Persistent (recurrent) Spitz nevi: a histopathologic, immunohistochemical, and molecular pathologic study of 22 cases.
  The American journal of surgical pathology 2002 Harvell JD, Bastian BC, LeBoit PE
• Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice.
  Proceedings of the National Academy of Sciences of the United States of America 2002 You MJ, Castrillon DH, Bastian BC, O'Hagan RC, Bosenberg MW, Parsons R, Chin L, DePinho RA
• Molecular cytogenetics as a diagnostic tool for typing melanocytic tumors.
  Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 2002 Bastian BC
• Genomic approaches to skin cancer diagnosis.
  Archives of dermatology 2001 Bastian BC, LeBoit PE, Pinkel D
• HDM2 protein overexpression, but not gene amplification, is related to tumorigenesis of cutaneous melanoma.
  Cancer research 2001 Polsky D, Bastian BC, Hazan C, Melzer K, Pack J, Houghton A, Busam K, Cordon-Cardo C, Osman I
• Dual inactivation of RB and p53 pathways in RAS-induced melanomas.
  Molecular and cellular biology 2001 Bardeesy N, Bastian BC, Hezel A, Pinkel D, DePinho RA, Chin L
• Pericardial lipoma: ultrasound, computed tomography and magnetic resonance imaging findings.
  Australasian radiology 2000 Puvaneswary M, Edwards JR, Bastian BC, Khatri SK
• Atrial myxoma demonstrated by cine gradient refocused echo magnetic resonance imaging.
  Australasian radiology 2000 Puvaneswary M, Edwards JR, Bastian BC, Bellamy GR, Khatri SK
• Gene amplifications characterize acral melanoma and permit the detection of occult tumor cells in the surrounding skin.
  Cancer research 2000 Bastian BC, Kashani-Sabet M, Hamm H, Godfrey T, Moore DH, Bröcker EB, LeBoit PE, Pinkel D
• Molecular cytogenetic analysis of Spitz nevi shows clear differences to melanoma.
  The Journal of investigative dermatology 1999 Bastian BC, Wesselmann U, Pinkel D, Leboit PE
• Signet-ring cell formation in cutaneous neoplasms.
  Journal of the American Academy of Dermatology 1999 Bastian BC, Kutzner H, Yen Ts, LeBoit PE
• [Pilomatrix carcinoma in an unusual location. Case report and review of the literature].
  Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 1999 Haferkamp B, Bastian BC, Bröcker EB, Hamm H
• Eosinophilic globules in spitz nevi: no evidence for apoptosis.
  The American Journal of dermatopathology 1998 Wesselmann U, Becker LR, Bröcker EB, LeBoit PE, Bastian BC
• Paraneoplastic pemphigus treated with dexamethasone/ cyclophosphamide pulse therapy.
  European journal of dermatology : EJD 1998 Becker LR, Bastian BC, Wesselmann U, Karl S, Hamm H, Bröcker EB
• Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization.
  Cancer research 1998 Bastian BC, LeBoit PE, Hamm H, Bröcker EB, Pinkel D
• Adult rhabdomyoma of the lip.
  The American Journal of dermatopathology 1998 Bastian BC, Bröcker EB
• A lymphohistiocytic variant of anaplastic large cell lymphoma with demonstration of the t(2;5)(p23;q35) chromosome translocation.
  British journal of haematology 1998 Ott G, Bastian BC, Katzenberger T, Decoteau JF, Kalla J, Rosenwald A, Weissinger F, Ott MM, Kadin ME, Müller-Hermelink HK
• Primary cutaneous natural killer/T-cell lymphoma.
  Archives of dermatology 1998 Bastian BC, Ott G, Müller-Deubert S, Bröcker EB, Müller-Hermelink HK
• Elevated serum levels of soluble CD30 are associated with atopic dermatitis, but not with respiratory atopic disorders and allergic contact dermatitis.
  The British journal of dermatology 1997 Dummer W, Bröcker EB, Bastian BC
• Primary neuroendocrine carcinoma of the skin with an unusual follicular lymphocytic infiltrate of the dermis.
  The American Journal of dermatopathology 1996 Bastian BC, Kreipe HH, Bröcker EB
• Melanoma in childhood: an EORTC-MCG multicenter study on the clinico-pathological aspects.
  International journal of cancer 1996 Spatz A, Ruiter D, Hardmeier T, Renard N, Wechsler J, Bailly C, Avril MF, Kwee H, Bastian BC, Hill C, De Potter C, Prade M
• Detection of elevated levels of IL-4, IL-6, and IL-10 in blister fluid of bullous pemphigoid.
  Archives of dermatological research 1996 Schmidt E, Bastian B, Dummer R, Tony HP, Bröcker EB, Zillikens D
• Interleukin-10 production in malignant melanoma: preferential detection of IL-10-secreting tumor cells in metastatic lesions.
  International journal of cancer 1996 Dummer W, Bastian BC, Ernst N, Schänzle C, Schwaaf A, Bröcker EB
• [Giant cell fibroblastoma. A rare soft tissue tumor in childhood].
  Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 1996 Bastian BC, Harms D, Kreipe HH, Hamm H, Bröcker EB
• [Microcystic adnexal carcinoma of the skin. An underestimated tumor].
  Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 1996 Rank C, Bastian BC, Pistner H, Bröcker EB, Hamm H
• Phospholipase A2 is secreted by murine keratinocytes after stimulation with IL-1 alpha and TNF-alpha.
  Archives of dermatological research 1996 Bastian BC, Schacht RJ, Kämpgen E, Bröcker EB
• Elevated levels of interleukin-8 in blister fluid of bullous pemphigoid compared with suction blisters of healthy control subjects.
  Journal of the American Academy of Dermatology 1996 Schmidt E, Ambach A, Bastian B, Bröcker EB, Zillikens D
• Preoperative characterization of pigmented skin lesions by epiluminescence microscopy and high-frequency ultrasound.
  Archives of dermatology 1995 Dummer W, Blaheta HJ, Bastian BC, Schenk T, Bröcker EV, Remy W
• Autoantibodies to annexins: a diagnostic marker for cutaneous disorders?
  Journal of dermatological science 1994 Bastian BC, Nuss B, Römisch J, Kraus M, Bröcker EB
• [Prognostic advantage for defined risk groups by lymphocyte dissection. Long-term study of 3,616 melanoma patients].
  Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 1994 Drepper H, Köhler CO, Bastian B, Breuninger H, Bröcker EB, Göhl J, Groth W, Hermanek P, Hohenberger W, Kölmel K
• [Is acrolentiginous melanoma (ALM) more malignant than superficially spreading melanoma (SSM) at a high-risk site? A matched-pair comparison between 113 ALM and SSM within the scope of a multicenter study].
  Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 1994 Breuninger H, Köhler C, Drepper H, Bastian B, Bröcker EB, Göhl J, Groth W, Hermanek P, Hohenberger W, Lippold A
• [Benign giant cell tumor of the tendon sheath. A differential diagnosis of cutaneous tumors near the joint].
  Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 1994 Bastian BC, Küchler A, Bröcker EB
• Localization of annexins in normal and diseased human skin.
  Journal of dermatological science 1993 Bastian BC, van der Piepen U, Römisch J, Pâques EP, Bröcker EB
• Inhibition of human skin phospholipase A2 by "lipocortins" is an indirect effect of substrate/lipocortin interaction.
  The Journal of investigative dermatology 1993 Bastian BC, Sellert C, Seekamp A, Römisch J, Pâques EP, Bröcker EB
• Benefit of elective lymph node dissection in subgroups of melanoma patients. Results of a multicenter study of 3616 patients.
  Cancer 1993 Drepper H, Köhler CO, Bastian B, Breuninger H, Bröcker EB, Göhl J, Groth W, Hermanek P, Hohenberger W, Lippold A
• Mitral stenosis in the Maroteaux-Lamy syndrome: a treatable cause of dyspnoea.
  Postgraduate medical journal 1992 Marwick TH, Bastian B, Hughes CF, Bailey BP