Bob Farese, MD
PROFESSOR IN RESIDENCE - FY
Business Service Ctr
Chancellor/EVC/FAS

University of Florida, Gainesville, FL, B.S., 1981 (Chemistry) Vanderbilt Medical School, Nashville, TN, M.D., 1985

POSTDOCTORAL TRAINING Internship And Residency 1985–1988 Internal Medicine, University of Colorado Affiliated Hospitals, Denver, CO 1988–1989 Chief Resident, Internal Medicine, University of Colorado Affiliated Hospitals, Denver, CO

FELLOWSHIPS 1989–1992 Endocrinology, Diabetes, and Metabolism, UCSF 1990–1992 Postdoctoral Fellow, Gladstone Institute of Cardiovascular Disease

• Structure and function of lipid droplet assembly complexes.
  Current opinion in structural biology 2023 Walther TC, Kim S, Arlt H, Voth GA, Farese RV
• Glycerolipid Synthesis and Lipid Droplet Formation in the Endoplasmic Reticulum.
  Cold Spring Harbor perspectives in biology 2023 Farese RV, Walther TC
• Fitm2 is required for ER homeostasis and normal function of murine liver.
  The Journal of biological chemistry 2023 Bond LM, Ibrahim A, Lai ZW, Walzem RL, Bronson RT, Ilkayeva OR, Walther TC, Farese RV
• Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis.
  Nature communications 2022 Boland S, Swarup S, Ambaw YA, Malia PC, Richards RC, Fischer AW, Singh S, Aggarwal G, Spina S, Nana AL, Grinberg LT, Seeley WW, Surma MA, Klose C, Paulo JA, Nguyen AD, Harper JW, Walther TC, Farese RV
• Identification of two pathways mediating protein targeting from ER to lipid droplets.
  Nature cell biology 2022 Song J, Mizrak A, Lee CW, Cicconet M, Lai ZW, Tang WC, Lu CH, Mohr SE, Farese RV, Walther TC
• Seipin transmembrane segments critically function in triglyceride nucleation and lipid droplet budding from the membrane.
  eLife 2022 Kim S, Chung J, Arlt H, Pak AJ, Farese RV, Walther TC, Voth GA
• Seipin forms a flexible cage at lipid droplet formation sites.
  Nature structural & molecular biology 2022 Arlt H, Sui X, Folger B, Adams C, Chen X, Remme R, Hamprecht FA, DiMaio F, Liao M, Goodman JM, Farese RV, Walther TC
• The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology.
  Developmental cell 2022 Mejhert N, Gabriel KR, Frendo-Cumbo S, Krahmer N, Song J, Kuruvilla L, Chitraju C, Boland S, Jang DK, von Grotthuss M, Costanzo MC, Rydén M, Olzmann JA, Flannick J, Burtt NP, Farese RV, Walther TC
• Key Factors Governing Initial Stages of Lipid Droplet Formation.
  The journal of physical chemistry. B 2022 Kim S, Li C, Farese RV, Walther TC, Voth GA
• Publisher Correction: An open-access volume electron microscopy atlas of whole cells and tissues.
  Nature 2021 Xu CS, Pang S, Shtengel G, Müller A, Ritter AT, Hoffman HK, Takemura SY, Lu Z, Pasolli HA, Iyer N, Chung J, Bennett D, Weigel AV, Freeman M, van Engelenburg SB, Walther TC, Farese RV, Lippincott-…
• An open-access volume electron microscopy atlas of whole cells and tissues.
  Nature 2021 Xu CS, Pang S, Shtengel G, Müller A, Ritter AT, Hoffman HK, Takemura SY, Lu Z, Pasolli HA, Iyer N, Chung J, Bennett D, Weigel AV, Freeman M, van Engelenburg SB, Walther TC, Farese RV, Lippincott-…
• The CYTOLD and ERTOLD pathways for lipid droplet-protein targeting.
  Trends in biochemical sciences 2021 Olarte MJ, Swanson JMJ, Walther TC, Farese RV
• Conditional targeting of phosphatidylserine decarboxylase to lipid droplets.
  Biology open 2021 Kumar S, Chitraju C, Farese RV, Walther TC, Burd CG
• Roles of hepatic atypical protein kinase C hyperactivity and hyperinsulinemia in insulin-resistant forms of obesity and type 2 diabetes mellitus.
  MedComm 2021 Sajan MP, Hansen BC, Acevedo-Duncan M, Kindy MS, Cooper DR, Farese RV
• The power of two: lessons from a scientific partnership.
  The Journal of clinical investigation 2021 Farese RV, Walther TC
• Control of β-Site Amyloid Precursor Protein-Cleaving Enzyme-1 Expression by Protein Kinase C-λ/ι and Nuclear Factor κ-B.
  Current Alzheimer research 2021 Sajan MP, Leitges M, Park C, Diamond DM, Wu J, Hansen BC, Duncan MA, Apostolatos CA, Apostolatos AH, Kindy M, Farese RV
• A Systematic Protein Turnover Map for Decoding Protein Degradation.
  Cell reports 2020 Christiano R, Arlt H, Kabatnik S, Mejhert N, Lai ZW, Farese RV, Walther TC
• Lipid Droplets in Brown Adipose Tissue Are Dispensable for Cold-Induced Thermogenesis.
  Cell reports 2020 Chitraju C, Fischer AW, Farese RV, Walther TC
• FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis.
  The Journal of cell biology 2020 Becuwe M, Bond LM, Pinto AFM, Boland S, Mejhert N, Elliott SD, Cicconet M, Graham MM, Liu XN, Ilkayeva O, Saghatelian A, Walther TC, Farese RV
• Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency.
  Nature 2020 Zhang J, Velmeshev D, Hashimoto K, Huang YH, Hofmann JW, Shi X, Chen J, Leidal AM, Dishart JG, Cahill MK, Kelley KW, Liddelow SA, Seeley WW, Miller BL, Walther TC, Farese RV, Taylor JP, Ullian EM, …
• Determinants of Endoplasmic Reticulum-to-Lipid Droplet Protein Targeting.
  Developmental cell 2020 Olarte MJ, Kim S, Sharp ME, Swanson JMJ, Farese RV, Walther TC
• Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme.
  Nature 2020 Sui X, Wang K, Gluchowski NL, Elliott SD, Liao M, Walther TC, Farese RV
• Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant wobbler mice, a model of motor neuron degeneration.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Petit CS, Lee JJ, Boland S, Swarup S, Christiano R, Lai ZW, Mejhert N, Elliott SD, McFall D, Haque S, Huang EJ, Bronson RT, Harper JW, Farese RV, Walther TC
• Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression.
  Molecular cell 2020 Mejhert N, Kuruvilla L, Gabriel KR, Elliott SD, Guie MA, Wang H, Lai ZW, Lane EA, Christiano R, Danial NN, Farese RV, Walther TC
• LDAF1 and Seipin Form a Lipid Droplet Assembly Complex.
  Developmental cell 2019 Chung J, Wu X, Lambert TJ, Lai ZW, Walther TC, Farese RV
• Un-phased: Lipid Droplets Modulate the Bioavailability of Antibiotics.
  Developmental cell 2019 Walther TC, Farese RV
• Hepatocyte Deletion of Triglyceride-Synthesis Enzyme Acyl CoA: Diacylglycerol Acyltransferase 2 Reduces Steatosis Without Increasing Inflammation or Fibrosis in Mice.
  Hepatology (Baltimore, Md.) 2019 Gluchowski NL, Gabriel KR, Chitraju C, Bronson RT, Mejhert N, Boland S, Wang K, Lai ZW, Farese RV, Walther TC
• The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes.
  Journal of lipid research 2019 Chitraju C, Walther TC, Farese RV
• Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids.
  Molecular cell 2019 Piccolis M, Bond LM, Kampmann M, Pulimeno P, Chitraju C, Jayson CBK, Vaites LP, Boland S, Lai ZW, Gabriel KR, Elliott SD, Paulo JA, Harper JW, Weissman JS, Walther TC, Farese RV
• Atypical PKC: therapeutic target for Alzheimer's?
  Aging 2018 Farese RV, Sajan MP
• Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.
  Molecular cell 2018 Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, Soldner F, Terry-Kantor E, Kim TE, Hofbauer HF, …
• Cryo-electron microscopy structure of the lipid droplet-formation protein seipin.
  The Journal of cell biology 2018 Sui X, Arlt H, Brock KP, Lai ZW, DiMaio F, Marks DS, Liao M, Farese RV, Walther TC
• Progranulin in the hematopoietic compartment protects mice from atherosclerosis.
  Atherosclerosis 2018 Nguyen AD, Nguyen TA, Singh RK, Eberlé D, Zhang J, Abate JP, Robles A, Koliwad S, Huang EJ, Maxfield FR, Walther TC, Farese RV
• Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells.
  Molecular biology of the cell 2018 Jayson CBK, Arlt H, Fischer AW, Lai ZW, Farese RV, Walther TC
• Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay.
  Proceedings of the National Academy of Sciences of the United States of America 2018 Nguyen AD, Nguyen TA, Zhang J, Devireddy S, Zhou P, Karydas AM, Xu X, Miller BL, Rigo F, Ferguson SM, Huang EJ, Walther TC, Farese RV
• Global Analyses of Selective Insulin Resistance in Hepatocytes Caused by Palmitate Lipotoxicity.
  Molecular & cellular proteomics : MCP 2018 Li Z, Lai ZW, Christiano R, Gazos-Lopes F, Walther TC, Farese RV
• Mechanism and Determinants of Amphipathic Helix-Containing Protein Targeting to Lipid Droplets.
  Developmental cell 2018 Prévost C, Sharp ME, Kory N, Lin Q, Voth GA, Farese RV, Walther TC
• Functional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets.
  Biochemistry 2017 Inloes JM, Kiosses WB, Wang H, Walther TC, Farese RV, Cravatt BF
• Coordinated regulation of hepatic FoxO1, PGC-1α and SREBP-1c facilitates insulin action and resistance.
  Cellular signalling 2017 Sajan MP, Lee MC, Foufelle F, Sajan J, Cleland C, Farese RV
• Atypical PKC, PKCλ/ι, activates β-secretase and increases Aβ1-40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's disease.
  Neurobiology of aging 2017 Sajan MP, Hansen BC, Higgs MG, Kahn CR, Braun U, Leitges M, Park CR, Diamond DM, Farese RV
• An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from GRN gene mutations.
  Alzheimer's & dementia (New York, N. Y.) 2017 Sha SJ, Miller ZA, Min SW, Zhou Y, Brown J, Mitic LL, Karydas A, Koestler M, Tsai R, Corbetta-Rastelli C, Lin S, Hare E, Fields S, Fleischmann KE, Powers R, Fitch R, Martens LH, Shamloo M, Fagan AM, …
• Lipid Droplet Biogenesis.
  Annual review of cell and developmental biology 2017 Walther TC, Chung J, Farese RV
• Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis.
  Cell metabolism 2017 Chitraju C, Mejhert N, Haas JT, Diaz-Ramirez LG, Grueter CA, Imbriglio JE, Pinto S, Koliwad SK, Walther TC, Farese RV
• Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.
  Proceedings of the National Academy of Sciences of the United States of America 2017 Krabbe G, Minami SS, Etchegaray JI, Taneja P, Djukic B, Davalos D, Le D, Lo I, Zhan L, Reichert MC, Sayed F, Merlini M, Ward ME, Perry DC, Lee SE, Sias A, Parkhurst CN, Gan WB, Akassoglou K, Miller BL…
• Lipid droplets and liver disease: from basic biology to clinical implications.
  Nature reviews. Gastroenterology & hepatology 2017 Gluchowski NL, Becuwe M, Walther TC, Farese RV
• Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea.
  Journal of lipid research 2017 Gluchowski NL, Chitraju C, Picoraro JA, Mejhert N, Pinto S, Xin W, Kamin DS, Winter HS, Chung WK, Walther TC, Farese RV
• Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity.
  Diabetes 2017 Dorfman MD, Krull JE, Scarlett JM, Guyenet SJ, Sajan MP, Damian V, Nguyen HT, Leitges M, Morton GJ, Farese RV, Schwartz MW, Thaler JP
• Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism.
  Journal of lipid research 2016 Kory N, Grond S, Kamat SS, Li Z, Krahmer N, Chitraju C, Zhou P, Fröhlich F, Semova I, Ejsing C, Zechner R, Cravatt BF, Farese RV, Walther TC
• Proteomic and phosphoproteomic analyses of yeast reveal the global cellular response to sphingolipid depletion.
  Proteomics 2016 Fröhlich F, Olson DK, Christiano R, Farese RV, Walther TC
• Seipin is required for converting nascent to mature lipid droplets.
  eLife 2016 Wang H, Becuwe M, Housden BE, Chitraju C, Porras AJ, Graham MM, Liu XN, Thiam AR, Savage DB, Agarwal AK, Garg A, Olarte MJ, Lin Q, Fröhlich F, Hannibal-Bach HK, Upadhyayula S, Perrimon N, Kirchhausen …
• Compensation for PKMζ in long-term potentiation and spatial long-term memory in mutant mice.
  eLife 2016 Tsokas P, Hsieh C, Yao Y, Lesburguères E, Wallace EJC, Tcherepanov A, Jothianandan D, Hartley BR, Pan L, Rivard B, Farese RV, Sajan MP, Bergold PJ, Hernández AI, Cottrell JE, Shouval HZ, Fenton AA, …
• Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation.
  Cell 2016 Lui H, Zhang J, Makinson SR, Cahill MK, Kelley KW, Huang HY, Shang Y, Oldham MC, Martens LH, Gao F, Coppola G, Sloan SA, Hsieh CL, Kim CC, Bigio EH, Weintraub S, Mesulam MM, Rademakers R, Mackenzie IR…
• Targeting Fat: Mechanisms of Protein Localization to Lipid Droplets.
  Trends in cell biology 2016 Kory N, Farese RV, Walther TC
• Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ1-40/42 and Phospho-Tau May Abet Alzheimer Development.
  Diabetes 2016 Sajan M, Hansen B, Ivey R, Sajan J, Ari C, Song S, Braun U, Leitges M, Farese-Higgs M, Farese RV
• Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice.
  Journal of lipid research 2016 Agarwal AK, Tunison K, Dalal JS, Yen CL, Farese RV, Horton JD, Garg A
• Lipid droplets go nuclear.
  The Journal of cell biology 2016 Farese RV, Walther TC
• Taming the sphinx: Mechanisms of cellular sphingolipid homeostasis.
  Biochimica et biophysica acta 2015 Olson DK, Fröhlich F, Farese RV, Walther TC
• Contraction stimulates muscle glucose uptake independent of atypical PKC.
  Physiological reports 2015 Yu H, Fujii NL, Toyoda T, An D, Farese RV, Leitges M, Hirshman MF, Mul JD, Goodyear LJ
• The GARP complex is required for cellular sphingolipid homeostasis.
  eLife 2015 Fröhlich F, Petit C, Kory N, Christiano R, Hannibal-Bach HK, Graham M, Liu X, Ejsing CS, Farese RV, Walther TC
• BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1α in livers of obese and type 2 diabetic humans.
  Metabolism: clinical and experimental 2015 Sajan MP, Ivey RA, Farese RV
• Protein Crowding Is a Determinant of Lipid Droplet Protein Composition.
  Developmental cell 2015 Kory N, Thiam AR, Farese RV, Walther TC
• Pharmacological TLR4 Inhibition Protects against Acute and Chronic Fat-Induced Insulin Resistance in Rats.
  PloS one 2015 Zhang N, Liang H, Farese RV, Li J, Musi N, Hussey SE
• Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation.
  Journal of lipid research 2014 Sajan MP, Ivey RA, Lee MC, Farese RV
• The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid droplets.
  The Journal of biological chemistry 2014 Camus G, Schweiger M, Herker E, Harris C, Kondratowicz AS, Tsou CL, Farese RV, Herath K, Previs SF, Roddy TP, Pinto S, Zechner R, Ott M
• MGAT2 deficiency and vertical sleeve gastrectomy have independent metabolic effects in the mouse.
  American journal of physiology. Endocrinology and metabolism 2014 Mul JD, Begg DP, Haller AM, Pressler JW, Sorrell J, Woods SC, Farese RV, Seeley RJ, Sandoval DA
• Atypical PKC: a target for treating insulin-resistant disorders of obesity, the metabolic syndrome and type 2 diabetes mellitus.
  Expert opinion on therapeutic targets 2014 Farese RV, Lee MC, Sajan MP
• Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.
  Nature medicine 2014 Minami SS, Min SW, Krabbe G, Wang C, Zhou Y, Asgarov R, Li Y, Martens LH, Elia LP, Ward ME, Mucke L, Farese RV, Gan L
• Cardiomyocyte-specific loss of diacylglycerol acyltransferase 1 (DGAT1) reproduces the abnormalities in lipids found in severe heart failure.
  The Journal of biological chemistry 2014 Liu L, Trent CM, Fang X, Son NH, Jiang H, Blaner WS, Hu Y, Yin YX, Farese RV, Homma S, Turnbull AV, Eriksson JW, Hu SL, Ginsberg HN, Huang LS, Goldberg IJ
• Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.
  The Journal of experimental medicine 2014 Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami S, Boscardin J, Martens LH, Seeley WW, Yu G, Herz J, Filiano AJ, Arrant AE, Roberson ED, Kraft TW, Farese RV, Green A, Gan L
• Requirements for pseudosubstrate arginine residues during autoinhibition and phosphatidylinositol 3,4,5-(PO₄)₃-dependent activation of atypical PKC.
  The Journal of biological chemistry 2014 Ivey RA, Sajan MP, Farese RV
• Hepatic Atypical Protein Kinase C: An Inherited Survival-Longevity Gene that Now Fuels Insulin-Resistant Syndromes of Obesity, the Metabolic Syndrome and Type 2 Diabetes Mellitus.
  Journal of clinical medicine 2014 Farese RV, Lee MC, Sajan MP
• In vivo metabolic fingerprinting of neutral lipids with hyperspectral stimulated Raman scattering microscopy.
  Journal of the American Chemical Society 2014 Fu D, Yu Y, Folick A, Currie E, Farese RV, Tsai TH, Xie XS, Wang MC
• PKCλ haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes.
  Molecular endocrinology (Baltimore, Md.) 2014 Sajan MP, Ivey RA, Lee M, Mastorides S, Jurczak MJ, Samuels VT, Shulman GI, Braun U, Leitges M, Farese RV
• High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation.
  Journal of lipid research 2014 Currie E, Guo X, Christiano R, Chitraju C, Kory N, Harrison K, Haas J, Walther TC, Farese RV
• Lipid droplet biogenesis.
  Current opinion in cell biology 2014 Wilfling F, Haas JT, Walther TC, Farese RV
• Akt-dependent phosphorylation of hepatic FoxO1 is compartmentalized on a WD40/ProF scaffold and is selectively inhibited by aPKC in early phases of diet-induced obesity.
  Diabetes 2014 Sajan MP, Acevedo-Duncan ME, Standaert ML, Ivey RA, Lee M, Farese RV
• Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting.
  eLife 2014 Wilfling F, Thiam AR, Olarte MJ, Wang J, Beck R, Gould TJ, Allgeyer ES, Pincet F, Bewersdorf J, Farese RV, Walther TC
• The biophysics and cell biology of lipid droplets.
  Nature reviews. Molecular cell biology 2013 Thiam AR, Farese RV, Walther TC
• Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations.
  PloS one 2013 Zhang Z, Almeida S, Lu Y, Nishimura AL, Peng L, Sun D, Wu B, Karydas AM, Tartaglia MC, Fong JC, Miller BL, Farese RV, Moore MJ, Shaw CE, Gao FB
• Impairment of insulin-stimulated glucose transport and ERK activation by adipocyte-specific knockout of PKC-λ produces a phenotype characterized by diminished adiposity and enhanced insulin suppression of hepatic gluconeogenesis.
  Adipocyte 2013 Sajan MP, Jurzak MJ, Samuels VT, Shulman GI, Braun U, Leitges M, Farese RV
• Progranulin: at the interface of neurodegenerative and metabolic diseases.
  Trends in endocrinology and metabolism: TEM 2013 Nguyen AD, Nguyen TA, Martens LH, Mitic LL, Farese RV
• Metformin action in human hepatocytes: coactivation of atypical protein kinase C alters 5'-AMP-activated protein kinase effects on lipogenic and gluconeogenic enzyme expression.
  Diabetologia 2013 Sajan MP, Ivey RA, Farese RV
• A lipid E-MAP identifies Ubx2 as a critical regulator of lipid saturation and lipid bilayer stress.
  Molecular cell 2013 Surma MA, Klose C, Peng D, Shales M, Mrejen C, Stefanko A, Braberg H, Gordon DE, Vorkel D, Ejsing CS, Farese R, Simons K, Krogan NJ, Ernst R
• Cellular fatty acid metabolism and cancer.
  Cell metabolism 2013 Currie E, Schulze A, Zechner R, Walther TC, Farese RV
• Balancing the fat: lipid droplets and human disease.
  EMBO molecular medicine 2013 Krahmer N, Farese RV, Walther TC
• Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Chen X, Chang J, Deng Q, Xu J, Nguyen TA, Martens LH, Cenik B, Taylor G, Hudson KF, Chung J, Yu K, Yu P, Herz J, Farese RV, Kukar T, Tansey MG
• A conserved role for atlastin GTPases in regulating lipid droplet size.
  Cell reports 2013 Klemm RW, Norton JP, Cole RA, Li CS, Park SH, Crane MM, Li L, Jin D, Boye-Doe A, Liu TY, Shibata Y, Lu H, Rapoport TA, Farese RV, Blackstone C, Guo Y, Mak HY
• Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Filiano AJ, Martens LH, Young AH, Warmus BA, Zhou P, Diaz-Ramirez G, Jiao J, Zhang Z, Huang EJ, Gao FB, Farese RV, Roberson ED
• Diacylglycerol acyltransferase-1 localizes hepatitis C virus NS5A protein to lipid droplets and enhances NS5A interaction with the viral capsid core.
  The Journal of biological chemistry 2013 Camus G, Herker E, Modi AA, Haas JT, Ramage HR, Farese RV, Ott M
• Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets.
  Developmental cell 2013 Wilfling F, Wang H, Haas JT, Krahmer N, Gould TJ, Uchida A, Cheng JX, Graham M, Christiano R, Fröhlich F, Liu X, Buhman KK, Coleman RA, Bewersdorf J, Farese RV, Walther TC
• Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL).
  The Journal of biological chemistry 2013 Nguyen AD, Nguyen TA, Cenik B, Yu G, Herz J, Walther TC, Davidson WS, Farese RV
• Protein correlation profiles identify lipid droplet proteins with high confidence.
  Molecular & cellular proteomics : MCP 2013 Krahmer N, Hilger M, Kory N, Wilfling F, Stoehr G, Mann M, Farese RV, Walther TC
• Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor.
  Science (New York, N.Y.) 2012 Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, Grueter CA, Lim H, Saunders LR, Stevens RD, Newgard CB, Farese RV, de Cabo R, Ulrich S, Akassoglou K, Verdin E
• DGAT1 mutation is linked to a congenital diarrheal disorder.
  The Journal of clinical investigation 2012 Haas JT, Winter HS, Lim E, Kirby A, Blumenstiel B, DeFelice M, Gabriel S, Jalas C, Branski D, Grueter CA, Toporovski MS, Walther TC, Daly MJ, Farese RV
• Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models.
  Nature genetics 2012 Armakola M, Higgins MJ, Figley MD, Barmada SJ, Scarborough EA, Diaz Z, Fang X, Shorter J, Krogan NJ, Finkbeiner S, Farese RV, Gitler AD
• Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases.
  The Journal of biological chemistry 2012 Eichmann TO, Kumari M, Haas JT, Farese RV, Zimmermann R, Lass A, Zechner R
• Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects.
  Cell reports 2012 Almeida S, Zhang Z, Coppola G, Mao W, Futai K, Karydas A, Geschwind MD, Tartaglia MC, Gao F, Gianni D, Sena-Esteves M, Geschwind DH, Miller BL, Farese RV, Gao FB
• The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier).
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2012 Boxer AL, Gold M, Huey E, Hu WT, Rosen H, Kramer J, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, Van Kammen D, Cantillon M…
• Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury.
  The Journal of clinical investigation 2012 Martens LH, Zhang J, Barmada SJ, Zhou P, Kamiya S, Sun B, Min SW, Gan L, Finkbeiner S, Huang EJ, Farese RV
• Frontotemporal degeneration, the next therapeutic frontier: molecules and animal models for frontotemporal degeneration drug development.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2012 Boxer AL, Gold M, Huey E, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, Van Kammen D, Cantillon M, Zahs K, Salloway S, …
• The FATP1-DGAT2 complex facilitates lipid droplet expansion at the ER-lipid droplet interface.
  The Journal of cell biology 2012 Xu N, Zhang SO, Cole RA, McKinney SA, Guo F, Haas JT, Bobba S, Farese RV, Mak HY
• Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression.
  Cell metabolism 2012 Haas JT, Miao J, Chanda D, Wang Y, Zhao E, Haas ME, Hirschey M, Vaitheesvaran B, Farese RV, Kurland IJ, Graham M, Crooke R, Foufelle F, Biddinger SB
• The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance.
  Cell metabolism 2012 Farese RV, Zechner R, Newgard CB, Walther TC
• Lipid droplets and cellular lipid metabolism.
  Annual review of biochemistry 2012 Walther TC, Farese RV
• Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood.
  Journal of lipid research 2012 Zhang J, Kelley KL, Marshall SM, Davis MA, Wilson MD, Sawyer JK, Farese RV, Brown JM, Rudel LL
• Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice.
  Aging 2012 Streeper RS, Grueter CA, Salomonis N, Cases S, Levin MC, Koliwad SK, Zhou P, Hirschey MD, Verdin E, Farese RV
• A guide to analysis of mouse energy metabolism.
  Nature methods 2011 Tschöp MH, Speakman JR, Arch JR, Auwerx J, Brüning JC, Chan L, Eckel RH, Farese RV, Galgani JE, Hambly C, Herman MA, Horvath TL, Kahn BB, Kozma SC, Maratos-Flier E, Müller TD, Münzberg H, Pfluger PT, …
• SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.
  Molecular cell 2011 Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, Stancáková A, Goetzman E, Lam MM, Schwer B, Stevens RD, Muehlbauer MJ, Kakar S, Bass NM, Kuusisto J, Laakso M, Alt FW, Newgard CB, …
• Hepatitis C virus core protein decreases lipid droplet turnover: a mechanism for core-induced steatosis.
  The Journal of biological chemistry 2011 Harris C, Herker E, Farese RV, Ott M
• Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase.
  Cell metabolism 2011 Krahmer N, Guo Y, Wilfling F, Hilger M, Lingrell S, Heger K, Newman HW, Schmidt-Supprian M, Vance DE, Mann M, Farese RV, Walther TC
• Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling.
  Neuron 2011 Rosen EY, Wexler EM, Versano R, Coppola G, Gao F, Winden KD, Oldham MC, Martens LH, Zhou P, Farese RV, Geschwind DH
• Hepatic acyl-CoA:diacylglcyerol acyltransferase (DGAT) overexpression, diacylglycerol, and insulin sensitivity.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Monetti M, Levin MC, Watt MJ, Hubbard BK, Newgard C, Farese RV, Hevener AL, Farese RV
• Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia.
  The Journal of biological chemistry 2011 Cenik B, Sephton CF, Dewey CM, Xian X, Wei S, Yu K, Niu W, Coppola G, Coughlin SE, Lee SE, Dries DR, Almeida S, Geschwind DH, Gao FB, Miller BL, Farese RV, Posner BA, Yu G, Herz J
• A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Kao AW, Eisenhut RJ, Martens LH, Nakamura A, Huang A, Bagley JA, Zhou P, de Luis A, Neukomm LJ, Cabello J, Farese RV, Kenyon C
• DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes.
  Journal of lipid research 2011 Harris CA, Haas JT, Streeper RS, Stone SJ, Kumari M, Yang K, Han X, Brownell N, Gross RW, Zechner R, Farese RV
• A new way to look at fat.
  Nature methods 2011 Bewersdorf J, Farese RV, Walther TC
• Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1.
  Nature medicine 2010 Herker E, Harris C, Hernandez C, Carpentier A, Kaehlcke K, Rosenberg AR, Farese RV, Ott M
• MicroRNA-29b regulates the expression level of human progranulin, a secreted glycoprotein implicated in frontotemporal dementia.
  PloS one 2010 Jiao J, Herl LD, Farese RV, Gao FB
• SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.
  Nature 2010 Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, Newgard CB, Farese RV, Alt FW, Kahn …
• DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation.
  The Journal of clinical investigation 2010 Koliwad SK, Streeper RS, Monetti M, Cornelissen I, Chan L, Terayama K, Naylor S, Rao M, Hubbard B, Farese RV
• Lipid droplets finally get a little R-E-S-P-E-C-T.
  Cell 2009 Farese RV, Walther TC
• SnapShot: Lipid Droplets.
  Cell 2009 Krahmer N, Guo Y, Farese RV, Walther TC
• Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids.
  Hepatology (Baltimore, Md.) 2009 Villanueva CJ, Monetti M, Shih M, Zhou P, Watkins SM, Bhanot S, Farese RV
• Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism.
  The Journal of biological chemistry 2009 Koliwad SK, Kuo T, Shipp LE, Gray NE, Backhed F, So AY, Farese RV, Wang JC
• Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding.
  Nature medicine 2009 Yen CL, Cheong ML, Grueter C, Zhou P, Moriwaki J, Wong JS, Hubbard B, Marmor S, Farese RV
• Lipid droplets at a glance.
  Journal of cell science 2009 Guo Y, Cordes KR, Farese RV, Walther TC
• The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria.
  The Journal of biological chemistry 2008 Stone SJ, Levin MC, Zhou P, Han J, Walther TC, Farese RV
• Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin.
  The Journal of biological chemistry 2008 Shih MY, Kane MA, Zhou P, Yen CL, Streeper RS, Napoli JL, Farese RV
• The life of lipid droplets.
  Biochimica et biophysica acta 2008 Walther TC, Farese RV
• Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis.
  Journal of lipid research 2008 Yen CL, Stone SJ, Koliwad S, Harris C, Farese RV
• Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice.
  Journal of lipid research 2008 Minehira K, Young SG, Villanueva CJ, Yetukuri L, Oresic M, Hellerstein MK, Farese RV, Horton JD, Preitner F, Thorens B, Tappy L
• Functional genomic screen reveals genes involved in lipid-droplet formation and utilization.
  Nature 2008 Guo Y, Walther TC, Rao M, Stuurman N, Goshima G, Terayama K, Wong JS, Vale RD, Walter P, Farese RV
• Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle.
  American journal of physiology. Endocrinology and metabolism 2007 Levin MC, Monetti M, Watt MJ, Sajan MP, Stevens RD, Bain JR, Newgard CB, Farese RV, Farese RV
• Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.
  Molecular and cellular biology 2007 Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV, …
• LPA3 receptor mediates chemotaxis of immature murine dendritic cells to unsaturated lysophosphatidic acid (LPA).
  Journal of leukocyte biology 2007 Chan LC, Peters W, Xu Y, Chun J, Farese RV, Cases S
• Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver.
  Cell metabolism 2007 Monetti M, Levin MC, Watt MJ, Sajan MP, Marmor S, Hubbard BK, Stevens RD, Bain JR, Newgard CB, Farese RV, Hevener AL, Farese RV
• Membrane topology and identification of key functional amino acid residues of murine acyl-CoA:diacylglycerol acyltransferase-2.
  The Journal of biological chemistry 2006 Stone SJ, Levin MC, Farese RV
• Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Feldman BJ, Streeper RS, Farese RV, Yamamoto KR
• The nine lives of ACAT inhibitors.
  Arteriosclerosis, thrombosis, and vascular biology 2006 Farese RV
• Short-term overexpression of DGAT1 or DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production.
  Journal of lipid research 2006 Millar JS, Stone SJ, Tietge UJ, Tow B, Billheimer JT, Wong JS, Hamilton RL, Farese RV, Rader DJ
• ACAT inhibition and the progression of coronary atherosclerosis.
  The New England journal of medicine 2006 Rudel LL, Farese RV
• Fat breakdown: a function for CGI-58 (ABHD5) provides a new piece of the puzzle.
  Cell metabolism 2006 Yen CL, Farese RV
• Effects of DGAT1 deficiency on energy and glucose metabolism are independent of adiponectin.
  American journal of physiology. Endocrinology and metabolism 2006 Streeper RS, Koliwad SK, Villanueva CJ, Farese RV
• A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters.
  Journal of lipid research 2005 Yen CL, Brown CH, Monetti M, Farese RV
• The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters.
  Journal of lipid research 2005 Yen CL, Monetti M, Burri BJ, Farese RV
• Inhibition of triglyceride synthesis as a treatment strategy for obesity: lessons from DGAT1-deficient mice.
  Arteriosclerosis, thrombosis, and vascular biology 2004 Chen HC, Farese RV
• ACAT2 deficiency limits cholesterol absorption in the cholesterol-fed mouse: impact on hepatic cholesterol homeostasis.
  Hepatology (Baltimore, Md.) 2004 Repa JJ, Buhman KK, Farese RV, Dietschy JM, Turley SD
• Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme a:cholesterol acyltransferase 2 have opposite atherosclerotic potential.
  Circulation research 2004 Lee RG, Kelley KL, Sawyer JK, Farese RV, Parks JS, Rudel LL
• Role of adipocyte-derived factors in enhancing insulin signaling in skeletal muscle and white adipose tissue of mice lacking Acyl CoA:diacylglycerol acyltransferase 1.
  Diabetes 2004 Chen HC, Rao M, Sajan MP, Standaert M, Kanoh Y, Miura A, Farese RV, Farese RV
• Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues.
  Development (Cambridge, England) 2004 Cases S, Zhou P, Shillingford JM, Wiseman BS, Fish JD, Angle CS, Hennighausen L, Werb Z, Farese RV
• Insulin-induced activation of atypical protein kinase C, but not protein kinase B, is maintained in diabetic (ob/ob and Goto-Kakazaki) liver. Contrasting insulin signaling patterns in liver versus muscle define phenotypes of type 2 diabetic and high fat-induced insulin-resistant states.
  The Journal of biological chemistry 2004 Standaert ML, Sajan MP, Miura A, Kanoh Y, Chen HC, Farese RV, Farese RV
• Lipopenia and skin barrier abnormalities in DGAT2-deficient mice.
  The Journal of biological chemistry 2003 Stone SJ, Myers HM, Watkins SM, Brown BE, Feingold KR, Elias PM, Farese RV
• Gene expression profile of oxidant stress and neurodegeneration in transgenic mice deficient in alpha-tocopherol transfer protein.
  Free radical biology & medicine 2003 Gohil K, Schock BC, Chakraborty AA, Terasawa Y, Raber J, Farese RV, Packer L, Cross CE, Traber MG
• Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1.
  The Journal of clinical investigation 2003 Chen HC, Jensen DR, Myers HM, Eckel RH, Farese RV
• Triglyceride accumulation protects against fatty acid-induced lipotoxicity.
  Proceedings of the National Academy of Sciences of the United States of America 2003 Listenberger LL, Han X, Lewis SE, Cases S, Farese RV, Ory DS, Schaffer JE
• MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine.
  The Journal of biological chemistry 2003 Yen CL, Farese RV
• Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice.
  Proceedings of the National Academy of Sciences of the United States of America 2003 Willner EL, Tow B, Buhman KK, Wilson M, Sanan DA, Rudel LL, Farese RV
• Dissociation of obesity and impaired glucose disposal in mice overexpressing acyl coenzyme a:diacylglycerol acyltransferase 1 in white adipose tissue.
  Diabetes 2002 Chen HC, Stone SJ, Zhou P, Buhman KK, Farese RV
• Analysis of energy expenditure at different ambient temperatures in mice lacking DGAT1.
  American journal of physiology. Endocrinology and metabolism 2002 Chen HC, Ladha Z, Smith SJ, Farese RV
• Deficiency of acyl coenzyme a:diacylglycerol acyltransferase 1 increases leptin sensitivity in murine obesity models.
  Endocrinology 2002 Chen HC, Ladha Z, Farese RV
• DGAT1 promoter polymorphism associated with alterations in body mass index, high density lipoprotein levels and blood pressure in Turkish women.
  Clinical genetics 2002 Ludwig EH, Mahley RW, Palaoglu E, Ozbayrakçi S, Balestra ME, Borecki IB, Innerarity TL, Farese RV
• Fatty acids, triglycerides, and glucose metabolism: recent insights from knockout mice.
  Current opinion in clinical nutrition and metabolic care 2002 Chen HC, Farese RV
• Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase.
  Proceedings of the National Academy of Sciences of the United States of America 2002 Yen CL, Stone SJ, Cases S, Zhou P, Farese RV
• Determination of adipocyte size by computer image analysis.
  Journal of lipid research 2002 Chen HC, Farese RV
• Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport.
  The Journal of biological chemistry 2002 Chen HC, Bandyopadhyay G, Sajan MP, Kanoh Y, Standaert M, Farese RV, Farese RV
• Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1.
  The Journal of clinical investigation 2002 Chen HC, Smith SJ, Ladha Z, Jensen DR, Ferreira LD, Pulawa LK, McGuire JG, Pitas RE, Eckel RH, Farese RV
• Incorporation of deuterated RRR- or all-rac-alpha-tocopherol in plasma and tissues of alpha-tocopherol transfer protein--null mice.
  The American journal of clinical nutrition 2002 Leonard SW, Terasawa Y, Farese RV, Traber MG
• Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands.
  The Journal of clinical investigation 2002 Chen HC, Smith SJ, Tow B, Elias PM, Farese RV
• Turning WAT into BAT gets rid of fat.
  Nature medicine 2001 Chen HC, Farese RV
• Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E.
  Proceedings of the National Academy of Sciences of the United States of America 2001 Raffai RL, Dong LM, Farese RV, Weisgraber KH
• The enzymes of neutral lipid synthesis.
  The Journal of biological chemistry 2001 Buhman KK, Chen HC, Farese RV
• Cholesterol esterification by host and parasite is essential for optimal proliferation of Toxoplasma gondii.
  The Journal of biological chemistry 2001 Sonda S, Ting LM, Novak S, Kim K, Maher JJ, Farese RV, Ernst JD
• Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages.
  The Journal of clinical investigation 2001 Fazio S, Major AS, Swift LL, Gleaves LA, Accad M, Linton MF, Farese RV
• Mammalian acyl-CoA:cholesterol acyltransferases.
  Biochimica et biophysica acta 2000 Buhman KF, Accad M, Farese RV
• Increased atherosclerosis in hyperlipidemic mice deficient in alpha -tocopherol transfer protein and vitamin E.
  Proceedings of the National Academy of Sciences of the United States of America 2000 Terasawa Y, Ladha Z, Leonard SW, Morrow JD, Newland D, Sanan D, Packer L, Traber MG, Farese RV
• Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice.
  Nature medicine 2000 Buhman KK, Accad M, Novak S, Choi RS, Wong JS, Hamilton RL, Turley S, Farese RV
• Essential role of NAT1/p97/DAP5 in embryonic differentiation and the retinoic acid pathway.
  The EMBO journal 2000 Yamanaka S, Zhang XY, Maeda M, Miura K, Wang S, Farese RV, Iwao H, Innerarity TL
• Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestine.
  The Journal of biological chemistry 2000 Chang CC, Sakashita N, Ornvold K, Lee O, Chang ET, Dong R, Lin S, Lee CY, Strom SC, Kashyap R, Fung JJ, Farese RV, Patoiseau JF, Delhon A, Chang TY
• DGAT and triglyceride synthesis: a new target for obesity treatment?
  Trends in cardiovascular medicine 2000 Chen HC, Farese RV
• Fatal bilateral chylothorax in mice lacking the integrin alpha9beta1.
  Molecular and cellular biology 2000 Huang XZ, Wu JF, Ferrando R, Lee JH, Wang YL, Farese RV, Sheppard D
• Triglyceride synthesis: insights from the cloning of diacylglycerol acyltransferase.
  Current opinion in lipidology 2000 Farese RV, Cases S, Smith SJ
• Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat.
  Nature genetics 2000 Smith SJ, Cases S, Jensen DR, Chen HC, Sande E, Tow B, Sanan DA, Raber J, Eckel RH, Farese RV
• Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1.
  The Journal of clinical investigation 2000 Accad M, Smith SJ, Newland DL, Sanan DA, King LE, Linton MF, Fazio S, Farese RV
• Normal development, wound healing, and adenovirus susceptibility in beta5-deficient mice.
  Molecular and cellular biology 2000 Huang X, Griffiths M, Wu J, Farese RV, Sheppard D
• Apolipoprotein B-related gene expression and ultrastructural characteristics of lipoprotein secretion in mouse yolk sac during embryonic development.
  Journal of lipid research 1999 Terasawa Y, Cases SJ, Wong JS, Jamil H, Jothi S, Traber MG, Packer L, Gordon DA, Hamilton RL, Farese RV
• Steroid hormones: Interactions with membrane-bound receptors.
  Current biology : CB 1999 Chen HC, Farese RV
• The LDL receptor gene family, apolipoprotein B and cholesterol in embryonic development.
  The Journal of nutrition 1999 Herz J, Farese RV
• Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis.
  Proceedings of the National Academy of Sciences of the United States of America 1998 Cases S, Smith SJ, Zheng YW, Myers HM, Lear SR, Sande E, Novak S, Collins C, Welch CB, Lusis AJ, Erickson SK, Farese RV
• ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization.
  The Journal of biological chemistry 1998 Cases S, Novak S, Zheng YW, Myers HM, Lear SR, Sande E, Welch CB, Lusis AJ, Spencer TA, Krause BR, Erickson SK, Farese RV
• Cholesterol homeostasis: a role for oxysterols.
  Current biology : CB 1998 Accad M, Farese RV
• A dual thrombin receptor system for platelet activation.
  Nature 1998 Kahn ML, Zheng YW, Huang W, Bigornia V, Zeng D, Moff S, Farese RV, Tam C, Coughlin SR
• Immunolocalization of acyl-coenzyme A:cholesterol O-acyltransferase in macrophages.
  The Journal of biological chemistry 1998 Khelef N, Buton X, Beatini N, Wang H, Meiner V, Chang TY, Farese RV, Maxfield FR, Tabas I
• Acyl CoA:cholesterol acyltransferase genes and knockout mice.
  Current opinion in lipidology 1998 Farese RV
• Cholesterol metabolism and embryogenesis.
  Trends in genetics : TIG 1998 Farese RV, Herz J
• Adrenocortical lipid depletion gene (ald) in AKR mice is associated with an acyl-CoA:cholesterol acyltransferase (ACAT) mutation.
  The Journal of biological chemistry 1998 Meiner VL, Welch CL, Cases S, Myers HM, Sande E, Lusis AJ, Farese RV
• Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice.
  The Journal of clinical investigation 1997 Boring L, Gosling J, Chensue SW, Kunkel SL, Farese RV, Broxmeyer HE, Charo IF
• Tissue expression studies on the mouse acyl-CoA: cholesterol acyltransferase gene (Acact): findings supporting the existence of multiple cholesterol esterification enzymes in mice.
  Journal of lipid research 1997 Meiner V, Tam C, Gunn MD, Dong LM, Weisgraber KH, Novak S, Myers HM, Erickson SK, Farese RV
• Cholesterol, hedgehog and embryogenesis.
  Nature genetics 1997 Herz J, Willnow TE, Farese RV
• Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals.
  Proceedings of the National Academy of Sciences of the United States of America 1996 Meiner VL, Cases S, Myers HM, Sande ER, Bellosta S, Schambelan M, Pitas RE, McGuire J, Herz J, Farese RV
• Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes.
  Journal of lipid research 1996 Welch CL, Xia YR, Shechter I, Farese R, Mehrabian M, Mehdizadeh S, Warden CH, Lusis AJ
• Phenotypic analysis of mice expressing exclusively apolipoprotein B48 or apolipoprotein B100.
  Proceedings of the National Academy of Sciences of the United States of America 1996 Farese RV, Véniant MM, Cham CM, Flynn LM, Pierotti V, Loring JF, Traber M, Ruland S, Stokowski RS, Huszar D, Young SG
• Role of the thrombin receptor in development and evidence for a second receptor.
  Nature 1996 Connolly AJ, Ishihara H, Kahn ML, Farese RV, Coughlin SR
• Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin.
  The Journal of cell biology 1996 Huang XZ, Wu JF, Cass D, Erle DJ, Corry D, Young SG, Farese RV, Sheppard D
• Targeted disruption of the mouse apobec-1 gene abolishes apolipoprotein B mRNA editing and eliminates apolipoprotein B48.
  The Journal of biological chemistry 1996 Hirano K, Young SG, Farese RV, Ng J, Sande E, Warburton C, Powell-Braxton LM, Davidson NO
• A novel function for apolipoprotein B: lipoprotein synthesis in the yolk sac is critical for maternal-fetal lipid transport in mice.
  Journal of lipid research 1996 Farese RV, Cases S, Ruland SL, Kayden HJ, Wong JS, Young SG, Hamilton RL
• A genetic model for absent chylomicron formation: mice producing apolipoprotein B in the liver, but not in the intestine.
  The Journal of clinical investigation 1995 Young SG, Cham CM, Pitas RE, Burri BJ, Connolly A, Flynn L, Pappu AS, Wong JS, Hamilton RL, Farese RV
• Transgenic mice expressing high levels of human apolipoprotein B develop severe atherosclerotic lesions in response to a high-fat diet.
  The Journal of clinical investigation 1995 Purcell-Huynh DA, Farese RV, Johnson DF, Flynn LM, Pierotti V, Newland DL, Linton MF, Sanan DA, Young SG
• Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes.
  Proceedings of the National Academy of Sciences of the United States of America 1995 Farese RV, Ruland SL, Flynn LM, Stokowski RP, Young SG
• The apolipoprotein C-II variant apoC-IILys19-->Thr is not associated with dyslipidemia in an affected kindred.
  Clinical genetics 1994 Zysow BR, Pullinger CR, Hennessy LK, Farese RV, Ghassemzadeh M, Kane JP
• Transgenic mice expressing human apoB100 and apoB48.
  Current opinion in lipidology 1994 Young SG, Farese RV, Pierotti VR, Taylor S, Grass DS, Linton MF
• Familial hypobetalipoproteinemia.
  Journal of lipid research 1993 Linton MF, Farese RV, Young SG
• Four new mutations in the apolipoprotein B gene causing hypobetalipoproteinemia, including two different frameshift mutations that yield truncated apolipoprotein B proteins of identical length.
  Journal of lipid research 1993 Young SG, Pullinger CR, Zysow BR, Hofmann-Radvani H, Linton MF, Farese RV, Terdiman JF, Snyder SM, Grundy SM, Vega GL
• Modification of the apolipoprotein B gene in HepG2 cells by gene targeting.
  The Journal of clinical investigation 1992 Farese RV, Flynn LM, Young SG
• Apolipoprotein B gene mutations affecting cholesterol levels.
  Journal of internal medicine 1992 Farese RV, Linton MF, Young SG
• A truncated species of apolipoprotein B, B-83, associated with hypobetalipoproteinemia.
  Journal of lipid research 1992 Farese RV, Garg A, Pierotti VR, Vega GL, Young SG
• Tissue-specific regulation of lipoprotein lipase activity by insulin/glucose in normal-weight humans.
  Metabolism: clinical and experimental 1991 Farese RV, Yost TJ, Eckel RH
• The mechanism of action of insulin on phospholipid metabolism in rat adipose tissue. Requirement for protein synthesis and a carbohydrate source, and relationship to activation of pyruvate dehydrogenase.
  Diabetes 1984 Farese RV, Farese RV, Sabir MA, Larson RE, Trudeau WL, Barnes D