Bob Bhisitkul, MD, PhD
Professor
Ophthalmology
School of Medicine

Websites

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• Clinical Profile at UCSF Medical Center (ucsfhealth.org)

Videos

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• Addressing Unmet Needs in Treating Ophthalmic Diseases (youtube.com)
• Defining Product Attributes Early Maximizes Development Success (youtube.com)
• Planning for Development Risk Promotes Successful Translation (youtube.com)
• Identifying the Right Partners within UCSF is Critical to Success (youtube.com)
• Bioengineer and Clinician Collaborate to Improve Treatment of Eye Diseases (youtube.com)

Publications (60)

Top publication keywords:
Vitreous BodyVascular Endothelial Growth Factor AIntravitreal InjectionsRetinal Vein OcclusionVitrectomyMacular EdemaAngiogenesis InhibitorsVisual AcuityRanibizumabPolyestersRetinal DetachmentGeographic AtrophyWet Macular DegenerationLens SubluxationMacular Degeneration

• Heterogeneity in disease activity, frequency of treatments, and visual outcomes among patients with retinal vein occlusion: relationship between injection need and vision with as-needed ranibizumab.
  The British journal of ophthalmology 2024 Bhisitkul RB, Campochiaro PA, Blotner S, Quezada-Ruiz C, Liu M, Haskova Z
• Safety and tolerability of intravitreal umedaptanib pegol (anti-FGF2) for neovascular age-related macular degeneration (nAMD): a phase 1, open-label study.
  Eye (London, England) 2023 Pereira DS, Akita K, Bhisitkul RB, Nishihata T, Ali Y, Nakamura E, Nakamura Y
• Clinical proof of concept for anti-FGF2 therapy in exudative age-related macular degeneration (nAMD): phase 2 trials in treatment-naïve and anti-VEGF pretreated patients.
  Eye (London, England) 2023 Pereira DS, Maturi RK, Akita K, Mahesh V, Bhisitkul RB, Nishihata T, Sakota E, Ali Y, Nakamura E, Bezwada P, Nakamura Y
• Injectable Devices for Delivery of Liquid or Solid Protein Formulations.
  ACS materials Au 2023 Bernards DA, Ma CJ, Zhang Y, Rodriguez TM, Dickson J, Kharbikar BN, Bhisitkul RB, Desai TA
• Macular Atrophy Incidence, Progression, and Visual Acuity Effects in 5-Year Treatment of Neovascular Age-Related Macular Degeneration.
  Ophthalmic surgery, lasers & imaging retina 2022 Richardson QR, Zhang Y, Deiner MS, Wang ST, Bhisitkul JM, Arnold BF, Bhisitkul RB

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• BILATERAL ENTEROCOCCUS FAECALIS ENDOPHTHALMITIS WITH MULTIPLE RECURRENCES.
  Retinal cases & brief reports 2021 Aderman CM, Chao DL, Obeid A, Schwartz DM, Bhisitkul RB, Chiu CS
• Rhegmatogenous retinal detachment masquerading as exudative panuveitis with intense anterior chamber inflammatory reaction.
  American journal of ophthalmology case reports 2020 Joye AS, Bhisitkul RB, Pereira DDS, Gonzales JA
• Glass intraocular foreign body removal with a nitinol stone basket.
  American journal of ophthalmology case reports 2019 Francis AW, Wu F, Zhu I, de Souza Pereira D, Bhisitkul RB
• Anti-Angiogenic and Anti-Scarring Dual Action of an Anti-Fibroblast Growth Factor 2 Aptamer in Animal Models of Retinal Disease.
  Molecular therapy. Nucleic acids 2019 Matsuda Y, Nonaka Y, Futakawa S, Imai H, Akita K, Nishihata T, Fujiwara M, Ali Y, Bhisitkul RB, Nakamura Y
• Co-Delivery of Timolol and Brimonidine with a Polymer Thin-Film Intraocular Device.
  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2019 Samy KE, Cao Y, Kim J, Konichi da Silva NR, Phone A, Bloomer MM, Bhisitkul RB, Desai TA
• Device design methodology and formulation of a protein therapeutic for sustained release intraocular delivery.
  Bioengineering & translational medicine 2018 Schlesinger EB, Bernards DA, Chen HH, Feindt J, Cao J, Dix D, Romano C, Bhisitkul RB, Desai TA
• Long-term intraocular pressure reduction with intracameral polycaprolactone glaucoma devices that deliver a novel anti-glaucoma agent.
  Journal of controlled release : official journal of the Controlled Release Society 2017 Kim J, Kudisch M, da Silva NRK, Asada H, Aya-Shibuya E, Bloomer MM, Mudumba S, Bhisitkul RB, Desai TA
• Manual Removal of Intraocular Lens Silicone Oil Droplets and Dystrophic Calcifications Using a Nitinol Loop: A Case Series.
  Ophthalmic surgery, lasers & imaging retina 2017 Moussa K, Leng T, Oatts JT, Bhisitkul RB, Hwang DG, Stewart JM
• In vivo and in vitro sustained release of ranibizumab from a nanoporous thin-film device.
  Drug delivery and translational research 2016 Lance KD, Bernards DA, Ciaccio NA, Good SD, Mendes TS, Kudisch M, Chan E, Ishikiriyama M, Bhisitkul RB, Desai TA
• Biocompatibility and Pharmacokinetic Analysis of an Intracameral Polycaprolactone Drug Delivery Implant for Glaucoma.
  Investigative ophthalmology & visual science 2016 Kim J, Kudisch M, Mudumba S, Asada H, Aya-Shibuya E, Bhisitkul RB, Desai TA
• Fellow Eye Comparisons for 7-Year Outcomes in Ranibizumab-Treated AMD Subjects from ANCHOR, MARINA, and HORIZON (SEVEN-UP Study).
  Ophthalmology 2016 Bhisitkul RB, Desai SJ, Boyer DS, Sadda SR, Zhang K
• Predictors of Macular Atrophy Detected by Fundus Autofluorescence in Patients With Neovascular Age-Related Macular Degeneration After Long-Term Ranibizumab Treatment.
  Ophthalmic surgery, lasers & imaging retina 2016 Kuehlewein L, Dustin L, Sagong M, Hariri A, Mendes TS, Rofagha S, Bhisitkul RB, Sadda SR
• Reply.
  American journal of ophthalmology 2015 Bhisitkul RB, Mendes TS, Rofagha S, Enanoria W, Boyer DS, Sadda SR, Zhang K
• In Vitro and In Vivo Sustained Zero-Order Delivery of Rapamycin (Sirolimus) From a Biodegradable Intraocular Device.
  Investigative ophthalmology & visual science 2015 Lance KD, Good SD, Mendes TS, Ishikiriyama M, Chew P, Estes LS, Yamada K, Mudumba S, Bhisitkul RB, Desai TA
• Correlation of Serial Scleral and Corneal Pneumatonometry.
  Ophthalmology 2015 Kuo DS, Ou Y, Jeng BH, Bhisitkul R, Stewart JM, Duncan JL, Han Y
• Macular atrophy progression and 7-year vision outcomes in subjects from the ANCHOR, MARINA, and HORIZON studies: the SEVEN-UP study.
  American journal of ophthalmology 2015 Bhisitkul RB, Mendes TS, Rofagha S, Enanoria W, Boyer DS, Sadda SR, Zhang K
• Same-Day Versus Next-Day Repair of Fovea-Threatening Primary Rhegmatogenous Retinal Detachments.
  Seminars in ophthalmology 2014 Gorovoy IR, Porco TC, Bhisitkul RB, de Juan E, Schwartz DM, Stewart JM
• Age-related macular degeneration and protective effect of HMG Co-A reductase inhibitors (statins): results from the National Health and Nutrition Examination Survey 2005-2008.
  Eye (London, England) 2014 Barbosa DT, Mendes TS, Cíntron-Colon HR, Wang SY, Bhisitkul RB, Singh K, Lin SC
• Seven-year outcomes in ranibizumab-treated patients in ANCHOR, MARINA, and HORIZON: a multicenter cohort study (SEVEN-UP).
  Ophthalmology 2013 Rofagha S, Bhisitkul RB, Boyer DS, Sadda SR, Zhang K, SEVEN-UP Study Group
• Predictive value in retinal vein occlusions of early versus late or incomplete ranibizumab response defined by optical coherence tomography.
  Ophthalmology 2013 Bhisitkul RB, Campochiaro PA, Shapiro H, Rubio RG
• Ocular biocompatibility and structural integrity of micro- and nanostructured poly(caprolactone) films.
  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2013 Bernards DA, Bhisitkul RB, Wynn P, Steedman MR, Lee OT, Wong F, Thoongsuwan S, Desai TA
• Vascular endothelial growth factor promotes progressive retinal nonperfusion in patients with retinal vein occlusion.
  Ophthalmology 2012 Campochiaro PA, Bhisitkul RB, Shapiro H, Rubio RG
• Risk factors for retinal detachment following cataract surgery.
  Current opinion in ophthalmology 2012 Haug SJ, Bhisitkul RB
• Sustained benefits from ranibizumab for macular edema following branch retinal vein occlusion: 12-month outcomes of a phase III study.
  Ophthalmology 2011 Brown DM, Campochiaro PA, Bhisitkul RB, Ho AC, Gray S, Saroj N, Adamis AP, Rubio RG, Murahashi WY
• Management of retained lens fragments in complicated cataract surgery.
  Current opinion in ophthalmology 2011 Rofagha S, Bhisitkul RB
• Bleb-associated infections after intravitreal injection.
  Retinal cases & brief reports 2011 Thoongsuwan S, Dawn Lam HH, Bhisitkul RB
• Safety monitoring with ocular anti-vascular endothelial growth factor therapies.
  The British journal of ophthalmology 2008 Fung AE, Bhisitkul RB
• Spontaneous resolution of a traumatic cataract caused by an intralenticular foreign body.
  Journal of cataract and refractive surgery 2008 Rofagha S, Day S, Winn BJ, Ou JI, Bhisitkul RB, Chiu CS
• Neuroprotective effect of intravitreal triamcinolone acetonide against photoreceptor apoptosis in a rabbit model of subretinal hemorrhage.
  Investigative ophthalmology & visual science 2008 Bhisitkul RB, Winn BJ, Lee OT, Wong J, Pereira Dde S, Porco TC, He X, Hahn P, Dunaief JL
• Iron homeostasis and toxicity in retinal degeneration.
  Progress in retinal and eye research 2007 He X, Hahn P, Iacovelli J, Wong R, King C, Bhisitkul R, Massaro-Giordano M, Dunaief JL
• Subgroup analysis of the MARINA study of ranibizumab in neovascular age-related macular degeneration.
  Ophthalmology 2007 Boyer DS, Antoszyk AN, Awh CC, Bhisitkul RB, Shapiro H, Acharya NR, MARINA Study Group
• Vascular endothelial growth factor biology: clinical implications for ocular treatments.
  The British journal of ophthalmology 2006 Bhisitkul RB
• Expanding treatment options in age-related macular degeneration.
  International ophthalmology clinics 2006 Bhisitkul RB, Rutar T
• Development of Microelectromechanical Systems (MEMS) forceps for intraocular surgery.
  The British journal of ophthalmology 2005 Bhisitkul RB, Keller CG
• Registration of clinical trials.
  Archives of ophthalmology (Chicago, Ill. : 1960) 2005 Levin LA, Gottlieb JL, Beck RW, Albert DM, Liesegang TJ, Hoyt CS, Dick A, Bhisitkul R, Schachat AP
• "Heavy oil" for intraocular tamponade in retinal detachment surgery.
  The British journal of ophthalmology 2005 Bhisitkul RB, Gonzalez VH
• An antisense oligodeoxynucleotide against vascular endothelial growth factor in a nonhuman primate model of iris neovascularization.
  Archives of ophthalmology (Chicago, Ill. : 1960) 2005 Bhisitkul RB, Robinson GS, Moulton RS, Claffey KP, Gragoudas ES, Miller JW
• Found in translation.
  The British journal of ophthalmology 2004 Kwok AH, Pereira DS, Bhisitkul RB
• BDNF reduces the retinal toxicity of verteporfin photodynamic therapy.
  Investigative ophthalmology & visual science 2004 Paskowitz DM, Nune G, Yasumura D, Yang H, Bhisitkul RB, Sharma S, Matthes MT, Zarbin MA, Lavail MM, Duncan JL
• Distinguishing features of nontraumatic and traumatic retinal dialyses.
  Retina (Philadelphia, Pa.) 2004 Hollander DA, Irvine AR, Poothullil AM, Bhisitkul RB
• Bloom syndrome: multiple retinopathies in a chromosome breakage disorder.
  The British journal of ophthalmology 2004 Bhisitkul RB, Rizen M
• Second generation vital stains in retinal surgery.
  The British journal of ophthalmology 2003 Bhisitkul RB
• A small number of older type 2 diabetic patients end up visually impaired,. by C. Hansson-Lundblad, K. Holm, C. D. Agardh, and E. Agardh. Acta Ophthalmol Scan 80:310-5, 2002.
  Survey of ophthalmology 2003 Bhisitkul R
• Systemic non-Hodgkin's lymphoma with optic nerve infiltration in a patient with AIDS.
  Retina (Philadelphia, Pa.) 2002 Lee LC, Howes EL, Bhisitkul RB
• Anticipation for enzymatic vitreolysis.
  The British journal of ophthalmology 2001 Bhisitkul RB
• Optic disk edema associated with peripapillary serous retinal detachment: an early sign of systemic Bartonella henselae infection.
  American journal of ophthalmology 2000 Wade NK, Levi L, Jones MR, Bhisitkul R, Fine L, Cunningham ET
• Bacterial subretinal abscess: a case report and review of the literature.
  American journal of ophthalmology 2000 Harris EW, D'Amico DJ, Bhisitkul R, Priebe GP, Petersen R
• Spontaneous central retinal artery occlusion in hemoglobin sickle cell disease.
  American journal of ophthalmology 2000 Fine LC, Petrovic' V, Irvine AR, Bhisitkul RB
• Soccer ball-related retinal injuries: a report of 13 cases.
  Retina (Philadelphia, Pa.) 2000 Horn EP, McDonald HR, Johnson RN, Ai E, Williams GA, Lewis JM, Rubsamen PE, Sternberg P, Bhisitkul RB, Mieler WF
• Emerging chemotherapeutic strategies in the management of intraocular retinoblastoma.
  International ophthalmology clinics 1997 Bhisitkul RB, Mukai S
• Diagnosis and ophthalmological features of Behçet's disease.
  International ophthalmology clinics 1996 Bhisitkul RB, Foster CS
• A voltage- and time-dependent rectification in rat dorsal spinal root axons.
  Journal of neurophysiology 1991 Birch BD, Kocsis JD, Di Gregorio F, Bhisitkul RB, Waxman SG
• Trophic influence of the distal nerve segment on GABAA receptor expression in axotomized adult sensory neurons.
  Experimental neurology 1990 Bhisitkul RB, Kocsis JD, Gordon TR, Waxman SG
• Axonal GABA receptors are selectively present on normal and regenerated sensory fibers in rat peripheral nerve.
  Experimental brain research 1987 Bhisitkul RB, Villa JE, Kocsis JD
• Adenosine selectively blocks parallel-fiber-mediated synaptic potentials in rat cerebellar cortex.
  Proceedings of the National Academy of Sciences of the United States of America 1984 Kocsis JD, Eng DL, Bhisitkul RB