Bin Liu, PhD
Professor
Anesthesia
School of Medicine

Education & Training

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• Ph.D. Biochemistry & Biophysics University of California 1994
• B.A. Molecular Biology Princeton University 1990

Websites

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• Profile at UCSF Cancer Center (cancer.ucsf.edu)

Grants and Projects

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• Novel radioimmunoconjugates for targeted alpha-particle therapy of metastatic prostatic cancer, NIH, 2018-2023
• Internalizing human antibody-targeted nanosized siRNA therapeutics, NIH, 2012-2019
• Mapping a clinically significant internalizing tumor epitope space, NIH, 2006-2016
• Identifying antigens bound by novel scFvs targeting all subtypes of mesothelioma, NIH, 2010-2015
• Selection of internalizing human antibodies targeting pancreatic tumor cells in s, NIH, 2009-2012
• Internalizing antibody-targeted nanosized siRNA therapeutics, NIH, 2008-2011
• Tumor specific cell sruface epitope- molecular evolution, NIH, 2004-2007

Publications (51)

Top publication keywords:
DNA-Directed RNA PolymerasesExonsAntigen-Antibody ReactionsProtein Processing, Post-TranslationalMesotheliomaOligonucleotide Array Sequence AnalysisCollodionSingle-Chain AntibodiesSaccharomyces cerevisiaeDNA ReplicationImmunoglobulin FragmentsImmunoconjugatesAntigens, NeoplasmGene LibraryTwo-Hybrid System Techniques

• Modular Design of Synthetic Receptors for Programmed Gene Regulation in Cell Therapies
  Cell 2022 Zhu, I., Liu, R., Garcia, J.M., Hyrenius-Wittsten, A., Piraner, D., Alavi, J., Israni, D.V., Liu, B., Khalil, A.S., Roybal, K.T.
• Phase 1a/1b study of FOR46, an antibody drug conjugate (ADC), targeting CD46 in metastatic castration-resistant prostate cancer (mCRPC)
  Journal of Clinical Oncology 2022 Aggarwal, R.R., Vuky, J., VanderWeele, D.J., Rettig, M., Heath, E.I., Beer, T.M., Huang, J., Pawlowska, N., Sinit, R., Abbey, J., Liu, B., Nasoff, M., Dorr, A., Small, E.J.
• Enhanced Solid Tumor Recognition and T cell Stemness with SynNotch CAR Circuits
  Science Translational Medicine 2021 Hyrenius-Wittsten, A., Su, Y., Park, M., Garcia, J.M., Perry, N., Montgomery, G., Liu, B*., Roybal, K.T*
• Molecular imaging of prostate cancer targeting CD46 using immunoPET
  Clinical Cancer Res 2020 Wang, S., Li, J., Hua, J., Su, Y., Beckford-Vera, D., Zhao, W., Jayaraman, M., Huynh, T.L., Zhao, N., Wang, Y.H., Huang, Y., Qin, F., Shen, S., Gioeli, D., Dreicer, R., Sriram, R., Egusa, E.A., Chou, …
• Potent activity of an anti-ICAM1 antibody-drug conjugate against multiple myeloma
  Clinical Cancer Res 2020 Sherbenou, D.W., Su, Y., Behrens, C.R., Aftab, B.T., Perez de Acha, O., Murnane, M., Bearrows, S.C., Hann, B.C., Wolf, J.L., Martin, T.G., and Liu, B.

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• ALPPL2 is a highly specific and targetable tumor cell surface antigen
  Cancer Res 2020 Su, Y., Zhang, X., Bidlingmaier, S., Behrens, C.R., Lee, N.K., and Liu, B.
• Quantitative (99m)Tc Labeling Kit for HYNIC-Conjugated Single Chain Antibody Fragments Targeting Malignant Mesothelioma
  Bioconjug Chem. 2020 He, J., Feng, J., Su, Y., Seo, Y., and Liu, B.
• Manipulation of cell-type selective antibody internalization by a guide-effector bispecific design
  Mol Cancer Ther. 2019 Lee, N.K., Su, Y., Bidlingmaier, S., and Liu, B.
• Targeting CD46 for both adenocarcinoma and neuroendocrine prostate cancer
  JCI Insight 2018 Su, Y., Liu, Y., Behrens, C.R., Bidlingmaier, S., Lee, N.K., Aggarwal, R., Sherbenou, D.W., Burlingame, A.L., Hann, B.C., Simko, J.P., Premasekharan, G., Paris, P.L., Shuman, M.A., Seo, Y., Small, E.J…
• Cell-type specific potent Wnt signaling blockade by bispecific antibody
  Sci Rep. 2018 Lee, N.K., Zhang, Y., Su, Y., Bidlingmaier, S., Sherbenou, D.W., Ha, K.D., Liu, B.
• Combine Phage Antibody Display Library Selection on Patient Tissue Specimens with Laser Capture Microdissection to Identify Novel Human Antibodies Targeting Clinically Relevant Tumor Antigens
  Methods Mol Biol. 2018 Su, Y., Bidlingmaier, S., Lee, N.K., Liu, B.
• Modular Construction of Large Non-Immune Human Antibody Phage-Display Libraries from Variable Heavy and Light Chain Gene Cassettes
  Methods Mol Biol. 2018 Lee, N.K., Bidlingmaier, S., Su, Y., Liu, B.
• Identification of Novel Macropinocytosing Human Antibodies by Phage Display and High-Content Analysis
  Methods Enzymol. 2017 Ha, K., Bidlingmaier, S., Su, Y., Lee, N.K., Liu, B.
• Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells
  J Clin Invest. 2016 Sherbenou, D.W., Aftab, B.T., Su, Y., Behrens, C.R., Wiita, A., Logan, A.C., Acosta-Alvear, D., Hann, B.C., Walter, P., Shuman, M.A., Wu, X., Atkinson, J.P., Wolf, J.L., Martin, T.G., Liu, B.
• Proteome-wide identification of novel ceramide-binding proteins by yeast surface cDNA display and deep sequencing
  Mol Cell Proteomics. 2016 Bidlingmaier, S., Ha, K., Lee, N.K., Su, Y., Liu, B.
• Macropinocytosis exploitation by cancers and cancer therapy
  Frontier Physiology 2016 Ha, K., Bidlingmaier, S., Su, Y., Lee, N.K., Liu, B.
• Combining phage and yeast cell surface antibody display to identify novel cell type-selective internalizing human monoclonal antibodies
  Methods Mol Biol. 2015 Bidlingmaier, S., Liu, B.
• Identification of Posttranslational Modification-Dependent Protein Interactions Using Yeast Surface Displayed Human Proteome Libraries
  Methods Mol Biol. 2015 Bidlingmaier, S., Su, Y., and Liu, B.
• Identification of novel protein-ligand interactions by exon microarray analysis of yeast surface displayed cDNA library selection outputs
  Methods Mol Biol. 2015 Bidlingmaier, S., Liu, B.
• The Development of Potential Antibody-Based Therapies for Multiple Myeloma
  Blood Rev. 2015 Sherbenou, D.W., Behrens, C.R. Yang Su, Wolf, J.L., Martin III, T.G., and Liu, B.
• Utilizing Yeast Surface Human Proteome Display Libraries to Identify Small Molecule-Protein Interactions
  Methods Mol Biol. 2015 Bidlingmaier, S. and Liu, B.
• Methods for site-specific drug conjugation to antibodies.
  mAbs 2014 Behrens CR, Liu B
• Enhanced growth inhibition of osteosarcoma by cytotoxic polymerized liposomal nanoparticles targeting the alcam cell surface receptor.
  Sarcoma 2012 Federman N, Chan J, Nagy JO, Landaw EM, McCabe K, Wu AM, Triche T, Kang H, Liu B, Marks JD, Denny CT
• An engineered cysteine-modified diabody for imaging activated leukocyte cell adhesion molecule (ALCAM)-positive tumors.
  Molecular imaging and biology 2012 McCabe KE, Liu B, Marks JD, Tomlinson JS, Wu H, Wu AM
• Novel human single chain antibody fragments that are rapidly internalizing effectively target epithelioid and sarcomatoid mesotheliomas.
  Cancer research 2011 Iyer AK, Lan X, Zhu X, Su Y, Feng J, Zhang X, Gao D, Seo Y, Vanbrocklin HF, Broaddus VC, Liu B, He J
• The effect of internalizing human single chain antibody fragment on liposome targeting to epithelioid and sarcomatoid mesothelioma.
  Biomaterials 2011 Iyer AK, Su Y, Feng J, Lan X, Zhu X, Liu Y, Gao D, Seo Y, Vanbrocklin HF, Courtney Broaddus V, Liu B, He J
• Construction of yeast surface-displayed cDNA libraries.
  Methods in molecular biology (Clifton, N.J.) 2011 Bidlingmaier S, Liu B
• Identification of protein/target molecule interactions using yeast surface-displayed cDNA libraries.
  Methods in molecular biology (Clifton, N.J.) 2011 Bidlingmaier S, Liu B
• Comprehensive analysis of yeast surface displayed cDNA library selection outputs by exon microarray to identify novel protein-ligand interactions.
  Molecular & cellular proteomics : MCP 2010 Bidlingmaier S, Wang Y, Liu Y, Zhang N, Liu B
• Nanoparticles modified with tumor-targeting scFv deliver siRNA and miRNA for cancer therapy.
  Molecular therapy : the journal of the American Society of Gene Therapy 2010 Chen Y, Zhu X, Zhang X, Liu B, Huang L
• Identification of internalizing human single antibodies targeting brain tumor stem cells
  Mol Cancer Ther. 2010 Zhu, X., Bidlingmaier, S., Hashizume, R., James, C.D., Berger, M.S., and Liu, B.
• Targeting prostate cancer cells in vivo using a rapidly internalizing novel human single chain antibody fragment
  J Nucl Med. 2010 He, J., Wang, Y., Feng, J., Zhu, J., Lan, X., Iyer, A.K., Zhang, N., Seo, Y., VanBrocklin, H.F., and Liu, B.
• Development of a highly stable and targetable nanoliposomal formulation of topotecan.
  Journal of controlled release : official journal of the Controlled Release Society 2009 Drummond DC, Noble CO, Guo Z, Hayes ME, Connolly-Ingram C, Gabriel BS, Hann B, Liu B, Park JW, Hong K, Benz CC, Marks JD, Kirpotin DB
• Identification of MCAM/CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma.
  Cancer research 2009 Bidlingmaier S, He J, Wang Y, An F, Feng J, Barbone D, Gao D, Franc B, Broaddus VC, Liu B
• Human antibodies targeting cell surface antigens overexpressed by the hormone refractory metastatic prostate cancer cells: ICAM-1 is a tumor antigen that mediates prostate cancer cell invasion
  J Mol Med. 2009 Conrad, F., Zhu, X., Zhang, X., Chalkley, R.J., Burlingame, A.L., Marks, J.D., and Liu, B.
• Targeted drug delivery to mesothelioma cells using functionally selected internalizing human single chain antibodies
  Mol Cancer Ther 2008 An, F., Drummond, D.C., Wilson, S., Kirpotin, D.B., Nishimura, S., Broaddus, C.V. and Liu, B.
• The utility and limitation of CD133 epitopes in defining tumor stem cell population
  J Mol Med. 2008 Bidlingmaier, S., Zhu, X., and Liu, B.
• Identification and characterization of tumor antigens by using antibody phage display and intrabody strategies.
  Molecular immunology 2007 Goenaga AL, Zhou Y, Legay C, Bougherara H, Huang L, Liu B, Drummond DC, Kirpotin DB, Auclair C, Marks JD, Poul MA
• Anti-CD166 single chain antibody-mediated intracellular delivery of liposomal drugs to prostate cancer cells
  Mol Cancer Ther 2007 Roth, A, Conrad, F., Hayes, M., Drummond, D.C., Kirpotin, D.B., Benz, C.C., Marks, J.D., and Liu, B.
• Explore Cell Type-Specific Internalizing Antibodies For Targeted siRNA Delivery
  Brief Funct Genomic Proteomic 2007 Liu, B.
• Interrogating yeast surface-displayed human proteome to identify small molecule-binding proteins
  Mol Cell Proteomics 2007 Bidlingmaier, S and Liu, B.
• Prostate cancer targeting recombinant human IgG1s
  J Mol Med 2007 Liu, B., Conrad, F., Roth, A., Drummond, D.C and Marks, J.D.
• Construction and application of a yeast surface-displayed human cDNA library to identify post-translational modification-dependent protein-protein interactions
  Mol Cell Proteomics 2006 Bidlingmaier, S. and Liu, B.
• Identification of clinically significant tumor antigens by selecting phage antibody library on tumor cells in situ using laser capture microdissection
  Mol Cell Proteomics 2006 Ruan, W., Sassoon, A., An, F., Simko, J.P., Liu, B.
• Mapping tumor epitope space by direct selection of single chain Fv antibody libraries on prostate cancer cells
  Cancer Res 2004 Liu, B., Conrad, F., Cooperberg, M.R., Kirpotin, D.B., Marks, J.D.
• Towards proteome-wide production of monoclonal antibody by phage display
  J Mol Biol 2002 Liu, B., Huang, L., Burlingame, A.L., Marks, J.D.
• Applying phage antibodies to proteomics: selecting single chain Fv antibodies to antigens blotted on nitrocellulose.
  Analytical biochemistry 2000 Liu B, Marks JD
• Head-on collision between a DNA replication apparatus and RNA polymerase transcription complex.
  Science (New York, N.Y.) 1995 Liu B, Alberts BM
• Organizational change as human process, not technique.
  NIDA research monograph 1995 Diamond MA
• A transcribing RNA polymerase molecule survives DNA replication without aborting its growing RNA chain.
  Proceedings of the National Academy of Sciences of the United States of America 1994 Liu B, Wong ML, Alberts B
• The DNA replication fork can pass RNA polymerase without displacing the nascent transcript.
  Nature 1993 Liu B, Wong ML, Tinker RL, Geiduschek EP, Alberts BM