Shoshana Zha, MD, PhD
Assistant Professor
Medicine
School of Medicine

Dr. Zha is a Pulmonary and Critical Care physician scientist. She specializes in the care of patients with bronchiectasis and nontuberculous mycobacterial pulmonary infections. She cofounded the Bronchiectasis and Pulmonary NTM Clinic at UCSF and attends in the Parnassus intensive care units. In addition, Dr. Zha conducts basic science research that focuses on understanding the innate immune response to mycobacterial infections.

Education & Training

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• Fellowship Pulmonary/Critical Care University of California, San Francisco 06/2020
• Residency Internal Medicine University of Washington 06/2016
• MD/PhD Medical College of Virginia 05/2013
• BS Neuroscience, Biochemistry College of William and Mary 05/2006

Interests

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• Bronchiectasis
• Innate Immunity
• Health Equity
• Nontuberculous mycobacterium
• Tuberculosis

Grants and Projects

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• Diversity and function of mononuclear phagocytes in the lung driven by mycobacterium tuberculosis infection, NHLBI, 2022-2027
• Describing the innate immune response of mycobacterium tuberculosis at a single-cell resolution, NIH, 2021-2022
• Mechanisms of HIV Protease Inhibitor-Induced Lipid Dysregulation in Adipocytes, NIH, 2009-2013

Publications (19)

Top publication keywords:
Macrophages, AlveolarAdipocytesHIV Protease InhibitorsAntibodies, ViralRitonavirAntibodies, NeutralizingMesotheliomaPeritoneal NeoplasmsEndoplasmic Reticulum StressAutophagyMycobacterium tuberculosisAntitubercular AgentsBerberineSpike Glycoprotein, CoronavirusTuberculosis

• Systematic functional interrogation of SARS-CoV-2 host factors using Perturb-seq.
  Nature communications 2023 Sunshine S, Puschnik AS, Replogle JM, Laurie MT, Liu J, Zha BS, Nuñez JK, Byrum JR, McMorrow AH, Frieman MB, Winkler J, Qiu X, Rosenberg OS, Leonetti MD, Ye CJ, Weissman JS, DeRisi JL, Hein MY
• A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling.
  iScience 2023 Hackney JA, Shivram H, Vander Heiden J, Overall C, Orozco L, Gao X, Kim E, West N, Qamra A, Chang D, Chakrabarti A, Choy DF, Combes AJ, Courau T, Fragiadakis GK, Rao AA, Ray A, Tsui J, Hu K, Kuhn NF, …
• Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection.
  Research square 2023 Zheng W, Chang IC, Limberis J, Budzik J, Zha BS, Howard Z, Chen L, Ernst J
• Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection.
  bioRxiv : the preprint server for biology 2023 Zheng W, Chang IC, Limberis J, Budzik JM, Zha BS, Howard Z, Chen L, Ernst JD
• Bacterial Strain-Dependent Dissociation of Cell Recruitment and Cell-to-Cell Spread in Early M. tuberculosis Infection.
  mBio 2022 Zha BS, Desvignes L, Fergus TJ, Cornelius A, Cheng TY, Moody DB, Ernst JD

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• Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
  medRxiv : the preprint server for health sciences 2021 Tsitsiklis A, Zha BS, Byrne A, DeVoe C, Rackaityte E, Levan S, Sunshine S, Mick E, Ghale R, Love C, Tarashansky AJ, Pisco A, Albright J, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, …
• Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS.
  Nature communications 2021 Sarma A, Christenson SA, Byrne A, Mick E, Pisco AO, DeVoe C, Deiss T, Ghale R, Zha BS, Tsitsiklis A, Jauregui A, Moazed F, Detweiler AM, Spottiswoode N, Sinha P, Neff N, Tan M, Serpa PH, Willmore A, …
• Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19.
  Research square 2021 Tsitsiklis A, Zha BS, Byrne A, Devoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson…
• COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone.
  Research square 2021 Sarma A, Christenson SA, Mick E, DeVoe C, Deiss T, Pisco AO, Ghale R, Jauregui A, Byrne A, Moazed F, Spottiswoode N, Sinha P, Zha BS, Neff N, Tan M, Serpa PH, Ansel KM, Wilson JG, Leligdowicz A, …
• An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
  Science (New York, N.Y.) 2020 Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE,…
• Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2.
  Nature chemical biology 2020 Bracken CJ, Lim SA, Solomon P, Rettko NJ, Nguyen DP, Zha BS, Schaefer K, Byrnes JR, Zhou J, Lui I, Liu J, Pance K, QCRG Structural Biology Consortium, Zhou XX, Leung KK, Wells JA
• Summary for Clinicians: 2020 Clinical Practice Guideline Summary for the Treatment of Nontuberculous Mycobacterial Pulmonary Disease.
  Annals of the American Thoracic Society 2020 Kurz SG, Zha BS, Herman DD, Holt MR, Daley CL, Ruminjo JK, Thomson CC
• Treatment of Drug-Susceptible Tuberculosis.
  Clinics in chest medicine 2019 Zha BS, Nahid P
• Difficult to Identify: Malignant Primary Peritoneal Mesothelioma.
  The American journal of medicine 2015 Zha BS, Flanagan M, Coulson C, Garvin KW
• HIV protease inhibitors disrupt lipid metabolism by activating endoplasmic reticulum stress and inhibiting autophagy activity in adipocytes.
  PloS one 2013 Zha BS, Wan X, Zhang X, Zha W, Zhou J, Wabitsch M, Wang G, Lyall V, Hylemon PB, Zhou H
• Inhibition of P-glycoprotein by HIV protease inhibitors increases intracellular accumulation of berberine in murine and human macrophages.
  PloS one 2013 Zha W, Wang G, Xu W, Liu X, Wang Y, Zha BS, Shi J, Zhao Q, Gerk PM, Studer E, Hylemon PB, Pandak WM, Zhou H
• The cellular pharmacokinetics of HIV protease inhibitors: current knowledge and future perspectives.
  Current drug metabolism 2012 Zha W, Zha BS, Zhou F, Zhou H, Wang G
• ER Stress and Lipid Metabolism in Adipocytes.
  Biochemistry research international 2012 Zha BS, Zhou H
• Cellular pharmacokinetic mechanisms of adriamycin resistance and its modulation by 20(S)-ginsenoside Rh2 in MCF-7/Adr cells.
  British journal of pharmacology 2012 Zhang J, Zhou F, Wu X, Zhang X, Chen Y, Zha BS, Niu F, Lu M, Hao G, Sun Y, Sun J, Peng Y, Wang G