Benoit Bruneau, PhD
Professor
Pediatrics
School of Medicine

We are primarily interested in regulation of these processes by transcriptional regulatory mechanisms that include DNA-binding transcription factors, chromatin remodeling complexes, and histone modifications. We have used this knowledge to understand disease mechanisms, but also to devise strategies for cardiac regeneration.

Why study heart development? We believe that primary defects in patterning in early heart development are at the root of congenital heart defects, which affect approximately 1% of live-born children, and we want to understand how these defects occur, to perhaps be able to uncover new and improved diagnostic or even therapeutic options. Also, by understanding how cardiac lineage specification occurs, we can better design stem cell-based interventions of cardiac repair, based on the knowledge of what drives an uncommitted cell towards a specific cardiac fate. We have recently focused our efforts on cardiac chromatin remodeling and modification factors, enzymes that unwind DNA or modify histones to turn genes on or off. We are particularly interested in how these factors control cardiac cell lineage decisions. These chromatin remodeling factors may also be key to pushing a stem cell into becoming a heart cell, perhaps opening up new avenues for cardiac regenerative medicine.

• TBXT dose sensitivity and the decoupling of nascent mesoderm specification from EMT progression in 2D human gastruloids.
  bioRxiv : the preprint server for biology 2023 Bulger EA, Muncie-Vasic I, Libby ARG, McDevitt TC, Bruneau BG
• Spatial and temporal organization of the genome: Current state and future aims of the 4D nucleome project.
  Molecular cell 2023 Dekker J, Alber F, Aufmkolk S, Beliveau BJ, Bruneau BG, Belmont AS, Bintu L, Boettiger A, Calandrelli R, Disteche CM, Gilbert DM, Gregor T, Hansen AS, Huang B, Huangfu D, Kalhor R, Leslie CS, Li W, Li…
• A Mesp1-dependent developmental breakpoint in transcriptional and epigenomic specification of early cardiac precursors.
  Development (Cambridge, England) 2023 Krup AL, Winchester SAB, Ranade SS, Agrawal A, Devine WP, Sinha T, Choudhary K, Dominguez MH, Thomas R, Black BL, Srivastava D, Bruneau BG
• Graded mesoderm assembly governs cell fate and morphogenesis of the early mammalian heart.
  Cell 2023 Dominguez MH, Krup AL, Muncie JM, Bruneau BG
• Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma.
  Nature communications 2023 Ferguson LP, Gatchalian J, McDermott ML, Nakamura M, Chambers K, Rajbhandari N, Lytle NK, Rosenthal SB, Hamilton M, Albini S, Wartenberg M, Zlobec I, Galván JA, Karamitopoulou E, Vavinskaya V, Wascher…
• Transcription Factor GATA4 Regulates Cell Type-Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitors.
  Circulation 2022 Zhu L, Choudhary K, Gonzalez-Teran B, Ang YS, Thomas R, Stone NR, Liu L, Zhou P, Zhu C, Ruan H, Huang Y, Jin S, Pelonero A, Koback F, Padmanabhan A, Sadagopan N, Hsu A, Costa MW, Gifford CA, van …
• Cell Layers: uncovering clustering structure in unsupervised single-cell transcriptomic analysis.
  Bioinformatics advances 2022 Blair AP, Hu RK, Farah EN, Chi NC, Pollard KS, Przytycki PF, Kathiriya IS, Bruneau BG
• Targeting transcription in heart failure via CDK7/12/13 inhibition.
  Nature communications 2022 Hsu A, Duan Q, Day DS, Luo X, McMahon S, Huang Y, Feldman ZB, Jiang Z, Zhang T, Liang Y, Alexanian M, Padmanabhan A, Brown JD, Lin CY, Gray NS, Young RA, Bruneau BG, Haldar SM
• Modeling congenital heart disease: lessons from mice, hPSC-based models, and organoids.
  Genes & development 2022 Rao KS, Kameswaran V, Bruneau BG
• Transcription factor protein interactomes reveal genetic determinants in heart disease.
  Cell 2022 Gonzalez-Teran B, Pittman M, Felix F, Thomas R, Richmond-Buccola D, Hüttenhain R, Choudhary K, Moroni E, Costa MW, Huang Y, Padmanabhan A, Alexanian M, Lee CY, Maven BEJ, Samse-Knapp K, Morton SU, …
• Brahma safeguards canalization of cardiac mesoderm differentiation.
  Nature 2022 Hota SK, Rao KS, Blair AP, Khalilimeybodi A, Hu KM, Thomas R, So K, Kameswaran V, Xu J, Polacco BJ, Desai RV, Chatterjee N, Hsu A, Muncie JM, Blotnick AM, Winchester SAB, Weinberger LS, Hüttenhain R, …
• Co-emergence of cardiac and gut tissues promotes cardiomyocyte maturation within human iPSC-derived organoids.
  Cell stem cell 2021 Silva AC, Matthys OB, Joy DA, Kauss MA, Natarajan V, Lai MH, Turaga D, Blair AP, Alexanian M, Bruneau BG, McDevitt TC
• Dissecting CTCF site function in a tense HoxD locus.
  Genes & development 2021 Bruneau BG
• Mechanisms of Congenital Heart Disease Caused by NAA15 Haploinsufficiency.
  Circulation research 2021 Ward T, Tai W, Morton S, Impens F, Van Damme P, Van Haver D, Timmerman E, Venturini G, Zhang K, Jang MY, Willcox JAL, Haghighi A, Gelb BD, Chung WK, Goldmuntz E, Porter GA, Lifton RP, Brueckner M, …
• Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease.
  Developmental cell 2020 Kathiriya IS, Rao KS, Iacono G, Devine WP, Blair AP, Hota SK, Lai MH, Garay BI, Thomas R, Gong HZ, Wasson LK, Goyal P, Sukonnik T, Hu KM, Akgun GA, Bernard LD, Akerberg BN, Gu F, Li K, Speir ML, …
• WAPL maintains a cohesin loading cycle to preserve cell-type-specific distal gene regulation.
  Nature genetics 2020 Liu NQ, Maresca M, van den Brand T, Braccioli L, Schijns MMGA, Teunissen H, Bruneau BG, Nora EP, de Wit E
• Molecular basis of CTCF binding polarity in genome folding.
  Nature communications 2020 Nora EP, Caccianini L, Fudenberg G, So K, Kameswaran V, Nagle A, Uebersohn A, Hajj B, Saux AL, Coulon A, Mirny LA, Pollard KS, Dahan M, Bruneau BG
• The developing heart: from The Wizard of Oz to congenital heart disease.
  Development (Cambridge, England) 2020 Bruneau BG
• Regulation of single-cell genome organization into TADs and chromatin nanodomains.
  Nature genetics 2020 Szabo Q, Donjon A, Jerkovic I, Papadopoulos GL, Cheutin T, Bonev B, Nora EP, Bruneau BG, Bantignies F, Cavalli G
• Author Correction: Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation.
  Nature immunology 2020 Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, Tognatta R, Yan Z, Pfaff …
• Author Correction: Defining the relative and combined contribution of CTCF and CTCFL to genomic regulation.
  Genome biology 2020 Nishana M, Ha C, Rodriguez-Hernaez J, Ranjbaran A, Chio E, Nora EP, Badri SB, Kloetgen A, Bruneau BG, Tsirigos A, Skok JA
• Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling.
  The Journal of clinical investigation 2020 Hsu A, Duan Q, McMahon S, Huang Y, Wood SA, Gray NS, Wang B, Bruneau BG, Haldar SM
• Cardiac natriuretic peptides.
  Nature reviews. Cardiology 2020 Goetze JP, Bruneau BG, Ramos HR, Ogawa T, de Bold MK, de Bold AJ
• Defining the relative and combined contribution of CTCF and CTCFL to genomic regulation.
  Genome biology 2020 Nishana M, Ha C, Rodriguez-Hernaez J, Ranjbaran A, Chio E, Nora EP, Badri SB, Kloetgen A, Bruneau BG, Tsirigos A, Skok JA
• Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation.
  Nature immunology 2020 Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, Tognatta R, Yan Z, Pfaff …
• Minimal in vivo requirements for developmentally regulated cardiac long intergenic non-coding RNAs.
  Development (Cambridge, England) 2019 George MR, Duan Q, Nagle A, Kathiriya IS, Huang Y, Rao K, Haldar SM, Bruneau BG
• CTCF confers local nucleosome resiliency after DNA replication and during mitosis.
  eLife 2019 Owens N, Papadopoulou T, Festuccia N, Tachtsidi A, Gonzalez I, Dubois A, Vandormael-Pournin S, Nora EP, Bruneau BG, Cohen-Tannoudji M, Navarro P
• Chromatin and epigenetics in development: a Special Issue.
  Development (Cambridge, England) 2019 Bruneau BG, Koseki H, Strome S, Torres-Padilla ME
• RNA Interactions Are Essential for CTCF-Mediated Genome Organization.
  Molecular cell 2019 Saldaña-Meyer R, Rodriguez-Hernaez J, Escobar T, Nishana M, Jácome-López K, Nora EP, Bruneau BG, Tsirigos A, Furlan-Magaril M, Skok J, Reinberg D
• Genome of the Komodo dragon reveals adaptations in the cardiovascular and chemosensory systems of monitor lizards.
  Nature ecology & evolution 2019 Lind AL, Lai YYY, Mostovoy Y, Holloway AK, Iannucci A, Mak ACY, Fondi M, Orlandini V, Eckalbar WL, Milan M, Rovatsos M, Kichigin IG, Makunin AI, Johnson Pokorná M, Altmanová M, Trifonov VA, Schijlen E…
• Dynamic BAF chromatin remodeling complex subunit inclusion promotes temporally distinct gene expression programs in cardiogenesis.
  Development (Cambridge, England) 2019 Hota SK, Johnson JR, Verschueren E, Thomas R, Blotnick AM, Zhu Y, Sun X, Pennacchio LA, Krogan NJ, Bruneau BG
• A De Novo Shape Motif Discovery Algorithm Reveals Preferences of Transcription Factors for DNA Shape Beyond Sequence Motifs.
  Cell systems 2019 Samee MAH, Bruneau BG, Pollard KS
• Identifying cis Elements for Spatiotemporal Control of Mammalian DNA Replication.
  Cell 2018 Sima J, Chakraborty A, Dileep V, Michalski M, Klein KN, Holcomb NP, Turner JL, Paulsen MT, Rivera-Mulia JC, Trevilla-Garcia C, Bartlett DA, Zhao PA, Washburn BK, Nora EP, Kraft K, Mundlos S, Bruneau …
• Heart enhancers with deeply conserved regulatory activity are established early in zebrafish development.
  Nature communications 2018 Yuan X, Song M, Devine P, Bruneau BG, Scott IC, Wilson MD
• Chromatin Domains Go on Repeat in Disease.
  Cell 2018 Bruneau BG, Nora EP
• A novel reporter allele for monitoring Dll4 expression within the embryonic and adult mouse.
  Biology open 2018 Herman AM, Rhyner AM, Devine WP, Marrelli SP, Bruneau BG, Wythe JD
• Cardiac-enriched BAF chromatin-remodeling complex subunit Baf60c regulates gene expression programs essential for heart development and function.
  Biology open 2018 Sun X, Hota SK, Zhou YQ, Novak S, Miguel-Perez D, Christodoulou D, Seidman CE, Seidman JG, Gregorio CC, Henkelman RM, Rossant J, Bruneau BG
• Targeted Degradation of CTCF Decouples Local Insulation of Chromosome Domains from Genomic Compartmentalization.
  Cell 2017 Nora EP, Goloborodko A, Valton AL, Gibcus JH, Uebersohn A, Abdennur N, Dekker J, Mirny LA, Bruneau BG
• Cooperative activation of cardiac transcription through myocardin bridging of paired MEF2 sites.
  Development (Cambridge, England) 2017 Anderson CM, Hu J, Thomas R, Gainous TB, Celona B, Sinha T, Dickel DE, Heidt AB, Xu SM, Bruneau BG, Pollard KS, Pennacchio LA, Black BL
• Single-Cell Resolution of Temporal Gene Expression during Heart Development.
  Developmental cell 2016 DeLaughter DM, Bick AG, Wakimoto H, McKean D, Gorham JM, Kathiriya IS, Hinson JT, Homsy J, Gray J, Pu W, Bruneau BG, Seidman JG, Seidman CE
• ATP-dependent chromatin remodeling during mammalian development.
  Development (Cambridge, England) 2016 Hota SK, Bruneau BG
• Loss of Iroquois homeobox transcription factors 3 and 5 in osteoblasts disrupts cranial mineralization.
  Bone reports 2016 Cain CJ, Gaborit N, Lwin W, Barruet E, Ho S, Bonnard C, Hamamy H, Shboul M, Reversade B, Kayserili H, Bruneau BG, Hsiao EC
• Expandable Cardiovascular Progenitor Cells Reprogrammed from Fibroblasts.
  Cell stem cell 2016 Zhang Y, Cao N, Huang Y, Spencer CI, Fu JD, Yu C, Liu K, Nie B, Xu T, Li K, Xu S, Bruneau BG, Srivastava D, Ding S
• KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation.
  Development (Cambridge, England) 2016 Ang SY, Uebersohn A, Spencer CI, Huang Y, Lee JE, Ge K, Bruneau BG
• Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis.
  Cell 2016 Luna-Zurita L, Stirnimann CU, Glatt S, Kaynak BL, Thomas S, Baudin F, Samee MA, He D, Small EM, Mileikovsky M, Nagy A, Holloway AK, Pollard KS, Müller CW, Bruneau BG
• Accelerated Evolution of Enhancer Hotspots in the Mammal Ancestor.
  Molecular biology and evolution 2015 Holloway AK, Bruneau BG, Sukonnik T, Rubenstein JL, Pollard KS
• Polycomb Regulates Mesoderm Cell Fate-Specification in Embryonic Stem Cells through Activation and Repression Mechanisms.
  Cell stem cell 2015 Morey L, Santanach A, Blanco E, Aloia L, Nora EP, Bruneau BG, Di Croce L
• Brg1 modulates enhancer activation in mesoderm lineage commitment.
  Development (Cambridge, England) 2015 Alexander JM, Hota SK, He D, Thomas S, Ho L, Pennacchio LA, Bruneau BG
• Human disease modeling reveals integrated transcriptional and epigenetic mechanisms of NOTCH1 haploinsufficiency.
  Cell 2015 Theodoris CV, Li M, White MP, Liu L, He D, Pollard KS, Bruneau BG, Srivastava D
• Evolution of lysine acetylation in the RNA polymerase II C-terminal domain.
  BMC evolutionary biology 2015 Simonti CN, Pollard KS, Schröder S, He D, Bruneau BG, Ott M, Capra JA
• Investigating the transcriptional control of cardiovascular development.
  Circulation research 2015 Kathiriya IS, Nora EP, Bruneau BG
• Looking inwards: opening a window onto human development.
  Development (Cambridge, England) 2015 Pourquié O, Bruneau B, Keller G, Smith A
• Ezh2-mediated repression of a transcriptional pathway upstream of Mmp9 maintains integrity of the developing vasculature.
  Development (Cambridge, England) 2014 Delgado-Olguín P, Dang LT, He D, Thomas S, Chi L, Sukonnik T, Khyzha N, Dobenecker MW, Fish JE, Bruneau BG
• Early patterning and specification of cardiac progenitors in gastrulating mesoderm.
  eLife 2014 Devine WP, Wythe JD, George M, Koshiba-Takeuchi K, Bruneau BG
• Finding a niche for cardiac precursors.
  eLife 2014 Bruneau BG
• HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles.
  Genes & development 2014 Saccone V, Consalvi S, Giordani L, Mozzetta C, Barozzi I, Sandoná M, Ryan T, Rojas-Muñoz A, Madaro L, Fasanaro P, Borsellino G, De Bardi M, Frigè G, Termanini A, Sun X, Rossant J, Bruneau BG, Mercola …
• Function-based identification of mammalian enhancers using site-specific integration.
  Nature methods 2014 Dickel DE, Zhu Y, Nord AS, Wylie JN, Akiyama JA, Afzal V, Plajzer-Frick I, Kirkpatrick A, Göttgens B, Bruneau BG, Visel A, Pennacchio LA
• Congenital heart disease: entering a new era of human genetics.
  Circulation research 2014 Bruneau BG, Srivastava D
• Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells.
  Molecular cell 2013 Schröder S, Herker E, Itzen F, He D, Thomas S, Gilchrist DA, Kaehlcke K, Cho S, Pollard KS, Capra JA, Schnölzer M, Cole PA, Geyer M, Bruneau BG, Adelman K, Ott M
• An interview with Benoit Bruneau.
  Development (Cambridge, England) 2013 Bruneau B
• Chromatin modulators as facilitating factors in cellular reprogramming.
  Current opinion in genetics & development 2013 Luna-Zurita L, Bruneau BG
• Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state.
  Stem cell reports 2013 Fu JD, Stone NR, Liu L, Spencer CI, Qian L, Hayashi Y, Delgado-Olguin P, Ding S, Bruneau BG, Srivastava D
• ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice.
  PLoS genetics 2013 Kelsey L, Flenniken AM, Qu D, Funnell AP, Pearson R, Zhou YQ, Voronina I, Berberovic Z, Wood G, Newbigging S, Weiss ES, Wong M, Quach I, Yeh SY, Deshwar AR, Scott IC, McKerlie C, Henkelman M, Backx P,…
• ETS factors regulate Vegf-dependent arterial specification.
  Developmental cell 2013 Wythe JD, Dang LT, Devine WP, Boudreau E, Artap ST, He D, Schachterle W, Stainier DY, Oettgen P, Black BL, Bruneau BG, Fish JE
• Stem cells and regeneration: a special issue.
  Development (Cambridge, England) 2013 Pourquié O, Bruneau B, Götz M, Keller G, Smith A
• The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage.
  Genome biology 2013 Shaffer HB, Minx P, Warren DE, Shedlock AM, Thomson RC, Valenzuela N, Abramyan J, Amemiya CT, Badenhorst D, Biggar KK, Borchert GM, Botka CW, Bowden RM, Braun EL, Bronikowski AM, Bruneau BG, Buck LT, …
• Signaling and transcriptional networks in heart development and regeneration.
  Cold Spring Harbor perspectives in biology 2013 Bruneau BG
• Regulation of retinal interneuron subtype identity by the Iroquois homeobox gene Irx6.
  Development (Cambridge, England) 2012 Star EN, Zhu M, Shi Z, Liu H, Pashmforoush M, Sauve Y, Bruneau BG, Chow RL
• Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology.
  Development (Cambridge, England) 2012 Gaborit N, Sakuma R, Wylie JN, Kim KH, Zhang SS, Hui CC, Bruneau BG
• Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage.
  Cell 2012 Wamstad JA, Alexander JM, Truty RM, Shrikumar A, Li F, Eilertson KE, Ding H, Wylie JN, Pico AR, Capra JA, Erwin G, Kattman SJ, Keller GM, Srivastava D, Levine SS, Pollard KS, Holloway AK, Boyer LA, …
• Iroquois homeodomain transcription factors in heart development and function.
  Circulation research 2012 Kim KH, Rosen A, Bruneau BG, Hui CC, Backx PH
• Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis.
  Nature genetics 2012 Delgado-Olguín P, Huang Y, Li X, Christodoulou D, Seidman CE, Seidman JG, Tarakhovsky A, Bruneau BG
• Epigenetics and cardiovascular development.
  Annual review of physiology 2011 Chang CP, Bruneau BG
• Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Zhang SS, Kim KH, Rosen A, Smyth JW, Sakuma R, Delgado-Olguín P, Davis M, Chi NC, Puviindran V, Gaborit N, Sukonnik T, Wylie JN, Brand-Arzamendi K, Farman GP, Kim J, Rose RA, Marsden PA, Zhu Y, Zhou …
• Atrial natriuretic factor in the developing heart: a signpost for cardiac morphogenesis.
  Canadian journal of physiology and pharmacology 2011 Bruneau BG
• Ezh2 regulates anteroposterior axis specification and proximodistal axis elongation in the developing limb.
  Development (Cambridge, England) 2011 Wyngaarden LA, Delgado-Olguin P, Su IH, Bruneau BG, Hopyan S
• Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species.
  The Journal of cell biology 2011 Qian L, Wythe JD, Liu J, Cartry J, Vogler G, Mohapatra B, Otway RT, Huang Y, King IN, Maillet M, Zheng Y, Crawley T, Taghli-Lamallem O, Semsarian C, Dunwoodie S, Winlaw D, Harvey RP, Fatkin D, Towbin …
• A Slit/miR-218/Robo regulatory loop is required during heart tube formation in zebrafish.
  Development (Cambridge, England) 2011 Fish JE, Wythe JD, Xiao T, Bruneau BG, Stainier DY, Srivastava D, Woo S
• Chromatin remodelling complex dosage modulates transcription factor function in heart development.
  Nature communications 2011 Takeuchi JK, Lou X, Alexander JM, Sugizaki H, Delgado-Olguín P, Holloway AK, Mori AD, Wylie JN, Munson C, Zhu Y, Zhou YQ, Yeh RF, Henkelman RM, Harvey RP, Metzger D, Chambon P, Stainier DY, Pollard KS…
• CTCF promotes muscle differentiation by modulating the activity of myogenic regulatory factors.
  The Journal of biological chemistry 2011 Delgado-Olguín P, Brand-Arzamendi K, Scott IC, Jungblut B, Stainier DY, Bruneau BG, Recillas-Targa F
• An endocardial pathway involving Tbx5, Gata4, and Nos3 required for atrial septum formation.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Nadeau M, Georges RO, Laforest B, Yamak A, Lefebvre C, Beauregard J, Paradis P, Bruneau BG, Andelfinger G, Nemer M
• Shox2 mediates Tbx5 activity by regulating Bmp4 in the pacemaker region of the developing heart.
  Human molecular genetics 2010 Puskaric S, Schmitteckert S, Mori AD, Glaser A, Schneider KU, Bruneau BG, Blaschke RJ, Steinbeisser H, Rappold G
• Chromatin remodeling in heart development.
  Current opinion in genetics & development 2010 Bruneau BG
• Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors.
  Cell 2010 Ieda M, Fu JD, Delgado-Olguin P, Vedantham V, Hayashi Y, Bruneau BG, Srivastava D
• Epigenetic regulation of the cardiovascular system: introduction to a review series.
  Circulation research 2010 Bruneau BG
• Lessons for cardiac regeneration and repair through development.
  Trends in molecular medicine 2010 Alexander JM, Bruneau BG
• Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes.
  Human molecular genetics 2010 Kuo YM, Li Z, Jiao Y, Gaborit N, Pani AK, Orrison BM, Bruneau BG, Giasson BI, Smeyne RJ, Gershon MD, Nussbaum RL
• The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1.
  The Journal of biological chemistry 2009 Fouladkou F, Lu C, Jiang C, Zhou L, She Y, Walls JR, Kawabe H, Brose N, Henkelman RM, Huang A, Bruneau BG, Rotin D
• Reptilian heart development and the molecular basis of cardiac chamber evolution.
  Nature 2009 Koshiba-Takeuchi K, Mori AD, Kaynak BL, Cebra-Thomas J, Sukonnik T, Georges RO, Latham S, Beck L, Beck L, Henkelman RM, Black BL, Olson EN, Wade J, Takeuchi JK, Nemer M, Gilbert SF, Bruneau BG
• NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes.
  PloS one 2009 Riazi AM, Takeuchi JK, Hornberger LK, Zaidi SH, Amini F, Coles J, Bruneau BG, Van Arsdell GS
• Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors.
  Nature 2009 Takeuchi JK, Bruneau BG
• Alternative induced pluripotent stem cell characterization criteria for in vitro applications.
  Cell stem cell 2009 Ellis J, Bruneau BG, Keller G, Lemischka IR, Nagy A, Rossant J, Srivastava D, Zandstra PW, Stanford WL
• Influence of cysteamine on in vitro maturation, in vitro and in vivo fertilization of equine oocytes.
  Reproduction in domestic animals = Zuchthygiene 2008 Deleuze S, Dubois CS, Caillaud M, Bruneau B, Goudet G, Duchamp G
• miR-126 regulates angiogenic signaling and vascular integrity.
  Developmental cell 2008 Fish JE, Santoro MM, Morton SU, Yu S, Yeh RF, Wythe JD, Ivey KN, Bruneau BG, Stainier DY, Srivastava D
• Tbx5-dependent pathway regulating diastolic function in congenital heart disease.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Zhu Y, Gramolini AO, Walsh MA, Zhou YQ, Slorach C, Friedberg MK, Takeuchi JK, Sun H, Henkelman RM, Backx PH, Redington AN, Maclennan DH, Bruneau BG
• The developmental genetics of congenital heart disease.
  Nature 2008 Bruneau BG
• 4D cardiac MRI in the mouse.
  NMR in biomedicine 2007 Feintuch A, Zhu Y, Bishop J, Davidson L, Dazai J, Bruneau BG, Henkelman RM
• The heart's Da Vinci code: a Renaissance at Keystone.
  Development (Cambridge, England) 2007 Bruneau BG, Black BL
• Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry.
  Proceedings of the National Academy of Sciences of the United States of America 2007 Takeuchi JK, Lickert H, Bisgrove BW, Sun X, Yamamoto M, Chawengsaksophak K, Hamada H, Yost HJ, Rossant J, Bruneau BG
• Irxl1, a divergent Iroquois homeobox family transcription factor gene.
  Gene expression patterns : GEP 2006 Takeuchi JK, Bruneau BG
• Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis.
  Developmental biology 2006 Mori AD, Zhu Y, Vahora I, Nieman B, Koshiba-Takeuchi K, Davidson L, Pizard A, Seidman JG, Seidman CE, Chen XJ, Henkelman RM, Bruneau BG
• Chromatin modification and remodeling in heart development.
  TheScientificWorldJournal 2006 Delgado-Olguín P, Takeuchi JK, Bruneau BG
• [Irx5: a transcription factor that regulates the cardiac repolarization gradient].
  Medecine sciences : M/S 2006 Bruneau BG
• Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart.
  Nature genetics 2005 Koshiba-Takeuchi K, Takeuchi JK, Arruda EP, Kathiriya IS, Mo R, Hui CC, Srivastava D, Bruneau BG
• The homeodomain transcription factor Irx5 establishes the mouse cardiac ventricular repolarization gradient.
  Cell 2005 Costantini DL, Arruda EP, Agarwal P, Kim KH, Zhu Y, Zhu W, Lebel M, Cheng CW, Park CY, Pierce SA, Guerchicoff A, Pollevick GD, Chan TY, Kabir MG, Cheng SH, Husain M, Antzelevitch C, Srivastava D, …
• A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia.
  Development (Cambridge, England) 2005 Flenniken AM, Osborne LR, Anderson N, Ciliberti N, Fleming C, Gittens JE, Gong XQ, Kelsey LB, Lounsbury C, Moreno L, Nieman BJ, Peterson K, Qu D, Roscoe W, Shao Q, Tong D, Veitch GI, Voronina I, …
• The Iroquois homeobox gene, Irx5, is required for retinal cone bipolar cell development.
  Developmental biology 2005 Cheng CW, Chow RL, Lebel M, Sakuma R, Cheung HO, Thanabalasingham V, Zhang X, Bruneau BG, Birch DG, Hui CC, McInnes RR, Cheng SH
• Genome-wide analysis of mouse transcripts using exon microarrays and factor graphs.
  Nature genetics 2005 Frey BJ, Mohammad N, Morris QD, Zhang W, Robinson MD, Mnaimneh S, Chang R, Pan Q, Sat E, Rossant J, Bruneau BG, Aubin JE, Blencowe BJ, Hughes TR
• Developmental biology: tiny brakes for a growing heart.
  Nature 2005 Bruneau BG
• Connexin 40, a target of transcription factor Tbx5, patterns wrist, digits, and sternum.
  Molecular and cellular biology 2005 Pizard A, Burgon PG, Paul DL, Bruneau BG, Seidman CE, Seidman JG
• Abnormal cardiac inflow patterns during postnatal development in a mouse model of Holt-Oram syndrome.
  American journal of physiology. Heart and circulatory physiology 2005 Zhou YQ, Zhu Y, Bishop J, Davidson L, Henkelman RM, Bruneau BG, Foster FS
• Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development.
  Development (Cambridge, England) 2005 Takeuchi JK, Mileikovskaia M, Koshiba-Takeuchi K, Heidt AB, Mori AD, Arruda EP, Gertsenstein M, Georges R, Davidson L, Mo R, Hui CC, Henkelman RM, Nemer M, Black BL, Nagy A, Bruneau BG
• Serum response factor, an enriched cardiac mesoderm obligatory factor, is a downstream gene target for Tbx genes.
  The Journal of biological chemistry 2004 Barron MR, Belaguli NS, Zhang SX, Trinh M, Iyer D, Merlo X, Lough JW, Parmacek MS, Bruneau BG, Schwartz RJ
• The functional landscape of mouse gene expression.
  Journal of biology 2004 Zhang W, Morris QD, Chang R, Shai O, Bakowski MA, Mitsakakis N, Mohammad N, Robinson MD, Zirngibl R, Somogyi E, Laurin N, Eftekharpour E, Sat E, Grigull J, Pan Q, Peng WT, Krogan N, Greenblatt J, …
• Baf60c is essential for function of BAF chromatin remodelling complexes in heart development.
  Nature 2004 Lickert H, Takeuchi JK, Von Both I, Walls JR, McAuliffe F, Adamson SL, Henkelman RM, Wrana JL, Rossant J, Bruneau BG
• Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity.
  The EMBO journal 2004 McPherson JP, Tamblyn L, Elia A, Migon E, Shehabeldin A, Matysiak-Zablocki E, Lemmers B, Salmena L, Hakem A, Fish J, Kassam F, Squire J, Bruneau BG, Hande MP, Hakem R
• The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system.
  Development (Cambridge, England) 2004 Moskowitz IP, Pizard A, Patel VV, Bruneau BG, Kim JB, Kupershmidt S, Roden D, Berul CI, Seidman CE, Seidman JG
• Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract.
  Development (Cambridge, England) 2004 Xu H, Morishima M, Wylie JN, Schwartz RJ, Bruneau BG, Lindsay EA, Baldini A
• TBX5 mutations and congenital heart disease: Holt-Oram syndrome revealed.
  Current opinion in cardiology 2004 Mori AD, Bruneau BG
• The Iroquois homeobox gene Irx2 is not essential for normal development of the heart and midbrain-hindbrain boundary in mice.
  Molecular and cellular biology 2003 Lebel M, Agarwal P, Cheng CW, Kabir MG, Chan TY, Thanabalasingham V, Zhang X, Cohen DR, Husain M, Cheng SH, Bruneau BG, Hui CC
• Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart.
  Developmental biology 2003 Stennard FA, Costa MW, Elliott DA, Rankin S, Haast SJ, Lai D, McDonald LP, Niederreither K, Dolle P, Bruneau BG, Zorn AM, Harvey RP
• Tbx5 is required for forelimb bud formation and continued outgrowth.
  Development (Cambridge, England) 2003 Rallis C, Bruneau BG, Del Buono J, Seidman CE, Seidman JG, Nissim S, Tabin CJ, Logan MP
• The developing heart and congenital heart defects: a make or break situation.
  Clinical genetics 2003 Bruneau BG
• Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo.
  Development (Cambridge, England) 2003 Agarwal P, Wylie JN, Galceran J, Arkhitko O, Li C, Deng C, Grosschedl R, Bruneau BG
• Transcriptional regulation of vertebrate cardiac morphogenesis.
  Circulation research 2002 Bruneau BG
• A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease.
  Cell 2001 Bruneau BG, Nemer G, Schmitt JP, Charron F, Robitaille L, Caron S, Conner DA, Gessler M, Nemer M, Seidman CE, Seidman JG
• Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression.
  Molecular and cellular biology 2001 Bruneau BG, Bao ZZ, Fatkin D, Xavier-Neto J, Georgakopoulos D, Maguire CT, Berul CI, Kass DA, Kuroski-de Bold ML, de Bold AJ, Conner DA, Rosenthal N, Cepko CL, Seidman CE, Seidman JG
• Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand.
  Developmental biology 2000 Bruneau BG, Bao ZZ, Tanaka M, Schott JJ, Izumo S, Cepko CL, Seidman JG, Seidman CE
• Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrome.
  Developmental biology 1999 Bruneau BG, Logan M, Davis N, Levi T, Tabin CJ, Seidman JG, Seidman CE
• Characterization of natriuretic peptide production by adult heart atria.
  The American journal of physiology 1999 Ogawa T, Vatta M, Bruneau BG, de Bold AJ
• Regulation of chamber-specific gene expression in the developing heart by Irx4.
  Science (New York, N.Y.) 1999 Bao ZZ, Bruneau BG, Seidman JG, Seidman CE, Cepko CL
• BNP gene expression is specifically modulated by stretch and ET-1 in a new model of isolated rat atria.
  The American journal of physiology 1997 Bruneau BG, Piazza LA, de Bold AJ
• Tissue-specific regulation of renal and cardiac atrial natriuretic factor gene expression in deoxycorticosterone acetate-salt rats.
  Hypertension (Dallas, Tex. : 1979) 1997 Ogawa T, Bruneau BG, Yokota N, de Bold ML, de Bold AJ
• Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome.
  Nature genetics 1997 Bamshad M, Lin RC, Law DJ, Watkins WC, Krakowiak PA, Moore ME, Franceschini P, Lala R, Holmes LB, Gebuhr TC, Bruneau BG, Schinzel A, Seidman JG, Seidman CE, Jorde LB
• Evidence for load-dependent and load-independent determinants of cardiac natriuretic peptide production.
  Circulation 1996 Ogawa T, Linz W, Stevenson M, Bruneau BG, Kuroski de Bold ML, Chen JH, Eid H, Schölkens BA, de Bold AJ
• Alpha 1-adrenergic stimulation of isolated rat atria results in discoordinate increases in natriuretic peptide secretion and gene expression and enhances Egr-1 and c-Myc expression.
  Endocrinology 1996 Bruneau BG, Piazza LA, de Bold AJ
• Mechanical and neuroendocrine regulation of the endocrine heart.
  Cardiovascular research 1996 de Bold AJ, Bruneau BG, Kuroski de Bold ML
• Dissociation of cardiac hypertrophy, myosin heavy chain isoform expression, and natriuretic peptide production in DOCA-salt rats.
  American journal of hypertension 1995 Yokota N, Bruneau BG, Fernandez BE, de Bold ML, Piazza LA, Eid H, de Bold AJ
• Atrial natriuretic factor significantly contributes to the mineralocorticoid escape phenomenon. Evidence for a guanylate cyclase-mediated pathway.
  The Journal of clinical investigation 1994 Yokota N, Bruneau BG, Kuroski de Bold ML, de Bold AJ
• Selective changes in natriuretic peptide and early response gene expression in isolated rat atria following stimulation by stretch or endothelin-1.
  Cardiovascular research 1994 Bruneau BG, de Bold AJ