Benjamin Tang, PhD
Associate Professor
Institute for Neurodegenerative Diseases
School of Medicine

Education & Training

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• Diversity, Equity, and Inclusion Champion Training University of California 2018
• PhD Chemical and Biomolecular Engineering Johns Hopkins University 06/2009
• BChE Chemical Engineering University of Delaware 05/2003

Interests

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• Drug metabolism
• Drug delivery
• Nanoparticles
• Neurodegenerative diseases
• Biomaterials
• Pharmacokinetics

Websites

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• IND (ind.ucsf.edu)

Publications (25)

Top publication keywords:
Boronic AcidsAngiotensin II Type 1 Receptor BlockersThiazolidinesEtoposideAnhydridesAntiparkinson AgentsDecanoic AcidsGlucoseDrug CarriersCervix MucusDicarboxylic AcidsPolyethylene GlycolsNanoparticlesDrug Delivery SystemsSmall Cell Lung Carcinoma

• A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons.
  eLife 2021 Kim GJ, Mo H, Liu H, Wu Z, Chen S, Zheng J, Zhao X, Nucum D, Shortland J, Peng L, Elepano M, Tang B, Olson S, Paras N, Li H, Renslo AR, Arkin MR, Huang B, Lu B, Sirota M, Guo S
• Inhibitors of heat shock protein 70 (Hsp70) with enhanced metabolic stability reduce tau levels.
  Bioorganic & medicinal chemistry letters 2021 Shao H, Li X, Hayashi S, Bertron JL, Schwarz DMC, Tang BC, Gestwicki JE
• Discovery of 4-Piperazine Isoquinoline Derivatives as Potent and Brain-Permeable Tau Prion Inhibitors with CDK8 Activity.
  ACS medicinal chemistry letters 2020 Grandjean JM, Jiu AY, West JW, Aoyagi A, Droege DG, Elepano M, Hirasawa M, Hirouchi M, Murakami R, Lee J, Sasaki K, Hirano S, Ohyama T, Tang BC, Vaz RJ, Inoue M, Olson SH, Prusiner SB, Conrad J, Paras…
• Nanoparticles that do not adhere to mucus provide uniform and long-lasting drug delivery to airways following inhalation.
  Science advances 2017 Schneider CS, Xu Q, Boylan NJ, Chisholm J, Tang BC, Schuster BS, Henning A, Ensign LM, Lee E, Adstamongkonkul P, Simons BW, Wang SS, Gong X, Yu T, Boyle MP, Suk JS, Hanes J
• Injectable and Glucose-Responsive Hydrogels Based on Boronic Acid-Glucose Complexation.
  Langmuir : the ACS journal of surfaces and colloids 2016 Dong Y, Wang W, Veiseh O, Appel EA, Xue K, Webber MJ, Tang BC, Yang XW, Weir GC, Langer R, Anderson DG

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• Frontline Science: Splenic progenitors aid in maintaining high neutrophil numbers at sites of sterile chronic inflammation.
  Journal of leukocyte biology 2016 Jhunjhunwala S, Alvarez D, Aresta-DaSilva S, Tang K, Tang BC, Greiner DL, Newburger PE, von Andrian UH, Langer R, Anderson DG
• Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo.
  Nano letters 2016 Dong Y, Dorkin JR, Wang W, Chang PH, Webber MJ, Tang BC, Yang J, Abutbul-Ionita I, Danino D, DeRosa F, Heartlein M, Langer R, Anderson DG
• Neutrophil Responses to Sterile Implant Materials.
  PloS one 2015 Jhunjhunwala S, Aresta-DaSilva S, Tang K, Alvarez D, Webber MJ, Tang BC, Lavin DM, Veiseh O, Doloff JC, Bose S, Vegas A, Ma M, Sahay G, Chiu A, Bader A, Langan E, Siebert S, Li J, Greiner DL, …
• Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Chou DH, Webber MJ, Tang BC, Lin AB, Thapa LS, Deng D, Truong JV, Cortinas AB, Langer R, Anderson DG
• Managing diabetes with nanomedicine: challenges and opportunities.
  Nature reviews. Drug discovery 2014 Veiseh O, Tang BC, Whitehead KA, Anderson DG, Langer R
• A perspective on the clinical translation of scaffolds for tissue engineering.
  Annals of biomedical engineering 2014 Webber MJ, Khan OF, Sydlik SA, Tang BC, Langer R
• Intraperitoneal delivery of paclitaxel by poly(ether-anhydride) microspheres effectively suppresses tumor growth in a murine metastatic ovarian cancer model.
  Drug delivery and translational research 2014 Yang M, Yu T, Wood J, Wang YY, Tang BC, Zeng Q, Simons BW, Fu J, Chuang CM, Lai SK, Wu TC, Hung CF, Hanes J
• Lipid-like nanomaterials for simultaneous gene expression and silencing in vivo.
  Advanced healthcare materials 2014 Dong Y, Eltoukhy AA, Alabi CA, Khan OF, Veiseh O, Dorkin JR, Sirirungruang S, Yin H, Tang BC, Pelet JM, Chen D, Gu Z, Xue Y, Langer R, Anderson DG
• Vaginal delivery of paclitaxel via nanoparticles with non-mucoadhesive surfaces suppresses cervical tumor growth.
  Advanced healthcare materials 2013 Yang M, Yu T, Wang YY, Lai SK, Zeng Q, Miao B, Tang BC, Simons BW, Ensign LM, Liu G, Chan KW, Juang CY, Mert O, Wood J, Fu J, McMahon MT, Wu TC, Hung CF, Hanes J
• Microneedle electrodes toward an amperometric glucose-sensing smart patch.
  Advanced healthcare materials 2013 Invernale MA, Tang BC, York RL, Le L, Hou DY, Anderson DG
• Glucose-responsive microgels integrated with enzyme nanocapsules for closed-loop insulin delivery.
  ACS nano 2013 Gu Z, Dang TT, Ma M, Tang BC, Cheng H, Jiang S, Dong Y, Zhang Y, Anderson DG
• Mucus-penetrating nanoparticles for vaginal drug delivery protect against herpes simplex virus.
  Science translational medicine 2012 Ensign LM, Tang BC, Wang YY, Tse TA, Hoen T, Cone R, Hanes J
• Real-time gene delivery vector tracking in the endo-lysosomal pathway of live cells.
  Microscopy research and technique 2011 Suh J, An Y, Tang BC, Dempsey C, Huang F, Hanes J
• N-acetylcysteine enhances cystic fibrosis sputum penetration and airway gene transfer by highly compacted DNA nanoparticles.
  Molecular therapy : the journal of the American Society of Gene Therapy 2011 Suk JS, Boylan NJ, Trehan K, Tang BC, Schneider CS, Lin JM, Boyle MP, Zeitlin PL, Lai SK, Cooper MJ, Hanes J
• Development of delivery methods for carbohydrate-based drugs: controlled release of biologically-active short chain fatty acid-hexosamine analogs.
  Glycoconjugate journal 2010 Aich U, Meledeo MA, Sampathkumar SG, Fu J, Jones MB, Weier CA, Chung SY, Tang BC, Yang M, Hanes J, Yarema KJ
• Pentastatin-1, a collagen IV derived 20-mer peptide, suppresses tumor growth in a small cell lung cancer xenograft model.
  BMC cancer 2010 Koskimaki JE, Karagiannis ED, Tang BC, Hammers H, Watkins DN, Pili R, Popel AS
• Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Tang BC, Dawson M, Lai SK, Wang YY, Suk JS, Yang M, Zeitlin P, Boyle MP, Fu J, Hanes J
• Enhanced efficacy of local etoposide delivery by poly(ether-anhydride) particles against small cell lung cancer in vivo.
  Biomaterials 2009 Tang BC, Fu J, Watkins DN, Hanes J
• PEGylation of nanoparticles improves their cytoplasmic transport.
  International journal of nanomedicine 2007 Suh J, Choy KL, Lai SK, Suk JS, Tang BC, Prabhu S, Hanes J
• Protein disulfide isomerase, but not binding protein, overexpression enhances secretion of a non-disulfide-bonded protein in yeast.
  Biotechnology and bioengineering 2004 Smith JD, Tang BC, Robinson AS