Benjamin Huang, MD
Assistant Professor
Pediatrics
School of Medicine

He is a contributing member within the UCSF Helen Diller Family Comprehensive Cancer Center and several national committees; including the Children's Oncology Group (COG) Myeloid Committee, the COG AML Biology Steering Committee, and the Leukemia and Lymphoma Society (LLS) Pediatric Acute Leukemia (PedAL) Initiative Translational Science Team Committee.

• 5G2 mutant mice model loss of a commonly deleted segment of chromosome 7q22 in myeloid malignancies.
  Leukemia 2024 Wong JC, Weinfurtner KM, Westover T, Kim J, Lebish EJ, Del Pilar Alzamora M, Huang BJ, Walsh M, Abdelhamed S, Ma J, Klco JM, Shannon K
• Prognostic Impact of Co-occurring Mutations in FLT3-ITD Pediatric Acute Myeloid Leukemia.
  Blood advances 2024 Tarlock K, Gerbing RB, Ries RE, Smith JL, Leonti AR, Huang BJ, Kirkey DC, Robinson L, Peplinski JH, Lange B, Cooper TM, Gamis AS, Kolb EA, Aplenc R, Pollard JA, Meshinchi S
• A new genomic framework to categorize pediatric acute myeloid leukemia.
  Nature genetics 2024 Umeda M, Ma J, Westover T, Ni Y, Song G, Maciaszek JL, Rusch M, Rahbarinia D, Foy S, Huang BJ, Walsh MP, Kumar P, Liu Y, Yang W, Fan Y, Wu G, Baker SD, Ma X, Wang L, Alonzo TA, Rubnitz JE, Pounds S, …
• Framework humanization optimizes potency of anti-CD72 nanobody CAR-T cells for B-cell malignancies.
  Journal for immunotherapy of cancer 2023 Temple WC, Nix MA, Naik A, Izgutdina A, Huang BJ, Wicaksono G, Phojanakong P, Serrano JAC, Young EP, Ramos E, Salangsang F, Steri V, Xirenayi S, Hermiston M, Logan AC, Stieglitz E, Wiita AP
• Structural surfaceomics reveals an AML-specific conformation of integrin β2 as a CAR T cellular therapy target.
  Nature cancer 2023 Mandal K, Wicaksono G, Yu C, Adams JJ, Hoopmann MR, Temple WC, Izgutdina A, Escobar BP, Gorelik M, Ihling CH, Nix MA, Naik A, Xie WH, Hübner J, Rollins LA, Reid SM, Ramos E, Kasap C, Steri V, Serrano …
• Hemophagocytic lymphohistiocytosis and clonally related T-cell malignancies in a pediatric patient.
  Pediatric blood & cancer 2023 Meyer LK, Huang I, Huang BJ, Chung JH, Pawar A, Hermiston ML, Loh ML, Ohgami RS, Ruiz-Cordero R, Bhargava P, Marinoff AE
• Opposing effects of KDM6A and JDP2 on glucocorticoid sensitivity in T-ALL.
  Blood advances 2023 Levinson AL, Tjoa K, Huang B, Meyer LK, Kim MO, Brady SW, Zhang J, Shannon K, Wandler AM
• Melanoma in infants, caused by a gene fusion involving the anaplastic lymphoma kinase (ALK).
  Pigment cell & melanoma research 2023 Perkins IU, Tan SY, McCalmont TH, Chou PM, Mully TW, Gerami P, Pomerantz JH, Reyes-Múgica M, Balkin DM, Kruse LL, Huang B, Reichek JL, Gangopadhyay N, Chiosea S, Green JR, Chamlin SL, Frieden IJ, …
• Proposal of a new genomic framework for categorization of pediatric acute myeloid leukemia associated with prognosis.
  Research square 2023 Umeda M, Ma J, Westover T, Ni Y, Song G, Maciaszek JL, Rusch M, Rahbarinia D, Foy S, Huang BJ, Walsh MP, Kumar P, Liu Y, Fan Y, Wu G, Baker SD, Ma X, Wang L, Rubnitz JE, Pounds S, Klco JM
• NFIA-ETO2, TP53, and erythroid leukemogenesis.
  Blood 2023 Huang BJ, Shannon K
• Venetoclax in combination with chemotherapy as treatment for pediatric advanced hematologic malignancies.
  Pediatric blood & cancer 2023 Marinoff AE, Aaronson K, Agrawal AK, Braun BS, Golden C, Huang BJ, Michlitsch J, Southworth E, Thrall A, Vo KT, Stieglitz E
• Etiology of oncogenic fusions in 5,190 childhood cancers and its clinical and therapeutic implication.
  Nature communications 2023 Liu Y, Klein J, Bajpai R, Dong L, Tran Q, Kolekar P, Smith JL, Ries RE, Huang BJ, Wang YC, Alonzo TA, Tian L, Mulder HL, Shaw TI, Ma J, Walsh MP, Song G, Westover T, Autry RJ, Gout AM, Wheeler DA, Wan…
• Machine learning classifier approaches for predicting response to RTK-type-III inhibitors demonstrate high accuracy using transcriptomic signatures and ex vivo data.
  Bioinformatics advances 2023 Ferrato MH, Marsh AG, Franke KR, Huang BJ, Kolb EA, DeRyckere D, Grahm DK, Chandrasekaran S, Crowgey EL
• Pediatric Blood & Cancer
  Clonally Related T-cell Malignancies and Hemophagocytic Lymphohistiocytosis in a Pediatric Patient 2023 Meyer L, Huang I, Huang BJ, Steen E, Chung JH, Pawar A, Hermiston M, Ohgami R, Ruiz-Cordero R, Bhargava P, Marinoff A
• Long Noncoding RNA Expression Independently Predicts Outcome in Pediatric Acute Myeloid Leukemia.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2023 Farrar JE, Smith JL, Othus M, Huang BJ, Wang YC, Ries R, Hylkema T, Pogosova-Agadjanyan EL, Challa S, Leonti A, Shaw TI, Triche TJ, Gamis AS, Aplenc R, Kolb EA, Ma X, Stirewalt DL, Alonzo TA, …
• Blood. American Society of Hematology
  A Robust Long Non-Coding RNA Expression Classifier for Risk Stratification in Pediatric AML 2022 Farrar JE, Smith JL, Othus M, Huang BJ, Wang Y-C, Ries RE, Hylkema TA, Pogosova-Agadjanyan EL, Challa S, Leonti AR, Shaw TI, Triche TJ, Gamis AS, Aplenc R, Kolb AE, Ma X, Stirewalt D, Alonzo TA, …
• Blood. American Society of Hematology
  Expanding the High-Risk Definition for Children with Newly Diagnosed Acute Myeloid Leukemia 2022 Lamble AJ, Ries RE, Alonzo TA, Wang Y-C, Farrar JE, Huang BJ, Kutny MA, Pollard JA, Aplenc R, Gamis AS, Kolb EA, Cooper TM, Meshinchi S
• Blood. American Society of Hematology
  Structural Surfaceomics Reveals an AML-Specific Conformation of Integrin-β2 As an Immunotherapeutic Target 2022 Mandal K, Wicaksono G, Yu C, Adams JJ, Hoopmann MR, Temple WC, Escobar BP, Gorelik M, Ihling C, Nix MA, Naik A, Ramos E, Kasap C, Steri V, Serrano JC, Salangsang F, Phojanakong P, McMillan M, Gavallos…
• Blood. American Society of Hematology
  A Transcriptional Classifier Identifies Pediatric T-Cell Acute Lymphoblastic Leukemias at High Risk for End of Induction Minimal Residual Disease 2022 Meyer LK, Roy RP, Pölönen P, Elsayed A, Huang BJ, Kimura S, Delgado-Martin C, Vincent TL, Ryan T, Wood BL, Chen Z, Liu Y, Zhang J, Horton TM, Loh ML, Devidas M, Raetz EA, Hayashi RJ, Winter SS, …
• Blood. American Society of Hematology
  Transcriptome Analysis and Machine Learning Prioritize Therapeutic Strategies for High-Risk Pediatric AML Patients of the KMT2A-Fusion Subgroup 2022 Obermayer A, Yao S, Smith JL, Ries RE, Wang Y-C, Farrar JE, Furlan SN, Triche R, Ma X, Huang BJ, Wang X, Meshinchi S, Shaw TI
• Blood. American Society of Hematology. 140: 5973-5974. 15 Nov 2022
  Opposing Effects of KDM6A and JDP2 on Glucocorticoid Sensitivity in T-ALL 2022 Levinson A, Tjoa K, Huang BJ, Meyer LK, Brady SW, Zhang J, Shannon KM, Wandler A
• CBFA2T3-GLIS2 model of pediatric acute megakaryoblastic leukemia identifies FOLR1 as a CAR T cell target.
  The Journal of clinical investigation 2022 Le Q, Hadland B, Smith JL, Leonti A, Huang BJ, Ries R, Hylkema TA, Castro S, Tang TT, McKay CN, Perkins L, Pardo L, Sarthy J, Beckman AK, Williams R, Idemmili R, Furlan S, Ishida T, Call L, Srivastava…
• Cancer Research
  Longitudinal monitoring of pediatric acute myeloid leukemia using duplex sequencing of patient-specific panels reveals ultra-low frequency MRD that marks persistent carcinogenesis and complex clonal evolution 2022 Smith TH, Higgins JE, Lo FY, Hipp MJ, Valentine CC, Leonti AR, Ries RE, Meshinchi S, Huang BJ, Salk JJ
• Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia.
  Blood cancer discovery 2022 Umeda M, Ma J, Huang BJ, Hagiwara K, Westover T, Abdelhamed S, Barajas JM, Thomas ME, Walsh MP, Song G, Tian L, Liu Y, Chen X, Kolekar P, Tran Q, Foy SG, Maciaszek JL, Kleist AB, Leonti AR, Ju B, …
• Inhibition of the Sec61 translocon overcomes cytokine-induced glucocorticoid resistance in T-cell acute lymphoblastic leukaemia.
  British journal of haematology 2022 Meyer LK, Delgado-Martin C, Sharp PP, Huang BJ, McMinn D, Vincent TL, Ryan T, Horton TM, Wood BL, Teachey DT, Taunton J, Kirk CJ, Hermiston ML
• Blood. American Society of Hematology
  Integrated Genomic Analysis Identifies UBTF Tandem Duplications As a Subtype-Defining Lesion in Pediatric Acute Myeloid Leukemia 2021 Umeda M, Ma J, Huang BJ, Hagiwara K, Westover T, Abdelhamed S, Barajas JM, Thomas ME, Walsh MP, Song G, Tian L, Liu Y, Chen X, Kolekar P, Tran Q, Foy S, Maciaszek JL, Kleist AB, Leonti AR, Ju B, …
• Blood. American Society of Hematology
  EZH2-Mediated MHC Class II Silencing Drives Immune Evasion in AML with t(16;21) FUS-ERG 2021 Buteyn NJ, Burke CG, Smith JL, Ries RE, Leonti AR, Shaw TI, Huang BJ, Alonzo TA, Furlan SN, Farrar JE, Meshinchi S, Triche TJ
• Blood. American Society of Hematology
  Integrated Transcriptomics and Proteomics Identifies Therapeutic Targets in Pediatric Acute Myeloid Leukemia 2021 Huang BJ, Smith JL, Shaw TI, Furlan SN, Ries RE, Leonti AR, Crowgey EL, Wei L, Farrar JE, Triche T, Ma X, Le Q, Meshinchi S
• Blood. American Society of Hematology
  Targeting FOLR1 in High-Risk CBF2AT3-GLIS2 AML with Stro-002 FOLR1-Directed Antibody-Drug Conjugate 2021 Le Q, Smith JL, Tang TT, Castro S, Nourigat-Mckay C, Perkins L, Huang BJ, Ries RE, Leonti AR, Hylkema TA, Pardo L, Abrahams C, Bedard K, Molina A, Eidenschink Brodersen L, Loken MR, Meshinchi S
• Blood. American Society of Hematology
  ETS Family Transcription Factor Fusions in Childhood AML: Distinct Expression Networks and Clinical Implications 2021 Smith JL, Ries RE, Wang Y-C, Leonti AR, Alonzo TA, Gamis AS, Aplenc R, Kolb AE, Huang BJ, Ma X, Shaw TI, Meshinchi S
• Journal of Clinical Oncology
  Targeted gene expression classifier identifies pediatric T-cell acute lymphoblastic leukemia (T-ALL) patients at high risk for end induction minimal residual disease positivity 2021 Meyer LK, Roy R, Huang BJ, Delgado-Martin C, Vincent TL, Wood BL, Liu Y, Zhang J, Mullighan CG, Horton TM, Loh ML, Devidas M, Raetz EA, Hayashi RJ, Winter SS, Dunsmore KP, Hunger S, Teachey DT, Olshen…
• Leukemia Research
  A Targeted Gene Expression Classifier Identifies Pediatric T-ALL Patient at High Risk for End Induction Minimal Residual Disease Positivity 2021 Meyer L, Roy RP, Huang BJ, Kimura S, Polonen P, Delgado-Martin C, Vincent T, Ryan T, Wood B, Liu Y, Zhang J, Mullighan C, Horton T, Loh M, Devidas M, Raetz E, Hayashi R, Winter S, Dunsmore K, Hunger S…
• Blood. American Society of Hematology
  Duplex Sequencing with Patient-Specific Hybrid Capture Panels Reveals Ultra-Low Frequency Measurable Residual Disease in Pediatric Acute Myeloid Leukemia 2020 Higgins J, Lo FY, Hipp MJ, Valentine CC, Williams LN, Leonti AR, Ries RE, Radich JP, Meshinchi S, Huang BJ, Salk JJ
• Blood. American Society of Hematology
  Integrated Stem Cell Signature and Cytomolecular Risk Determination in Pediatric Acute Myeloid Leukemia 2020 Huang BJ, Smith JL, Ries RE, Leonti AR, Crowgey EL, Furlan SN, Shaw T, Wei L, Wang Y-C, Gerbing RB, Alonzo TA, Cooper TM, Kolb EA, Ma X, Farrar JE, Triche TJ, Meshinchi S
• Blood. American Society of Hematology
  Co-Targeting BET Bromodomain Proteins and Aberrant Signaling in AML 2020 Huang BJ, Wang X, Harris M, Wandler A, Hwang E, Burgess MR, Li Q, Severson P, Powell B, Kolb EA, Meshinchi S, Taylor BS, Bollag G, Shannon KM
• Blood. American Society of Hematology
  Genome and Transcriptome Profiling of Monosomy 7 AML Defines Novel Risk and Therapeutic Cohorts 2020 Ries RE, Triche TJ, Smith JL, Leonti AR, Alonzo TA, Farrar JE, Chen X, Liu Y, Shaw T, Huang BJ, Wang Y-C, Gerbing RB, Hirsch BA, Raimondi SC, Gamis AS, Aplenc R, Zhang J, Kolb EA, Ma X, Meshinchi S
• Nf1-Mutant Tumors Undergo Transcriptome and Kinome Remodeling after Inhibition of either mTOR or MEK.
  Molecular cancer therapeutics 2020 Pucciarelli D, Angus SP, Huang B, Zhang C, Nakaoka HJ, Krishnamurthi G, Bandyopadhyay S, Clapp DW, Shannon K, Johnson GL, Nakamura JL
• Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice.
  Blood 2020 Zambetti NA, Firestone AJ, Remsberg JR, Huang BJ, Wong JC, Long AM, Predovic M, Suciu RM, Inguva A, Kogan SC, Haigis KM, Cravatt BF, Shannon K
• Loss of glucocorticoid receptor expression mediates in vivo dexamethasone resistance in T-cell acute lymphoblastic leukemia.
  Leukemia 2020 Wandler AM, Huang BJ, Craig JW, Hayes K, Yan H, Meyer LK, Scacchetti A, Monsalve G, Dail M, Li Q, Wong JC, Weinberg O, Hasserjian RP, Kogan SC, Jonsson P, Yamamoto K, Sampath D, Nakitandwe J, Downing …
• Glucocorticoids paradoxically facilitate steroid resistance in T cell acute lymphoblastic leukemias and thymocytes.
  The Journal of clinical investigation 2020 Meyer LK, Huang BJ, Delgado-Martin C, Roy RP, Hechmer A, Wandler AM, Vincent TL, Fortina P, Olshen AB, Wood BL, Horton TM, Shannon KM, Teachey DT, Hermiston ML
• Journal of Clinical Oncology. American Society of Clinical Oncology
  Gene expression signature associated with in vitro dexamethasone resistance and post-induction minimal residual disease in pediatric T-cell acute lymphoblastic leukemia 2019 Meyer LK, Delgado-Martin C, Roy R, Huang BJ, Vincent T, Olshen A, Wood BL, Liu Y, Zhang J, Mullighan CG, Horton TM, Loh ML, Devidas M, Raetz EA, Hayashi RJ, Winter S, Dunsmore KP, Hunger S, Teachey DT…
• Blood. American Society of Hematology
  Glucocorticoids Paradoxically Induce Intrinsic Steroid Resistance through a STAT5-Mediated Survival Mechanism in T-Cell Acute Lymphoblastic Leukemia 2018 Meyer LK, Huang BJ, Roy R, Hechmer A, Wandler A, Delgado-Martin C, Olshen AB, Horton TM, Teachey DT, Shannon KM, Hermiston ML
• British Journal of Haematology
  Glucocorticoids paradoxically induce steroid resistance through a STAT5-mediated survival mechanism in T-cell acute lymphoblastic leukemia/lymphoma 2018 Meyer LK, Delgado-Martin C, Huang BJ, Wandler AM, Horton TM, Teachey DT, Shannon KM, Hermiston ML
• JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias.
  Leukemia 2017 Delgado-Martin C, Meyer LK, Huang BJ, Shimano KA, Zinter MS, Nguyen JV, Smith GA, Taunton J, Winter SS, Roderick JR, Kelliher MA, Horton TM, Wood BL, Teachey DT, Hermiston ML
• KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer.
  Cell 2017 Burgess MR, Hwang E, Mroue R, Bielski CM, Wandler AM, Huang BJ, Firestone AJ, Young A, Lacap JA, Crocker L, Asthana S, Davis EM, Xu J, Akagi K, Le Beau MM, Li Q, Haley B, Stokoe D, Sampath D, Taylor …
• Blood. American Society of Hematology
  Response and Resistance to Bromodomain Inhibition in AML Driven By Hyperactive Ras Signaling 2016 Huang BJ, Hwang E, Wandler AM, Powell B, Bollag G, Shannon K
• Blood. American Society of Hematology
  Resistant T-Cell Acute Lymphoblastic Leukemias That Emerge after In Vivo Treatment with Dexamethasone Frequently Down-Regulate Glucocorticoid Receptor Protein Expression 2016 Wandler AM, Huang B, Scacchetti A, Craig J, Yan H, Monsalve G, Li Q, Dail M, Wong JC, Nakitandwe J, Weinberg O, Hasserjian RP, Kogan SC, Sampath D, Downing JR, Yamamoto K, Taylor BS, Aster JC, Zhang J…
• Blood. American Society of Hematology
  Risk Factors for Graft Failure with Busulfan/Fludarabine-Based Conditioning in Children Undergoing Allogeneic Hematopoietic Cell Transplantation for Nonmalignant Disorders 2014 Huang BJ, Dvorak CC, Wahlstrom J, Hwang J, Long-Boyle JR, Cowan MJ, Horn BN
• Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Dail M, Li Q, McDaniel A, Wong J, Akagi K, Huang B, Kang HC, Kogan SC, Shokat K, Wolff L, Braun BS, Shannon K
• Blood. American Society of Hematology
  Expressing N-Ras(G12D) from the endogenous promoter induces myeloproliferative disease (MPD) and cooperates with retroviral insertional mutagenesis (RIM) to generate acute myeloid leukemia (AML) 2007 Li Q, Haigis K, McDaniel A, Huang BJ, Miller M, Shieh A, Kogan S, Wolff L, Jacks T, Shannon K