Ben Cheyette
Professor Emeritus
Psychiatry
School of Medicine
Awards
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- NARSAD Independent Investigator Award, UCSF, 2014-2016
- NARSAD Young Investigator Award, UW & University of California, San Francisco, 2001-2003
- NARSAD Young Investigator Award, University of Washington (UW), 1999-2001
- Academic Excellence, University of Washington, Psychiatry, 1999
- Excellence in Psychiatry Residency, American Psychiatric Association, 1998
- Special Achievement as a Resident in Psychiatry, National Institute of Mental Health, 1997
- Emil Bogen Prize for Outstanding Research Achievement, UCLA School of Medicine, 1995
- Charles M. Cannon Prize for Research Achievement, Princeton University, 1988
- Magna Cum Laude, Biology, Princeton University, 1988
- Sigma Xi National Scientific Honor Society, Princeton University, 1988
- National Merit Scholar, -, 1984
Education & Training
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- Postdoctoral Research Fellowship Molecular Pharmacology University of Washington 2002
- Clinical Specialty Training Psychiatry University of Washington 1999
- M.D. David Geffen School of Medicine University of California Los Angeles 1995
- Ph.D Molecular Biology University of California Los Angeles 1994
- A.B. Biology Princeton University 1988
Websites
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- Cheyette Lab at UCSF (cheyettelab.ucsf.edu)
- Cheyette Lab at UCSF (psych.ucsf.edu)
Grants and Projects
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Publications (35)
Top publication keywords:
Wnt1 ProteinEmbryonic Developmentbeta CateninSynapsesNerve Tissue ProteinsWnt Signaling PathwayDendritic SpinesIntracellular Signaling Peptides and ProteinsCarrier ProteinsPhosphoproteinsNeuropeptidesAdaptor Proteins, Signal TransducingProto-Oncogene Proteins c-bcrProsencephalonrac1 GTP-Binding Protein
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Enhancing WNT Signaling Restores Cortical Neuronal Spine Maturation and Synaptogenesis in Tbr1 Mutants.
Cell reports 2020 Fazel Darbandi S, Robinson Schwartz SE, Pai EL, Everitt A, Turner ML, Cheyette BNR, Willsey AJ, State MW, Sohal VS, Rubenstein JLR -
Sestd1 Encodes a Developmentally Dynamic Synapse Protein That Complexes With BCR Rac1-GAP to Regulate Forebrain Dendrite, Spine and Synapse Formation.
Cerebral cortex (New York, N.Y. : 1991) 2019 Yang XY, Stanley RE, Ross AP, Robitaille AM, Gray JA, Cheyette BNR -
Sestd1 Encodes a Developmentally Dynamic Synapse Protein That Complexes With BCR Rac1-GAP to Regulate Forebrain Dendrite, Spine and Synapse Formation.
Cerebral cortex (New York, N.Y. : 1991) 2019 Yang XY, Stanley RE, Ross AP, Robitaille AM, Gray JA, Cheyette BNR -
Sestd1 encodes a developmentally dynamic synapse protein that complexes with BCR Rac1-GAP to regulate forebrain dendrite, spine and synapse formation
Cerebral Cortex 2017 Yang XY, Stanley RE, Ross AP, Robitaille AM, Gray JA, Cheyette BNR -
Neurodevelopmental Perspectives on Wnt Signaling in Psychiatry.
Molecular neuropsychiatry 2017 Mulligan KA, Cheyette BN
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DIXDC1 contributes to psychiatric susceptibility by regulating dendritic spine and glutamatergic synapse density via GSK3 and Wnt/β-catenin signaling.
Molecular psychiatry 2016 Martin PM, Stanley RE, Ross AP, Freitas AE, Moyer CE, Brumback AC, Iafrati J, Stapornwongkul KS, Dominguez S, Kivimäe S, Mulligan KA, Pirooznia M, McCombie WR, Potash JB, Zandi PP, Purcell SM, Sanders… -
Acute exacerbation of irritable bowel syndrome prevented by prn oral triptan
Clin J Gastroenterology 2016 <strong>Cheyette BN</strong>, Cheyette SN -
"The Wnt Signaling Pathways." In R. P. Erickson & A. J. Wynshaw-Boris (Eds.) <em>Inborn Errors of Development, 3rd edition</em>
2016 Mulligan K, <strong>Cheyette BN</strong> -
The Planar Cell Polarity Transmembrane Protein Vangl2 Promotes Dendrite, Spine and Glutamatergic Synapse Formation in the Mammalian Forebrain.
Molecular neuropsychiatry 2016 Okerlund ND, Stanley RE, Cheyette BN -
<em>ADHD & The Focused Mind</em>
<em>ADHD & The Focused Mind</em> 2016 Cheyette SR, Johnson P, <strong>Cheyette BN</strong> -
SEC14 and Spectrin Domains 1 (Sestd1), Dishevelled 2 (Dvl2) and Dapper Antagonist of Catenin-1 (Dact1) co-regulate the Wnt/Planar Cell Polarity (PCP) pathway during mammalian development.
Communicative & integrative biology 2013 Yang X, Fisher DA, Cheyette BN -
Dapper Antagonist of Catenin-1 (Dact1) contributes to dendrite arborization in forebrain cortical interneurons.
Communicative & integrative biology 2013 Arguello A, Cheyette BN -
A rare WNT1 missense variant overrepresented in ASD leads to increased Wnt signal pathway activation.
Translational psychiatry 2013 Martin PM, Yang X, Robin N, Lam E, Rabinowitz JS, Erdman CA, Quinn J, Weiss LA, Hamilton SP, Kwok PY, Moon RT, Cheyette BN -
Dapper antagonist of catenin-1 cooperates with Dishevelled-1 during postsynaptic development in mouse forebrain GABAergic interneurons.
PloS one 2013 Arguello A, Yang X, Vogt D, Stanco A, Rubenstein JL, Cheyette BN -
SEC14 and spectrin domains 1 (Sestd1) and Dapper antagonist of catenin 1 (Dact1) scaffold proteins cooperatively regulate the Van Gogh-like 2 (Vangl2) four-pass transmembrane protein and planar cell polarity (PCP) pathway during embryonic development in mice.
The Journal of biological chemistry 2013 Yang X, Cheyette BN -
Wnt signaling in vertebrate neural development and function.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2012 Mulligan KA, Cheyette BN -
Abnormal behavior in mice mutant for the Disc1 binding partner, Dixdc1.
Translational psychiatry 2011 Kivimäe S, Martin PM, Kapfhamer D, Ruan Y, Heberlein U, Rubenstein JL, Cheyette BN -
All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases.
BMC biochemistry 2011 Kivimäe S, Yang XY, Cheyette BN -
Synaptic Wnt signaling-a contributor to major psychiatric disorders?
Journal of neurodevelopmental disorders 2011 Okerlund ND, Cheyette BN -
Dact1 is a postsynaptic protein required for dendrite, spine, and excitatory synapse development in the mouse forebrain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Okerlund ND, Kivimäe S, Tong CK, Peng IF, Ullian EM, Cheyette BN -
Dact1-3 mRNAs exhibit distinct expression domains during tooth development.
Gene expression patterns : GEP 2010 Kettunen P, Kivimäe S, Keshari P, Klein OD, Cheyette BN, Luukko K -
Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak.
Nature genetics 2009 Suriben R, Kivimäe S, Fisher DA, Moon RT, Cheyette BN -
Modulation of the beta-catenin signaling pathway by the dishevelled-associated protein Hipk1.
PloS one 2009 Louie SH, Yang XY, Conrad WH, Muster J, Angers S, Moon RT, Cheyette BN -
Dact1, a nutritionally regulated preadipocyte gene, controls adipogenesis by coordinating the Wnt/beta-catenin signaling network.
Diabetes 2008 Lagathu C, Christodoulides C, Virtue S, Cawthorn WP, Franzin C, Kimber WA, Nora ED, Campbell M, Medina-Gomez G, Cheyette BN, Vidal-Puig AJ, Sethi JK -
"Wnt Signaling." In S. Offermanns & W. Rosenthal (Eds.) <em>Encyclopedia of Molecular Pharmacology, 2nd edition</em>
2008 Okerlund N, <strong>Cheyette BN</strong> -
DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications.
Cancer cell 2008 Jiang X, Tan J, Li J, Kivimäe S, Yang X, Zhuang L, Lee PL, Chan MT, Stanton LW, Liu ET, Cheyette BN, Yu Q -
Dopa-responsive dystonia presenting as delayed and awkward gait.
Pediatric neurology 2008 Cheyette BN, Cheyette SN, Cusmano-Ozog K, Enns GM -
Dact1 presomitic mesoderm expression oscillates in phase with Axin2 in the somitogenesis clock of mice.
Developmental dynamics : an official publication of the American Association of Anatomists 2006 Suriben R, Fisher DA, Cheyette BN -
Three Dact gene family members are expressed during embryonic development and in the adult brains of mice.
Developmental dynamics : an official publication of the American Association of Anatomists 2006 Fisher DA, Kivimäe S, Hoshino J, Suriben R, Martin PM, Baxter N, Cheyette BN -
D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 Kovoor A, Seyffarth P, Ebert J, Barghshoon S, Chen CK, Schwarz S, Axelrod JD, Cheyette BN, Simon MI, Lester HA, Schwarz J -
Ryk: another heretical Wnt receptor defies the canon.
Science's STKE : signal transduction knowledge environment 2004 Cheyette BN -
"Wnt Protein Family." In H. L. Henry & A. W. Norman (Eds.) <em>Encyclopedia of Hormones, vol. 3</em>
2003 <strong>Cheyette BN</strong> and Moon RT -
Homeobox genes and connective tissue patterning.
Development (Cambridge, England) 1995 Oliver G, Wehr R, Jenkins NA, Copeland NG, Cheyette BN, Hartenstein V, Zipursky SL, Gruss P -
The Drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system.
Neuron 1994 Cheyette BN, Green PJ, Martin K, Garren H, Hartenstein V, Zipursky SL -
The Drosophila anachronism locus: a glycoprotein secreted by glia inhibits neuroblast proliferation.
Cell 1993 Ebens AJ, Garren H, Cheyette BN, Zipursky SL