Barbara Panning, PhD
Professor
Biochemistry and Biophysics
School of Medicine

Grants and Projects

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• OGT as a dosage sensor, NIH, 2019-2023
• Role of SOX2 O-GIcNAcylation in pluripotency, NIH, 2016-2020
• Investigation of X chromosome organization before the onset of X-inactivation, NIH, 2012-2016
• Regulation of Xist RNA processing in embryonic stem cells, NIH, 2010-2015
• Bio-Organic Biomedical Mass Spectrometry Resource, NIH, 1982-2015
• Resource for X-ray Tomography of Whole Cells, NIH, 2004-2013
• Investigation of the Tip60-p400 complex role in embryonic stem cell self-ren, NIH, 2009-2013
• Xist RNA and Regulation of Chromatin Structure, NIH, 2001-2006

Publications (75)

Top publication keywords:
X Chromosome InactivationRNA, Long NoncodingChromatinMouse Embryonic Stem CellsN-AcetylglucosaminyltransferasesRepetitive Sequences, Nucleic AcidChromatin Assembly and DisassemblyCell NucleusEmbryonic Stem CellsHistonesDioxygenasesRNA, UntranslatedX ChromosomePluripotent Stem CellsDosage Compensation, Genetic

• Histone 3 lysine 9 dimethylation by the G9a-GLP heterodimer requires intranucleosomal product reading.
  bioRxiv : the preprint server for biology 2026 Yousefi F, Simental EA, Du Y, Whedon S, Trnka MJ, Darling D, Jia S, Panning B, Cole PA, Halic M, Al-Sady B
• The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate.
  Nature cell biology 2025 Marin HC, Allen C, Simental E, Martin EW, Panning B, Al-Sady B, Buchwalter A
• O-GlcNAc modifications regulate lamin A tail processing.
  bioRxiv : the preprint server for biology 2025 Augspurger K, Martin E, Maynard J, Welle K, Ghaemmaghami S, Burlingame A, Panning B, Buchwalter A
• Aging activates escape of the silent X chromosome in the female mouse hippocampus.
  Science advances 2025 Gadek M, Shaw CK, Abdulai-Saiku S, Saloner R, Marino F, Wang D, Bonham LW, Yokoyama JS, Panning B, Benayoun BA, Casaletto KB, Ramani V, Dubal DB
• The maternal X chromosome affects cognition and brain ageing in female mice.
  Nature 2025 Abdulai-Saiku S, Gupta S, Wang D, Marino F, Moreno AJ, Huang Y, Srivastava D, Panning B, Dubal DB

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• The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate.
  bioRxiv : the preprint server for biology 2024 Marin H, Simental E, Allen C, Martin E, Panning B, Al-Sady B, Buchwalter A
• X Chromosome Factor Kdm6a Enhances Cognition Independent of Its Demethylase Function in the Aging XY Male Brain.
  The journals of gerontology. Series A, Biological sciences and medical sciences 2023 Shaw CK, Abdulai-Saiku S, Marino F, Wang D, Davis EJ, Panning B, Dubal DB
• A second X chromosome contributes to resilience in a mouse model of Alzheimer's disease.
  Science translational medicine 2020 Davis EJ, Broestl L, Abdulai-Saiku S, Worden K, Bonham LW, Miñones-Moyano E, Moreno AJ, Wang D, Chang K, Williams G, Garay BI, Lobach I, Devidze N, Kim D, Anderson-Bergman C, Yu GQ, White CC, Harris …
• OGT binds a conserved C-terminal domain of TET1 to regulate TET1 activity and function in development.
  eLife 2018 Hrit J, Goodrich L, Li C, Wang BA, Nie J, Cui X, Martin EA, Simental E, Fernandez J, Liu MY, Nery JR, Castanon R, Kohli RM, Tretyakova N, He C, Ecker JR, Goll M, Panning B
• Autotaxin-mediated lipid signaling intersects with LIF and BMP signaling to promote the naive pluripotency transcription factor program.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Kime C, Sakaki-Yumoto M, Goodrich L, Hayashi Y, Sami S, Derynck R, Asahi M, Panning B, Yamanaka S, Tomoda K
• Activators and repressors: A balancing act for X-inactivation.
  Seminars in cell & developmental biology 2016 Goodrich L, Panning B, Leung KN
• SOX2 O-GlcNAcylation alters its protein-protein interactions and genomic occupancy to modulate gene expression in pluripotent cells.
  eLife 2016 Myers SA, Peddada S, Chatterjee N, Friedrich T, Tomoda K, Krings G, Thomas S, Maynard J, Broeker M, Thomson M, Pollard K, Yamanaka S, Burlingame AL, Panning B
• Editorial overview: Genome architecture and expression.
  Current opinion in genetics & development 2015 Panning B, Segal E
• Quantitatively imaging chromosomes by correlated cryo-fluorescence and soft x-ray tomographies.
  Biophysical journal 2014 Smith EA, McDermott G, Do M, Leung K, Panning B, Le Gros MA, Larabell CA
• Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation.
  Cell 2014 Gilbert LA, Horlbeck MA, Adamson B, Villalta JE, Chen Y, Whitehead EH, Guimaraes C, Panning B, Ploegh HL, Bassik MC, Qi LS, Kampmann M, Weissman JS
• X-inactivation: Xist RNA uses chromosome contacts to coat the X.
  Current biology : CB 2014 Leung KN, Panning B
• The Topological Organization of the Inactive X Chromosome in its Native State.
  Biophysical Journal 2014 Elizabeth A. Smith, Gerry McDermott, Karen Leung, Barbara Panning, Carolyn A. Larabell, Mark A. Le Gros
• The imprinted polycomb group gene Sfmbt2 is required for trophoblast maintenance and placenta development.
  Development (Cambridge, England) 2013 Miri K, Latham K, Panning B, Zhong Z, Andersen A, Varmuza S
• Quantitative genetic-interaction mapping in mammalian cells.
  Nature methods 2013 Roguev A, Talbot D, Negri GL, Shales M, Cagney G, Bandyopadhyay S, Panning B, Krogan NJ
• Derivation conditions impact X-inactivation status in female human induced pluripotent stem cells.
  Cell stem cell 2012 Tomoda K, Takahashi K, Leung K, Okada A, Narita M, Yamada NA, Eilertson KE, Tsang P, Baba S, White MP, Sami S, Srivastava D, Conklin BR, Panning B, Yamanaka S
• Polycomb repressive complex 2 is necessary for the normal site-specific O-GlcNAc distribution in mouse embryonic stem cells.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Myers SA, Panning B, Burlingame AL
• Control of embryonic stem cell identity by nucleosome remodeling enzymes.
  Current opinion in genetics & development 2010 Fazzio TG, Panning B
• The A-repeat links ASF/SF2-dependent Xist RNA processing with random choice during X inactivation.
  Nature structural & molecular biology 2010 Royce-Tolland ME, Andersen AA, Koyfman HR, Talbot DJ, Wutz A, Tonks ID, Kay GF, Panning B
• Condensin complexes regulate mitotic progression and interphase chromatin structure in embryonic stem cells.
  The Journal of cell biology 2010 Fazzio TG, Panning B
• High resolution electron transfer dissociation studies of unfractionated intact histones from murine embryonic stem cells using on-line capillary LC separation: determination of abundant histone isoforms and post-translational modifications.
  Molecular & cellular proteomics : MCP 2010 Eliuk SM, Maltby D, Panning B, Burlingame AL
• Fine-tuning silencing.
  Cell stem cell 2010 Panning B
• The zinc finger protein Zn72D and DEAD box helicase Belle interact and control maleless mRNA and protein levels.
  BMC molecular biology 2009 Worringer KA, Chu F, Panning B
• Chromatin regulation Tip(60)s the balance in embryonic stem cell self-renewal.
  Cell cycle (Georgetown, Tex.) 2008 Fazzio TG, Huff JT, Panning B
• X-chromosome inactivation: the molecular basis of silencing.
  Journal of biology 2008 Panning B
• Epigenomics: a roadmap, but to where?
  Science (New York, N.Y.) 2008 Madhani HD, Francis NJ, Kingston RE, Kornberg RD, Moazed D, Narlikar GJ, Panning B, Struhl K
• Transcriptional regulation: it takes a village.
  Molecular cell 2008 Panning B, Taatjes DJ
• An RNAi screen of chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity.
  Cell 2008 Fazzio TG, Huff JT, Panning B
• The colocalization transition of homologous chromosomes at meiosis.
  Physical review. E, Statistical, nonlinear, and soft matter physics 2008 Nicodemi M, Panning B, Prisco A
• A thermodynamic switch for chromosome colocalization.
  Genetics 2008 Nicodemi M, Panning B, Prisco A
• X-inactivation: it takes two to count.
  Current biology : CB 2008 Royce-Tolland M, Panning B
• IRE1 signaling affects cell fate during the unfolded protein response.
  Science (New York, N.Y.) 2007 Lin JH, Li H, Yasumura D, Cohen HR, Zhang C, Panning B, Shokat KM, Lavail MM, Walter P
• Differences between homologous alleles of olfactory receptor genes require the Polycomb Group protein Eed.
  The Journal of cell biology 2007 Alexander MK, Mlynarczyk-Evans S, Royce-Tolland M, Plocik A, Kalantry S, Magnuson T, Panning B
• Zinc finger protein Zn72D promotes productive splicing of the maleless transcript.
  Molecular and cellular biology 2007 Worringer KA, Panning B
• The histone domain of macroH2A1 contains several dispersed elements that are each sufficient to direct enrichment on the inactive X chromosome.
  Journal of molecular biology 2007 Nusinow DA, Sharp JA, Morris A, Salas S, Plath K, Panning B
• The polycomb group protein SUZ12 regulates histone H3 lysine 9 methylation and HP1 alpha distribution.
  Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2007 de la Cruz CC, Kirmizis A, Simon MD, Isono K, Koseki H, Panning B
• The XIST noncoding RNA functions independently of BRCA1 in X inactivation.
  Cell 2007 Xiao C, Sharp JA, Kawahara M, Davalos AR, Difilippantonio MJ, Hu Y, Li W, Cao L, Buetow K, Ried T, Chadwick BP, Deng CX, Panning B
• The site-specific installation of methyl-lysine analogs into recombinant histones.
  Cell 2007 Simon MD, Chu F, Racki LR, de la Cruz CC, Burlingame AL, Panning B, Narlikar GJ, Shokat KM
• XIST RNA exhibits nuclear retention and exhibits reduced association with the export factor TAP/NXF1.
  Chromosoma 2007 Cohen HR, Panning B
• Poly(ADP-ribose) polymerase 1 is inhibited by a histone H2A variant, MacroH2A, and contributes to silencing of the inactive X chromosome.
  The Journal of biological chemistry 2007 Nusinow DA, Hernández-Muñoz I, Fazzio TG, Shah GM, Kraus WL, Panning B
• X chromosomes alternate between two states prior to random X-inactivation.
  PLoS biology 2006 Mlynarczyk-Evans S, Royce-Tolland M, Alexander MK, Andersen AA, Kalantry S, Gribnau J, Panning B
• Mapping post-translational modifications of the histone variant macroH2A1 using tandem mass spectrometry.
  The FASEB Journal 2006 Feixia Chu, Dmitri A Nusinow, Robert J Chalkley, Kathrin Plath, Barbara Panning, Alma L Burlingame
• The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation.
  Nature cell biology 2006 Kalantry S, Mills KC, Yee D, Otte AP, Panning B, Magnuson T
• Counting chromosomes: not as easy as 1, 2, 3.
  Current biology : CB 2005 Alexander MK, Panning B
• Mapping post-translational modifications of the histone variant MacroH2A1 using tandem mass spectrometry.
  Molecular & cellular proteomics : MCP 2005 Chu F, Nusinow DA, Chalkley RJ, Plath K, Panning B, Burlingame AL
• Developmental regulation of Suz 12 localization.
  Chromosoma 2005 de la Cruz CC, Fang J, Plath K, Worringer KA, Nusinow DA, Zhang Y, Panning B
• Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Hernández-Muñoz I, Lund AH, van der Stoop P, Boutsma E, Muijrers I, Verhoeven E, Nusinow DA, Panning B, Marahrens Y, van Lohuizen M
• Recognition and modification of seX chromosomes.
  Current opinion in genetics & development 2005 Nusinow DA, Panning B
• Chromatin modifications on the inactive X chromosome.
  Progress in molecular and subcellular biology 2005 Cohen HR, Royce-Tolland ME, Worringer KA, Panning B
• Chromatin remodeling in dosage compensation.
  Annual review of genetics 2005 Lucchesi JC, Kelly WG, Panning B
• Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosome.
  The Journal of cell biology 2004 Plath K, Talbot D, Hamer KM, Otte AP, Yang TP, Jaenisch R, Panning B
• MACRO-H2A: A STRUCTURALLY AND FUNCTIONALLY DIVERSE HISTONE VARIANT.
  Cold Spring Harbor Symposia on Quantitative Biology 2004 Srinivas Chakravarthy, Dmitri Nusinow, Kathrin Plath, Pierre-Yves Perche, Saadi Khochbin, Barbara Panning, Karolin Luger
• X inactivation in mouse ES cells: histone modifications and FISH.
  Methods in enzymology 2004 Panning B
• Epigenetic gene regulation by noncoding RNAs.
  Current Opinion in Cell Biology 2003 Angela A Andersen, Barbara Panning
• Epigenetic gene regulation by noncoding RNAs.
  Current opinion in cell biology 2003 Andersen AA, Panning B
• Role of histone H3 lysine 27 methylation in X inactivation.
  Science (New York, N.Y.) 2003 Plath K, Fang J, Mlynarczyk-Evans SK, Cao R, Worringer KA, Wang H, de la Cruz CC, Otte AP, Panning B, Zhang Y
• Xist RNA and the mechanism of X chromosome inactivation.
  Annual review of genetics 2002 Plath K, Mlynarczyk-Evans S, Nusinow DA, Panning B
• Identification of an autoimmune serum containing antibodies against the Barr body.
  Proceedings of the National Academy of Sciences of the United States of America 2001 Hong B, Reeves P, Panning B, Swanson MS, Yang TP
• X inactivation: Tsix and Xist as yin and yang.
  Current biology : CB 2000 Mlynarczyk SK, Panning B
• Messenger RNAs encoding mouse histone macroH2A1 isoforms are expressed at similar levels in male and female cells and result from alternative splicing.
  Nucleic acids research 1999 Rasmussen TP, Huang T, Mastrangelo MA, Loring J, Panning B, Jaenisch R
• Conditional deletion of Xist disrupts histone macroH2A localization but not maintenance of X inactivation.
  Nature genetics 1999 Csankovszki G, Panning B, Bates B, Pehrson JR, Jaenisch R
• RNA and the epigenetic regulation of X chromosome inactivation.
  Cell 1998 Panning B, Jaenisch R
• Mammalian X chromosome inactivation.
  Novartis Foundation symposium 1998 Jaenisch R, Beard C, Lee J, Marahrens Y, Panning B
• X chromosome inactivation is mediated by Xist RNA stabilization.
  Cell 1997 Panning B, Dausman J, Jaenisch R
• Herpes simplex virus immediate-early proteins ICP0 and ICP4 activate the endogenous human alpha-globin gene in nonerythroid cells.
  Journal of virology 1997 Cheung P, Panning B, Smiley JR
• Xist-deficient mice are defective in dosage compensation but not spermatogenesis.
  Genes & development 1997 Marahrens Y, Panning B, Dausman J, Strauss W, Jaenisch R
• DNA hypomethylation can activate Xist expression and silence X-linked genes.
  Genes & development 1996 Panning B, Jaenisch R
• Activation of expression of multiple subfamilies of human Alu elements by adenovirus type 5 and herpes simplex virus type 1.
  Journal of molecular biology 1995 Panning B, Smiley JR
• Activation of RNA polymerase III transcription of human Alu elements by herpes simplex virus.
  Virology 1994 Panning B, Smiley JR
• Activation of RNA polymerase III transcription of human Alu repetitive elements by adenovirus type 5: requirement for the E1b 58-kilodalton protein and the products of E4 open reading frames 3 and 6.
  Molecular and cellular biology 1993 Panning B, Smiley JR
• Regulation of cellular genes transduced by herpes simplex virus.
  Journal of virology 1989 Panning B, Smiley JR