Barbara Malynn, PhD
Professor
Medicine
School of Medicine

Education & Training

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• Postdoctoral Columbia College of Physicians & Surgeons
• PhD Tufts Sackler School of Biomedical Sciences

Publications (59)

Top publication keywords:
UbiquitinB-LymphocytesGenes, mycCysteine EndopeptidasesAutoimmune DiseasesLupus Erythematosus, SystemicProtein Processing, Post-TranslationalNF-kappa BImmunomodulationUbiquitin-Conjugating EnzymesIntracellular Signaling Peptides and ProteinsUbiquitinationTumor Necrosis Factor alpha-Induced Protein 3DNA-Binding ProteinsNuclear Proteins

• Sa1536: TISSUE SPECIFIC PATHOGENIC CD4 T CELLS DRIVE ENTEROCOLITIS IN MICE EXPRESSING MUTATIONS IN A20’S ZF7 MOTIF.
  Gastroenterology 2022 Dorothea Stibor, Xiaofei Sun, Christopher Bowman, Yang Sun, Bahram Razani, Min Cheol Kim, Rommel Advincula, Philip Achacoso, Barbara Malynn, Chun Ye, Averil Ma
• Tu1517: MICROBIAL SIGNALS, MYD88, AND LYMPHOTOXIN DRIVE TNFINDEPENDENT DEATH OF A20 AND ABIN-1 DEFICIENT EPITHELIUM.
  Gastroenterology 2022 Iulia Rusu, Elvira Mennillo, Jared L. Bain, Zhongmei Li, Xiaofei Sun, Kimberly Ly, Yenny Y. Rosli, Mohammad Naser, Zunqiu Wang, Rommel Advincula, Philip Achacoso, Ling Shao, Bahram Razani, Ophir D. …
• Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage.
  The Journal of clinical investigation 2022 Rusu I, Mennillo E, Bain JL, Li Z, Sun X, Ly KM, Rosli YY, Naser M, Wang Z, Advincula R, Achacoso P, Shao L, Razani B, Klein OD, Marson A, Turnbaugh JA, Turnbaugh PJ, Malynn BA, Ma A, Kattah MG
• Preserving immune homeostasis with A20.
  Advances in immunology 2020 Razani B, Malynn BA, Ma A
• Editorial: Modulating Cytokines as Treatment for Autoimmune Diseases and Cancer.
  Frontiers in immunology 2020 Mortier E, Ma A, Malynn BA, Neurath MF

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• Non-catalytic ubiquitin binding by A20 prevents psoriatic arthritis-like disease and inflammation.
  Nature immunology 2020 Razani B, Whang MI, Kim FS, Nakamura MC, Sun X, Advincula R, Turnbaugh JA, Pendse M, Tanbun P, Achacoso P, Turnbaugh PJ, Malynn BA, Ma A
• A20 in dendritic cells restrains intestinal anti-bacterial peptide expression and preserves commensal homeostasis.
  PloS one 2019 Talpin A, Kattah MG, Advincula R, Fadrosh D, Lynch K, LaMere B, Fujimura KE, Nagalingam NA, Malynn BA, Lynch SV, Ma A
• 474 Binding of ubiquitin by A20 restricts psoriatic skin and joint disease.
  Journal of Investigative Dermatology 2019 B. Razani, M. Whang, R. Advincula, J. Oses, A. Burlingame, B. Malynn, A. Ma
• A20: A multifunctional tool for regulating immunity and preventing disease.
  Cellular immunology 2019 Malynn BA, Ma A
• OTUB1 non-catalytically stabilizes the E2 ubiquitin-conjugating enzyme UBE2E1 by preventing its autoubiquitination.
  The Journal of biological chemistry 2018 Pasupala N, Morrow ME, Que LT, Malynn BA, Ma A, Wolberger C
• A20 and ABIN-1 synergistically preserve intestinal epithelial cell survival.
  The Journal of experimental medicine 2018 Kattah MG, Shao L, Rosli YY, Shimizu H, Whang MI, Advincula R, Achacoso P, Shah S, Duong BH, Onizawa M, Tanbun P, Malynn BA, Ma A
• Ubiquitin-Modifying Enzymes and Regulation of the Inflammasome.
  Journal of molecular biology 2017 Kattah MG, Malynn BA, Ma A
• Hypomorphic A20 expression confers susceptibility to psoriasis.
  PloS one 2017 Aki A, Nagasaki M, Malynn BA, Ma A, Kagari T
• The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagasome Induction and the Metabolic Transition of Activated T Cells.
  Immunity 2017 Whang MI, Tavares RM, Benjamin DI, Kattah MG, Advincula R, Nomura DK, Debnath J, Malynn BA, Ma A
• P-285 A20 and ABIN-1 Cooperate to Preserve Intestinal Epithelial Homeostasis.
  Inflammatory Bowel Diseases 2017 Michael Kattah, Ling Shao, Yenny Rosli, Michael Whang, Rommel Advincula, Barbara Malynn, Averil Ma
• 245 A20 and ABIN-1 Cooperate to Restrict Intestinal Epithelial Cell Death and Maintain Mucosal Immune Homeostasis.
  Gastroenterology 2016 Ling Shao, Michael G. Kattah, Michael Whang, Bao Duong, Michio Onizawa, Sadeea Abbasi, Yenny Rosli, Joseph Callahan, Mihir Pendse, Julio Barrera, Alison Glazier, Rommel Advincula, Barbara Malynn, …
• Erratum: The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis.
  Nature immunology 2015 Onizawa M, Oshima S, Schulze-Topphoff U, Oses-Prieto JA, Lu T, Tavares R, Prodhomme T, Duong B, Whang MI, Advincula R, Agelidis A, Barrera J, Wu H, Burlingame A, Malynn BA, Zamvil SS, Ma A
• The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis.
  Nature immunology 2015 Onizawa M, Oshima S, Schulze-Topphoff U, Oses-Prieto JA, Lu T, Tavares R, Prodhomme T, Duong B, Whang MI, Advincula R, Agelidis A, Barrera J, Wu H, Burlingame A, Malynn BA, Zamvil SS, Ma A
• A20 restricts ubiquitination of pro-interleukin-1β protein complexes and suppresses NLRP3 inflammasome activity.
  Immunity 2015 Duong BH, Onizawa M, Oses-Prieto JA, Advincula R, Burlingame A, Malynn BA, Ma A
• Cutting edge: ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells.
  Journal of immunology (Baltimore, Md. : 1950) 2013 Callahan JA, Hammer GE, Agelides A, Duong BH, Oshima S, North J, Advincula R, Shifrin N, Truong HA, Paw J, Barrera J, DeFranco A, Rosenblum MD, Malynn BA, Ma A
• A20 restricts wnt signaling in intestinal epithelial cells and suppresses colon carcinogenesis.
  PloS one 2013 Shao L, Oshima S, Duong B, Advincula R, Barrera J, Malynn BA, Ma A
• 823 A20 Restricts Canonical Wnt Signaling in Intestinal Epithelial Cells and Suppresses Colon Carcinogenesis.
  Gastroenterology 2013 Ling Shao, Shigeru Oshima, Bao Duong, Rommel Advincula, Julio Barrera, Barbara Malynn, Averil I.
• Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme.
  Immunity 2013 Lu TT, Onizawa M, Hammer GE, Turer EE, Yin Q, Damko E, Agelidis A, Shifrin N, Advincula R, Barrera J, Malynn BA, Wu H, Ma A
• A20: linking a complex regulator of ubiquitylation to immunity and human disease.
  Nature reviews. Immunology 2012 Ma A, Malynn BA
• Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis.
  Nature immunology 2011 Hammer GE, Turer EE, Taylor KE, Fang CJ, Advincula R, Oshima S, Barrera J, Huang EJ, Hou B, Malynn BA, Reizis B, DeFranco A, Criswell LA, Nakamura MC, Ma A
• Ubiquitin makes its mark on immune regulation.
  Immunity 2010 Malynn BA, Ma A
• A20 Tumor Suppressor Deletion and BCL6 Oncogene Activation Cooperate In Deregulating B Cell Differentiation In Vivo.
  Blood 2010 Jonathan Mandelbaum, Qiong Shen, Hongyan Tang, Tongwei Mo, Barbara Malynn, Averil Ma, Riccardo Dalla-Favera, Laura Pasqualucci
• The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity.
  Immunity 2010 Tavares RM, Turer EE, Liu CL, Advincula R, Scapini P, Rhee L, Barrera J, Lowell CA, Utz PJ, Malynn BA, Ma A
• Macrophage- and dendritic-cell-derived interleukin-15 receptor alpha supports homeostasis of distinct CD8+ T cell subsets.
  Immunity 2009 Mortier E, Advincula R, Kim L, Chmura S, Barrera J, Reizis B, Malynn BA, Ma A
• A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme.
  The Journal of Cell Biology 2009 Barbara A. Malynn, Averil Ma
• A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme.
  The Journal of experimental medicine 2009 Malynn BA, Ma A
• Erratum: ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development.
  Nature 2009 Shigeru Oshima, Emre E. Turer, Joseph A. Callahan, Sophia Chai, Rommel Advincula, Julio Barrera, Nataliya Shifrin, Bettina Lee, T. S. Benedict Yen, Tammy Woo, Barbara A. Malynn, Averil Ma
• ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development.
  Nature 2008 Oshima S, Turer EE, Callahan JA, Chai S, Advincula R, Barrera J, Shifrin N, Lee B, Benedict Yen TS, Yen B, Woo T, Malynn BA, Ma A
• The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals.
  Immunity 2008 Hitotsumatsu O, Ahmad RC, Tavares R, Wang M, Philpott D, Turer EE, Lee BL, Shiffin N, Advincula R, Malynn BA, Werts C, Ma A
• Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20.
  The Journal of experimental medicine 2008 Turer EE, Tavares RM, Mortier E, Hitotsumatsu O, Advincula R, Lee B, Shifrin N, Malynn BA, Ma A
• Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease.
  Proceedings of the National Academy of Sciences of the United States of America 2005 Takeuchi O, Fisher J, Suh H, Harada H, Malynn BA, Korsmeyer SJ
• Truncated immunoglobulin Dmu causes incomplete developmental progression of RAG-deficient pro-B cells.
  Molecular immunology 2002 Malynn BA, Shaw AC, Young F, Stewart V, Alt FW
• Analysis of C-MYC function in normal cells via conditional gene-targeted mutation.
  Immunity 2001 de Alboran IM, O'Hagan RC, Gärtner F, Malynn B, Davidson L, Rickert R, Rajewsky K, DePinho RA, Alt FW
• Cloning and functional characterization of the early-lymphocyte-specific Pb99 gene.
  Molecular and cellular biology 2000 Sleckman BP, Khan WN, Xu W, Bassing CH, Malynn BA, Copeland NG, Bardon CG, Breit TM, Davidson L, Oltz EM, Jenkins NA, Berman JE, Alt FW
• N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation.
  Genes & development 2000 Malynn BA, de Alboran IM, O'Hagan RC, Bronson R, Davidson L, DePinho RA, Alt FW
• A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis.
  Cell 1998 Gao Y, Sun Y, Frank KM, Dikkes P, Fujiwara Y, Seidl KJ, Sekiguchi JM, Rathbun GA, Swat W, Wang J, Bronson RT, Malynn BA, Bryans M, Zhu C, Chaudhuri J, Davidson L, Ferrini R, Stamato T, Orkin SH, …
• Generation of normal lymphocytes derived from N-myc-deficient embryonic stem cells.
  International immunology 1995 Malynn BA, Demengeot J, Stewart V, Charron J, Alt FW
• Defective B cell development and function in Btk-deficient mice.
  Immunity 1995 Khan WN, Alt FW, Gerstein RM, Malynn BA, Larsson I, Rathbun G, Davidson L, Müller S, Kantor AB, Herzenberg LA
• Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene.
  Genes & development 1992 Charron J, Malynn BA, Fisher P, Stewart V, Jeannotte L, Goff SP, Robertson EJ, Alt FW
• Normal recombination substrate VH to DJH rearrangements in pre-B cell lines from scid mice.
  The Journal of experimental medicine 1990 Ferrier P, Covey LR, Li SC, Suh H, Malynn BA, Blackwell TK, Morrow MA, Alt FW
• High-Frequency Disruption of the N-myc Gene in Embryonic Stem and Pre-B Cell Lines by Homologous Recombination.
  Molecular and Cellular Biology 1990 Jean Charron, Barbara A. Malynn, Elizabeth J. Robertson, Stephen P. Goff, Frederick W. Alt
• High-frequency disruption of the N-myc gene in embryonic stem and pre-B cell lines by homologous recombination.
  Molecular and cellular biology 1990 Charron J, Malynn BA, Robertson EJ, Goff SP, Alt FW
• High-frequency disruption of the N-myc gene in embryonic stem and pre-B cell lines by homologous recombination.
  Molecular and Cellular Biology 1990 J Charron, B A Malynn, E J Robertson, S P Goff, F W Alt
• Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice.
  The Journal of experimental medicine 1990 Malynn BA, Yancopoulos GD, Barth JE, Bona CA, Alt FW
• Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins.
  The EMBO journal 1989 Blackwell TK, Malynn BA, Pollock RR, Ferrier P, Covey LR, Fulop GM, Phillips RA, Yancopoulos GD, Alt FW
• B Cell Differentiation: Development of Antibody Repertoires.
  Progress in Immunology 1989 F. W. Alt, G. Rathbun, J. Berman, B. Malynn, M. Morrow, T. Logtenberg, G. Yancopoulos
• The effect of the scid mutation on mechanism and control of immunoglobulin heavy and light chain gene rearrangement.
  Current topics in microbiology and immunology 1989 Blackwell TK, Ferrier P, Malynn BA, Pollock RR, Covey LR, Suh HY, Heinke LB, Fulop GM, Phillips RA, Yancopoulos GD
• The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism.
  Cell 1988 Malynn BA, Blackwell TK, Fulop GM, Rathbun GA, Furley AJ, Ferrier P, Heinke LB, Phillips RA, Yancopoulos GD, Alt FW
• Developmentally regulated and strain-specific expression of murine VH gene families.
  The Journal of experimental medicine 1988 Yancopoulos GD, Malynn BA, Alt FW
• Control of recombination events during lymphocyte differentiation. Heavy chain variable region gene assembly and heavy chain class switching.
  Annals of the New York Academy of Sciences 1988 Alt FW, Ferrier P, Malynn B, Lutzker S, Rothman P, Berman J, Blackwell K, Mellis S, Pollock R, Furley A
• Expression of the immunoglobulin heavy-chain variable gene repertoire.
  Current topics in microbiology and immunology 1987 Malynn BA, Berman JE, Yancopoulos GD, Bona CA, Alt FW
• Regulation fo immunoglobulin variable region gene assembly: development of the primary antibody repertoire.
  BioEssays : news and reviews in molecular, cellular and developmental biology 1986 Berman JE, Malynn BA, Blackwell TK, Alt FW
• Antigen-specific B cells efficiently present low doses of antigen for induction of T cell proliferation.
  Journal of immunology (Baltimore, Md. : 1950) 1985 Malynn BA, Romeo DT, Wortis HH
• Role of antigen-specific B cells in the induction of SRBC-specific T cell proliferation.
  Journal of immunology (Baltimore, Md. : 1950) 1984 Malynn BA, Wortis HH