Bani Tamraz, PharmD, PhD
Associate Professor
Clinical Pharmacy
School of Pharmacy

I have nested several PGx studies within WIHS, providing me with the opportunity to examine how PGx factors interact with other pharmacokinetic factors to determine drug exposure and treatment outcome. In particular, my work with WIHS has enabled me to examine PGx variations associated with ethnicity which is an understudied, but high priority area of research. Besides PGx studies in HIV, I have studies in the areas of pediatric bone marrow transplant, ophthalmology and in vitro fertilization.

In addition to discovery work, I am leading projects with an overarching vision of creating the UCSF Health-School of Pharmacy service for translating known PGx findings into clinical practice. At present, I am completing CLIA-certification of a gene panel that can provide PGx guidance for the use of 42 medications in UCSF Health. Following CLIA validation, the clinical application will be launched first with lung transplant service to pre-emptively genotype patients wait listed for transplant and use PGx to guide tacrolimus dosing post- transplant. I am leading several spin off projects related to clinical application of PGx at UCSF: a cost-effectiveness analysis of PGx in transplant and development of clinical decision support (CDS) structure for delivering the PGx-based treatment recommendations to clinicians.

In summary, I have numerous active research projects, various collaborations and a growing clinical project that I am certain will produce meaningful results.

• Dual Trajectories of Antiretroviral Therapy Adherence and Polypharmacy in Women with HIV in the United States.
  Research square 2023 Elbur AI, Ghebremichael M, Konkle-Parker D, Jones DL, Collins S, Adimora AA, Schneider MF, Cohen MH, Tamraz B, Plankey M, Wilson T, Adedimeji A, Haberer JE, Jacobson DL
• A Patient Decision Aid (i.ARTs) to Facilitate Women's Choice Between Oral and Long-Acting Injectable Antiretroviral Treatment for HIV: Protocols for its Development and Randomized Controlled Pilot Trial.
  JMIR research protocols 2022 Philbin MM, McCrimmon T, Shaffer VA, Kerrigan D, Pereyra M, Cohen MH, Sosanya O, Sheth AN, Adimora AA, Topper EF, Rana A, Tamraz B, Goparaju L, Wilson TE, Alcaide M
• Polypharmacy Is Associated With Falls in Women With and Without HIV.
  Journal of acquired immune deficiency syndromes (1999) 2022 Psomas CK, Hoover DR, Shi Q, Brown TT, Vance DE, Holman S, Plankey MW, Tien PC, Weber KM, Floris-Moore M, Bolivar HH, Golub ET, McDonnell Holstad M, Radtke KK, Tamraz B, Erlandson KM, Rubin LH, Sharma…
• Degree of Polypharmacy and Cognitive Function in Older Women with HIV.
  AIDS research and human retroviruses 2022 Rubin LH, Neijna AG, Shi Q, Hoover DR, Tamraz B, Anastos K, Edmonds A, Fischl MA, Gustafson D, Maki PM, Merenstein D, Sheth AN, Springer G, Vance D, Weber KM, Sharma A
• eP467 Are clinicians ready for genomic medicine?: assessing educational needs.
  Molecular Genetics and Metabolism 2021 Matthew Ryan, Karla Lindquist, Anica Wandler, Cynthia Morgan, Sawona Biswas, Elena Flowers, Patrick Devine, Teresa Sparks, Maren Scheuner, Bani Tamraz, Thomas Hoffmann, Joseph Shieh, Neil Risch, …
• Association Between Medication-Taking and Refractive Error in a Large General Population-Based Cohort.
  Investigative ophthalmology & visual science 2021 Patasova K, Khawaja AP, Tamraz B, Williams KM, Mahroo OA, Freidin M, Solebo AL, Vehof J, Falchi M, Rahi JS, Hammond CJ, Hysi PG
• Prescribing Prevalence of Medications With Potential Genotype-Guided Dosing in Pediatric Patients.
  JAMA network open 2020 Ramsey LB, Ong HH, Schildcrout JS, Shi Y, Tang LA, Hicks JK, El Rouby N, Cavallari LH, Tuteja S, Aquilante CL, Beitelshees AL, Lemkin DL, Blake KV, Williams H, Cimino JJ, Davis BH, Limdi NA, Empey PE,…
• Food Insecurity Is Associated With Lower Levels of Antiretroviral Drug Concentrations in Hair Among a Cohort of Women Living With Human Immunodeficiency Virus in the United States.
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2020 Leddy AM, Sheira LA, Tamraz B, Sykes C, Kashuba ADM, Wilson TE, Adedimeji A, Merenstein D, Cohen MH, Wentz EL, Adimora AA, Ofotokun I, Metsch LR, Turan JM, Bacchetti P, Weiser SD
• Intracellular Tenofovir and Emtricitabine Concentrations in Younger and Older Women with HIV Receiving Tenofovir Disoproxil Fumarate/Emtricitabine.
  Antimicrobial agents and chemotherapy 2020 Dumond JB, Bay CP, Nelson JAE, Davalos A, Edmonds A, De Paris K, Sykes C, Anastos K, Sharma R, Kassaye S, Tamraz B, French AL, Gange S, Ofotokun I, Fischl MA, Vance DE, Adimora AA
• CYP2C19 Allele Frequencies in Over 2.2 Million Direct-to-Consumer Genetics Research Participants and the Potential Implication for Prescriptions in a Large Health System.
  Clinical and translational science 2020 Ionova Y, Ashenhurst J, Zhan J, Nhan H, Kosinski C, Tamraz B, Chubb A
• A pharmacokinetic and pharmacogenetic evaluation of contraceptive implants and antiretroviral therapy among women in Kenya and Uganda.
  AIDS (London, England) 2019 Patel RC, Stalter RM, Thomas KK, Tamraz B, Blue SW, Erikson DW, Kim CJ, Kelly EJ, Nanda K, Kourtis AP, Lingappa JR, Mugo N, Baeten JM, Scarsi KK, Partners PrEP Study Team
• Association of Pharmacogenetic Markers With Atazanavir Exposure in HIV-Infected Women.
  Clinical pharmacology and therapeutics 2019 Tamraz B, Huang Y, French AL, Kassaye S, Anastos K, Nowicki MJ, Gange S, Gustafson DR, Bacchetti P, Greenblatt RM, Hysi PG, Aouizerat BE, Women's Interagency HIV Study
• Association between Use of Methadone, Other Central Nervous System Depressants, and QTc Interval-Prolonging Medications and Risk of Mortality in a Large Cohort of Women Living with or at Risk for Human Immunodeficiency Virus Infection.
  Pharmacotherapy 2019 Tamraz B, Reisner L, French AL, King ST, Fischl MA, Ofotokun I, Kashuba A, Milam J, Murphy K, Augenbraun M, Liu C, Finley PR, Aouizerat B, Cocohoba J, Gange S, Bacchetti P, Greenblatt RM
• A practical first step using needs assessment and a survey approach to implementing a clinical pharmacogenomics consult service
  Journal of American College of Clinical Pharmacy 2019 Zakinova, Angela, Long-Boyle, Janel R., French, Deborah, Croci, Rhiannon, Wilson, Leslie, Phillips, Kathryn A., Kroetz, Deanna L., Shin, Jaekyu., Tamraz, Bani.
• A Practical First Step Using Needs Assessment and a Survey Approach to Implementing a Clinical Pharmacogenomics Consult Service.
  Journal of the American College of Clinical Pharmacy : JACCP 2018 Zakinova A, Long-Boyle JR, French D, Croci R, Wilson L, Phillips KA, Kroetz DL, Shin J, Tamraz B
• Ascorbic acid metabolites are involved in intraocular pressure control in the general population.
  Redox biology 2018 Hysi PG, Khawaja AP, Menni C, Tamraz B, Wareham N, Khaw KT, Foster PJ, Benet LZ, Spector TD, Hammond CJ
• Development and validation of an LC-MS/MS assay for the quantification of dolutegravir extracted from human hair.
  Analytical and bioanalytical chemistry 2018 Sykes C, Blake K, White N, Schauer AP, Guzman BB, Cottrell ML, Tamraz B, Kashuba ADM
• Cognitive Burden of Common Non-antiretroviral Medications in HIV-Infected Women.
  Journal of acquired immune deficiency syndromes (1999) 2018 Rubin LH, Radtke KK, Eum S, Tamraz B, Kumanan KN, Springer G, Maki PM, Anastos K, Merenstein D, Karim R, Weber KM, Gustafson D, Greenblatt RM, Bishop JR
• A Genome-Wide Association Study Identifies a Candidate Gene Associated With Atazanavir Exposure Measured in Hair.
  Clinical pharmacology and therapeutics 2018 Tamraz B, Huang Y, French AL, Kassaye S, Anastos K, Nowicki MJ, Gange S, Gustafson DR, Bacchetti P, Greenblatt RM, Hysi PG, Aouizerat BE
• Pharmacogenetic Associations with ADME Variants and Virologic Response to an Initial HAART Regimen in HIV-Infected Women.
  International journal of HIV/AIDS and research 2017 Pearce CL, Stram D, Wiensch A, Frasco MA, Kono N, Den Berg DV, Anastos K, Cohen MH, DeHovitz J, Golub ET, Tamraz B, Liu C, Mack WJ
• OATP1B1-related drug-drug and drug-gene interactions as potential risk factors for cerivastatin-induced rhabdomyolysis.
  Pharmacogenetics and genomics 2013 Tamraz B, Fukushima H, Wolfe AR, Kaspera R, Totah RA, Floyd JS, Ma B, Chu C, Marciante KD, Heckbert SR, Psaty BM, Kroetz DL, Kwok PY
• A screening study of drug-drug interactions in cerivastatin users: an adverse effect of clopidogrel.
  Clinical pharmacology and therapeutics 2012 Floyd JS, Kaspera R, Marciante KD, Weiss NS, Heckbert SR, Lumley T, Wiggins KL, Tamraz B, Kwok PY, Totah RA, Psaty BM
• Cerivastatin, genetic variants, and the risk of rhabdomyolysis.
  Pharmacogenetics and genomics 2011 Marciante KD, Durda JP, Heckbert SR, Lumley T, Rice K, McKnight B, Totah RA, Tamraz B, Kroetz DL, Fukushima H, Kaspera R, Bis JC, Glazer NL, Li G, Austin TR, Taylor KD, Rotter JI, Jaquish CE, Kwok PY,…
• Cerivastatin in vitro metabolism by CYP2C8 variants found in patients experiencing rhabdomyolysis.
  Pharmacogenetics and genomics 2010 Kaspera R, Naraharisetti SB, Tamraz B, Sahele T, Cheesman MJ, Kwok PY, Marciante K, Heckbert SR, Psaty BM, Totah RA
• Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations.
  The Journal of allergy and clinical immunology 2009 Trivedi NN, Tamraz B, Chu C, Kwok PY, Caughey GH
• An Inactivating, Frame-shifted Mutation of ,III Tryptase is Common in People of Northern and Western European Ancestory.
  Journal of Allergy and Clinical Immunology 2009 N. Trivedi, B. Tamraz, P.Y. Kwok, G.H. Caughey
• Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels.
  American journal of human genetics 2007 Reich D, Patterson N, Ramesh V, De Jager PL, McDonald GJ, Tandon A, Choy E, Hu D, Tamraz B, Pawlikowska L, Wassel-Fyr C, Huntsman S, Waliszewska A, Rossin E, Li R, Garcia M, Reiner A, Ferrell R, …