Babak Javid, PhD
Associate Professor
Medicine
School of Medicine

(1) how does alteration of the bacterial protein synthesis machinery (ribosomes, pre-ribosomal pathways) allow mycobacteria to adapt to hostile environments such as the host and antibiotic treatment? (2) what is the role and mechanism of antibody-mediated immunity to tuberculosis. (3) what the molecular mechanisms that allow Mycobacterium tuberculosis to survive antibiotics -- necessitating months-long treatment regimens.

I am always delighted to explore new collaborations and work with people who are curious and passionate about making exciting new discoveries.

• A quest for novel antimicrobial targets: Inhibition of Asp-tRNAAsn/Glu-tRNAGln amidotransferase (GatCAB) by synthetic analogs of aminoacyl-adenosine in vitro and live bacteria.
  Bioorganic chemistry 2024 Sangsuwan W, Taweesablamlert A, Boonkerd A, Isarangkool Na Ayutthaya C, Yoo S, Javid B, Faikhruea K, Vilaivan T, Aonbangkhen C, Chuawong P
• Rifampicin tolerance and growth fitness among isoniazid-resistant clinical Mycobacterium tuberculosis isolates: an in-vitro longitudinal study.
  bioRxiv : the preprint server for biology 2024 Vijay S, Bao NLH, Vinh DN, Nhat LTH, Thu DDA, Quang NL, Trieu LPT, Nhung HN, Ha VTN, Thai PVK, Ha DTM, Lan NH, Caws M, Thwaites GE, Javid B, Thuong NTT
• A teenage girl with altered mental status and paraparesis.
  Journal of clinical tuberculosis and other mycobacterial diseases 2024 Miyakawa R, Louie J, Keh C, Chen L, Javid B, Ernst JD, Goswami N, Chow FC
• Mechanical morphotype switching as an adaptive response in mycobacteria.
  Science advances 2024 Eskandarian HA, Chen YX, Toniolo C, Belardinelli JM, Palcekova Z, Hom L, Ashby PD, Fantner GE, Jackson M, McKinney JD, Javid B
• Author Correction: An anti-LpqH human monoclonal antibody from an asymptomatic individual mediates protection against Mycobacterium tuberculosis.
  NPJ vaccines 2023 Krishnananthasivam S, Li H, Bouzeyen R, Shunmuganathan B, Purushotorman K, Liao X, Du F, Friis CGK, Crawshay-Williams F, Boon LH, Xinlei Q, Chan CEZ, Sobota R, Kozma M, Barcelli V, Wang G, Huang H, …
• Navigating a Path to Rifampicin Resistance in Tuberculosis.
  mBio 2023 Agarwal S, Javid B
• Therapeutic Vaccines for Tuberculosis: An Overview.
  Frontiers in immunology 2022 Bouzeyen R, Javid B
• The 2021 WHO catalogue of Mycobacterium tuberculosis complex mutations associated with drug resistance: A genotypic analysis.
  The Lancet. Microbe 2022 Walker TM, Miotto P, Köser CU, Fowler PW, Knaggs J, Iqbal Z, Hunt M, Chindelevitch L, Farhat M, Cirillo DM, Comas I, Posey J, Omar SV, Peto TE, Suresh A, Uplekar S, Laurent S, Colman RE, Nathanson CM,…
• Harnessing Twitter data to survey public attention and attitudes towards COVID-19 vaccines in the UK.
  Scientific reports 2021 Fazel S, Zhang L, Javid B, Brikell I, Chang Z
• 100 years of antibody solitude in TB.
  Nature immunology 2021 Divangahi M, Javid B, Kaufmann E
• Clinically Relevant Mutations of Mycobacterial GatCAB Inform Regulation of Translational Fidelity.
  mBio 2021 Li YY, Cai RJ, Yang JY, Hendrickson TL, Xiang Y, Javid B
• Should masks be worn outdoors?
  BMJ (Clinical research ed.) 2021 Javid B, Bassler D, Bryant MB, Cevik M, Tufekci Z, Baral S
• Direct and indirect evidence of efficacy and safety of rapid exercise tests for exertional desaturation in Covid-19: a rapid systematic review.
  Systematic reviews 2021 Kalin A, Javid B, Knight M, Inada-Kim M, Greenhalgh T
• Most-Probable-Number-Based Minimum Duration of Killing Assay for Determining the Spectrum of Rifampicin Susceptibility in Clinical Mycobacterium tuberculosis Isolates.
  Antimicrobial agents and chemotherapy 2021 Vijay S, Nhung HN, Bao NLH, Thu DDA, Trieu LPT, Phu NH, Thwaites GE, Javid B, Thuong NTT
• Managing outbreaks of highly contagious diseases in prisons: a systematic review.
  BMJ global health 2020 Beaudry G, Zhong S, Whiting D, Javid B, Frater J, Fazel S
• Forward Genetics Reveals a gatC-gatA Fusion Polypeptide Causes Mistranslation and Rifampicin Tolerance in Mycobacterium smegmatis.
  Frontiers in microbiology 2020 Cai RJ, Su HW, Li YY, Javid B
• Premature termination codon readthrough in Drosophila varies in a developmental and tissue-specific manner.
  Scientific reports 2020 Chen Y, Sun T, Bi Z, Ni JQ, Pastor-Pareja JC, Javid B
• Clinically relevant mutations in mycobacterial LepA cause rifampicin-specific phenotypic resistance.
  Scientific reports 2020 Wang BW, Zhu JH, Javid B
• Covid-19: should the public wear face masks?
  BMJ (Clinical research ed.) 2020 Javid B, Weekes MP, Matheson NJ
• HspX promotes the polar localization of mycobacterial protein aggregates.
  Scientific reports 2019 Zhang YW, Zhu JH, Wang ZQ, Wu Y, Meng X, Zheng X, Javid B
• Derivatives of Natural Product Agrimophol as Disruptors of Intrabacterial pH Homeostasis in Mycobacterium tuberculosis.
  ACS infectious diseases 2019 Wu J, Mu R, Sun M, Zhao N, Pan M, Li H, Dong Y, Sun Z, Bai J, Hu M, Nathan CF, Javid B, Liu G
• Measurement of Specific Mycobacterial Mistranslation Rates with Gain-of-function Reporter Systems.
  Journal of visualized experiments : JoVE 2019 Chen YX, Pan M, Chen YM, Javid B
• More than merely drug resistance.
  Nature microbiology 2018 Chen YX, Javid B
• Transmission of toxigenic Corynebacterium diphtheriae by a fully immunised resident returning from a visit to West Africa, United Kingdom, 2017.
  Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 2018 Edwards D, Kent D, Lester C, Brown CS, Murphy ME, Brown NM, Sule O, Itani A, Chand M, Trindall A, Pearson C, Roddick I, Fry NK, Hoffmann J, Iyanger N, Kemp L, White J, Javid B, Ramsay ID, Zenner D, …
• Over-Expression of the Mycobacterial Trehalose-Phosphate Phosphatase OtsB2 Results in a Defect in Macrophage Phagocytosis Associated with Increased Mycobacterial-Macrophage Adhesion.
  Frontiers in microbiology 2016 Li H, Wu M, Shi Y, Javid B
• The essential mycobacterial amidotransferase GatCAB is a modulator of specific translational fidelity.
  Nature microbiology 2016 Su HW, Zhu JH, Li H, Cai RJ, Ealand C, Wang X, Chen YX, Kayani MU, Zhu TF, Moradigaravand D, Huang H, Kana BD, Javid B
• Plasma Membrane Profiling Reveals Upregulation of ABCA1 by Infected Macrophages Leading to Restriction of Mycobacterial Growth.
  Frontiers in microbiology 2016 Long J, Basu Roy R, Zhang YJ, Antrobus R, Du Y, Smith DL, Weekes MP, Javid B
• dfrA thyA Double Deletion in para-Aminosalicylic Acid-Resistant Mycobacterium tuberculosis Beijing Strains.
  Antimicrobial agents and chemotherapy 2016 Moradigaravand D, Grandjean L, Martinez E, Li H, Zheng J, Coronel J, Moore D, Török ME, Sintchenko V, Huang H, Javid B, Parkhill J, Peacock SJ, Köser CU
• Whole-genome sequencing for the diagnosis of drug-resistant tuberculosis.
  The Lancet. Infectious diseases 2016 Javid B, Török ME
• Translational misreading in Mycobacterium smegmatis increases in stationary phase.
  Tuberculosis (Edinburgh, Scotland) 2015 Leng T, Pan M, Xu X, Javid B
• Uniform and amorphous rifampicin microspheres obtained by freezing induced LLPS during lyophilization.
  International journal of pharmaceutics 2015 Liu C, Kong C, Wu G, Zhu J, Javid B, Qian F
• Transmitted Extended-Spectrum Extensively Drug-Resistant Tuberculosis in Beijing, China, with Discordant Whole-Genome Sequencing Analysis Results.
  Journal of clinical microbiology 2015 Li H, Kayani Mu, Gu Y, Wang X, Zhu T, Duan H, Ma Y, Huang H, Javid B
• Tuberculosis: hey there, lonely guy!
  Molecular cell 2015 Zhu JH, Javid B
• Drug-resistance mechanisms and tuberculosis drugs.
  Lancet (London, England) 2015 Köser CU, Javid B, Liddell K, Ellington MJ, Feuerriegel S, Niemann S, Brown NM, Burman WJ, Abubakar I, Ismail NA, Moore D, Peacock SJ, Török ME
• Protein mistranslation: friend or foe?
  Trends in biochemical sciences 2014 Ribas de Pouplana L, Santos MA, Zhu JH, Farabaugh PJ, Javid B
• Prevalence and drug resistance of nontuberculous mycobacteria, northern China, 2008-2011.
  Emerging infectious diseases 2014 Wang X, Li H, Jiang G, Zhao L, Ma Y, Javid B, Huang H
• Novel diagnostics and therapeutics for drug-resistant tuberculosis.
  British medical bulletin 2014 Toosky M, Javid B
• Mycobacterial mistranslation is necessary and sufficient for rifampicin phenotypic resistance.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Javid B, Sorrentino F, Toosky M, Zheng W, Pinkham JT, Jain N, Pan M, Deighan P, Rubin EJ
• Functional role of methylation of G518 of the 16S rRNA 530 loop by GidB in Mycobacterium tuberculosis.
  Antimicrobial agents and chemotherapy 2013 Wong SY, Javid B, Addepalli B, Piszczek G, Strader MB, Limbach PA, Barry CE
• MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212.
  Antimicrobial agents and chemotherapy 2011 La Rosa V, Poce G, Canseco JO, Buroni S, Pasca MR, Biava M, Raju RM, Porretta GC, Alfonso S, Battilocchio C, Javid B, Sorrentino F, Ioerger TR, Sacchettini JC, Manetti F, Botta M, De Logu A, Rubin EJ,…
• Nanotubes: shaking hands, talking, or sharing?
  Frontiers in microbiology 2011 Javid B, Derbyshire KM
• Human H+ATPase a4 subunit mutations causing renal tubular acidosis reveal a role for interaction with phosphofructokinase-1.
  American journal of physiology. Renal physiology 2008 Su Y, Blake-Palmer KG, Sorrell S, Javid B, Bowers K, Zhou A, Chang SH, Qamar S, Karet FE
• A 58-year-old woman with abdominal symptoms and elevated C-reactive protein.
  PLoS medicine 2008 Daly ML, Cartwright DJ, Lehner PJ, Javid B
• A case of Mycoplasma hominis septic arthritis postpartum.
  The Journal of infection 2007 Phuah CL, Javid B, Aliyu SH, Lever AM
• Structure and function: heat shock proteins and adaptive immunity.
  Journal of immunology (Baltimore, Md. : 1950) 2007 Javid B, MacAry PA, Lehner PJ
• Schistosomal colonic polyposis in an HIV-positive man.
  AIDS (London, England) 2007 Javid B, Aliyu SH, Save VE, Carmichael AJ, Lever AM
• Peptides complexed with the protein HSP70 generate efficient human cytolytic T-lymphocyte responses.
  Biochemical Society transactions 2004 Javid B, MacAry PA, Oehlmann W, Singh M, Lehner PJ
• Molecular studies of anti-HLA-A2 using light-chain shuffling: a structural model for HLA antibody binding.
  Tissue antigens 2004 Watkins NA, Dafforn TR, Kuijpers M, Brown C, Javid B, Lehner PJ, Navarrete C, Ouwehand WH
• HSP70 peptide binding mutants separate antigen delivery from dendritic cell stimulation.
  Immunity 2004 MacAry PA, Javid B, Floto RA, Smith KG, Oehlmann W, Singh M, Lehner PJ
• High rates of tuberculosis in end-stage renal failure: the impact of international migration.
  Emerging infectious diseases 2002 Moore DA, Lightstone L, Javid B, Friedland JS