Avisek Majumder, PhD
Associate Specialist
Medicine
School of Medicine

In one project, I’m doing structure-function studies of HER2 and HER3 in HER2-positive breast cancer to identify new structural features that are critical for signaling so that we can develop a new generation of drugs that are both highly effective and have fewer side effects than the current treatment regimen for these patients. In another project, I’m working on the development of novel SynNotch CART cell therapy to target HER2-positive breast tumors. Apart from these, I am also involved with several other projects that are currently going on in our lab

• Genes and genetics in hyperhomocysteinemia and the "1-carbon metabolism": implications for retinal structure and eye functions.
  Canadian journal of physiology and pharmacology 2019 George AK, Majumder A, Ice H, Homme RP, Eyob W, Tyagi SC, Singh M
• Hydrogen sulfide intervention in cystathionine-β-synthase mutant mouse helps restore ocular homeostasis.
  International journal of ophthalmology 2019 George AK, Homme RP, Majumder A, Laha A, Metreveli N, Sandhu HS, Tyagi SC, Singh M
• Expression Analysis of the Circular RNA Molecules in the Human Retinal Cells Treated with Homocysteine.
  Current eye research 2018 Singh M, George AK, Homme RP, Majumder A, Laha A, Sandhu HS, Tyagi SC
• Circular RNAs constitute an inherent gene regulatory axis in the mammalian eye and brain 1.
  Canadian journal of physiology and pharmacology 2018 George AK, Master K, Majumder A, Homme RP, Laha A, Sandhu HS, Tyagi SC, Singh M
• Restoration of skeletal muscle homeostasis by hydrogen sulfide during hyperhomocysteinemia-mediated oxidative/ER stress condition 1.
  Canadian journal of physiology and pharmacology 2018 Majumder A, Singh M, George AK, Tyagi SC
• Remote ischemic conditioning as a cytoprotective strategy in vasculopathies during hyperhomocysteinemia: An emerging research perspective.
  Journal of cellular biochemistry 2018 Majumder A, Singh M, George AK, Homme RP, Laha A, Tyagi SC
• Remodeling of Retinal Architecture in Diabetic Retinopathy: Disruption of Ocular Physiology and Visual Functions by Inflammatory Gene Products and Pyroptosis.
  Frontiers in physiology 2018 Homme RP, Singh M, Majumder A, George AK, Nair K, Sandhu HS, Tyagi N, Lominadze D, Tyagi SC
• Hydrogen sulfide improves postischemic neoangiogenesis in the hind limb of cystathionine-β-synthase mutant mice via PPAR-γ/VEGF axis.
  Physiological reports 2018 Majumder A, Singh M, George AK, Behera J, Tyagi N, Tyagi SC
• Hydrogen sulfide alleviates hyperhomocysteinemia-mediated skeletal muscle atrophy via mitigation of oxidative and endoplasmic reticulum stress injury.
  American journal of physiology. Cell physiology 2018 Majumder A, Singh M, Behera J, Theilen NT, George AK, Tyagi N, Metreveli N, Tyagi SC
• Connecting homocysteine and obesity through pyroptosis, gut microbiome, epigenetics, peroxisome proliferator-activated receptor γ, and zinc finger protein 407.
  Canadian journal of physiology and pharmacology 2018 Laha A, Majumder A, Singh M, Tyagi SC
• Circular RNAs profiling in the cystathionine-β-synthase mutant mouse reveals novel gene targets for hyperhomocysteinemia induced ocular disorders.
  Experimental eye research 2018 Singh M, George AK, Homme RP, Majumder A, Laha A, Sandhu HS, Tyagi SC
• A hypothesis for treating inflammation and oxidative stress with hydrogen sulfide during age-related macular degeneration.
  International journal of ophthalmology 2018 George AK, Singh M, Homme RP, Majumder A, Sandhu HS, Tyagi SC
• Post-menopausal breast cancer: from estrogen to androgen receptor.
  Oncotarget 2017 Majumder A, Singh M, Tyagi SC
• Hypermethylation: Causes and Consequences in Skeletal Muscle Myopathy.
  Journal of cellular biochemistry 2017 Majumder A, Behera J, Jeremic N, Tyagi SC