Avi Samelson, PhD
Postdoctoral Scholar
Institute for Neurodegenerative Diseases
School of Medicine

Grants and Projects

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• Mechanisms of tau misfolding in neurons elucidated by deep mutational scanning and CRISPR screening, NIH, 2019-2022

Publications (14)

Top publication keywords:
RibosomesMonomeric GTP-Binding ProteinsModels, MolecularProtein ConformationProteinsProteolysisProtein FoldingTranscription FactorsAntiviral AgentsEscherichia coliCellular ReprogrammingProtein StabilityEpithelial CellsRibonuclease HProtein Refolding

• Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.
  Cell 2024 Parra Bravo C, Giani AM, Perez JM, Zhao Z, Wan Y, Samelson AJ, Wong MY, Evangelisti A, Cordes E, Fan L, Ye P, Zhu D, Pozner T, Mercedes M, Patel T, Yarahmady A, Carling GK, Sterky FH, Lee VMY, Lee EB,…
• CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.
  bioRxiv : the preprint server for biology 2023 Samelson AJ, Ariqat N, McKetney J, Rohanitazangi G, Bravo CP, Goodness D, Tian R, Grosjean P, Abskharon R, Eisenberg D, Kanaan NM, Gan L, Condello C, Swaney DL, Kampmann M
• Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.
  bioRxiv : the preprint server for biology 2023 Bravo CP, Giani AM, Perez JM, Zhao Z, Samelson A, Wong MY, Evangelisti A, Fan L, Pozner T, Mercedes M, Ye P, Patel T, Yarahmady A, Carling G, Lee VMY, Sharma M, Mok SA, Luo W, Zhao M, Kampmann M, Gong…
• CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions.
  bioRxiv : the preprint server for biology 2023 Li E, Benitez C, Boggess SC, Koontz M, Rose IVL, Draeger N, Teter OM, Samelson AJ, Ullian EM, Kampmann M
• BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.
  Nature cell biology 2022 Samelson AJ, Tran QD, Robinot R, Carrau L, Rezelj VV, Kain AM, Chen M, Ramadoss GN, Guo X, Lim SA, Lui I, Nuñez JK, Rockwood SJ, Wang J, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, Weissman…

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• BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.
  bioRxiv : the preprint server for biology 2021 Samelson AJ, Tran QD, Robinot R, Carrau L, Rezelj VV, Mac Kain A, Chen M, Ramadoss GN, Guo X, Lim SA, Lui I, Nunez J, Rockwood SJ, Wang J, Liu N, Carlson-Stevermer J, Oki J, Maures T, Holden K, …
• Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing.
  Cell 2021 Nuñez JK, Chen J, Pommier GC, Cogan JZ, Replogle JM, Adriaens C, Ramadoss GN, Shi Q, Hung KL, Samelson AJ, Pogson AN, Kim JYS, Chung A, Leonetti MD, Chang HY, Kampmann M, Bernstein BE, Hovestadt V, …
• The folding and unfolding behavior of ribonuclease H on the ribosome.
  The Journal of biological chemistry 2020 Jensen MK, Samelson AJ, Steward A, Clarke J, Marqusee S
• Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals.
  IUCrJ 2020 Wolff AM, Young ID, Sierra RG, Brewster AS, Martynowycz MW, Nango E, Sugahara M, Nakane T, Ito K, Aquila A, Bhowmick A, Biel JT, Carbajo S, Cohen AE, Cortez S, Gonzalez A, Hino T, Im D, Koralek JD, …
• Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex.
  Science (New York, N.Y.) 2019 Lawrence RE, Fromm SA, Fu Y, Yokom AL, Kim DJ, Thelen AM, Young LN, Lim CY, Samelson AJ, Hurley JH, Zoncu R
• Kinetic and structural comparison of a protein's cotranslational folding and refolding pathways.
  Science advances 2018 Samelson AJ, Bolin E, Costello SM, Sharma AK, O'Brien EP, Marqusee S
• Quantitative determination of ribosome nascent chain stability.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Samelson AJ, Jensen MK, Soto RA, Cate JH, Marqusee S
• HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold.
  Proceedings of the National Academy of Sciences of the United States of America 2012 Chou S, Upton H, Bao K, Schulze-Gahmen U, Samelson AJ, He N, Nowak A, Lu H, Krogan NJ, Zhou Q, Alber T
• Accessing protein conformational ensembles using room-temperature X-ray crystallography.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Fraser JS, van den Bedem H, Samelson AJ, Lang PT, Holton JM, Echols N, Alber T