Audrey Parent, PhD
Associate Professor
Diabetes Center
School of Medicine

Websites

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• Parent Lab (diabetes.ucsf.edu)

Publications (26)

Top publication keywords:
Islets of LangerhansDiabetes Mellitus, Type 1Graft RejectionInduced Pluripotent Stem CellsInsulin-Secreting CellsHLA AntigensGene DeletionReceptors, Thromboxane A2, Prostaglandin H2Epithelial CellsIntracellular MembranesThymus GlandSingle-Cell AnalysisPluripotent Stem CellsThymocytesGenetic Heterogeneity

• Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes.
  Nature cell biology 2024 F De Jesus D, Zhang Z, Brown NK, Li X, Xiao L, Hu J, Gaffrey MJ, Fogarty G, Kahraman S, Wei J, Basile G, Rana TM, Mathews C, Powers AC, Parent AV, Atkinson MA, Dhe-Paganon S, Eizirik DL, Qian WJ, He C…
• Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency.
  Nature 2023 Le Voyer T, Parent AV, Liu X, Cederholm A, Gervais A, Rosain J, Nguyen T, Perez Lorenzo M, Rackaityte E, Rinchai D, Zhang P, Bizien L, Hancioglu G, Ghillani-Dalbin P, Charuel JL, Philippot Q, Gueye MS…
• Ikaros is a principal regulator of Aire+ mTEC homeostasis, thymic mimetic cell diversity, and central tolerance.
  Science immunology 2023 Sin JH, Sucharov J, Kashyap S, Wang Y, Proekt I, Liu X, Parent AV, Gupta A, Kastner P, Chan S, Gardner JM, Ntranos V, Miller CN, Anderson MS, Schjerven H, Waterfield MR
• Redox Regulation of m 6 A Methyltransferase METTL3 in Human β-cells Controls the Innate Immune Response in Type 1 Diabetes.
  bioRxiv : the preprint server for biology 2023 De Jesus DF, Zhang Z, Brown NK, Li X, Gaffrey MJ, Kahraman S, Wei J, Hu J, Basile G, Xiao L, Rana TM, Mathews C, Powers AC, Atkinson MA, Eizirik DL, Dhe-Paganon S, Parent AV, Qian WJ, He C, Kulkarni …
• Autoantibodies to Perilipin-1 Define a Subset of Acquired Generalized Lipodystrophy.
  Diabetes 2023 Mandel-Brehm C, Vazquez SE, Liverman C, Cheng M, Quandt Z, Kung AF, Parent A, Miao B, Disse E, Cugnet-Anceau C, Dalle S, Orlova E, Frolova E, Alba D, Michels A, Oftedal BE, Lionakis MS, Husebye ES, …

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• Stem cell-based multi-tissue platforms to model human autoimmune diabetes.
  Molecular metabolism 2022 Leavens KF, Alvarez-Dominguez JR, Vo LT, Russ HA, Parent AV
• Development of a scalable method to isolate subsets of stem cell-derived pancreatic islet cells.
  Stem cell reports 2022 Parent AV, Ashe S, Nair GG, Li ML, Chavez J, Liu JS, Zhong Y, Streeter PR, Hebrok M
• Modeling human T1D-associated autoimmune processes.
  Molecular metabolism 2021 Khosravi-Maharlooei M, Madley R, Borsotti C, Ferreira LMR, Sharp RC, Brehm MA, Greiner DL, Parent AV, Anderson MS, Sykes M, Creusot RJ
• Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection.
  Cell reports 2021 Parent AV, Faleo G, Chavez J, Saxton M, Berrios DI, Kerper NR, Tang Q, Hebrok M
• From type 1 diabetes biology to therapy: The Human Islet Research Network.
  Molecular metabolism 2021 Kaddis JS, Rouse L, Parent AV, Saunders DC, Shalev A, Stabler CL, Stoffers DA, Wagner BK, Niland JC
• Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla.
  Nature communications 2021 Bautista JL, Cramer NT, Miller CN, Chavez J, Berrios DI, Byrnes LE, Germino J, Ntranos V, Sneddon JB, Burt TD, Gardner JM, Ye CJ, Anderson MS, Parent AV
• High-resolution epitope mapping of anti-Hu and anti-Yo autoimmunity by programmable phage display.
  Brain communications 2020 O'Donovan B, Mandel-Brehm C, Vazquez SE, Liu J, Parent AV, Anderson MS, Kassimatis T, Zekeridou A, Hauser SL, Pittock SJ, Chow E, Wilson MR, DeRisi JL
• Landscape of stimulation-responsive chromatin across diverse human immune cells.
  Nature genetics 2019 Calderon D, Nguyen MLT, Mezger A, Kathiria A, Müller F, Nguyen V, Lescano N, Wu B, Trombetta J, Ribado JV, Knowles DA, Gao Z, Blaeschke F, Parent AV, Burt TD, Anderson MS, Criswell LA, Greenleaf WJ, …
• Supporting Survival of Transplanted Stem-Cell-Derived Insulin-Producing Cells in an Encapsulation Device Augmented with Controlled Release of Amino Acids.
  Advanced biosystems 2019 Chendke GS, Faleo G, Juang C, Parent AV, Bernards DA, Hebrok M, Tang Q, Desai TA
• Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development.
  Nature 2018 Miller CN, Proekt I, von Moltke J, Wells KL, Rajpurkar AR, Wang H, Rattay K, Khan IS, Metzger TC, Pollack JL, Fries AC, Lwin WW, Wigton EJ, Parent AV, Kyewski B, Erle DJ, Hogquist KA, Steinmetz LM, …
• Mitigating Ischemic Injury of Stem Cell-Derived Insulin-Producing Cells after Transplant.
  Stem cell reports 2017 Faleo G, Russ HA, Wisel S, Parent AV, Nguyen V, Nair GG, Freise JE, Villanueva KE, Szot GL, Hebrok M, Tang Q
• Nanoporous Immunoprotective Device for Stem-Cell-Derived β-Cell Replacement Therapy.
  ACS nano 2017 Chang R, Faleo G, Russ HA, Parent AV, Elledge SK, Bernards DA, Allen JL, Villanueva K, Hebrok M, Tang Q, Desai TA
• Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro.
  The EMBO journal 2015 Russ HA, Parent AV, Ringler JJ, Hennings TG, Nair GG, Shveygert M, Guo T, Puri S, Haataja L, Cirulli V, Blelloch R, Szot GL, Arvan P, Hebrok M
• Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development.
  Cell stem cell 2013 Parent AV, Russ HA, Khan IS, LaFlam TN, Metzger TC, Anderson MS, Hebrok M
• Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Landsman L, Parent A, Hebrok M
• WDR36 acts as a scaffold protein tethering a G-protein-coupled receptor, Gαq and phospholipase Cβ in a signalling complex.
  Journal of cell science 2011 Cartier A, Parent A, Labrecque P, Laroche G, Parent JL
• ANKRD13C acts as a molecular chaperone for G protein-coupled receptors.
  The Journal of biological chemistry 2010 Parent A, Roy SJ, Iorio-Morin C, Lépine MC, Labrecque P, Gallant MA, Slipetz D, Parent JL
• Characterization of C-terminal tail determinants involved in CRTH2 receptor trafficking: identification of a recycling motif.
  European journal of pharmacology 2009 Roy SJ, Parent A, Gallant MA, de Brum-Fernandes AJ, Stanková J, Parent JL
• Rab11 regulates the recycling of the beta2-adrenergic receptor through a direct interaction.
  The Biochemical journal 2009 Parent A, Hamelin E, Germain P, Parent JL
• RACK1 regulates the cell surface expression of the G protein-coupled receptor for thromboxane A(2).
  Traffic (Copenhagen, Denmark) 2007 Parent A, Laroche G, Hamelin E, Parent JL
• Peroxiredoxin-4 interacts with and regulates the thromboxane A(2) receptor.
  FEBS letters 2007 Giguère P, Turcotte ME, Hamelin E, Parent A, Brisson J, Laroche G, Labrecque P, Dupuis G, Parent JL