Ashutosh Lal, MD
Professor
Pediatrics
School of Medicine

The Thalassemia Program in Oakland is the largest clinical program in the country managing over 300 active patients. My research portfolio extends from natural history studies, molecular diagnostics, iron quantification, micronutrient deficiencies, to clinical trials in iron chelation, new disease-modifying agents, and gene therapy for beta thalassemia. My center is supported by HRSA and CDC to study the prevalence and complications of thalassemia in the U.S. and to develop evidence-based standards care for thalassemia. I am the coordinator of the Thalassemia Western Consortium, an association of twelve academic hematology programs in the western states, to improve training and management of thalassemia care. Alpha thalassemia is a special emphasis area where we have delineated the genotype-phenotype relationship in alpha thalassemia, published international guidelines for managing HbH disease, postnatal care of alpha thalassemia major. I am invested in the development of gene therapy approaches to severe forms of thalassemia. I provide consultation and care for complex iron overload in non-hematological conditions in children and adults.

• 385 Long-term Outcomes of 63 Patients with Transfusion-Dependent ß-Thalassemia (TDT) Followed-up to 7 Years after Treatment with betibeglogene autotemcel (beti-cel) Gene Therapy (GT) and Factors Impacting Neutrophil and Platelet Engraftment.
  Transplantation and Cellular Therapy 2023 Timothy S. Olson, Mark C. Walters, Janet L. Kwiatkowski, John B. Porter, Jennifer Schneiderman, Suradej Hongeng, Andreas E. Kulozik, Marina Cavazzana, Martin G. Sauer, Adrian J. Thrasher, Isabelle …
• Long Term Outcomes of 63 Patients with Transfusion-Dependent ß-Thalassemia (TDT) Followed up to 7 Years Post-Treatment with betibeglogene autotemcel (beti-cel) Gene Therapy and Exploratory Analysis of Predictors of Successful Treatment Outcomes in Phase 3 Trials.
  Blood 2022 Mark C. Walters, Janet L. Kwiatkowski, John B. Porter, Jennifer Schneiderman, Suradej Hongeng, Andreas E. Kulozik, Marina Cavazzana, Martin G. Sauer, Adrian J. Thrasher, Isabelle Thuret, Ashutosh Lal,…
• Mitapivat Improves Markers of Erythropoietic Activity in Long-Term Study of Adults with Alpha- or Beta-Non-Transfusion-Dependent Thalassemia.
  Blood 2022 Kevin H.M. Kuo, D. Mark Layton, Ashutosh Lal, Hanny Al-Samkari, Penelope A. Kosinski, Bo Tong, Jeremie H. Estepp, Katrin Uhlig, Elliott P. Vichinsky
• PSUN160 Transfusion Related Endocrinopathies and Thalassemia (TREAT) Study.
  Journal of the Endocrine Society 2022 Ayca Erkin-Cakmak, Tariq Ahmad, Anne Rishon, Marcela Weyhmiller, Ellen Fung, Maya Lodish, Ashutosh Lal
• LONG-TERM EFFICACY AND SAFETY OF THE ORAL PYRUVATE KINASE ACTIVATOR MITAPIVAT IN ADULTS WITH NON–TRANSFUSION-DEPENDENT ALPHA- OR BETA-THALASSEMIA.
  Hematology Transfusion and Cell Therapy 2022 KH Kuo, DM Layton, A Lal, H Al-Samkari, J Bhatia, PA Kosinski, B Tong, M Lynch, K Uhlig, EP Vichinsky
• Safety and efficacy of mitapivat, an oral pyruvate kinase activator, in adults with non-transfusion dependent α-thalassaemia or β-thalassaemia: an open-label, multicentre, phase 2 study.
  Lancet (London, England) 2022 Kuo KHM, Layton DM, Lal A, Al-Samkari H, Bhatia J, Kosinski PA, Tong B, Lynch M, Uhlig K, Vichinsky EP
• Relationships among Physical Activity, Pain, and Bone Health in Youth and Adults with Thalassemia: An Observational Study.
  Thalassemia reports 2022 Fung EB, Goldberg EK, Bambot S, Manzo R, Lal A
• P-055: TRIAL IN PROGRESS: A PHASE 2, OPEN-LABEL STUDY EVALUATING THE SAFETY AND EFFICACY OF THE ERYTHROCYTE PYRUVATE KINASE ACTIVATOR ETAVOPIVAT IN PATIENTS WITH THALASSEMIA OR SICKLE CELL DISEASE.
  HemaSphere 2022 COATES T., LAL A., BROWN R., KALFA T., KWIATKOWSKI J., BREVARD J., TRENOR C., WOOD K., SHETH S.
• P1518: LONG-TERM SAFETY RESULTS OF THE BELIEVE STUDY OF LUSPATERCEPT IN ADULTS WITH ?ETA-THALASSEMIA.
  HemaSphere 2022 V. Viprakasit, M. D. Cappellini, J. B. Porter, K. H. M. Kuo, T. D. Coates, E. Voskaridou, V. M. Pinto, I. Tartaglione, A. Khelif, A. Lal, A. Kattamis, A. Piga, O. Hermine, N. Holot, F. Lersch, J. K. …
• P1522: LONG-TERM EFFICACY AND SAFETY OF THE ORAL PYRUVATE KINASE ACTIVATOR MITAPIVAT IN ADULTS WITH NON–TRANSFUSION-DEPENDENT ALPHA- OR BETA-THALASSEMIA.
  HemaSphere 2022 K. H. M. Kuo, D. M. Layton, A. Lal, H. Al-Samkari, J. Bhatia, P. A. Kosinski, B. Tong, M. Lynch, K. Uhlig, E. P. Vichinsky
• PB2232: TRIAL IN PROGRESS: A PHASE 2, OPEN-LABEL STUDY EVALUATING THE SAFETY AND EFFICACY OF THE ERYTHROCYTE PYRUVATE KINASE ACTIVATOR ETAVOPIVAT IN PATIENTS WITH THALASSEMIA OR SICKLE CELL DISEASE.
  HemaSphere 2022 A. Lal, R. C. Brown, T. Coates, T. Kalfa, J. Kwiatkowski, J. Brevard, C. Trenor, K. Wood, S. Sheth
• S270: LONGER-TERM ANALYSIS OF EFFICACY OF LUSPATERCEPT VERSUS PLACEBO IN PATIENTS WITH TRANSFUSION-DEPENDENT BETA-THALASSEMIA ENROLLED IN THE BELIEVE STUDY.
  HemaSphere 2022 M. D. Cappellini, A. T. Taher, J. B. Porter, K. H. Kuo, T. D. Coates, E. Voskaridou, G. L. Forni, S. Perrotta, A. Khelif, A. Lal, A. Kattamis, A. Piga, O. Hermine, N. Holot, F. Lersch, J. K. Shetty, S…
• Noninvasive Prenatal Test for β-Thalassemia and Sickle Cell Disease Using Probe Capture Enrichment and Next-Generation Sequencing of DNA in Maternal Plasma.
  The journal of applied laboratory medicine 2022 Erlich HA, López-Peña C, Carlberg KT, Shih S, Bali G, Yamaguchi KD, Salamon H, Das R, Lal A, Calloway CD
• 28 Efficacy and Safety of Betibeglogene Autotemcel (beti-cel) Gene Therapy in 63 Patients with Transfusion-Dependent ß-Thalassemia (TDT): 7-Year Post-Infusion Follow-up of Phase 1/2 and Phase 3 Studies.
  Transplantation and Cellular Therapy 2022 Jennifer Schneiderman, Franco Locatelli, Alexis A. Thompson, Janet L. Kwiatkowski, John B. Porter, Suradej Hongeng, Andreas E. Kulozik, Marina Cavazzana, Martin G. Sauer, Adrian J. Thrasher, Isabelle …
• S103: TRIAL IN PROGRESS: A PHASE 2, OPEN-LABEL STUDY EVALUATING THE SAFETY AND EFFICACY OF THE PKR ACTIVATOR ETAVOPIVAT (FT-4202) IN PATIENTS WITH THALASSEMIA OR SICKLE CELL DISEASE.
  HemaSphere 2022 A. Lal, C. Brown, T. Coates, T. Kalfa, J.L. Kwiatkowski, J. Brevard, C. Trenor, K. Wood, S. Sheth
• S116: LONG-TERM EFFICACY AND SAFETY OF THE ORAL PYRUVATE KINASE ACTIVATOR MITAPIVAT IN ADULTS WITH NON—TRANSFUSION-DEPENDENT ALPHA- OR BETA-THALASSEMIA.
  HemaSphere 2022 K Kuo, D Layton, A Lal, H Al-Samkari, J Bhatia, P Kosinski, B Tong, M Lynch, K Uhlig, E Vichinsky
• Nutrition in Thalassemia: A Systematic Review of Deficiency, Relations to Morbidity, and Supplementation Recommendations.
  Journal of pediatric hematology/oncology 2022 Goldberg EK, Lal A, Fung EB
• Consensus statement for the perinatal management of patients with α thalassemia major.
  Blood advances 2021 MacKenzie TC, Amid A, Angastiniotis M, Butler C, Gilbert S, Gonzalez J, Keller RL, Kharbanda S, Kirby-Allen M, Koenig BA, Kyono W, Lal A, Lianoglou BR, Norton ME, Ogasawara KK, Panchalee T, Rosner M, …
• Betibeglogene Autotemcel Gene Therapy for Non-β0/β0 Genotype β-Thalassemia.
  The New England journal of medicine 2021 Locatelli F, Thompson AA, Kwiatkowski JL, Porter JB, Thrasher AJ, Hongeng S, Sauer MG, Thuret I, Lal A, Algeri M, Schneiderman J, Olson TS, Carpenter B, Amrolia PJ, Anurathapan U, Schambach A, …
• Improvement in Health-Related Quality of Life Following Treatment with Betibeglogene Autotemcel in Patients with Transfusion-Dependent ß-Thalassemia Enrolled in Phase 3 Studies.
  Blood 2021 Janet L. Kwiatkowski, Franco Locatelli, Mark C. Walters, John B. Porter, Suradej Hongeng, Evangelia Yannaki, Andreas E. Kulozik, Martin G. Sauer, Adrian J. Thrasher, Isabelle Thuret, Ashutosh Lal, …
• Long-Term Efficacy and Safety of the Oral Pyruvate Kinase Activator Mitapivat in Adults with Non-Transfusion-Dependent Alpha- or Beta-Thalassemia.
  Blood 2021 Kevin H.M. Kuo, D. Mark Layton, Ashutosh Lal, Hanny Al-Samkari, Joy Bhatia, Penelope A. Kosinski, Bo Tong, Megan Lynch, Katrin Uhlig, Elliott Vichinsky
• Restoring Iron Homeostasis in Pts Who Achieved Transfusion Independence after Treatment with Betibeglogene Autotemcel Gene Therapy: Results from up to 7 Years of Follow-up.
  Blood 2021 Alexis A. Thompson, Franco Locatelli, Evangelia Yannaki, Mark C. Walters, John B. Porter, Suradej Hongeng, Andreas E. Kulozik, Martin G. Sauer, Adrian J. Thrasher, Isabelle Thuret, Ashutosh Lal, …
• Trial in Progress: A Phase 2, Open-Label Study Evaluating the Safety and Efficacy of the PKR Activator Etavopivat (FT-4202) in Patients with Thalassemia or Sickle Cell Disease.
  Blood 2021 Ashutosh Lal, R. Clark Clark Brown, Thomas D. Coates, Theodosia A. Kalfa, Janet L. Kwiatkowski, Julie Brevard, Von Potter, Ken W. Wood, Sujit Sheth
• RESULTS FROM A PHASE 2 STUDY OF MITAPIVAT IN ADULTS WITH NON–TRANSFUSION-DEPENDENT ALPHA- OR BETA-THALASSEMIA.
  Hematology Transfusion and Cell Therapy 2021 KH Kuo, DM Layton, A Lal, H Al-Samkari, J Bhatia, B Tong, M Lynch, K Uhlig, EP Vichinsky
• The transfusion management of beta thalassemia in the United States.
  Transfusion 2021 Lal A, Wong T, Keel S, Pagano M, Chung J, Kamdar A, Rao L, Ikeda A, Puthenveetil G, Shah S, Yu J, Vichinsky E
• Pituitary iron and factors predictive of fertility status in transfusion dependent thalassemia.
  Haematologica 2021 Singer ST, Fischer R, Allen I, Lal A, Vichinsky E, Yuan Q, Wang ZJ
• 1 Efficacy and Safety of Betibeglogene Autotemcel (beti-cel; LentiGlobin for ß-thalassemia) Gene Therapy in 60 Patients with Transfusion-Dependent ß-Thalassemia (TDT) Followed for up to 6 Years Post-Infusion.
  2021 Suradej Hongeng, Alexis A. Thompson, Janet L. Kwiatkowski, Franco Locatelli, John B. Porter, John Rasko, Marina Cavazzana, Martin G. Sauer, Adrian J. Thrasher, Isabelle Thuret, Ashutosh Lal, Andreas E…
• 122 Safety and Efficacy Outcomes in Pediatric Patients with Transfusion-Dependent ß-Thalassemia (TDT) Receiving Betibeglogene Autotemcel (beti-cel; LentiGlobin for ß-thalassemia) Gene Therapy in the Phase 3 Hgb-207 (Northstar-2) and Hgb-212 (Northstar-3) Studies.
  2021 Mark C. Walters, Janet L. Kwiatkowski, John B. Porter, Suradej Hongeng, Evangelia Yannaki, Andreas E. Kulozik, Martin G. Sauer, Adrian J. Thrasher, Isabelle Thuret, Ashutosh Lal, Ruiting Guo, Weijian …
• Challenges in chronic transfusion for patients with thalassemia.
  Hematology. American Society of Hematology. Education Program 2020 Lal A
• Favorable Outcomes in Pediatric Patients in the Phase 3 Hgb-207 (Northstar-2) and Hgb-212 (Northstar-3) Studies of Betibeglogene Autotemcel Gene Therapy for the Treatment of Transfusion-Dependent ß-Thalassemia.
  Blood 2020 Alexis A. Thompson, Janet L. Kwiatkowski, John B. Porter, Suradej Hongeng, Evangelia Yannaki, Andreas E. Kulozik, Martin G. Sauer, Adrian J. Thrasher, Isabelle Thuret, Ashutosh Lal, Ruiting Guo, …
• Longitudinal Effect of Luspatercept Treatment on Iron Overload and Iron Chelation Therapy (ICT) in Adult Patients (Pts) with ß-Thalassemia in the Believe Trial.
  Blood 2020 Olivier Hermine, Maria Domenica Cappellini, Ali T. Taher, Thomas D. Coates, Vip Viprakasit, Ersi Voskaridou, Ashutosh Lal, Hong Keng Liew, Silverio Perrotta, Abderrahim Khelif, Antonis Kattamis, …
• Response of Patients with Transfusion-Dependent ß-Thalassemia (TDT) to Betibeglogene Autotemcel (beti-cel; LentiGlobin for ß-Thalassemia) Gene Therapy Based on HBB Genotype and Disease Genetic Modifiers.
  Blood 2020 Mark C. Walters, David H.K. Chui, John J Farrell, Ashutosh Lal, Franco Locatelli, Janet L. Kwiatkowski, John B. Porter, Martin G. Sauer, Isabelle Thuret, Suradej Hongeng, Andreas E. Kulozik, Adrian J.…
• Zinc supplementation improves markers of glucose homeostasis in thalassaemia.
  British journal of haematology 2020 Fung EB, Ahmad T, Killilea DW, Hussain R, Lal A
• A Phase 3 Trial of Luspatercept in Patients with Transfusion-Dependent β-Thalassemia.
  The New England journal of medicine 2020 Cappellini MD, Viprakasit V, Taher AT, Georgiev P, Kuo KHM, Coates T, Voskaridou E, Liew HK, Pazgal-Kobrowski I, Forni GL, Perrotta S, Khelif A, Lal A, Kattamis A, Vlachaki E, Origa R, Aydinok Y, …
• Interim Results from the Phase 3 Hgb-207 (Northstar-2) and Hgb-212 (Northstar-3) Studies of Betibeglogene Autotemcel Gene Therapy (LentiGlobin) for the Treatment of Transfusion-Dependent ß-Thalassemia.
  Biology of Blood and Marrow Transplantation 2020 Jennifer Schneiderman, Alexis A. Thompson, Mark C. Walters, Janet L. Kwiatkowski, Andreas E. Kulozik, Martin G. Sauer, John B. Porter, Isabelle Thuret, Suradej Hongeng, Ashutosh Lal, Adrian J. …
• Taking Stock of Hemophilia, Immune Thrombocytopenia, and Bone Marrow Failure.
  Indian journal of pediatrics 2020 Bansal D, Lal A
• Iron Metabolism, Hemolytic Anemia, and Thalassemia.
  Indian journal of pediatrics 2019 Bansal D, Lal A
• Northstar-3: Interim Results from a Phase 3 Study Evaluating Lentiglobin Gene Therapy in Patients with Transfusion-Dependent ß-Thalassemia and Either a ß0 or IVS-I-110 Mutation at Both Alleles of the HBB Gene.
  Blood 2019 Ashutosh Lal, Franco Locatelli, Janet L. Kwiatkowski, Andreas E. Kulozik, Evangelia Yannaki, John B. Porter, Isabelle Thuret, Martin G. Sauer, Heidi Elliot, Ying Chen, Richard A. Colvin, Alexis A. …
• Trends in Iron Overload over Past Two Decades: Results from the Natural History of Iron Burden Study with the SQUID Biosusceptometer.
  Blood 2019 Ashutosh Lal, Roland Fischer, Elliott Vichinsky, Marcela Weyhmiller
• Thalassemia: Common Clinical Queries in Management.
  Indian journal of pediatrics 2019 Lal A, Bansal D
• Multicomponent Nutrient Bar Promotes Weight Loss and Improves Dyslipidemia and Insulin Resistance.
  Journal of the Academy of Nutrition and Dietetics 2019 R. McKinnon, J. McCann, B. Ames, M. Shigenaga, A. Lal, J. Suh, R. Krauss, G. Gildengorin, A. Goldrich, S. Shenvi
• Iron in Health and Disease: An Update.
  Indian journal of pediatrics 2019 Lal A
• RESULTS FROM THE PHASE 3 NORTHSTAR-3 STUDY EVALUATING LENTIGLOBIN GENE THERAPY IN PATIENTS WITH TRANSFUSION-DEPENDENT ß-THALASSAEMIA AND A ß0 OR IVS-I-110 MUTATION AT BOTH ALLELES OF THE HBB GENE.
  HemaSphere 2019 A. E. Kulozik, F. Locatelli, E. Yannaki, J. B. Porter, I. Thuret, M. G. Sauer, A. Lal, J. L. Kwiatkowski, H. Elliot, G. Tao, R. A. Colvin, A. A. Thompson
• Advances in Biomagnetic Liver Susceptometry Allow the Measurement of Liver Iron Concentration with a Room Temperature Sensor.
  Blood 2018 Ashutosh Lal, William Avrin, Viktoriia Kolotovska, Lisa Calvelli, Marcela Weyhmiller
• Lentiglobin Gene Therapy for Patients with Transfusion-Dependent ß-Thalassemia (TDT): Results from the Phase 3 Northstar-2 and Northstar-3 Studies.
  Blood 2018 Franco Locatelli, Mark C. Walters, Janet L. Kwiatkowski, John Porter, Martin G. Sauer, Isabelle Thuret, Suradej Hongeng, Andreas E. Kulozik, Ashutosh Lal, Adrian J. Thrasher, Evangelia Yannaki, Heidi …
• Thalassemia Management Checklists: Quick Reference Guides to Reduce Disparities in the Care of Patients with Transfusion-Dependent Thalassemia.
  Blood 2018 Ashutosh Lal, Sujit Sheth, Sandra Gilbert, Janet L. Kwiatkowski
• Nutritional Deficiencies Are Common in Patients with Transfusion-Dependent Thalassemia and Associated with Iron Overload.
  Journal of food and nutrition research (Newark, Del.) 2018 Goldberg EK, Neogi S, Lal A, Higa A, Fung E
• Transfusion practices and complications in thalassemia.
  Transfusion 2018 Lal A, Wong TE, Andrews J, Balasa VV, Chung JH, Forester CM, Ikeda AK, Keel SB, Pagano MB, Puthenveetil G, Shah SJ, Yu JC, Vichinsky EP
• A novel nutritional intervention improves lung function in overweight/obese adolescents with poorly controlled asthma: the Supplemental Nutrition in Asthma Control (SNAC) pilot study.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Bseikri M, McCann JC, Lal A, Fong E, Graves K, Goldrich A, Block D, Gildengoren GL, Mietus-Snyder M, Shigenaga M, Suh J, Hardy K, Ames BN
• Epidemiologic and clinical characteristics of nontransfusion-dependent thalassemia in the United States.
  Pediatric blood & cancer 2018 Vichinsky E, Cohen A, Thompson AA, Giardina PJ, Lal A, Paley C, Cheng WY, McCormick N, Sasane M, Qiu Y, Kwiatkowski JL
• Favorable outcomes after in utero transfusion in fetuses with alpha thalassemia major: a case series and review of the literature.
  Prenatal diagnosis 2016 Kreger EM, Singer ST, Witt RG, Sweeters N, Lianoglou B, Lal A, Mackenzie TC, Vichinsky E
• Assessing Bone Quality Using Trabecular Bone Score in Patients with Hemoglobinopathies.
  Blood 2016 Melissa Cervantes, Ashutosh Lal, Anne M Marsh, Ellen B. Fung
• Implications of Low Zinc and Copper Levels As Well As Altered Iron Trafficking Proteins on Oxidant Stress in Patients with Transfusion Dependant Thalassemia.
  Blood 2016 Patrick B Walter, Michael Minkley, Caitlin Curtis, Hodge Maeve, Razavi Morty, Sarah Ewing, Ashutosh Lal, Anne Higa, David Killilea, Terry Pearson, Ellen B. Fung
• Threshold Ferritin Values to Predict Control of Liver Iron Burden in Thalassemia.
  Blood 2016 Ashutosh Lal, Marcela G Weyhmiller, Elliott Vichinsky
• Towards the Development of a Noninvasive Prenatal Test for Beta-Thalassemia: Utilization of Probe Capture Enrichment and Next Generation Sequencing.
  Blood 2016 Katie Carlberg, Nikhil Bose, Jingyi Deng, Ashutosh Lal, Henry Erlich, Cassandra Calloway
• 469 Implications of Altered Trace Minerals and Iron Trafficking Proteins on Oxidant Stress in Thalassemia.
  Free Radical Biology and Medicine 2016 Patrick B Walter, Michael Minkley, Caitlin Curtis, Maeve Hodge, Razavi Morty, Sarah Ewing, Zoe Ennis, Ashutosh Lal, Annie Higa, David Killilea, Terry Pearson, Ellen Fung
• Increased mitochondrial DNA deletions and copy number in transfusion-dependent thalassemia.
  JCI insight 2016 Lal A, Gomez E, Calloway C
• Assessment and treatment of pain in thalassemia.
  Annals of the New York Academy of Sciences 2016 Lal A
• 19. Nutrition for patients with thalassemia.
  Handbook of nutrition and diet in leukemia and blood disease therapy 2016 E.B. Fung, C. Schroepfer, A. Lal
• Iron Level and Monocyte Morphology Predict TLR4 Expression and Reactive Oxygen Species Production Which Influences Chronic Inflammation in ß-Thalassemia.
  Blood 2015 Patrick B. Walter, Nick Slater, Paul Harmatz, Annie Higa, Vivian Ng, Marcels Weyhmiller, Patricia Evans, John B Porter, Nancy Sweeters, Jackson Price, David Killilea, Lynne Neumayr, Ashutosh Lal, …
• The effect of iron chelators on bone health in patients with thalassemia.
  Bone Abstracts 2015 Ellen Fung, Nan Luo, Ginny Gildengorin, Ashutosh Lal
• Zinc status affects glucose homeostasis and insulin secretion in patients with thalassemia.
  Nutrients 2015 Fung EB, Gildengorin G, Talwar S, Hagar L, Lal A
• A multicomponent nutrient bar promotes weight loss and improves dyslipidemia and insulin resistance in the overweight/obese: chronic inflammation blunts these improvements.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 McCann JC, Shigenaga MK, Mietus-Snyder ML, Lal A, Suh JH, Krauss RM, Gildengorin GL, Goldrich AM, Block DS, Shenvi SV, McHugh TH, Olson DA, Ames BN
• Point-of-care end-tidal carbon monoxide reflects severity of hemolysis in sickle cell anemia.
  Pediatric blood & cancer 2015 Lal A, Patterson L, Goldrich A, Marsh A
• Dietary Intake Insufficient to Support Nutritional Adequacy in Patients with Thalassemia.
  Blood 2014 Ellen B. Fung, Neogi Sushrita, Drucilla Haines, Connie Schroepfer, Ashutosh Lal
• Elevated End-Tidal Carbon Monoxide Concentration in Children with Sickle Cell Anemia.
  Blood 2014 Ashutosh Lal, Kristen Yen, Lasandra Patterson, Alisa Goldrich, Anne M Marsh, Anish Bhatnagar
• 138 Iron Overload and Hemolysis Modulate Monocytes and Inflammation in ß-Thalassemia.
  Free Radical Biology and Medicine 2014 Nicholas Richard Slater, Paul Harmatz, Annie Higa, Vivian Ng, Marcela G G Weyhmiller, Patricia Evans, John B Porter, Nancy Sweeters, Jackson Price, Alisha Manji, Angela Manocha, David W Killilea, …
• Association Of Cardiac Iron By T2* With Innate Immune Markers In Transfusion-Dependent Thalassemia Patients Undergoing Combined Chelation Therapy.
  Blood 2013 Patrick B Walter, Annie Higa, Vivian Ng, Marcela G Weyhmiller, Nick R Slater, Patricia Evans, John B Porter, Nancy Sweeters, Jackson Price, Alisha Manji, David Killilea, Ashutosh Lal, Elliott …
• In-Accuracy Of Bone Density Measurements By DXA In Patients With Hemoglobinopathies and Iron Overload.
  Blood 2013 Haven M. Allard, Marcela G. Weyhmiller, Ashutosh Lal, Ellen B. Fung
• Mitochondrial Genome Changes As a Measure Of Iron-Induced Mitochondrial Stress In Transfusion-Dependent Thalassemia.
  Blood 2013 Esteban Gomez, Cassandra Calloway, Sang Hoon Lee, Jay Kim, Navpreet Dhillon, Ginny Gildengorin, Ashutosh Lal
• Innate Immune Cell Expression of Pattern Recognition Receptors From ß-Thalassemia Patients During Intensive Combination Chelation Therapy.
  Blood 2012 Patrick B Walter, Paul Harmatz, Annie Higa, Vivian Ng, Marcela G Weyhmiller, Patricia Evans, John B. Porter, Nancy Sweeters, Jackson Price, Alisha Manji, David Killilea, Ashutosh Lal, Elliott …
• Combined chelation therapy with deferasirox and deferoxamine in thalassemia.
  Blood cells, molecules & diseases 2012 Lal A, Porter J, Sweeters N, Ng V, Evans P, Neumayr L, Kurio G, Harmatz P, Vichinsky E
• A nutrient-dense, high-fiber, fruit-based supplement bar increases HDL cholesterol, particularly large HDL, lowers homocysteine, and raises glutathione in a 2-wk trial.
  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Mietus-Snyder ML, Shigenaga MK, Suh JH, Shenvi SV, Lal A, McHugh T, Olson D, Lilienstein J, Krauss RM, Gildengoren G, McCann JC, Ames BN
• Abstract P217: Metabolic Effects of a Nutrient-Dense High Fiber Supplement.
  Circulation 2012 Michele Mietus-Snyder, Mark K Shigenaga, Jung H Suh, Swapna V Shenvi, Ashutosh Lal, Tara McHugh, Donald Olson, Joyce C McCann, Ronald M Krauss, Bruce N Ames
• Exploring Vertebral Height Deficits in Patients with Thalassemia and Sickle Cell Disease,.
  Blood 2011 Ellen B Fung, Kathryn N Reget, Drucilla Haines, Aenor Sawyer, Ashutosh Lal
• Oxidative Stress and Reproductive Capacity in Iron Overload Thalassemia Major Women.
  Blood 2011 Sylvia T Singer, Elliott Vichinsky, Marcelle Cedars, Ginny Gildengorin, Jung H Suh, Ashutosh Lal
• Treatment of vitamin D deficiency in transfusion-dependent thalassemia.
  American journal of hematology 2011 Fung EB, Aguilar C, Micaily I, Haines D, Lal A
• Heterogeneity of hemoglobin H disease in childhood.
  The New England journal of medicine 2011 Lal A, Goldrich ML, Haines DA, Azimi M, Singer ST, Vichinsky EP
• Association of chromosome damage detected as micronuclei with hematological diseases and micronutrient status.
  Mutagenesis 2011 Lal A, Ames BN
• A Simple Regimen to Correct Vitamin D Deficiency In Transfusion-Dependent Thalassemia with High-Dose Ergocalciferol.
  Blood 2010 Ashutosh Lal, Ida Micaily, Drucilla Foote, Ellen Fung
• Combined Chelation Therapy with Deferasirox and Deferoxamine In Transfusion-Dependent Thalassemia.
  Blood 2010 Ashutosh Lal, Nancy Sweeters, Vivian Ng, Drucilla Foote, Patricia Evans, Lynne Neumayr, Gregory Kurio, Paul Harmatz, John B. Porter, Elliott Vichinsky
• Longitudinal Follow-up From Newborn Screening Reveals Deletional Hemoglobin H Disease and Hemoglobin H Constant Spring Disease Are Distinct Thalassemia Syndromes.
  Blood 2010 Ashutosh Lal, Michael Lee Goldrich, Drucilla Foote, Mahin Azimi, Sylvia Titi Singer, Elliott Vichinsky
• Reduced Physical Activity In Adult and Pediatric Patients with Thalassemia.
  Blood 2010 Catherine Garie´py, Ashutosh Lal, Ellen Fung
• Sickle Cell Disease.
  Postgraduate Haematology 2010 Ashutosh Lal, Elliott P Vichinsky
• Heightened Sulfur Amino Acid Oxidation in Plasma and Erythrocytes in ß-Thalassemia Major.
  Blood 2009 Anurag K. Agrawal, Jung H. Suh, Bruce N. Ames, Elliott P. Vichinsky, Ashutosh Lal
• Safety of Combined Chelation Therapy with Deferasirox and Deferoxamine in Transfusion-Dependent Thalassemia.
  Blood 2009 Ashutosh Lal, Nancy Sweeters, Matt Herz, Dru Foote, Lynne Neumayr, Greg Kurio, Paul R Harmatz, Elliott P Vichinsky
• Clinical assay of four thiol amino acid redox couples by LC-MS/MS: utility in thalassemia.
  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009 Suh JH, Kim R, Yavuz B, Lee D, Lal A, Ames BN, Shigenaga MK
• Body Composition and Its Relationship to Growth and Bone Mass in Patients with Thalassemia.
  Blood 2008 Ellen Fung, Yan Xu, Janet Kwiatkowski, Sylvia Titi Singer, Ashutosh Lal, Maria G Vogiatzi, Nancy F. Olivieri, Ellis J. Neufeld, Elliott Vichinsky, Patricia Giardina
• Hemoglobin H-Constant Spring in North America: A Common Alpha Thalassemia with Frequent Complications.
  Blood 2008 Titi Singer, Hae-Young Kim, Nancy F Olivieri, Janet Kwiatkowski, Ashutosh Lal, Thomas D. Coates, Susan Carson, Melody J. Cunningham, Patricia J Giardina, Brigitta U Mueller, Charles Quinn, Elliott …
• Lipoic acid and acetyl-carnitine reverse iron-induced oxidative stress in human fibroblasts.
  Redox report : communications in free radical research 2008 Lal A, Atamna W, Killilea DW, Suh JH, Ames BN
• Anti-Oxidant Treatment with a-Lipoic Acid and Acetyl L-Carnitine in Hemoglobinopathies.
  Blood 2007 Ashutosh Lal, Jung Suh, Wafa Atamna, Bridget Canty, Ward Hagar, Elliott Vichinsky, Frans Kuypers, Bruce Ames
• Bone mineral density in children with sickle cell anemia.
  Pediatric blood & cancer 2006 Lal A, Fung EB, Pakbaz Z, Hackney-Stephens E, Vichinsky EP
• Bone mineral density in children and young adults with beta-thalassemia major conventionally treated—RESPONSE.
  Pediatric Blood & Cancer 2006 A. Lal, E.B. Fung, Z. Pakbaz, E.P. Vichinsky
• Efficacy of Alpha-Lipoic Acid in Iron-Induced Oxidative Stress.
  Blood 2005 Ashutosh Lal, Jung H. Suh, Bruce N. Ames
• Increased Chromosomal Breaks in Sickle Cell Disease as Evidenced by the Presence of Micronuclei in Erythrocytes.
  Blood 2005 Ashutosh Lal, Amrita Bhagat, Wafa Atamna, Tal Offer, Elliott P. Vichinsky, Frans A. Kuypers, Bruce N. Ames
• Favorable prognosis for patients 12 to 18 months of age with stage 4 nonamplified MYCN neuroblastoma: a Children's Cancer Group Study.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005 Schmidt ML, Lal A, Seeger RC, Maris JM, Shimada H, O'Leary M, Gerbing RB, Matthay KK
• Sickle Cell Disease.
  Postgraduate Haematology 2005 Ashutosh Lal, Elliott P Vichinsky
• Measuring chromosome breaks in patients with thalassemia.
  Annals of the New York Academy of Sciences 2005 Offer T, Bhagat A, Lal A, Atamna W, Singer ST, Vichinsky EP, Kuypers FA, Ames BN
• Evaluation of Bone Mineral Density in Children with Sickle Cell Anemia.
  Blood 2004 Ashutosh Lal, Ellen Fung, Bamidele Kammen, Zahra Pakbaz, Nancy Sweeters, Ekua Hackney-Stevens, Keith Quirolo, Elliott Vichinsky
• The role of fetal hemoglobin-enhancing agents in thalassemia.
  Seminars in hematology 2004 Lal A, Vichinsky E