Arun Wiita, MD, PhD
Associate Professor
Laboratory Medicine
School of Medicine

We are particularly interested in questions related to translational regulation after cancer therapy as well as how clinically-relevant genomic alterations result in phenotypic changes at the level of the proteome. Furthermore, my group includes the UCSF Stephen and Nancy Grand Multiple Myeloma Translational Initiative Laboratory. In this role, we collaborate with industry and academic partners to advance preclinical evaluation of novel myeloma therapeutics using a suite of in vitro and in vivo approaches.

In my clinical work, I am Assistant Director of the UCSF Clinical Cytogenetics laboratory. In this role, I interpret molecular genetic testing for the prenatal and postnatal diagnosis of microdeletion and microduplication syndromes. In this area we have translational interests in emerging technologies for determination of DNA copy number variation, integration of single-nucleotide variants and CNV interpretation, and cell-free DNA for prenatal testing. In my research laboratory we are also using quantitative proteomics to evaluate the role of protein homeostasis in determining the phenotypic effects of CNVs, as well using CRISPR/Cas9 genome engineering to generate new functional models of syndromic CNVs.

• Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma.
  Scientific reports 2024 Nejo T, Wang L, Leung KK, Wang A, Lakshmanachetty S, Gallus M, Kwok DW, Hong C, Chen LH, Carrera DA, Zhang MY, Stevers NO, Maldonado GC, Yamamichi A, Watchmaker PB, Naik A, Shai A, Phillips JJ, Chang …
• Alternative target recognition elements for chimeric antigen receptor (CAR) T cells: beyond standard antibody fragments.
  Cytotherapy 2024 Nix MA, Wiita AP
• CD46-Targeted Theranostics for PET and 225Ac-Radiopharmaceutical Therapy of Multiple Myeloma.
  Clinical cancer research : an official journal of the American Association for Cancer Research 2024 Wadhwa A, Wang S, Patiño-Escobar B, Bidkar AP, Bobba KN, Chan E, Meher N, Bidlingmaier S, Su Y, Dhrona S, Geng H, Sarin V, VanBrocklin HF, Wilson DM, He J, Zhang L, Steri V, Wong SW, Martin TG, Seo Y,…
• Targeting high-risk multiple myeloma genotypes with optimized anti-CD70 CAR-T cells.
  bioRxiv : the preprint server for biology 2024 Kasap C, Izgutdina A, Patiño-Escobar B, Kang A, Chilakapati N, Akagi N, Johnson H, Rashid T, Werner J, Barpanda A, Geng H, Lin YT, Rampersaud S, Gil-Alós D, Sobh A, Dupéré-Richer D, Wicaksono G, …
• Thalamocortical organoids enable in vitro modeling of 22q11.2 microdeletion associated with neuropsychiatric disorders.
  Cell stem cell 2024 Shin D, Kim CN, Ross J, Hennick KM, Wu SR, Paranjape N, Leonard R, Wang JC, Keefe MG, Pavlovic BJ, Donohue KC, Moreau C, Wigdor EM, Larson HH, Allen DE, Cadwell CR, Bhaduri A, Popova G, Bearden CE, …
• Preclinical Development and Characterization of Humanized Anti-CD72 Nanobody Chimeric Antigen Receptor T Cells for B Cell Malignancies.
  Transplantation and Cellular Therapy 2024 William C. Temple, Adila Izgutdina, Matthew A. Nix, Benjamin J. Huang, Paul Phojanakong, Juan Antonio Camara Serrano, Fernando Salangsang, Veronica Steri, Simayijiang Xirenayi, Elliot Stieglitz, Arun …
• Cell type specificity of mosaic chromosome 1q gain resolved by snRNA-seq in a case of epilepsy with hyaline protoplasmic astrocytopathy.
  bioRxiv : the preprint server for biology 2024 Leng K, Cadwell CR, Patrick Devine W, Tihan T, Qi Z, Singhal N, Glenn O, Kamiya S, Wiita A, Berger A, Shieh JT, Titus EW, Paredes MF, Upadhyay V
• Affinity Matured CD72 CAR-T Improves Efficacy Versus Low Antigen Density B-Cell Non-Hodgkin Lymphoma Models.
  Blood 2023 Adila Izgutdina, William C Temple, Matthew Andrew Nix, Huimin Geng, Emilio Ramos, Akul Naik, Rebecca Larson, Fernando Salangsang, Paul Phojanakong, Juan Antonio Camara Serrano, Ons Zakraoui, Isa Tariq…
• Discovery and Development of CD70 As a Cellular Therapy Target in High Risk Multiple Myeloma.
  Blood 2023 Corynn Kasap, Adila Izgutdina, Bonell Patino Escobar, Yu-Hsiu Tony Lin, Huimin Geng, Gianina Wicaksono, Daphne Dupere-Richer, Emilio Ramos, Abhilash Barpanda, Anjanaa Vijayanarayanan, Fernando …
• Framework humanization optimizes potency of anti-CD72 nanobody CAR-T cells for B-cell malignancies.
  Journal for immunotherapy of cancer 2023 Temple WC, Nix MA, Naik A, Izgutdina A, Huang BJ, Wicaksono G, Phojanakong P, Serrano JAC, Young EP, Ramos E, Salangsang F, Steri V, Xirenayi S, Hermiston M, Logan AC, Stieglitz E, Wiita AP
• IMMU-16. PUBLIC TUMOR-WIDE NEOANTIGENS DERIVED FROM CLONAL ABERRANT SPLICING EVENTS DRIVE TUMOR-SPECIFIC T-CELL RESPONSES.
  Neuro-Oncology 2023 Darwin Kwok, Nicholas Stevers, Takahide Nejo, Jangham Jung, Lee Chen, Senthilnath Lakshmanachetty, Inaki Etxeberria, Marco Gallus, Akane Yamamichi, Emilio Ramos, Chibo Hong, Maggie Colton, Gary Chan, …
• Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma.
  bioRxiv : the preprint server for biology 2023 Nejo T, Wang L, Leung KK, Wang A, Lakshmanachetty S, Gallus M, Kwok DW, Hong C, Chen LH, Carrera DA, Zhang MY, Stevers NO, Maldonado GC, Yamamichi A, Watchmaker P, Naik A, Shai A, Phillips JJ, Chang …
• O-77 Molecular imaging and radiopharmaceutical therapy of Multiple Myeloma targeting CD46 using 89Zr and 225Ac-YS5.
  Nuclear Medicine and Biology 2023 Anju Wadhwa, Sinan Wang, Bonell Escobar, Anil Bidkar, Kondapa Bobba, Niranjan Meher, Suchi Dhrona, Sandy Wong, David Wilson, Henry VanBrocklin, Youngho Seo, Bin Liu, Arun Wiita, Robert Flavell
• Structural surfaceomics reveals an AML-specific conformation of integrin β2 as a CAR T cellular therapy target.
  Nature cancer 2023 Mandal K, Wicaksono G, Yu C, Adams JJ, Hoopmann MR, Temple WC, Izgutdina A, Escobar BP, Gorelik M, Ihling CH, Nix MA, Naik A, Xie WH, Hübner J, Rollins LA, Reid SM, Ramos E, Kasap C, Steri V, Serrano …
• Tumor-wide RNA splicing aberrations generate immunogenic public neoantigens.
  bioRxiv : the preprint server for biology 2023 Kwok DW, Stevers NO, Nejo T, Chen LH, Etxeberria I, Jung J, Okada K, Cove MC, Lakshmanachetty S, Gallus M, Barpanda A, Hong C, Chan GKL, Wu SH, Ramos E, Yamamichi A, Liu J, Watchmaker P, Ogino H, …
• Transcriptional repression upon S phase entry protects genome integrity in pluripotent cells.
  Nature structural & molecular biology 2023 Gökbuget D, Lenshoek K, Boileau RM, Bayerl J, Huang H, Wiita AP, Laird DJ, Blelloch R
• P985: CLL-1 IS AN ADOPTIVE IMMUNOTHERAPY TARGET IN JUVENILE MYELOMONOCYTIC LEUKEMIA.
  HemaSphere 2023 Juwita Huebner, Sherin Xirenayi, Jose Rivera, Bonell Patiño Escobar, Alex G Lee, Kamal Mandal, Ernesto Diaz-Flores, Arun Wiita, Elliot Stieglitz
• Overcoming proteasome inhibitor resistance in the immunotherapy era.
  Trends in pharmacological sciences 2023 Patiño-Escobar B, Talbot A, Wiita AP
• A CRISPR-engineered isogenic model of the 22q11.2 A-B syndromic deletion.
  Scientific reports 2023 Paranjape N, Lin YT, Flores-Ramirez Q, Sarin V, Johnson AB, Chu J, Paredes M, Wiita AP
• SLAPSHOT reveals rapid dynamics of extracellularly exposed proteome in response to calcium-activated plasma membrane phospholipid scrambling.
  bioRxiv : the preprint server for biology 2023 Tuomivaara ST, Teo CF, Jan YN, Jan LY, Wiita AP
• "Cell Surface Capture" Workflow for Label-Free Quantification of the Cell Surface Proteome.
  Journal of visualized experiments : JoVE 2023 Naik A, Srivastava S, Wiita AP
• Cytomegalovirus seropositivity is associated with improved responses to CD38 monoclonal antibody therapies in multiple myeloma: A single-centre retrospective study.
  British journal of haematology 2023 Ge AY, Huang CY, Banerjee R, Knoche J, Chung A, Arora S, Martin TG, Wolf J, Wong SW, Wiita AP, Shah N
• Humanized Nanobody Anti-CD72 CAR-T Cells Efficiently Eliminate B-Cell Malignancies Via Improved Affinity for CD72 but Induce Persistent Antigen Downregulation In Vivo.
  Blood 2022 William C Temple, Gianina Wicaksono, Akul Naik, Adila Izgutdina, Matthew A Nix, Elizabeth Young, Paul Phojanakong, Juan Antonio Camara Serrano, Veronica Steri, Fernando Salangsang, Arun P Wiita
• Integrating Transcriptomics and Proteomics for the Discovery of Novel Antigen Targets on Surface of Malignant Plasma Cells Amenable for Chimeric Antigen Receptor-T (CAR-T) Cell Approach in the Treatment of Patients with Relapsed/Refractory Multiple Myeloma.
  Blood 2022 Alexis Talbot, Solène Weill, Eléonore Fox, Léa Meunier, Guillaume Appé, Camille Marijon, Abdelkader Behdenna, Arun P Wiita, Akpéli Nordor, Justin Eyquem
• Profiling the Cell Surface of MPN Blast Phase Suggests Unique Biology and Therapeutic Targets.
  Blood 2022 Emilio Ramos, Arun Wiita
• Structural Surfaceomics Reveals an AML-Specific Conformation of Integrin-ß2 As an Immunotherapeutic Target.
  Blood 2022 Kamal Mandal, Gianina Wicaksono, Clinton Yu, Jarrett J Adams, Michael R Hoopmann, William C Temple, Bonell Patino Escobar, Maryna Gorelik, Christian Ihling, Matthew A Nix, Akul Naik, Emilio Ramos, …
• Unraveling the surface proteomic profile of multiple myeloma to reveal new immunotherapeutic targets and markers of drug resistance.
  Cell stress 2022 Patiño-Escobar B, Ferguson ID, Wiita AP
• 010 CD72 NANOBODY CAR-T CELLS HAVE POTENT ANTITUMOR EFFICACY IN B CELL MALIGNANCIES.
  Leukemia Research 2022 W. Temple, M. Nix, G. Wicaksono, D. Wang, P. Phojanakong, V. Steri, B. Hann, M. Hermiston, A. Wiita
• Therapeutic implications of mitochondrial stress-induced proteasome inhibitor resistance in multiple myeloma.
  Science advances 2022 Sharma A, Nair R, Achreja A, Mittal A, Gupta P, Balakrishnan K, Edgar CL, Animasahun O, Dwivedi B, Barwick BG, Gupta VA, Matulis SM, Bhasin M, Lonial S, Nooka AK, Wiita AP, Boise LH, Nagrath D, …
• P-100: Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma.
  Clinical Lymphoma Myeloma & Leukemia 2022 Ian Ferguson, Tony Lin, Christine Lam, Hao Shao, Kevin Tharp, Brian Van Ness, Jason Gestwicki, Arun Wiita
• ECM dimensionality tunes actin tension to modulate endoplasmic reticulum function and spheroid phenotypes of mammary epithelial cells.
  The EMBO journal 2022 Kai F, Ou G, Tourdot RW, Stashko C, Gaietta G, Swift MF, Volkmann N, Long AF, Han Y, Huang HH, Northey JJ, Leidal AM, Viasnoff V, Bryant DM, Guo W, Wiita AP, Guo M, Dumont S, Hanein D, Radhakrishnan R…
• Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma.
  Cell chemical biology 2022 Ferguson ID, Lin YT, Lam C, Shao H, Tharp KM, Hale M, Kasap C, Mariano MC, Kishishita A, Patiño Escobar B, Mandal K, Steri V, Wang D, Phojanakong P, Tuomivaara ST, Hann B, Driessen C, Van Ness B, …
• The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance.
  Nature communications 2022 Ferguson ID, Patiño-Escobar B, Tuomivaara ST, Lin YT, Nix MA, Leung KK, Kasap C, Ramos E, Nieves Vasquez W, Talbot A, Hale M, Naik A, Kishishita A, Choudhry P, Lopez-Girona A, Miao W, Wong SW, Wolf JL…
• Secretory autophagy maintains proteostasis upon lysosome inhibition.
  The Journal of cell biology 2022 Solvik TA, Nguyen TA, Tony Lin YH, Marsh T, Huang EJ, Wiita AP, Debnath J, Leidal AM
• CD72 Nanobody-Based CAR-T Cells Have Potent Anti-Tumor Efficacy in B Cell Malignancies.
  Blood 2021 Matthew A Nix, William C Temple, William Karlon, Donghui Wang, Paul Phojanakong, Veronica Steri, Byron Hann, Arun P Wiita
• Functional Multi-Omics Reveals Genetic and Pharmacologic Regulation of Surface CD38 in Multiple Myeloma.
  Blood 2021 Priya Choudhry, Olivia Gugliemini, Huimin Geng, Vishesh Sarin, Letitia Sarah, Yu-Hsiu T. Lin, Neha Paranjape, Poornima Ramkumar, Makeba Marcoulis, Donghui Wang, Paul Phojanakong, Veronica Steri, Byron…
• Mitochondrial Electron Transport Chain Inhibition Promotes Resistance to Proteasome Inhibitors in Multiple Myeloma.
  Blood 2021 Aditi Sharma, Abhinav Achreja, Remya Nair, Pulkit Gupta, Claudia L Edgar, Olamide Animasahun, Anjali Mittal, Bhakti Dwivedi, Manoj Bhasin, Vikas A Gupta, Benjamin G Barwick, Shannon M Matulis, Sagar …
• GRASP55 restricts early-stage autophagy and regulates spatial organization of the early secretory network.
  Biology open 2021 Liu JY, Lin YT, Leidal AM, Huang HH, Ye J, Wiita AP, Debnath J
• P-103: Profiling the myeloma cell surface proteome reveals CCR10 as a potential immunotherapeutic target.
  Clinical Lymphoma Myeloma & Leukemia 2021 Bonell Patino-Escobar, Corynn Kasap, Ian Ferguson, Martina Hale, Arun Wiita
• FcεRIγ-negative NK cells persist in vivo and enhance efficacy of therapeutic monoclonal antibodies in multiple myeloma.
  Blood advances 2021 Bigley AB, Spade S, Agha NH, Biswas S, Tang S, Malik MH, Dai L, Masoumi S, Patiño-Escobar B, Hale M, DiPierro G, Martell R, Hann B, Shah N, Wiita AP, Liu X
• Author Correction: IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells.
  Nature 2021 Lee J, Robinson ME, Ma N, Artadji D, Ahmed MA, Xiao G, Sadras T, Deb G, Winchester J, Cosgun KN, Geng H, Chan LN, Kume K, Miettinen TP, Zhang Y, Nix MA, Klemm L, Chen CW, Chen J, Khairnar V, Wiita AP,…
• Surface Proteomics Reveals CD72 as a Target for In Vitro-Evolved Nanobody-Based CAR-T Cells in KMT2A/MLL1-Rearranged B-ALL.
  Cancer discovery 2021 Nix MA, Mandal K, Geng H, Paranjape N, Lin YT, Rivera JM, Marcoulis M, White KL, Whitman JD, Bapat SP, Parker KR, Ramirez J, Deucher A, Phojanokong P, Steri V, Fattahi F, Hann BC, Satpathy AT, Manglik…
• A Guide to Using ClinTAD for Interpretation of DNA Copy Number Variants in the Context of Topologically Associated Domains.
  Current protocols in human genetics 2020 Spector JD, Wiita AP
• Phase II Study of Daratumumab in Combination with Azacitidine and Dexamethasone in Relapsed/Refractory Multiple Myeloma Patients Previously Treated with Daratumumab: Darazadex.
  Blood 2020 Swetha Kambhampati, Sandy W. Wong, Thomas Martin, Jeffrey L. Wolf, Priya Choudhry, William Karlon, Arun P. Wiita, Nina Shah
• IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells.
  Nature 2020 Lee J, Robinson ME, Ma N, Artadji D, Ahmed MA, Xiao G, Sadras T, Deb G, Winchester J, Cosgun KN, Geng H, Chan LN, Kume K, Miettinen TP, Zhang Y, Nix MA, Klemm L, Chen CW, Chen J, Khairnar V, Wiita AP,…
• Engineered ACE2 receptor traps potently neutralize SARS-CoV-2.
  Proceedings of the National Academy of Sciences of the United States of America 2020 Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Lim SA, Zhou XX, Hobman TC, Kortemme T, Wells JA
• MM-378: Inhibitory and Stimulatory Interplay Between Myeloma Tumor and T Cells.
  Clinical Lymphoma Myeloma & Leukemia 2020 August Dietrich, Cassandra Burnett, Thomas Martin, Arun Wiita, Kole Roybal, Justin Eyquem
• Variants of uncertain significance in prenatal microarrays: a retrospective cohort study.
  BJOG : an international journal of obstetrics and gynaecology 2020 Mardy AH, Wiita AP, Wayman BV, Drexler K, Sparks TN, Norton ME
• Abstract 1630: FceR1g negative NK-cells (g-NK) enhance antibody-dependent cellular cytotoxicity and in vivo efficacy of therapeutic monoclonal antibodies against hematologic malignanices.
  Cancer Research 2020 Austin Basil Bigley, Nadia H. Agha, Shanae Spade, Gaetano Dipierro, Ronald Martell, Byron C. Hann, Nina Shah, Arun P. Wiita
• Engineered ACE2 receptor traps potently neutralize SARS-CoV-2.
  bioRxiv : the preprint server for biology 2020 Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Lim SA, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Zhou XX, Hobman TC, Kortemme T, Wells JA
• Signalling input from divergent pathways subverts B cell transformation.
  Nature 2020 Chan LN, Murakami MA, Robinson ME, Caeser R, Sadras T, Lee J, Cosgun KN, Kume K, Khairnar V, Xiao G, Ahmed MA, Aghania E, Deb G, Hurtz C, Shojaee S, Hong C, Pölönen P, Nix MA, Chen Z, Chen CW, Chen J,…
• CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma.
  Blood advances 2020 Ramkumar P, Abarientos AB, Tian R, Seyler M, Leong JT, Chen M, Choudhry P, Hechler T, Shah N, Wong SW, Martin TG, Wolf JL, Roybal KT, Pahl A, Taunton J, Wiita AP, Kampmann M
• Prevalence of Partial Hydatidiform Mole in Products of Conception From Gestations With Fetal Triploidy Merits Reflex Genotype Testing Independent of the Morphologic Appearance of the Chorionic Villi.
  The American journal of surgical pathology 2020 Han LM, Grenert JP, Wiita AP, Quinn M, Fujimoto VY, Rabban JT
• Investigating macrophage function as a mechanism of resistance to daratumumab in relapsed refractory multiple myeloma patients.
  Journal of Clinical Oncology 2020 Swetha Kambhampati, Kwun Wah Wen, Victoria Sung, Sandy Wai Kuan Wong, Thomas G. Martin, Jeffrey Lee Wolf, Nina Shah, Arun Wiita
• Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma.
  Nature communications 2020 Huang HH, Ferguson ID, Thornton AM, Bastola P, Lam C, Lin YT, Choudhry P, Mariano MC, Marcoulis MD, Teo CF, Malato J, Phojanakong PJ, Martin TG, Wolf JL, Wong SW, Shah N, Hann B, Brooks AN, Wiita AP
• Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway.
  Nature 2020 Guo X, Aviles G, Liu Y, Tian R, Unger BA, Lin YT, Wiita AP, Xu K, Correia MA, Kampmann M
• Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis.
  Leukemia 2020 Sarin V, Yu K, Ferguson ID, Gugliemini O, Nix MA, Hann B, Sirota M, Wiita AP
• The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles.
  Nature cell biology 2020 Leidal AM, Huang HH, Marsh T, Solvik T, Zhang D, Ye J, Kai F, Goldsmith J, Liu JY, Huang YH, Monkkonen T, Vlahakis A, Huang EJ, Goodarzi H, Yu L, Wiita AP, Debnath J
• Lessons Learned from Proteasome Inhibitors, the Paradigm for Targeting Protein Homeostasis in Cancer.
  Advances in experimental medicine and biology 2020 Kambhampati S, Wiita AP
• X-linked duplication copy number variation in a familial overgrowth condition.
  American journal of medical genetics. Part C, Seminars in medical genetics 2019 Ha TK, Mardy AH, Beleford D, Spanier A, Wayman BV, Penon-Portmann M, Wiita AP, Shieh JT
• Ifitm3 Is Essential for PI(3,4,5)P3-Dependent B-Cell Activation and Leukemogenesis.
  Blood 2019 Jaewoong Lee, Gang Xiao, Kadriye Nehir Nehir Cosgun, Huimin Geng, Ning Ma, Lai N Chan, Kohei Kume, Matthew Nix, Zhengshan Chen, Chun-Wei David Chen, Jianjun Chen, Vishal Khairnar, Arun P. Wiita, …
• In Vitro-Selected Nanobody-Based Cellular Therapy Targeting CD72 for Treatment of Refractory B-Cell Malignancies.
  Blood 2019 Matthew Nix, Yu-Hsiu T. Lin, Huimin Geng, Makeba Marcoulis, Paul Phojanakong, Donghui Wang, Veronica Steri, Jeffrey Whitman, Sagar Bapat, Elliot Stieglitz, Anne Deucher, Kristie L White, Byron C Hann,…
• Profiling the Cell Surface Landscape of Proteasome Inhibitor-Treated and -Resistant Multiple Myeloma to Guide Immunotherapy Targeting, Diagnosis, and Biology.
  Blood 2019 Ian Ferguson, Yu-Hsiu T. Lin, Sami Tuomivaara, Jeffrey L. Wolf, Thomas G. Martin, Sandy W. Wong, Nina D. Shah, Christoph Driessen, Brian G. Van Ness, Arun P. Wiita
• Signaling Input from Divergent Pathways Subverts Malignant B-Cell Transformation.
  Blood 2019 Lai N Chan, Mark A. Murakami, Rebecca Caesar, Christian Hurtz, Kohei Kume, Teresa Sadras, Seyedmehdi Shojaee, Petri Pölönen, Amol Ugale, Jaewoong Lee, Kadriye Nehir Cosgun, Huimin Geng, Merja …
• Integrated phosphoproteomics and transcriptional classifiers reveal hidden RAS signaling dynamics in multiple myeloma.
  Blood advances 2019 Lin YT, Way GP, Barwick BG, Mariano MC, Marcoulis M, Ferguson ID, Driessen C, Boise LH, Greene CS, Wiita AP
• DNA methyltransferase inhibitors upregulate CD38 protein expression and enhance daratumumab efficacy in multiple myeloma.
  Leukemia 2019 Choudhry P, Mariano MC, Geng H, Martin TG, Wolf JL, Wong SW, Shah N, Wiita AP
• DNA methyltransferase inhibitors upregulate CD38 expression and enhance daratumumab efficacy in multiple myeloma.
  Clinical Lymphoma Myeloma & Leukemia 2019 Priya Choudhry, Margarette Mariano, Huimin Geng, Arun Wiita
• Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis.
  Clinical Lymphoma Myeloma & Leukemia 2019 Vishesh Sarin, Katharine Yu, Marina Sirota, Arun Wiita
• Abstract 1554: Uncoupling tumor-cell cytotoxicity from cytokine release with novel T-cell engaging bispecific antibodies.
  Immunology 2019 Kyle Lorentsen, Preethi Sankaran, Nathan D. Trinklein, Duy Pham, Ute Schellenberger, Ben Buelow, Andrew Boudreau, Priya Choudhry, Starlynn C. Clarke, Kevin Dang, Katherine E. Harris, Suhasini Iyer, …
• TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis.
  Proceedings of the National Academy of Sciences of the United States of America 2019 Crottès D, Lin YT, Peters CJ, Gilchrist JM, Wiita AP, Jan YN, Jan LY
• Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies.
  mAbs 2019 Trinklein ND, Pham D, Schellenberger U, Buelow B, Boudreau A, Choudhry P, Clarke SC, Dang K, Harris KE, Iyer S, Jorgensen B, Pratap PP, Rangaswamy US, Ugamraj HS, Vafa O, Wiita AP, van Schooten W, …
• ClinTAD: a tool for copy number variant interpretation in the context of topologically associated domains.
  Journal of human genetics 2019 Spector JD, Wiita AP
• 880: Variants of uncertain significance in prenatal microarrays.
  American Journal of Obstetrics and Gynecology 2019 Anne H. Mardy, Teresa N. Sparks, Arun P. Wiita, Kathryn Drexler, Brette V. Wayman, Allan Nadel, Mary E. Norton
• Targeting CD74 in multiple myeloma with the novel, site-specific antibody-drug conjugate STRO-001.
  Oncotarget 2018 Abrahams CL, Li X, Embry M, Yu A, Krimm S, Krueger S, Greenland NY, Wen KW, Jones C, DeAlmeida V, Solis WA, Matheny S, Kline T, Yam AY, Stafford R, Wiita AP, Hallam T, Lupher M, Molina A
• DNA Methyltransferase Inhibitors Increase Expression of CD38 and Enhance Daratumumab Efficacy in Multiple Myeloma.
  Blood 2018 Priya Choudhry, Margarette C. Mariano, Arun P Wiita
• IFITM3-Mediated Regulation of Cell Membrane Dynamics Is Essential for Malignant B-Cell Transformation.
  Blood 2018 Jae-Woong Lee, Huimin Geng, Derek S Dinson, Gang Xiao, Kadriye Nehir Cosgun, Lai N Chan, Zhengshan Chen, Michael Farzan, Jae U Jung, Arun P Wiita, Markus Muschen
• Identifying Factors in Multiple Myeloma Controlling Response to B-Cell Maturation Antigen (BCMA)-Targeted Immunotherapy Using CRISPR-Based Functional Genomics.
  Blood 2018 Poornima Ramkumar, Jaime Leong, Meghan Seyler, Stratton J Georgoulis, Axel Hyrenius Wittsten, Priya Choudhry, Kole Roybal, Arun P Wiita, Martin Kampmann
• Integrating Phosphoproteomics and Transcriptional Classifiers Reveals "Hidden Signaling" in Multiple Myeloma Including Differential KRAS and NRAS Mutant Effects.
  Blood 2018 Yu-Hsiu T. Lin, Gergory P. Way, Margarette C. Mariano, Makeba Marcoulis, Ian Ferguson, Casey S. Greene, Arun P Wiita
• Novel Allosteric Inhibitors of Heat Shock Protein 70 As Agents to Probe Protein Homeostasis and Overcome Proteasome Inhibitor Resistance in Multiple Myeloma.
  Blood 2018 Ian Ferguson, Christine Lam, Margarette C. Mariano, Donghui Wang, Paul Phojanakong, Sami Toumivaara, Hao Shao, Byron C Hann, Jason Gestwicki, Arun P Wiita
• Fine Needle Aspiration is an Effective Method for Cell Surface Proteomics: Towards a Personalized Cancer Surfaceome.
  Journal of the American Society of Cytopathology 2018 Jeffrey Whitman, Dianna Ng, Matthew Nix, Kevin Leung, Ronald Balassanian, Arun Wiita
• Seeking Convergence and Cure with New Myeloma Therapies.
  Trends in cancer 2018 Choudhry P, Galligan D, Wiita AP
• Pre-clinical development of TNB-383B, a fully human T-cell engaging bispecific antibody targeting BCMA for the treatment of multiple myeloma.
  Journal of Clinical Oncology 2018 Ben Buelow, Priya Choudry, Starlynn Clarke, Kevin Dang, Laura Davison, Shelley Force Aldred, Katherine Harris, Payal Pratap, Duy Pham, Udaya Rangaswamy, Ute Schellenberger, Nina Shah, Nathan Trinklein…
• Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment.
  Haematologica 2018 Lam C, Ferguson ID, Mariano MC, Lin YT, Murnane M, Liu H, Smith GA, Wong SW, Taunton J, Liu JO, Mitsiades CS, Hann BC, Aftab BT, Wiita AP
• A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle.
  Nature communications 2018 Goode B, Mondal G, Hyun M, Ruiz DG, Lin YH, Van Ziffle J, Joseph NM, Onodera C, Talevich E, Grenert JP, Hewedi IH, Snuderl M, Brat DJ, Kleinschmidt-DeMasters BK, Rodriguez FJ, Louis DN, Yong WH, Lopes…
• Development of a fully human t-cell engaging bispecific antibody for the treatment of multiple myeloma.
  Journal of Clinical Oncology 2018 Ben Buelow, Priya Choudhry, Starlynn Clarke, Kevin Dang, Laura Davison, Shelley Force Aldred, Katherine Harris, Duy Pham, Payal Pratap, Udaya Rangaswamy, Ute Schellenberger, Nina Shah, Nathan …
• Cellular Phenotypes in Human iPSC-Derived Neurons from a Genetic Model of Autism Spectrum Disorder.
  Cell reports 2017 Deshpande A, Yadav S, Dao DQ, Wu ZY, Hokanson KC, Cahill MK, Wiita AP, Jan YN, Ullian EM, Weiss LA
• The p97 Inhibitor CB-5083 Is a Unique Disrupter of Protein Homeostasis in Models of Multiple Myeloma.
  Molecular cancer therapeutics 2017 Le Moigne R, Aftab BT, Djakovic S, Dhimolea E, Valle E, Murnane M, King EM, Soriano F, Menon MK, Wu ZY, Wong ST, Lee GJ, Yao B, Wiita AP, Lam C, Rice J, Wang J, Chesi M, Bergsagel PL, Kraus M, …
• Time-Resolved Proteomics Extends Ribosome Profiling-Based Measurements of Protein Synthesis Dynamics.
  Cell systems 2017 Liu TY, Huang HH, Wheeler D, Xu Y, Wells JA, Song YS, Wiita AP
• Development of a fully human T cell engaging bispecific antibody for the treatment of multiple myeloma.
  Journal of Clinical Oncology 2017 Ben Buelow, Duy Pham, Starlynn Clarke, Shelley Force Aldred, Kevin Dang, Payal Pratap, Harshad Ugamraj, Katherine Harris, Nathan Trinklein, Ute Schellenberger, Arun Wiita, Wim Van Schooten, Ben Buelow
• False negative fetal cell free DNA screening for microdeletion syndromes in the presence of an unbalanced translocation involving monosomy 4p.
  Prenatal diagnosis 2017 Qi Z, Madaan S, Chetty S, Yu J, Wiita AP
• Hijacking Myeloma Metabolism to Target Cytotoxic Chemotherapy to Malignant Plasma Cells With Decreased Bone Marrow Toxicity.
  Clinical Lymphoma Myeloma & Leukemia 2017 Arun Wiita, Hui Liu, Christine Lam, Bernd Jandeleit, Wolf-Nicolas Fischer, Kerry Koller, Byron Hann
• CD46 Is Amplified in High-Risk Myeloma with Gain of Chromosome 1q and Selectively Targeted By a Novel Anti-CD46 Antibody-Drug Conjugate.
  Blood 2016 Daniel W. Sherbenou, Blake T. Aftab, Yang Su, Christopher R. Behrens, Arun P. Wiita, Aaron C. Logan, Diego Acosta-Alvear, Byron C. Hann, Peter Walter, Xiaobo Wu, John P. Atkinson, Jeffrey L. Wolf, …
• Tofacitinib Reverses Growth Promoting Effects of the Bone Marrow Stromal Environment Though Inhibition of JAK1/STAT3 Signaling in Multiple Myeloma.
  Blood 2016 Christine Lam, Megan Murnane, Geoffrey A. Smith, Jack Taunton, Blake T. Aftab, Arun P. Wiita
• Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells.
  The Journal of clinical investigation 2016 Sherbenou DW, Aftab BT, Su Y, Behrens CR, Wiita A, Logan AC, Acosta-Alvear D, Hann BC, Walter P, Shuman MA, Wu X, Atkinson JP, Wolf JL, Martin TG, Liu B
• False positive cell free DNA screening for microdeletions due to non-pathogenic copy number variants.
  Prenatal diagnosis 2016 Mather CA, Qi Z, Wiita AP
• Phosphorylation of β-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis.
  Neuron 2016 Ori-McKenney KM, McKenney RJ, Huang HH, Li T, Meltzer S, Jan LY, Vale RD, Wiita AP, Jan YN
• Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles.
  Proceedings of the National Academy of Sciences of the United States of America 2016 Julien O, Zhuang M, Wiita AP, O'Donoghue AJ, Knudsen GM, Craik CS, Wells JA
• Defining Primary Marrow Microenvironment-Induced Synthetic Lethality and Resistance for 2,684 Approved Drugs Across Molecularly Distinct Forms of Multiple Myeloma.
  Blood 2015 Megan Murnane, Eugen Dhimolea, Ruojing Li, Megan A. Bariteau, Diamond D. Wheeler, Rosemary J. Akhurst, Aaron C. Logan, Pamela Munster, Arun Wiita, Thomas G. Martin, Jeffrey L. Wolf, Jun O. Liu, …
• Circulating proteolytic signatures of chemotherapy-induced cell death in humans discovered by N-terminal labeling.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Wiita AP, Hsu GW, Lu CM, Esensten JH, Wells JA
• Targeted peptide measurements in biology and medicine: best practices for mass spectrometry-based assay development using a fit-for-purpose approach.
  Molecular & cellular proteomics : MCP 2014 Carr SA, Abbatiello SE, Ackermann BL, Borchers C, Domon B, Deutsch EW, Grant RP, Hoofnagle AN, Hüttenhain R, Koomen JM, Liebler DC, Liu T, MacLean B, Mani DR, Mansfield E, Neubert H, Paulovich AG, …
• Global analysis of cellular proteolysis by selective enzymatic labeling of protein N-termini.
  Methods in enzymology 2014 Wiita AP, Seaman JE, Wells JA
• Global cellular response to chemotherapy-induced apoptosis.
  eLife 2013 Wiita AP, Ziv E, Wiita PJ, Urisman A, Julien O, Burlingame AL, Weissman JS, Wells JA
• Evaluation of Glutamate Dehydrogenase Immunoassay Screening with Toxin Confirmation for the Diagnosis of Clostridium difficile Infection.
  Lab Medicine 2013 Steve Miller, Arun Wiita, Carolyn Wright, Helen Reyes, Catherine Liu
• Longitudinal management with crossmatch-compatible platelets for refractory patients: alloimmunization, response to transfusion, and clinical outcomes (CME).
  Transfusion 2012 Wiita AP, Nambiar A
• Cytomegalovirus disease and infection in lung transplant recipients in the setting of planned indefinite valganciclovir prophylaxis.
  Transplant infectious disease : an official journal of the Transplantation Society 2012 Wiita AP, Roubinian N, Khan Y, Chin-Hong PV, Singer JP, Golden JA, Miller S
• Clinical application of high throughput molecular screening techniques for pharmacogenomics.
  Pharmacogenomics and personalized medicine 2011 Wiita AP, Schrijver I
• Erratum: Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy.
  Nature Structural & Molecular Biology 2009 Raul Perez-Jimenez, Jingyuan Li, Pallav Kosuri, Inmaculada Sanchez-Romero, Arun P Wiita, David Rodriguez-Larrea, Ana Chueca, Arne Holmgren, Antonio Miranda-Vizuete, Katja Becker, Seung-Hyun Cho, Jon …
• Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy.
  Nature structural & molecular biology 2009 Perez-Jimenez R, Li J, Kosuri P, Sanchez-Romero I, Wiita AP, Rodriguez-Larrea D, Chueca A, Holmgren A, Miranda-Vizuete A, Becker K, Cho SH, Beckwith J, Gelhaye E, Jacquot JP, Gaucher EA, Gaucher E, …
• Force-clamp spectroscopy detects residue co-evolution in enzyme catalysis.
  The Journal of biological chemistry 2008 Perez-Jimenez R, Wiita AP, Rodriguez-Larrea D, Kosuri P, Gavira JA, Sanchez-Ruiz JM, Fernandez JM
• Single-molecule force spectroscopy measurements of bond elongation during a bimolecular reaction.
  Journal of the American Chemical Society 2008 Koti Ainavarapu SR, Wiita AP, Dougan L, Uggerud E, Fernandez JM
• A single-molecule assay to directly identify solvent-accessible disulfide bonds and probe their effect on protein folding.
  Journal of the American Chemical Society 2007 Ainavarapu SR, Wiita AP, Huang HH, Fernandez JM
• Dwell time analysis of a single-molecule mechanochemical reaction.
  Langmuir : the ACS journal of surfaces and colloids 2007 Szoszkiewicz R, Ainavarapu SR, Wiita AP, Perez-Jimenez R, Sanchez-Ruiz JM, Fernandez JM
• Probing the chemistry of thioredoxin catalysis with force.
  Nature 2007 Wiita AP, Perez-Jimenez R, Walther KA, Gräter F, Berne BJ, Holmgren A, Sanchez-Ruiz JM, Fernandez JM
• Contour length and refolding rate of a small protein controlled by engineered disulfide bonds.
  Biophysical journal 2006 Ainavarapu SR, Brujic J, Huang HH, Wiita AP, Lu H, Li L, Walther KA, Carrion-Vazquez M, Li H, Fernandez JM
• Force-dependent chemical kinetics of disulfide bond reduction observed with single-molecule techniques.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Wiita AP, Ainavarapu SR, Huang HH, Fernandez JM