Arun Rangaswami, MD
Professor
Pediatrics
School of Medicine

I was the US National PI for the International Hepatoblastoma therapeutic trials, SIOPEL 4 and SIOPEL 6.I am currently the senior sub-PI for the Hepatocellular Carcinoma treatment arm of the Pediatric Hepatic tumors International Therapeutic Trial (PHITT). I am also the Co-chair of the Children's Hepatic tumors International Collaboration (CHIC), the largest extant database for pediatric rare tumors. I facilitate an International Hepatobiliary Multicenter Tumor Board, where we consider therapeutic strategies for children with relapsed and refractory liver cancers from around the world, with expert participants from North America, Europe, and Asia.

• Outcomes for Children With Type II and Type III Pleuropulmonary Blastoma Following Chemotherapy: A Report From the International PPB/DICER1 Registry.
  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2022 Schultz KAP, Harris AK, Nelson AT, Watson D, Lucas JT, Miniati D, Stewart DR, Hagedorn KN, Mize W, Kamihara J, Mitchell SG, Wilson DB, Gettinger K, Rangaswami AA, Harney LA, Rodriguez Galindo C, …
• Single-cell analysis of hepatoblastoma identifies tumor signatures that predict chemotherapy susceptibility using patient-specific tumor spheroids.
  Nature communications 2022 Song H, Bucher S, Rosenberg K, Tsui M, Burhan D, Hoffman D, Cho SJ, Rangaswami A, Breese M, Leung S, Ventura MVP, Sweet-Cordero EA, Huang FW, Nijagal A, Wang B
• Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults.
  Journal of hepatology 2022 Sumazin P, Peters TL, Sarabia SF, Kim HR, Urbicain M, Hollingsworth EF, Alvarez KR, Perez CR, Pozza A, Najaf Panah MJ, Epps JL, Scorsone K, Zorman B, Katzenstein H, O'Neill AF, Meyers R, Tiao G, …
• The Use of Fluorescence in situ Hybridization to Confirm PRKACA Gene Rearrangement in Fibrolamellar Hepatocellular Carcinoma: A Validation Study.
  Annals of clinical and laboratory science 2022 Weiel JJ, Forgo B, Sage J, Rangaswami A, Hazard FK
• Current Approaches in Hepatoblastoma-New Biological Insights to Inform Therapy.
  Current oncology reports 2022 Wu PV, Rangaswami A
• Therapy-related myeloid neoplasms resembling juvenile myelomonocytic leukemia: a case series and review of the literature.
  Pediatric blood & cancer 2021 Wintering A, Smith S, Fuh B, Rangaswami A, Dahl G, Chien M, Gruber TA, Dang J, Li LS, Lenzen A, Savelli S, Dvorak CC, Agrawal AK, Stieglitz E
• A Comprehensive Circulating Tumor DNA Assay for Detection of Translocation and Copy-Number Changes in Pediatric Sarcomas.
  Molecular cancer therapeutics 2021 Shah AT, Azad TD, Breese MR, Chabon JJ, Hamilton EG, Straessler K, Kurtz DM, Leung SG, Spillinger A, Liu HY, Behroozfard IH, Wittber FM, Hazard FK, Cho SJ, Daldrup-Link HE, Vo KT, Rangaswami A, …
• Multimodality treatment including whole pleura radiation therapy for DICER1-associated pediatric pleuropulmonary blastoma.
  Pediatric blood & cancer 2021 Hui C, Shin DH, Wakeling A, Donaldson SS, Hazard FK, Rangaswami A, Hiniker SM
• Diagnostic criteria for constitutional mismatch repair deficiency (CMMRD): recommendations from the international consensus working group.
  Journal of medical genetics 2021 Aronson M, Colas C, Shuen A, Hampel H, Foulkes WD, Baris Feldman H, Goldberg Y, Muleris M, Wolfe Schneider K, McGee RB, Jasperson K, Rangaswami A, Brugieres L, Tabori U
• The importance of age as prognostic factor for the outcome of patients with hepatoblastoma: Analysis from the Children's Hepatic tumors International Collaboration (CHIC) database.
  Pediatric blood & cancer 2020 Haeberle B, Rangaswami A, Krailo M, Czauderna P, Hiyama E, Maibach R, Lopez-Terrada D, Aronson DC, Alaggio R, Ansari M, Malogolowkin MH, Perilongo G, O'Neill AF, Trobaugh-Lotrario AD, Watanabe K, …
• QTc Prolongation and Risk of Torsades de Pointes in Hospitalized Pediatric Oncology Patients.
  The Journal of pediatrics 2019 Lim TR, Rangaswami AA, Dubin AM, Kapphahn KI, Sakarovitch C, Long J, Motonaga KS, Trela T, Ceresnak SR
• Comparative RNA-seq analysis aids in diagnosis of a rare pediatric tumor.
  Cold Spring Harbor molecular case studies 2019 Sanders LM, Rangaswami A, Bjork I, Lam DL, Beale HC, Kephart ET, Durbin A, Learned K, Currie R, Lyle AG, Pfeil J, Shah AT, Lee AG, Leung SG, Behroozfard IH, Breese MR, Peralez J, Hazard FK, Lacayo N, …
• Comparative Tumor RNA Sequencing Analysis for Difficult-to-Treat Pediatric and Young Adult Patients With Cancer.
  JAMA network open 2019 Vaske OM, Bjork I, Salama SR, Beale H, Tayi Shah A, Sanders L, Pfeil J, Lam DL, Learned K, Durbin A, Kephart ET, Currie R, Newton Y, Swatloski T, McColl D, Vivian J, Zhu J, Lee AG, Leung SG, …
• Orthotopic Liver Transplantation After Stereotactic Body Radiotherapy for Pediatric Hepatocellular Carcinoma with Central Biliary Obstruction and Nodal Involvement.
  Cureus 2018 Chen E, Rangaswami A, Esquivel CO, Concepcion W, Lungren M, Thakor AS, Yoo CH, Donaldson SS, Hiniker SM
• Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss.
  The New England journal of medicine 2018 Brock PR, Maibach R, Childs M, Rajput K, Roebuck D, Sullivan MJ, Laithier V, Ronghe M, Dall'Igna P, Hiyama E, Brichard B, Skeen J, Mateos ME, Capra M, Rangaswami AA, Ansari M, Rechnitzer C, Veal GJ, …
• Transarterial chemoembolization in children to treat unresectable hepatocellular carcinoma.
  Pediatric transplantation 2018 Weiss KE, Sze DY, Rangaswami AA, Esquivel CO, Concepcion W, Lebowitz EA, Kothary N, Lungren MP
• CD47 is not Over-Expressed in Fibrolamellar Hepatocellular Carcinoma.
  Annals of clinical and laboratory science 2017 Cooney T, Wei MC, Rangaswami A, Xu L, Sage J, Hazard FK
• Risk-stratified staging in paediatric hepatoblastoma: a unified analysis from the Children's Hepatic tumors International Collaboration.
  The Lancet. Oncology 2016 Meyers RL, Maibach R, Hiyama E, Häberle B, Krailo M, Rangaswami A, Aronson DC, Malogolowkin MH, Perilongo G, von Schweinitz D, Ansari M, Lopez-Terrada D, Tanaka Y, Alaggio R, Leuschner I, Hishiki T, …
• Stereotactic body radiotherapy for pediatric hepatocellular carcinoma with central biliary obstruction.
  Pediatric blood & cancer 2016 Hiniker SM, Rangaswami A, Lungren MP, Thakor AS, Concepcion W, Balazy KE, Kovalchuk N, Donaldson SS
• Hepatoblastoma Arising in a Pigmented β-catenin-activated Hepatocellular Adenoma: Case Report and Review of the Literature.
  The American journal of surgical pathology 2016 Louie CY, Concepcion W, Park JK, Rangaswami A, Finegold MJ, Hazard FK
• The Children's Hepatic tumors International Collaboration (CHIC): Novel global rare tumor database yields new prognostic factors in hepatoblastoma and becomes a research model.
  European journal of cancer (Oxford, England : 1990) 2015 Czauderna P, Haeberle B, Hiyama E, Rangaswami A, Krailo M, Maibach R, Rinaldi E, Feng Y, Aronson D, Malogolowkin M, Yoshimura K, Leuschner I, Lopez-Terrada D, Hishiki T, Perilongo G, von Schweinitz D,…
• Synchronous Hepatoblastoma, Neuroblastoma, and Cutaneous Capillary Hemangiomas: A Case Report.
  Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 2015 Ozawa MG, Cooney T, Rangaswami A, Hazard FK
• Genomic analysis of fibrolamellar hepatocellular carcinoma.
  Human molecular genetics 2014 Xu L, Hazard FK, Zmoos AF, Jahchan N, Chaib H, Garfin PM, Rangaswami A, Snyder MP, Sage J
• Increased utilization of pediatric specialty care: a population study of pediatric oncology inpatients in California.
  Journal of pediatric hematology/oncology 2014 Chamberlain LJ, Pineda N, Winestone L, Saynina O, Rangaswami A, Link M, Wise PH
• Dose-dense cisplatin-based chemotherapy and surgery for children with high-risk hepatoblastoma (SIOPEL-4): a prospective, single-arm, feasibility study.
  The Lancet. Oncology 2013 Zsiros J, Brugieres L, Brock P, Roebuck D, Maibach R, Zimmermann A, Childs M, Pariente D, Laithier V, Otte JB, Branchereau S, Aronson D, Rangaswami A, Ronghe M, Casanova M, Sullivan M, Morland B, …
• Congenital pancreatoblastoma: report of an atypical case and review of the literature.
  Journal of pediatric hematology/oncology 2012 Chisholm KM, Hsu CH, Kim MJ, Rangaswami A, Gray Hazard FK
• Effects of poloxamer 188 treatment on sickle cell vaso-occlusive crisis: computer-assisted intravital microscopy study.
  Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2004 Cheung AT, Chan MS, Ramanujam S, Rangaswami A, Curl K, Franklin P, Wun T
• Predictors of bacteremia in febrile children with sickle cell disease.
  Journal of pediatric hematology/oncology 2002 West DC, Andrada E, Azari R, Rangaswami AA, Kuppermann N
• Activated monocytes and platelet-monocyte aggregates in patients with sickle cell disease.
  Clinical and laboratory haematology 2002 Wun T, Cordoba M, Rangaswami A, Cheung AW, Paglieroni T
• Bcl-2 overexpression results in enhanced capacitative calcium entry and resistance to SKF-96365-induced apoptosis.
  Cancer research 2000 Williams SS, French JN, Gilbert M, Rangaswami AA, Walleczek J, Knox SJ
• Platelet activation in patients with sickle cell disease.
  British journal of haematology 1998 Wun T, Paglieroni T, Rangaswami A, Franklin PH, Welborn J, Cheung A, Tablin F