Arun Prakash Budde, MD, PhD
Professor
Anesthesia
School of Medicine

Awards

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• Laboratory Safety Award, UCSF, 2019

Education & Training

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• Post-doctoral Fellowship/Clinical Instructor University of California San Francisco 07/2011
• Anesthesiology University of California San Francisco 07/2009
• Internship in Internal Medicine Santa Clara Valley Medical Center 06/2006
• MD/PhD Medicine/Immunology New York University School of Medicine 06/2005
• Bachelors of Science/Arts Chemistry/History University of Rochester 06/1996

Interests

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• Gut Microbiome
• NLRP3 inflammasome
• Lung Injury
• Short-chain fatty acids
• Anesthesiology
• Sterile Lung Injury
• Lung Ischemia Reperfusion (IR) injury

Websites

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• Prakash Lab (internal UCSF website) (prakashlab.ucsf.edu)
• Prakash Lab (external wix site) (arunprakashmdphd.wix.com)

Grants and Projects

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• The Gut-Lung Axis: Immunometabolism Linking the Gut Microbiome and Lung Imunity, NIH, 2020-2025
• Role of Innate Immune Cells and Pathways in Ventilated Lung Ischemia Reperfusion, NIH, 2015-2020

Publications (25)

Top publication keywords:
LungGastrointestinal TractReceptors, Pattern RecognitionInterferon Type IComplement Pathway, AlternativeReperfusion InjuryFatty Acids, VolatileInterferon Regulatory Factor-7Receptors, G-Protein-CoupledToll-Like Receptor 2Complement Factor BMacrophages, AlveolarToll-Like Receptor 4Interleukin-1betaLipopolysaccharides

• Sequential Blood Collection from Inferior Vena Cava Followed by Portal Vein to Evaluate Gut Microbial Metabolites in Mice
  J. Vis. Exp. 2024 Doan, T. N. M., Maruyama, D., Tian, X., Prakash, A
• Regulation of Lung Immune Tone by the Gut-Lung Axis via Dietary Fiber, Gut Microbiota, and Short-Chain Fatty Acids
  BioRxiv 2023 Maruyama D, Liao WI, Tian X, Bredon M, Knapp J, Tat C, Doan TNM, Chassaing B, Bhargava A, Sokol H, Prakash A.
• A Mouse Model of Orotracheal Intubation and Ventilated Lung Ischemia Reperfusion Surgery
  J. Vis. Exp. 2022 Liao, W. I., Maruyama, D., Kianian, F., Tat, C., Tian, X., Hellman, J., Dodd-o, J. M., Prakash, A.
• Lung immune tone via gut-lung axis: gut-derived LPS and short-chain fatty acids' immunometabolic regulation of lung IL-1β, FFAR2, and FFAR3 expression.
  American journal of physiology. Lung cellular and molecular physiology 2021 Liu Q, Tian X, Maruyama D, Arjomandi M, Prakash A
• Clinical Evaluation of a COVID-19 Antibody Lateral Flow Assay using Point of Care Samples.
  medRxiv : the preprint server for health sciences 2020 Lee W, Straube S, Sincic R, Noble JA, Montoy JC, Kornblith AE, Prakash A, Wang R, Bainton RJ, Kurien PA

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• A journey upstream: Fluctuating platelet-specific genes in cell-free plasma as proof-of-concept for using ribonucleic acid sequencing to improve understanding of postinjury platelet biology.
  The journal of trauma and acute care surgery 2020 Kornblith LZ, Bainton CMV, Fields AT, Matthay ZA, Magid NT, Nunez-Garcia B, Prakash A, Kurien PA, Callcut RA, Cohen MJ, Bainton RJ
• Corrigendum: Elevated Gut Microbiome-Derived Propionate Levels Are Associated With Reduced Sterile Lung Inflammation and Bacterial Immunity in Mice.
  Frontiers in microbiology 2019 Tian X, Hellman J, Horswill AR, Crosby HA, Francis KP, Prakash A
• Elevated Gut Microbiome-Derived Propionate Levels Are Associated With Reduced Sterile Lung Inflammation and Bacterial Immunity in Mice.
  Frontiers in microbiology 2019 Tian X, Hellman J, Horswill AR, Crosby HA, Francis KP, Prakash A
• NLRP3 Inflammasome Mediates Dormant Neutrophil Recruitment following Sterile Lung Injury and Protects against Subsequent Bacterial Pneumonia in Mice.
  Frontiers in immunology 2017 Tian X, Sun H, Casbon AJ, Lim E, Francis KP, Hellman J, Prakash A
• N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1.
  Journal of immunology (Baltimore, Md. : 1950) 2017 Lawton SK, Xu F, Tran A, Wong E, Prakash A, Schumacher M, Hellman J, Wilhelmsen K
• Lung Ischemia-Reperfusion is a Sterile Inflammatory Process Influenced by Commensal Microbiota in Mice.
  Shock (Augusta, Ga.) 2015 Prakash A, Sundar SV, Zhu YG, Tran A, Lee JW, Lowell C, Hellman J
• Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation.
  Science signaling 2015 Wilhelmsen K, Xu F, Farrar K, Tran A, Khakpour S, Sundar S, Prakash A, Wang J, Gray NS, Hellman J
• Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS.
  American journal of physiology. Lung cellular and molecular physiology 2015 Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS
• Enhanced detection of myeloperoxidase activity in deep tissues through luminescent excitation of near-infrared nanoparticles.
  Nature medicine 2013 Zhang N, Francis KP, Prakash A, Ansaldi D
• Alveolar macrophages and Toll-like receptor 4 mediate ventilated lung ischemia reperfusion injury in mice.
  Anesthesiology 2012 Prakash A, Mesa KR, Wilhelmsen K, Xu F, Dodd-o JM, Hellman J
• Activation of endothelial TLR2 by bacterial lipoprotein upregulates proteins specific for the neutrophil response.
  Innate immunity 2011 Wilhelmsen K, Mesa KR, Prakash A, Xu F, Hellman J
• Bacterial lipoprotein TLR2 agonists broadly modulate endothelial function and coagulation pathways in vitro and in vivo.
  Journal of immunology (Baltimore, Md. : 1950) 2010 Shin HS, Xu F, Bagchi A, Herrup E, Prakash A, Valentine C, Kulkarni H, Wilhelmsen K, Warren S, Hellman J
• Editorial: Pattern recognition receptors and factor B: "complement"ary pathways converge.
  Journal of leukocyte biology 2010 Prakash A, Hellman J
• Regulation of IRF7 through cell type-specific protein stability.
  Biochemical and biophysical research communications 2006 Prakash A, Levy DE
• Tissue-specific positive feedback requirements for production of type I interferon following virus infection.
  The Journal of biological chemistry 2005 Prakash A, Smith E, Lee CK, Levy DE
• Ringing the interferon alarm: differential regulation of gene expression at the interface between innate and adaptive immunity.
  Current opinion in immunology 2003 Levy DE, Marié I, Prakash A
• Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding.
  The Journal of biological chemistry 2002 Caillaud A, Prakash A, Smith E, Masumi A, Hovanessian AG, Levy DE, Marié I
• Enhancement and diversification of IFN induction by IRF-7-mediated positive feedback.
  Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002 Levy DE, Marié I, Smith E, Prakash A
• IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein.
  The Journal of biological chemistry 2000 Smith EJ, Marié I, Prakash A, García-Sastre A, Levy DE
• Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain.
  Molecular and cellular biology 2000 Marié I, Smith E, Prakash A, Levy DE