Arun Padmanabhan, MD, PhD
Assistant Professor
Medicine
School of Medicine

CLINICAL INTERESTS: Dr. Padmanabhan is a cardiologist specializing in general cardiology. His specific interests include preventive cardiology, lamin A/C gene (LMNA) associated cardiomyopathies, and right heart disease in athletes. RESEARCH INTERESTS: Dr. Padmanabhan’s research focuses on understanding the gene-regulatory and epigenetic pathways that govern cell fate decisions during early cardiac development and cell state transitions in the pathophysiology of heart failure.

Education & Training

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• Cardiovascular Disease Fellowship University of California San Francisco 2017
• Internal Medicine Residency Massachusetts General Hospital, Harvard Medical School 2014
• M.D. University of Pennsylvania 2012
• Ph.D. Cell & Developmental Biology University of Pennsylvania 2010
• A.B. Biochemistry & Molecular Biology Washington University in St. Louis 2003

Publications (39)

Top publication keywords:
Nuclear ProteinsHeart FailureGATA4 Transcription FactorInduced Pluripotent Stem CellsKynurenineReceptors, Aryl HydrocarbonCRISPR-Cas SystemsNeurofibromatosis 1Infarction, Middle Cerebral ArteryGenes, Neurofibromatosis 1ChromatinTranscription FactorsVentricular Dysfunction, LeftMyocytes, CardiacMitochondria, Heart

• Molecular convergence of risk variants for congenital heart defects leveraging a regulatory map of the human fetal heart.
  medRxiv : the preprint server for health sciences 2024 Ma XR, Conley SD, Kosicki M, Bredikhin D, Cui R, Tran S, Sheth MU, Qiu WL, Chen S, Kundu S, Kang HY, Amgalan D, Munger CJ, Duan L, Dang K, Rubio OM, Kany S, Zamirpour S, DePaolo J, Padmanabhan A, …
• Chromatin remodelling drives immune cell-fibroblast communication in heart failure.
  Nature 2024 Alexanian M, Padmanabhan A, Nishino T, Travers JG, Ye L, Pelonero A, Lee CY, Sadagopan N, Huang Y, Auclair K, Zhu A, An Y, Ekstrand CA, Martinez C, Teran BG, Flanigan WR, Kim CK, Lumbao-Conradson K, …
• Transcriptomic Profiling of Human Myocardium at Sudden Death to Define Vulnerable Substrate for Lethal Arrhythmias.
  JACC. Clinical electrophysiology 2024 Caudal A, Liu Y, Pang PD, Maison DP, Nakasuka K, Feng J, Schwarzer-Sperber HS, Schwarzer R, Moffatt E, Henrich TJ, Padmanabhan A, Connolly AJ, Wu JC, Tseng ZH
• Single-nucleus RNA/ATAC-seq in early-stage HCM models predicts SWI/SNF-activation in mutant-myocytes, and allele-specific differences in fibroblasts.
  bioRxiv : the preprint server for biology 2024 Thottakara T, Padmanabhan A, Tanriverdi T, Thambidurai T, Diaz-Rg JA, Amonkar SR, Olgin JE, Long CS, Roselle Abraham M
• A genome-wide CRISPR screen identifies BRD4 as a regulator of cardiomyocyte differentiation.
  Nature cardiovascular research 2024 Padmanabhan A, de Soysa TY, Pelonero A, Sapp V, Shah PP, Wang Q, Li L, Lee CY, Sadagopan N, Nishino T, Ye L, Yang R, Karnay A, Poleshko A, Bolar N, Linares-Saldana R, Ranade SS, Alexanian M, Morton SU…

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• Single Cell Multimodal Analyses Reveal Epigenomic and Transcriptomic Basis for Birth Defects in Maternal Diabetes.
  Nature cardiovascular research 2023 Nishino T, Ranade SS, Pelonero A, van Soldt BJ, Ye L, Alexanian M, Koback F, Huang Y, Sadagopan N, Lam A, Zholudeva LV, Li F, Padmanabhan A, Thomas R, van Bemmel JG, Gifford CA, Costa MW, Srivastava D
• Rapid Multiplexed Flow Cytometric Validation of CRISPRi sgRNAs in Tissue Culture.
  Bio-protocol 2023 Chorba JS, Xia VQ, Smith GA, Padmanabhan A
• Chromatin Remodeling Drives Immune-Fibroblast Crosstalk in Heart Failure Pathogenesis.
  bioRxiv : the preprint server for biology 2023 Alexanian M, Padmanabhan A, Nishino T, Travers JG, Ye L, Lee CY, Sadagopan N, Huang Y, Pelonero A, Auclair K, Zhu A, Teran BG, Flanigan W, Kim CK, Lumbao-Conradson K, Costa M, Jain R, Charo I, Haldar …
• Cold shock domain-containing protein E1 is a posttranscriptional regulator of the LDL receptor.
  Science translational medicine 2022 Smith GA, Padmanabhan A, Lau BH, Pampana A, Li L, Lee CY, Pelonero A, Nishino T, Sadagopan N, Xia VQ, Jain R, Natarajan P, Wu RS, Black BL, Srivastava D, Shokat KM, Chorba JS
• Transcription Factor GATA4 Regulates Cell Type-Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitors.
  Circulation 2022 Zhu L, Choudhary K, Gonzalez-Teran B, Ang YS, Thomas R, Stone NR, Liu L, Zhou P, Zhu C, Ruan H, Huang Y, Jin S, Pelonero A, Koback F, Padmanabhan A, Sadagopan N, Hsu A, Costa MW, Gifford CA, van …
• Targeting transcription in heart failure via CDK7/12/13 inhibition.
  Nature communications 2022 Hsu A, Duan Q, Day DS, Luo X, McMahon S, Huang Y, Feldman ZB, Jiang Z, Zhang T, Liang Y, Alexanian M, Padmanabhan A, Brown JD, Lin CY, Gray NS, Young RA, Bruneau BG, Haldar SM
• Transcription factor protein interactomes reveal genetic determinants in heart disease.
  Cell 2022 Gonzalez-Teran B, Pittman M, Felix F, Thomas R, Richmond-Buccola D, Hüttenhain R, Choudhary K, Moroni E, Costa MW, Huang Y, Padmanabhan A, Alexanian M, Lee CY, Maven BEJ, Samse-Knapp K, Morton SU, …
• Publisher Correction: BRD4 orchestrates genome folding to promote neural crest differentiation.
  Nature genetics 2021 Linares-Saldana R, Kim W, Bolar NA, Zhang H, Koch-Bojalad BA, Yoon S, Shah PP, Karnay A, Park DS, Luppino JM, Nguyen SC, Padmanabhan A, Smith CL, Poleshko A, Wang Q, Li L, Srivastava D, Vahedi G, Eom …
• BRD4 orchestrates genome folding to promote neural crest differentiation.
  Nature genetics 2021 Linares-Saldana R, Kim W, Bolar NA, Zhang H, Koch-Bojalad BA, Yoon S, Shah PP, Karnay A, Park DS, Luppino JM, Nguyen SC, Padmanabhan A, Smith CL, Poleshko A, Wang Q, Li L, Srivastava D, Vahedi G, Eom …
• Responsiveness to perturbations is a hallmark of transcription factors that maintain cell identity in vitro.
  Cell systems 2021 Mellis IA, Edelstein HI, Truitt R, Goyal Y, Beck LE, Symmons O, Dunagin MC, Linares Saldana RA, Shah PP, Pérez-Bermejo JA, Padmanabhan A, Yang W, Jain R, Raj A
• A transcriptional switch governs fibroblast activation in heart disease.
  Nature 2021 Alexanian M, Przytycki PF, Micheletti R, Padmanabhan A, Ye L, Travers JG, Gonzalez-Teran B, Silva AC, Duan Q, Ranade SS, Felix F, Linares-Saldana R, Li L, Lee CY, Sadagopan N, Pelonero A, Huang Y, …
• BRD4 (Bromodomain-Containing Protein 4) Interacts with GATA4 (GATA Binding Protein 4) to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes.
  Circulation 2020 Padmanabhan A, Alexanian M, Linares-Saldana R, González-Terán B, Andreoletti G, Huang Y, Connolly AJ, Kim W, Hsu A, Duan Q, Winchester SAB, Felix F, Perez-Bermejo JA, Wang Q, Li L, Shah PP, Haldar SM,…
• Drugging transcription in heart failure.
  The Journal of physiology 2019 Padmanabhan A, Haldar SM
• Epigenetic therapies in heart failure.
  Journal of molecular and cellular cardiology 2019 Alexanian M, Padmanabhan A, McKinsey TA, Haldar SM
• A Wide Complex Tachycardia in a Woman During Exercise: Did She Tread Into Dangerous Territory?
  JAMA internal medicine 2019 Muniyappa A, Padmanabhan A, Goldschlager N
• Unusual transcription factor protects against heart failure.
  Science (New York, N.Y.) 2018 Padmanabhan A, Haldar SM
• Electrical Alternans in Disguise-A Curious Case of Atrial Flutter.
  JAMA internal medicine 2018 Cedarbaum ER, Padmanabhan A, Goldschlager N
• Not Your Typical ST-Elevation Myocardial Infarction.
  JAMA internal medicine 2018 Morehead-Gee A, Padmanabhan A, Goldschlager N
• Plasma MicroRNA Clusters in Human Left Ventricular Remodeling: A Biomarker and Discovery Platform.
  Circulation. Heart failure 2018 Padmanabhan A, Haldar SM
• Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos.
  eLife 2015 Yzaguirre AD, Padmanabhan A, de Groh ED, Engleka KA, Li J, Speck NA, Epstein JA
• HEART DEVELOPMENT. Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts.
  Science (New York, N.Y.) 2015 Jain R, Li D, Gupta M, Manderfield LJ, Ifkovits JL, Wang Q, Liu F, Liu Y, Poleshko A, Padmanabhan A, Raum JC, Li L, Morrisey EE, Lu MM, Won KJ, Epstein JA
• Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung.
  Nature communications 2015 Jain R, Barkauskas CE, Takeda N, Bowie EJ, Aghajanian H, Wang Q, Padmanabhan A, Manderfield LJ, Gupta M, Li D, Li L, Trivedi CM, Hogan BLM, Epstein JA
• Metastatic pancreatic neuroendocrine tumor with ectopic adrenocorticotropic hormone production.
  Proceedings (Baylor University. Medical Center) 2015 Vaduganathan M, Nagarur A, Kerr DA, Lauter KB, Padmanabhan A, Raghavan S, Pallais JC, Fenves AZ
• Neuroprotection in ischemic stroke: AhR we making progress?
  Circulation 2014 Padmanabhan A, Haldar SM
• Hopx expression defines a subset of multipotent hair follicle stem cells and a progenitor population primed to give rise to K6+ niche cells.
  Development (Cambridge, England) 2013 Takeda N, Jain R, Leboeuf MR, Padmanabhan A, Wang Q, Li L, Lu MM, Millar SE, Epstein JA
• Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development.
  Disease models & mechanisms 2012 Shin J, Padmanabhan A, de Groh ED, Lee JS, Haidar S, Dahlberg S, Guo F, He S, Wolman MA, Granato M, Lawson ND, Wolfe SA, Kim SH, Solnica-Krezel L, Kanki JP, Ligon KL, Epstein JA, Look AT
• Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish.
  Development (Cambridge, England) 2011 Zhu C, Smith T, McNulty J, Rayla AL, Lakshmanan A, Siekmann AF, Buffardi M, Meng X, Shin J, Padmanabhan A, Cifuentes D, Giraldez AJ, Look AT, Epstein JA, Lawson ND, Wolfe SA
• Oligodendrocyte progenitor cell numbers and migration are regulated by the zebrafish orthologs of the NF1 tumor suppressor gene.
  Human molecular genetics 2010 Lee JS, Padmanabhan A, Shin J, Zhu S, Guo F, Kanki JP, Epstein JA, Look AT
• Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS.
  Nature 2010 Elden AC, Kim HJ, Hart MP, Chen-Plotkin AS, Johnson BS, Fang X, Armakola M, Geser F, Greene R, Lu MM, Padmanabhan A, Clay-Falcone D, McCluskey L, Elman L, Juhr D, Gruber PJ, Rüb U, Auburger G, …
• Rapid 3D phenotyping of cardiovascular development in mouse embryos by micro-CT with iodine staining.
  Circulation. Cardiovascular imaging 2010 Degenhardt K, Wright AC, Horng D, Padmanabhan A, Epstein JA
• Distinct enhancers at the Pax3 locus can function redundantly to regulate neural tube and neural crest expressions.
  Developmental biology 2010 Degenhardt KR, Milewski RC, Padmanabhan A, Miller M, Singh MK, Lang D, Engleka KA, Wu M, Li J, Zhou D, Antonucci N, Li L, Epstein JA
• Cardiac and vascular functions of the zebrafish orthologues of the type I neurofibromatosis gene NFI.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Padmanabhan A, Lee JS, Ismat FA, Lu MM, Lawson ND, Kanki JP, Look AT, Epstein JA
• Investigating magnetically aligned phospholipid bilayers with various lanthanide ions for X-band spin-label EPR studies.
  Biochimica et biophysica acta 2003 Caporini MA, Padmanabhan A, Cardon TB, Lorigan GA
• Magnetically aligned phospholipid bilayers at the parallel and perpendicular orientations for X-band spin-label EPR studies.
  Journal of the American Chemical Society 2001 Cardon TB, Tiburu EK, Padmanabhan A, Howard KP, Lorigan GA