Arthur Weiss, MD, PhD
Professor Emeritus
Medicine
School of Medicine

The response of lymphocytes to antigen which initiates an antigen specific immune response also represents a unique opportunity to study how complex molecular interactions between cells can lead to developmental decisions, cell differentiation and proliferation. We are interested in understanding how receptors involved in antigen recognition can initiate signal transduction events that regulate cell responses in the immune system. We know that receptors involved in antigen recognition functionally interact with tyrosine kinases and phosphatases, enzymes that regulate protein phosphorylation, to induce signaling pathways that regulate cellular responses and gene expression. We are using genetically selective small molecule inhibitors of kinases together with phosphatase mutants to study how thresholds for the initiation of immune responses are set and how feedback circuits influence responses. We would like to understand how the tyrosine kinases and phosphatases in these pathways are regulated and how they control cellular responses in development, in normal immune responses and in autoimmune diseases such as lupus and rheumatoid arthritis.

• The phosphatidylinositol-transfer protein Nir3 modulates T cell development and function.
  The Journal of Immunology 2022 Wen Lu, Ynes A Helou, Byron B Au-Yeung, Krishna Shrinivas, Jen Liou, Arthur Weiss
• ZAP70, too little, too much can lead to autoimmunity.
  Immunological reviews 2021 Ashouri JF, Lo WL, Nguyen TTT, Shen L, Weiss A
• Reversible phosphorylation of cyclin T1 promotes assembly and stability of P-TEFb.
  eLife 2021 Huang F, Nguyen TT, Echeverria I, Rakesh R, Cary DC, Paculova H, Sali A, Weiss A, Peterlin BM, Fujinaga K
• Acute Csk inhibition hinders B cell activation by constraining the PI3 kinase pathway.
  Proceedings of the National Academy of Sciences of the United States of America 2021 Lu W, Skrzypczynska KM, Weiss A
• Frank W. Fitch, M.D. Ph.D., 1929–2021.
  The Journal of Immunology 2021 Jeffrey Bluestone, Arthur Weiss
• Cbl-b deficiency prevents functional but not phenotypic T cell anergy.
  The Journal of experimental medicine 2021 Nguyen TTT, Wang ZE, Shen L, Schroeder A, Eckalbar W, Weiss A
• Adapting T Cell Receptor Ligand Discrimination Capability via LAT.
  Frontiers in immunology 2021 Lo WL, Weiss A
• A disease-associated mutation that weakens ZAP70 autoinhibition enhances responses to weak and self-ligands.
  Science signaling 2021 Shen L, Matloubian M, Kadlecek TA, Weiss A
• Basal TCR signaling drives the functional heterogeneity of naïve CD4+ T cells.
  The Journal of Immunology 2020 Byron B Au-Yeung, Arthur Weiss, Wendy Zinzow-Kramer
• CD4+ T cells are more sensitive to inhibition of TCR signaling under Th17 polarizing conditions.
  The Journal of Immunology 2020 Wendy M. Zinzow-Kramer, Arthur Weiss, Byron B Au-Yeung
• The phosphatidinositol-transfer protein Nir3 is a modulator of T cell development.
  The Journal of Immunology 2020 Ynes Helou, Byron B Au-Yeung, Arthur Weiss
• Bruton's Tyrosine Kinase Membrane Dynamics and Signaling.
  Biophysical Journal 2020 Laura M. Nocka, Jean K. Chung, Aubrianna Decker, Theresa Kadlecek, Arthur Weiss, John Kuriyan, Jay T. Groves
• How the T Cell Signaling Network Processes Information to Discriminate between Self and Cognate Ligands.
  Biophysical Journal 2020 Raman S. Ganti, Wan-Lin Lo, Darren McAffee, Jay T. Groves, Arthur Weiss, Arup K. Chakraborty
• CD45 functions as a signaling gatekeeper in T cells.
  Science signaling 2019 Courtney AH, Shvets AA, Lu W, Griffante G, Mollenauer M, Horkova V, Lo WL, Yu S, Stepanek O, Chakraborty AK, Weiss A
• Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination.
  Nature immunology 2019 Lo WL, Shah NH, Rubin SA, Zhang W, Horkova V, Fallahee IR, Stepanek O, Zon LI, Kuriyan J, Weiss A
• Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis.
  Proceedings of the National Academy of Sciences of the United States of America 2019 Ashouri JF, Hsu LY, Yu S, Rychkov D, Chen Y, Cheng DA, Sirota M, Hansen E, Lattanza L, Zikherman J, Weiss A
• CRACR2a is a calcium-activated dynein adaptor protein that regulates endocytic traffic.
  The Journal of cell biology 2019 Wang Y, Huynh W, Skokan TD, Lu W, Weiss A, Vale RD
• The Gp1ba-Cre transgenic mouse: a new model to delineate platelet and leukocyte functions.
  Blood 2018 Nagy Z, Vögtle T, Geer MJ, Mori J, Heising S, Di Nunzio G, Gareus R, Tarakhovsky A, Weiss A, Neel BG, Desanti GE, Mazharian A, Senis YA
• Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT.
  Nature immunology 2018 Lo WL, Shah NH, Ahsan N, Horkova V, Stepanek O, Salomon AR, Kuriyan J, Weiss A
• Fine-tuning of substrate preferences of the Src-family kinase Lck revealed through a high-throughput specificity screen.
  eLife 2018 Shah NH, Löbel M, Weiss A, Kuriyan J
• Maintenance of murine platelet homeostasis by the kinase Csk and phosphatase CD148.
  Blood 2018 Mori J, Nagy Z, Di Nunzio G, Smith CW, Geer MJ, Al Ghaithi R, van Geffen JP, Heising S, Boothman L, Tullemans BME, Correia JN, Tee L, Kuijpers MJE, Harrison P, Heemskerk JWM, Jarvis GE, Tarakhovsky A,…
• IL-2Rβ abundance differentially tunes IL-2 signaling dynamics in CD4+ and CD8+ T cells.
  Science signaling 2017 Smith GA, Taunton J, Weiss A
• TCR Signaling: Mechanisms of Initiation and Propagation.
  Trends in biochemical sciences 2017 Courtney AH, Lo WL, Weiss A
• A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45.
  Molecular cell 2017 Courtney AH, Amacher JF, Kadlecek TA, Mollenauer MN, Au-Yeung BB, Kuriyan J, Weiss A
• Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness.
  The Journal of experimental medicine 2017 Hsu LY, Cheng DA, Chen Y, Liang HE, Weiss A
• IL-2 Modulates the TCR Signaling Threshold for CD8 but Not CD4 T Cell Proliferation on a Single-Cell Level.
  Journal of immunology (Baltimore, Md. : 1950) 2017 Au-Yeung BB, Smith GA, Mueller JL, Heyn CS, Jaszczak RG, Weiss A, Zikherman J
• Identification of Inhibitors of the Association of ZAP-70 with the T Cell Receptor by High-Throughput Screen.
  SLAS discovery : advancing life sciences R & D 2016 Visperas PR, Wilson CG, Winger JA, Yan Q, Lin K, Arkin MR, Weiss A, Kuriyan J
• Endogenous Nur77 Is a Specific Indicator of Antigen Receptor Signaling in Human T and B Cells.
  Journal of immunology (Baltimore, Md. : 1950) 2016 Ashouri JF, Weiss A
• Positive Regulation of Lyn Kinase by CD148 Is Required for B Cell Receptor Signaling in B1 but Not B2 B Cells.
  Immunity 2016 Skrzypczynska KM, Zhu JW, Weiss A
• Abstract A074: A Zap70-dependent negative feedback loop governs Lck activation by CD45.
  Other Topics 2016 Adam H. Courtney, Theresa A. Kadlecek, Byron Au-Yeung, Arthur Weiss
• An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor.
  eLife 2016 Shah NH, Wang Q, Yan Q, Karandur D, Kadlecek TA, Fallahee IR, Russ WP, Ranganathan R, Weiss A, Kuriyan J
• Human LAT mutation results in immune deficiency and autoimmunity but also raises questions about signaling pathways.
  The Journal of experimental medicine 2016 Weiss A
• CD28 Costimulation: From Mechanism to Therapy.
  Immunity 2016 Esensten JH, Helou YA, Chopra G, Weiss A, Bluestone JA
• Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling.
  Nature chemical biology 2016 Smith GA, Uchida K, Weiss A, Taunton J
• A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70.
  The Journal of experimental medicine 2016 Chan AY, Punwani D, Kadlecek TA, Cowan MJ, Olson JL, Mathes EF, Sunderam U, Fu SM, Srinivasan R, Kuriyan J, Brenner SE, Weiss A, Puck JM
• Abstract B042: Regulation of Lck activity by a cryptic phosphosite.
  Immune Regulation of T Cell Responses/ Evolving Concepts in Cancer Immunology 2016 Adam H. Courtney, Hanna E. Sjolin-Goodfellow, Qinqin Ji, Theresa A. Kadlecek, Arthur R. Salomon, Arthur Weiss
• Targeted Activation of B Cell Autoimmunity Checkpoints in Acute Lymphoblastic Leukemia.
  Blood 2015 Zhengshan Chen, Huimin Geng, Clifford A. Lowell, Arthur Weiss, Stephen P. Hunger, Ari Melnick, Markus Muschen
• An extracatalytic function of CD45 in B cells is mediated by CD22.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Coughlin S, Noviski M, Mueller JL, Chuwonpad A, Raschke WC, Weiss A, Zikherman J
• LynA regulates an inflammation-sensitive signaling checkpoint in macrophages.
  eLife 2015 Freedman TS, Tan YX, Skrzypczynska KM, Manz BN, Sjaastad FV, Goodridge HS, Lowell CA, Weiss A
• Small molecule inhibition of Csk alters affinity recognition by T cells.
  eLife 2015 Manz BN, Tan YX, Courtney AH, Rutaganira F, Palmer E, Shokat KM, Weiss A
• The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.
  Science signaling 2015 Goodfellow HS, Frushicheva MP, Ji Q, Cheng DA, Kadlecek TA, Cantor AJ, Kuriyan J, Chakraborty AK, Salomon A, Weiss A
• Commentary: "The Role of T3 Surface Molecules in the Activation of Human Cells: A Two-Stimulus Requirement for IL-2 Production Reflects Events Occurring at a Pretranslational Level".
  Frontiers in immunology 2015 Weiss A, Stobo JD
• Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.
  Nature 2015 Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung JU, Coligan JE, Bolland S, Mak TW,…
• Combinatorial proteomic analysis of intercellular signaling applied to the CD28 T-cell costimulatory receptor.
  Proceedings of the National Academy of Sciences of the United States of America 2015 Tian R, Wang H, Gish GD, Petsalaki E, Pasculescu A, Shi Y, Mollenauer M, Bagshaw RD, Yosef N, Hunter T, Gingras AC, Weiss A, Pawson T
• Unbiased modifier screen reveals that signal strength determines the regulatory role murine TLR9 plays in autoantibody production.
  Journal of immunology (Baltimore, Md. : 1950) 2015 Mills RE, Lam VC, Tan A, Cresalia N, Oksenberg N, Zikherman J, Anderson M, Weiss A, Hermiston ML
• Erratum: Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.
  Nature Immunology 2015 Byron B Au-Yeung, Heather J Melichar, Jenny O Ross, Debra A Cheng, Julie Zikherman, Kevan M Shokat, Ellen A Robey, Arthur Weiss
• Combined immunodeficiency due to MALT1 mutations, treated by hematopoietic cell transplantation.
  Journal of clinical immunology 2015 Punwani D, Wang H, Chan AY, Cowan MJ, Mallott J, Sunderam U, Mollenauer M, Srinivasan R, Brenner SE, Mulder A, Claas FH, Weiss A, Puck JM
• Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding.
  The Biochemical journal 2015 Visperas PR, Winger JA, Horton TM, Shah NH, Aum DJ, Tao A, Barros T, Yan Q, Wilson CG, Arkin MR, Weiss A, Kuriyan J
• Insights into the initiation of TCR signaling.
  Nature immunology 2014 Chakraborty AK, Weiss A
• A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Au-Yeung BB, Zikherman J, Mueller JL, Ashouri JF, Matloubian M, Cheng DA, Chen Y, Shokat KM, Weiss A
• Zap70 is essential for long-term survival of naive CD8 T cells.
  Journal of immunology (Baltimore, Md. : 1950) 2014 Schim van der Loeff I, Hsu LY, Saini M, Weiss A, Seddon B
• Distinct phases in the positive selection of CD8+ T cells distinguished by intrathymic migration and T-cell receptor signaling patterns.
  Proceedings of the National Academy of Sciences of the United States of America 2014 Ross JO, Melichar HJ, Au-Yeung BB, Herzmark P, Weiss A, Robey EA
• Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.
  Nature immunology 2014 Au-Yeung BB, Melichar HJ, Ross JO, Cheng DA, Zikherman J, Shokat KM, Robey EA, Weiss A
• Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation.
  eLife 2014 Phee H, Au-Yeung BB, Pryshchep O, O'Hagan KL, Fairbairn SG, Radu M, Kosoff R, Mollenauer M, Cheng D, Chernoff J, Weiss A
• Negative regulation of Hif1a expression and TH17 differentiation by the hypoxia-regulated microRNA miR-210.
  Nature immunology 2014 Wang H, Flach H, Onizawa M, Wei L, McManus MT, Weiss A
• Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL.
  eLife 2014 Jenkins MR, Stinchcombe JC, Au-Yeung BB, Asano Y, Ritter AT, Weiss A, Griffiths GM
• Protein kinase Cδ promotes transitional B cell-negative selection and limits proximal B cell receptor signaling to enforce tolerance.
  Molecular and cellular biology 2014 Limnander A, Zikherman J, Lau T, Leitges M, Weiss A, Roose JP
• Investigation of Novel Zap-70 Functionality in T Cell Signaling Pathways using Computational Modeling.
  Biophysical Journal 2014 Maria P. Frushicheva, Arthur Weiss, Arup K. Chakraborty
• Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling.
  Nature immunology 2013 Tan YX, Manz BN, Freedman TS, Zhang C, Shokat KM, Weiss A
• Tony Pawson: Modular protein domains and the links to intracellular signaling.
  Proceedings of the National Academy of Sciences of the United States of America 2013 Weiss A
• Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the phosphatase CD45.
  Cold Spring Harbor symposia on quantitative biology 2013 Tan YX, Zikherman J, Weiss A
• Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4⁺ T cells.
  Immunity 2013 Gardner JM, Metzger TC, McMahon EJ, Au-Yeung BB, Krawisz AK, Lu W, Price JD, Johannes KP, Satpathy AT, Murphy KM, Tarbell KV, Weiss A, Anderson MS
• DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape.
  Nature genetics 2013 Xie M, Hong C, Zhang B, Lowdon RF, Xing X, Li D, Zhou X, Lee HJ, Maire CL, Ligon KL, Gascard P, Sigaroudinia M, Tlsty TD, Kadlecek T, Weiss A, O'Geen H, Farnham PJ, Madden PA, Mungall AJ, Tam A, Kamoh…
• The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases.
  The Journal of clinical investigation 2013 Katsumoto TR, Kudo M, Chen C, Sundaram A, Callahan EC, Zhu JW, Lin J, Rosen CE, Manz BN, Lee JW, Matthay MA, Huang X, Sheppard D, Weiss A
• Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker.
  Molecular and cellular biology 2013 Yan Q, Barros T, Visperas PR, Deindl S, Kadlecek TA, Weiss A, Kuriyan J
• The structural wedge domain of the receptor-like tyrosine phosphatase CD45 enforces B cell tolerance by regulating substrate specificity.
  Journal of immunology (Baltimore, Md. : 1950) 2013 Zikherman J, Parameswaran R, Hermiston M, Weiss A
• Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases.
  Science signaling 2013 Mukherjee S, Zhu J, Zikherman J, Parameswaran R, Kadlecek TA, Wang Q, Au-Yeung B, Ploegh H, Kuriyan J, Das J, Weiss A
• Science Signaling Podcast: 1 January 2013.
  Science Signaling 2013 Arthur Weiss, Jayajit Das, Annalisa M. VanHook
• Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function.
  The Journal of clinical investigation 2012 Charles JF, Hsu LY, Niemi EC, Weiss A, Aliprantis AO, Nakamura MC
• Endogenous antigen tunes the responsiveness of naive B cells but not T cells.
  Nature 2012 Zikherman J, Parameswaran R, Weiss A
• Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells.
  Nature 2012 Wei P, Wong WW, Park JS, Corcoran EE, Peisajovich SG, Onuffer JJ, Weiss A, Lim WA
• A resource for the conditional ablation of microRNAs in the mouse.
  Cell reports 2012 Park CY, Jeker LT, Carver-Moore K, Oh A, Liu HJ, Cameron R, Richards H, Li Z, Adler D, Yoshinaga Y, Martinez M, Nefadov M, Abbas AK, Weiss A, Lanier LL, de Jong PJ, Bluestone JA, Srivastava D, McManus…
• The membrane environment can promote or suppress bistability in cell signaling networks.
  The journal of physical chemistry. B 2012 Abel SM, Roose JP, Groves JT, Weiss A, Chakraborty AK
• Lymphocyte signaling: a Tuscan affair.
  Nature immunology 2011 Baldari CT, Acuto O, Batista F, Koretzky G, Weiss A
• Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival.
  Proceedings of the National Academy of Sciences of the United States of America 2011 Zikherman J, Doan K, Parameswaran R, Raschke W, Weiss A
• Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease.
  The Journal of clinical investigation 2011 Zikherman J, Weiss A
• Receptor-like tyrosine phosphatases CD45 and CD148 have distinct functions in chemoattractant-mediated neutrophil migration and response to S. aureus.
  Immunity 2011 Zhu JW, Doan K, Park J, Chau AH, Zhang H, Lowell CA, Weiss A
• Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression.
  PloS one 2011 Markegard E, Trager E, Yang CW, Zhang W, Weiss A, Roose JP
• SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling.
  Molecular and cellular biology 2011 Draber P, Vonkova I, Stepanek O, Hrdinka M, Kucova M, Skopcova T, Otahal P, Angelisova P, Horejsi V, Yeung M, Weiss A, Brdicka T
• Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling.
  Science signaling 2011 Schoenborn JR, Tan YX, Zhang C, Shokat KM, Weiss A
• Ca-dependent Ras/Erk signaling mediates negative selection of autoreactive B cells.
  Small GTPases 2011 Limnander A, Weiss A
• Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148.
  The Journal of biological chemistry 2011 Stepanek O, Kalina T, Draber P, Skopcova T, Svojgr K, Angelisova P, Horejsi V, Weiss A, Brdicka T
• Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'.
  Nature 2011 Goodridge HS, Reyes CN, Becker CA, Katsumoto TR, Ma J, Wolf AJ, Bose N, Chan AS, Magee AS, Danielson ME, Weiss A, Vasilakos JP, Underhill DM
• A genetically selective inhibitor reveals ZAP-70 kinase-dependent checkpoints in T cell development (64.15).
  The Journal of Immunology 2011 Byron Au-Yeung, Debra Cheng, Chao Zhang, Kevan Shokat, Arthur Weiss
• A novel analog-sensitive allele of Csk reveals its kinase-independent role in the regulation of T cell receptor signaling (109.35).
  The Journal of Immunology 2011 Ying Xim Tan, Jamie Schoenborn, Chao Zhang, Kevan Shokat, Arthur Weiss
• Impact of TLR9 on hyper-responsive ITAM signaling in a mouse model of SLE (47.24).
  The Journal of Immunology 2011 Robyn Mills, Viola Lam, Diana Tobler, Nir Oksenberg, Nicole Cresalia, Mark Anderson, Jian-Hua Mao, Arthur Weiss, Michelle Hermiston
• Regulation of thymocyte positive selection and motility by GIT2 (113.9).
  The Journal of Immunology 2011 Hyewon Phee, Ivan Dzhagalov, Marianne Mollenauer, Yana Wang, Darrell Irvine, Ellen Robey, Arthur Weiss
• Stim1, PKCd and RasGRP proteins set a threshold for pro-apoptotic Erk signaling during B cell development (109.6).
  The Journal of Immunology 2011 Andre Limnander, Philippe Depeille, Tanya Freedman, Jen Liou, Michael Leitges, Tomohiro Kurosaki, Jeroen Roose, Arthur Weiss
• Titration of CD45 expression regulates sequential tolerance checkpoints during B cell development (45.2).
  The Journal of Immunology 2011 Julie Zikherman, Kristin Doan, William Raschke, Arthur Weiss
• STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development.
  Nature immunology 2011 Limnander A, Depeille P, Freedman TS, Liou J, Leitges M, Kurosaki T, Roose JP, Weiss A
• Differential requirements for CD45 in NK-cell function reveal distinct roles for Syk-family kinases.
  Blood 2011 Hesslein DG, Palacios EH, Sun JC, Beilke JN, Watson SR, Weiss A, Lanier LL
• The Src-like adaptor protein regulates GM-CSFR signaling and monocytic dendritic cell maturation.
  Journal of immunology (Baltimore, Md. : 1950) 2011 Liontos LM, Dissanayake D, Ohashi PS, Weiss A, Dragone LL, McGlade CJ
• A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity.
  Nature immunology 2010 Au-Yeung BB, Levin SE, Zhang C, Hsu LY, Cheng DA, Killeen N, Shokat KM, Weiss A
• Proline-rich tyrosine kinase-2 is critical for CD8 T-cell short-lived effector fate.
  Proceedings of the National Academy of Sciences of the United States of America 2010 Beinke S, Phee H, Clingan JM, Schlessinger J, Matloubian M, Weiss A
• Regulation of thymocyte positive selection and motility by GIT2.
  Nature immunology 2010 Phee H, Dzhagalov I, Mollenauer M, Wang Y, Irvine DJ, Robey E, Weiss A
• ZAP-70: an essential kinase in T-cell signaling.
  Cold Spring Harbor perspectives in biology 2010 Wang H, Kadlecek TA, Au-Yeung BB, Goodfellow HE, Hsu LY, Freedman TS, Weiss A
• CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development.
  Immunity 2010 Zikherman J, Jenne C, Watson S, Doan K, Raschke W, Goodnow CC, Weiss A
• The right team at the right time to go for a home run: tyrosine kinase activation by the TCR.
  Nature immunology 2010 Weiss A
• Chapter 95 CD45.
  Handbook of Cell Signaling 2010 Michelle L. Hermiston, Vikas Gupta, Arthur Weiss
• Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Deindl S, Kadlecek TA, Cao X, Kuriyan J, Weiss A
• SLAP, a regulator of immunoreceptor ubiquitination, signaling, and trafficking.
  Immunological reviews 2009 Dragone LL, Shaw LA, Myers MD, Weiss A
• A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity.
  The Journal of experimental medicine 2009 Hsu LY, Tan YX, Xiao Z, Malissen M, Weiss A
• TCR signal transduction: opening the black box.
  Journal of immunology (Baltimore, Md. : 1950) 2009 Weiss A
• Molecular origin and functional consequences of digital signaling and hysteresis during Ras activation in lymphocytes.
  Science signaling 2009 Chakraborty AK, Das J, Zikherman J, Yang M, Govern CC, Ho M, Weiss A, Roose J
• A chemical-genetic approach to inhibit Csk activates T cells independently of the T cell receptor (35.4).
  The Journal of Immunology 2009 Jamie R Schoenborn, Chao Zhang, Kevan M Shokat, Arthur Weiss
• A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity (49.6).
  The Journal of Immunology 2009 Lih-Yun Hsu, Ying-Xim Tan, Arthur Weiss
• An allelic series of CD45 dosages uncouples basal and inducible TCR signaling during thymic development (84.13).
  The Journal of Immunology 2009 Julie Zikherman, Susan Watson, Craig Jenne, William C. Raschke, Christopher Goodnow, Arthur Weiss
• Identifying ZAP-70 kinase-dependent and -independent functions in T cells using a chemical genetic approach (35.5).
  The Journal of Immunology 2009 Byron B Au-Yeung, Susan E Levin, Chao Zhang, Kevan Shokat, Arthur Weiss
• PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background.
  Journal of immunology (Baltimore, Md. : 1950) 2009 Zikherman J, Hermiston M, Steiner D, Hasegawa K, Chan A, Weiss A
• Role of GIT2 in T cell migration and development (95.8).
  The Journal of Immunology 2009 Hyewon Phee, Marianne N. Mollenauer, Arthur Weiss
• The structure, regulation, and function of ZAP-70.
  Immunological reviews 2009 Au-Yeung BB, Deindl S, Hsu LY, Palacios EH, Levin SE, Kuriyan J, Weiss A
• The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis.
  Blood 2009 Senis YA, Tomlinson MG, Ellison S, Mazharian A, Lim J, Zhao Y, Kornerup KN, Auger JM, Thomas SG, Dhanjal T, Kalia N, Zhu JW, Weiss A, Watson SP
• Antigen receptor signaling in the rheumatic diseases.
  Arthritis research & therapy 2009 Zikherman J, Weiss A
• Digital signaling and hysteresis characterize ras activation in lymphoid cells.
  Cell 2009 Das J, Ho M, Zikherman J, Govern C, Yang M, Weiss A, Chakraborty AK, Roose JP
• Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses.
  Proceedings of the National Academy of Sciences of the United States of America 2009 Hermiston ML, Zikherman J, Tan AL, Lam VC, Cresalia NM, Oksenberg N, Goren N, Brassat D, Oksenberg JR, Weiss A
• Alternative splicing of CD45: the tip of the iceberg.
  Immunity 2008 Zikherman J, Weiss A
• Origin of the sharp boundary that discriminates positive and negative selection of thymocytes.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Prasad A, Zikherman J, Das J, Roose JP, Weiss A, Chakraborty AK
• Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice.
  Proceedings of the National Academy of Sciences of the United States of America 2008 Louvet C, Szot GL, Lang J, Lee MR, Martinier N, Bollag G, Zhu S, Weiss A, Bluestone JA
• B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency.
  The Journal of experimental medicine 2008 Gupta VA, Hermiston ML, Cassafer G, Daikh DI, Weiss A
• The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes.
  Nature immunology 2008 Mingueneau M, Sansoni A, Grégoire C, Roncagalli R, Aguado E, Weiss A, Malissen M, Malissen B
• Inhibition of ZAP-70 kinase activity via an analog-sensitive allele blocks T cell receptor and CD28 superagonist signaling.
  The Journal of biological chemistry 2008 Levin SE, Zhang C, Kadlecek TA, Shokat KM, Weiss A
• Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling.
  Immunity 2008 Zhu JW, Brdicka T, Katsumoto TR, Lin J, Weiss A
• Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions.
  Immunity 2007 Siggs OM, Miosge LA, Yates AL, Kucharska EM, Sheahan D, Brdicka T, Weiss A, Liston A, Goodnow CC
• Distinct roles for Syk and ZAP-70 during early thymocyte development.
  The Journal of experimental medicine 2007 Palacios EH, Weiss A
• Differential expression of the ARF GAP genes GIT1 and GIT2 in mouse tissues.
  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007 Schmalzigaug R, Phee H, Davidson CE, Weiss A, Premont RT
• Structural basis for the inhibition of tyrosine kinase activity of ZAP-70.
  Cell 2007 Deindl S, Kadlecek TA, Brdicka T, Cao X, Weiss A, Kuriyan J
• Coupling Ca2+ store release to Icrac channel activation in B lymphocytes requires the activity of Lyn and Syk kinases.
  The Journal of cell biology 2007 Chung SC, Limnander A, Kurosaki T, Weiss A, Korenbrot JI
• Generation and characterization of GIT1 and GIT2 deficient mice (87.18).
  The Journal of Immunology 2007 Hyewon Phee, Arthur Weiss
• Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes.
  Molecular and cellular biology 2007 Roose JP, Mollenauer M, Ho M, Kurosaki T, Weiss A
• The ubiquitin ligase Cbl-b limits Pseudomonas aeruginosa exotoxin T-mediated virulence.
  The Journal of clinical investigation 2007 Balachandran P, Dragone L, Garrity-Ryan L, Lemus A, Weiss A, Engel J
• Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Dragone LL, Myers MD, White C, Gadwal S, Sosinowski T, Gu H, Weiss A
• The Phenotypic Consequences of an Activating Mutation in the Juxtamembrane Wedge of CD45 Is Sensitive to Genetic Modifiers.
  Blood 2006 Michelle L. Hermiston, Nicole M. Cresalia, Viola Lam, Allison L. Tan, Arthur Weiss
• ZAP-70 Enhances IgM Signaling in Chronic Lymphocytic Leukemia Cells Independent of Its Tyrosine Kinase Activity.
  Blood 2006 Liguang Chen, Lang Huynh, Arthur Weiss, Thomas J. Kipps
• Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4.
  The Journal of experimental medicine 2006 Nirula A, Ho M, Phee H, Roose J, Weiss A
• Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production.
  Proceedings of the National Academy of Sciences of the United States of America 2006 Hesslein DG, Takaki R, Hermiston ML, Weiss A, Lanier LL
• Small molecule inhibition of ZAP-70 kinase activity.
  The FASEB Journal 2006 Susan E Levin, Chao Zhang, Kevan Shokat, Arthur Weiss
• SRC-like adaptor protein regulates B cell development and function.
  Journal of immunology (Baltimore, Md. : 1950) 2006 Dragone LL, Myers MD, White C, Sosinowski T, Weiss A
• Src-like adaptor protein regulates TCR expression on thymocytes by linking the ubiquitin ligase c-Cbl to the TCR complex.
  Nature immunology 2005 Myers MD, Sosinowski T, Dragone LL, White C, Band H, Gu H, Weiss A
• The juxtamembrane wedge negatively regulates CD45 function in B cells.
  Immunity 2005 Hermiston ML, Tan AL, Gupta VA, Majeti R, Weiss A
• Discovering the TCR beta-chain by subtraction.
  Journal of immunology (Baltimore, Md. : 1950) 2005 Weiss A
• Src-like adaptor protein down-regulates T cell receptor (TCR)-CD3 expression by targeting TCRzeta for degradation.
  The Journal of cell biology 2005 Myers MD, Dragone LL, Weiss A
• A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells.
  Molecular and cellular biology 2005 Roose JP, Mollenauer M, Gupta VA, Stone J, Weiss A
• Intramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinases.
  Molecular and cellular biology 2005 Brdicka T, Kadlecek TA, Roose JP, Pastuszak AW, Weiss A
• Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1.
  Nature immunology 2005 Phee H, Abraham RT, Weiss A
• Twisting tails exposed: the evidence for TCR conformational change.
  The Journal of experimental medicine 2005 Levin SE, Weiss A
• Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.
  Oncogene 2004 Palacios EH, Weiss A
• SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase.
  The Journal of biological chemistry 2004 Tomlinson MG, Heath VL, Turck CW, Watson SP, Weiss A
• Regulated expression of the receptor-like tyrosine phosphatase CD148 on hemopoietic cells.
  Journal of immunology (Baltimore, Md. : 1950) 2004 Lin J, Zhu JW, Baker JE, Weiss A
• Lymphocyte activation.
  Current Opinion in Immunology 2004 Arthur Weiss, John C Cambier
• A proline-rich motif in the C terminus of Akt contributes to its localization in the immunological synapse.
  Journal of immunology (Baltimore, Md. : 1950) 2004 Kane LP, Mollenauer MN, Weiss A
• T cell receptor engagement leads to phosphorylation of clathrin heavy chain during receptor internalization.
  The Journal of experimental medicine 2004 Crotzer VL, Mabardy AS, Weiss A, Brodsky FM
• Jurkat T cells and development of the T-cell receptor signalling paradigm.
  Nature reviews. Immunology 2004 Abraham RT, Weiss A
• Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation.
  Nature immunology 2004 Andres PG, Howland KC, Nirula A, Kane LP, Barron L, Dresnek D, Sadra A, Imboden J, Weiss A, Abbas AK
• Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec.
  Molecular and cellular biology 2004 Tomlinson MG, Kane LP, Su J, Kadlecek TA, Mollenauer MN, Weiss A
• T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression.
  PLoS biology 2003 Roose JP, Diehn M, Tomlinson MG, Lin J, Alizadeh AA, Botstein D, Brown PO, Weiss A
• The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling.
  The Journal of cell biology 2003 Lin J, Weiss A
• Linker for activation of T cells, zeta-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization.
  Journal of immunology (Baltimore, Md. : 1950) 2003 Kuhné MR, Lin J, Yablonski D, Mollenauer MN, Ehrlich LI, Huppa J, Davis MM, Weiss A
• The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3.
  Immunological reviews 2003 Kane LP, Weiss A
• Synergistic assembly of linker for activation of T cells signaling protein complexes in T cell plasma membrane domains.
  The Journal of biological chemistry 2003 Hartgroves LC, Lin J, Langen H, Zech T, Weiss A, Harder T
• Chapter 114 CD45.
  Handbook of Cell Signaling 2003 Zheng Xu, Michelle L. Hermiston, Arthur Weiss
• Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation.
  Immunity 2002 Ehrlich LI, Ebert PJ, Krummel MF, Weiss A, Davis MM
• Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription.
  Molecular and cellular biology 2002 Kane LP, Mollenauer MN, Xu Z, Turck CW, Weiss A
• It's all Rel-ative: NF-kappaB and CD28 costimulation of T-cell activation.
  Trends in immunology 2002 Kane LP, Lin J, Weiss A
• Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms.
  Nature immunology 2002 Xu Z, Weiss A
• The inducible expression of the tumor suppressor gene PTEN promotes apoptosis and decreases cell size by inhibiting the PI3K/Akt pathway in Jurkat T cells.
  Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2002 Xu Z, Stokoe D, Kane LP, Weiss A
• Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases.
  The Journal of clinical investigation 2002 Hermiston ML, Xu Z, Majeti R, Weiss A
• PTPRC (CD45) is not associated with the development of multiple sclerosis in U.S. patients.
  Nature genetics 2001 Barcellos LF, Caillier S, Dragone L, Elder M, Vittinghoff E, Bucher P, Lincoln RR, Pericak-Vance M, Haines JL, Weiss A, Hauser SL, Oksenberg JR
• The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection.
  Immunity 2001 Sosinowski T, Killeen N, Weiss A
• Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes.
  The Journal of biological chemistry 2001 Sauer K, Liou J, Singh SB, Yablonski D, Weiss A, Perlmutter RM
• Regulatory mechanisms for receptor protein tyrosine phosphatases.
  Chemical reviews 2001 Majeti R, Weiss A
• Endogenous CD28 expressed on myeloma cells up-regulates interleukin-8 production: implications for multiple myeloma progression.
  Blood 2001 Shapiro VS, Mollenauer MN, Weiss A
• Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT.
  Molecular and cellular biology 2001 Yablonski D, Kadlecek T, Weiss A
• Identification of the minimal tyrosine residues required for linker for activation of T cell function.
  The Journal of biological chemistry 2001 Lin J, Weiss A
• A CD45 polymorphism associated with multiple sclerosis disrupts an exonic splicing silencer.
  The Journal of biological chemistry 2001 Lynch KW, Weiss A
• Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation.
  Molecular and cellular biology 2001 Baker JE, Majeti R, Tangye SG, Weiss A
• A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT.
  The EMBO journal 2001 Ku GM, Yablonski D, Manser E, Lim L, Weiss A
• Characterization of promoter region and genomic structure of the murine and human genes encoding Src like adapter protein.
  Gene 2001 Kratchmarova I, Sosinowski T, Weiss A, Witter K, Vincenz C, Pandey A
• Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines.
  Nature immunology 2001 Kane LP, Andres PG, Howland KC, Abbas AK, Weiss A
• Distinct T cell developmental consequences in humans and mice expressing identical mutations in the DLAARN motif of ZAP-70.
  Journal of immunology (Baltimore, Md. : 1950) 2001 Elder ME, Skoda-Smith S, Kadlecek TA, Wang F, Wu J, Weiss A
• Mechanisms of signaling by the hematopoietic-specific adaptor proteins, SLP-76 and LAT and their B cell counterpart, BLNK/SLP-65.
  Advances in immunology 2001 Yablonski D, Weiss A
• T cell receptor signalling.
  Journal of cell science 2001 Lin J, Weiss A
• An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity.
  Cell 2000 Majeti R, Xu Z, Parslow TG, Olson JL, Daikh DI, Killeen N, Weiss A
• Lymphocytes with a complex: adapter proteins in antigen receptor signaling.
  Immunology today 2000 Tomlinson MG, Lin J, Weiss A
• Signal transduction by the TCR for antigen.
  Current opinion in immunology 2000 Kane LP, Lin J, Weiss A
• HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1.
  Immunity 2000 Liou J, Kiefer F, Dang A, Hashimoto A, Cobb MH, Kurosaki T, Weiss A
• Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling.
  The Journal of experimental medicine 2000 Sosinowski T, Pandey A, Dixit VM, Weiss A
• A guanine nucleotide exchange factor-independent function of Vav1 in transcriptional activation.
  The Journal of biological chemistry 2000 Kuhne MR, Ku G, Weiss A
• Tetracycline-controllable selection of CD4(+) T cells: half-life and survival signals in the absence of major histocompatibility complex class II molecules.
  The Journal of experimental medicine 2000 Witherden D, van Oers N, Waltzinger C, Weiss A, Benoist C, Mathis D
• A model system for activation-induced alternative splicing of CD45 pre-mRNA in T cells implicates protein kinase C and Ras.
  Molecular and cellular biology 2000 Lynch KW, Weiss A
• Localization of LAT in glycolipid-enriched microdomains is required for T cell activation.
  The Journal of biological chemistry 1999 Lin J, Weiss A, Finco TS
• Pre-T cell receptor signals are responsible for the down-regulation of Syk protein tyrosine kinase expression.
  Journal of immunology (Baltimore, Md. : 1950) 1999 Chu DH, van Oers NS, Malissen M, Harris J, Elder M, Weiss A
• Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus.
  Proceedings of the National Academy of Sciences of the United States of America 1999 Lagunoff M, Majeti R, Weiss A, Ganem D
• Interdomain B in ZAP-70 regulates but is not required for ZAP-70 signaling function in lymphocytes.
  Molecular and cellular biology 1999 Zhao Q, Williams BL, Abraham RT, Weiss A
• The adapter proteins LAT and SLP-76 are required for T-cell activation.
  Cold Spring Harbor symposia on quantitative biology 1999 Finco TS, Yablonski D, Lin J, Weiss A
• Nuclear factor of activated T cells and AP-1 are insufficient for IL-2 promoter activation: requirement for CD28 up-regulation of RE/AP.
  Journal of immunology (Baltimore, Md. : 1950) 1998 Shapiro VS, Mollenauer MN, Weiss A
• Differential requirements for ZAP-70 in TCR signaling and T cell development.
  Journal of immunology (Baltimore, Md. : 1950) 1998 Kadlecek TA, van Oers NS, Lefrancois L, Olson S, Finlay D, Chu DH, Connolly K, Killeen N, Weiss A
• LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway.
  Immunity 1998 Finco TS, Kadlecek T, Zhang W, Samelson LE, Weiss A
• A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK.
  The EMBO journal 1998 Yablonski D, Kane LP, Qian D, Weiss A
• Switching signals on or off by receptor dimerization.
  Cell 1998 Weiss A, Schlessinger J
• Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell.
  Science (New York, N.Y.) 1998 Yablonski D, Kuhne MR, Kadlecek T, Weiss A
• Lymphocyte activation and effector functions Turning lymphocytes on and off.
  Current Opinion in Immunology 1998 AnthonyL DeFranco, Arthur Weiss
• Anti-peptide antibodies detect conformational changes of the inter-SH2 domain of ZAP-70 due to binding to the zeta chain and to intramolecular interactions.
  The Journal of biological chemistry 1998 Grazioli L, Germain V, Weiss A, Acuto O
• Regulation of TCR signal transduction in murine thymocytes by multiple TCR zeta-chain signaling motifs.
  Journal of immunology (Baltimore, Md. : 1950) 1998 van Oers NS, Love PE, Shores EW, Weiss A
• Itk and Fyn make independent contributions to T cell activation.
  The Journal of experimental medicine 1997 Liao XC, Littman DR, Weiss A
• Itk negatively regulates induction of T cell proliferation by CD28 costimulation.
  The Journal of experimental medicine 1997 Liao XC, Fournier S, Killeen N, Weiss A, Allison JP, Littman DR
• CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites.
  Molecular and cellular biology 1997 Shapiro VS, Truitt KE, Imboden JB, Weiss A
• ZAP-70 protein tyrosine kinase is constitutively targeted to the T cell cortex independently of its SH2 domains.
  The Journal of cell biology 1997 Huby RD, Iwashima M, Weiss A, Ley SC
• The Vav binding site (Y315) in ZAP-70 is critical for antigen receptor-mediated signal transduction.
  The Journal of experimental medicine 1997 Wu J, Zhao Q, Kurosaki T, Weiss A
• Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling.
  The Journal of experimental medicine 1997 Qian D, Lev S, van Oers NS, Dikic I, Schlessinger J, Weiss A
• T cell antigen receptor signal transduction.
  Current opinion in cell biology 1997 Qian D, Weiss A
• The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling.
  The EMBO journal 1996 Chu DH, Spits H, Peyron JF, Rowley RB, Bolen JB, Weiss A
• Reconstitution of T cell receptor signaling in ZAP-70-deficient cells by retroviral transduction of the ZAP-70 gene.
  The Journal of experimental medicine 1996 Taylor N, Bacon KB, Smith S, Jahn T, Kadlecek TA, Uribe L, Kohn DB, Gelfand EW, Weiss A, Weinberg K
• alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases.
  Immunity 1996 van Oers NS, Lowin-Kropf B, Finlay D, Connolly K, Weiss A
• c-rel regulation of IL-2 gene expression may be mediated through activation of AP-1.
  The Journal of experimental medicine 1996 Shapiro VS, Mollenauer MN, Greene WC, Weiss A
• Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C.
  The Journal of experimental medicine 1996 Fry AM, Lanier LL, Weiss A
• Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation.
  Immunity 1996 Wu J, Motto DG, Koretzky GA, Weiss A
• SH2 domain function is essential for the role of the Lck tyrosine kinase in T cell receptor signal transduction.
  The Journal of biological chemistry 1996 Straus DB, Chan AC, Patai B, Weiss A
• Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes.
  The Journal of experimental medicine 1996 van Oers NS, Killeen N, Weiss A
• Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling.
  The Journal of experimental medicine 1996 Qian D, Mollenauer MN, Weiss A
• CD28-mediated costimulation in the absence of phosphatidylinositol 3-kinase association and activation.
  Molecular and cellular biology 1995 Crooks ME, Littman DR, Carter RH, Fearon DT, Weiss A, Stein PH
• Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes.
  The Journal of experimental medicine 1995 Gelfand EW, Weinberg K, Mazer BD, Kadlecek TA, Weiss A
• Molecular and genetic insights into T-cell antigen receptor signaling.
  Annals of the New York Academy of Sciences 1995 Weiss A, Kadlecek T, Iwashima M, Chan A, Van Oers N
• Molecular and genetic insights into the role of protein tyrosine kinases in T cell receptor signaling.
  Clinical immunology and immunopathology 1995 Weiss A
• A functional T-cell receptor signaling pathway is required for p95vav activity.
  Molecular and cellular biology 1995 Wu J, Katzav S, Weiss A
• Multiple kinases mediate T-cell-receptor signaling.
  Trends in biochemical sciences 1995 Howe LR, Weiss A
• The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav.
  The Journal of biological chemistry 1994 Katzav S, Sutherland M, Packham G, Yi T, Weiss A
• ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR zeta in murine thymocytes and lymph node T cells.
  Immunity 1994 van Oers NS, Killeen N, Weiss A
• The role of protein kinase C in the regulation of extracellular signal-regulated kinase by the T cell antigen receptor.
  European journal of immunology 1994 Izquierdo M, Leevers SJ, Williams DH, Marshall CJ, Weiss A, Cantrell D
• The catalytic activity of the CD45 membrane-proximal phosphatase domain is required for TCR signaling and regulation.
  The EMBO journal 1994 Desai DM, Sap J, Silvennoinen O, Schlessinger J, Weiss A
• GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation.
  Molecular and Cellular Biology 1994 M Sieh, A Batzer, J Schlessinger, A Weiss
• GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation.
  Molecular and cellular biology 1994 Sieh M, Batzer A, Schlessinger J, Weiss A
• Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase.
  Science (New York, N.Y.) 1994 Elder ME, Lin D, Clever J, Chan AC, Hope TJ, Weiss A, Parslow TG
• ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency.
  Science (New York, N.Y.) 1994 Chan AC, Kadlecek TA, Elder ME, Filipovich AH, Kuo WL, Iwashima M, Parslow TG, Weiss A
• Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling.
  Journal of immunology (Baltimore, Md. : 1950) 1994 Chan AC, van Oers NS, Tran A, Turka L, Law CL, Ryan JC, Clark EA, Weiss A
• The Cytoplasmic Domain of CD28 Is both Necessary and Sufficient for Costimulation of Interleukin-2 Secretion and Association with Phosphatidylinositol 3'-Kinase.
  Molecular and Cellular Biology 1994 Peter H. Stein, James D. Fraser, Arthur Weiss
• The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase.
  Molecular and Cellular Biology 1994 P H Stein, J D Fraser, A Weiss
• The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase.
  Molecular and cellular biology 1994 Stein PH, Fraser JD, Weiss A
• Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex.
  The Journal of biological chemistry 1994 Law CL, Sidorenko SP, Chandran KA, Draves KE, Chan AC, Weiss A, Edelhoff S, Disteche CM, Clark EA
• Production and characterization of monoclonal antibodies specific for the murine T cell receptor zeta chain.
  Journal of immunological methods 1994 van Oers NS, Teh SJ, Irving BA, Tiong J, Weiss A, Teh HS
• Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases.
  Science (New York, N.Y.) 1994 Iwashima M, Irving BA, van Oers NS, Chan AC, Weiss A
• Signal transduction by lymphocyte antigen receptors.
  Cell 1994 Weiss A, Littman DR
• Molecular and genetic insights into T cell antigen receptor signal transduction.
  Advances in experimental medicine and biology 1994 Weiss A, Iwashima M, Irving B, van Oers NS, Kadlecek TA, Straus D, Chan A
• The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction.
  Annual review of immunology 1994 Chan AC, Desai DM, Weiss A
• Signal transduction events leading to T-cell lymphokine gene expression.
  Immunology today 1993 Fraser JD, Straus D, Weiss A
• Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase.
  Cell 1993 Desai DM, Sap J, Schlessinger J, Weiss A
• T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases.
  Cell 1993 Weiss A
• Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain.
  The Journal of experimental medicine 1993 Irving BA, Chan AC, Weiss A
• CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck.
  The EMBO journal 1993 Sieh M, Bolen JB, Weiss A
• Molecular Dissection of T-Cell Antigen Receptor Signal Transduction.
  Progress in Immunology Vol. VIII 1993 M. Iwashima, A. C. Chan, B. Irving, D. Straus, A. Weiss
• ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain.
  Cell 1992 Chan AC, Iwashima M, Turck CW, Weiss A
• The protein tyrosine kinase inhibitor herbimycin A, but not genistein, specifically inhibits signal transduction by the T cell antigen receptor.
  International immunology 1992 Graber M, June CH, Samelson LE, Weiss A
• Regulation of T-cell lymphokine gene transcription by the accessory molecule CD28.
  Molecular and cellular biology 1992 Fraser JD, Weiss A
• Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor.
  Cell 1992 Straus DB, Weiss A
• Restoration of T cell receptor-mediated signal transduction by transfection of CD45 cDNA into a CD45-deficient variant of the Jurkat T cell line.
  Journal of immunology (Baltimore, Md. : 1950) 1992 Koretzky GA, Kohmetscher MA, Kadleck T, Weiss A
• New insights into T-cell antigen receptor structure and signal transduction.
  Current opinion in immunology 1992 Chan AC, Irving BA, Weiss A
• CD28 and T cell antigen receptor signal transduction coordinately regulate interleukin 2 gene expression in response to superantigen stimulation.
  The Journal of experimental medicine 1992 Fraser JD, Newton ME, Weiss A
• Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs.
  Nature 1992 Margolis B, Hu P, Katzav S, Li W, Oliver JM, Ullrich A, Weiss A, Schlessinger J
• Regulation of protein tyrosine kinase activation by the T-cell antigen receptor zeta chain.
  Cold Spring Harbor symposia on quantitative biology 1992 Weiss A, Chan AC, Iwashima M, Straus D, Irving BA
• The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein.
  Proceedings of the National Academy of Sciences of the United States of America 1991 Chan AC, Irving BA, Fraser JD, Weiss A
• Signal transduction by the T cell antigen receptor.
  Seminars in immunology 1991 Weiss A, Irving BA, Tan LK, Koretzky GA
• Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1.
  Proceedings of the National Academy of Sciences of the United States of America 1991 Weiss A, Koretzky G, Schatzman RC, Kadlecek T
• Regions of the T cell receptor alpha and beta chains that are responsible for interactions with CD3.
  The Journal of experimental medicine 1991 Tan L, Turner J, Weiss A
• Signaling via the inositol phospholipid pathway by T cell antigen receptor is limited by receptor number.
  Journal of immunology (Baltimore, Md. : 1950) 1991 Graber M, Bockenstedt LK, Weiss A
• Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production.
  Proceedings of the National Academy of Sciences of the United States of America 1991 Koretzky GA, Picus J, Schultz T, Weiss A
• The regulation of T-cell antigen receptor signal transduction function.
  Transplantation proceedings 1991 Weiss A, Desai D, Graber M, Picus J, Koretzky G
• Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28.
  Science (New York, N.Y.) 1991 Fraser JD, Irving BA, Crabtree GR, Weiss A
• Molecular and genetic insights into T cell antigen receptor structure and function.
  Annual review of genetics 1991 Weiss A
• Stimulation of the phosphatidylinositol pathway can induce T-cell activation.
  Nature 1990 Desai DM, Newton ME, Kadlecek T, Weiss A
• Structure and function of the T cell antigen receptor.
  The Journal of clinical investigation 1990 Weiss A
• Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway.
  Nature 1990 Koretzky GA, Picus J, Thomas ML, Weiss A
• T-lymphocyte-antigen interactions in transplant rejection.
  The New England journal of medicine 1990 Krensky AM, Weiss A, Crabtree G, Davis MM, Parham P
• A transfected human muscarinic receptor fails to substitute for the T cell antigen receptor complex in CD2-initiated signal transduction.
  International immunology 1990 Desai DM, Goldsmith MA, Weiss A
• Function of a heterologous muscarinic receptor in T cell antigen receptor signal transduction mutants.
  The Journal of biological chemistry 1989 Goldsmith MA, Desai DM, Schultz T, Weiss A
• Heterogeneity of protein kinase C isoenzyme gene expression in human T cell lines. Protein kinase C-beta is not required for several T cell functions.
  Journal of immunology (Baltimore, Md. : 1950) 1989 Koretzky GA, Wahi M, Newton ME, Weiss A
• Ligand-induced association between the T-cell antigen receptor and two glycoproteins.
  Proceedings of the National Academy of Sciences of the United States of America 1989 Fraser JD, Goldsmith MA, Weiss A
• Use of somatic cell mutants to study the signal transduction function of the T cell antigen receptor.
  Advances in experimental medicine and biology 1989 Goldsmith MA, Bockenstedt LK, Dazin P, Weiss A
• The lysine residue in the membrane-spanning domain of the beta chain is necessary for cell surface expression of the T cell antigen receptor.
  The Journal of experimental medicine 1988 Morley BJ, Chin KN, Newton ME, Weiss A
• At least two non-antigen-binding molecules are required for signal transduction by the T-cell antigen receptor.
  Proceedings of the National Academy of Sciences of the United States of America 1988 Goldsmith MA, Dazin PF, Weiss A
• The CD2 ligand LFA-3 activates T cells but depends on the expression and function of the antigen receptor.
  Journal of immunology (Baltimore, Md. : 1950) 1988 Bockenstedt LK, Goldsmith MA, Dustin M, Olive D, Springer TA, Weiss A
• New clues about T-cell antigen receptor complex function.
  Immunology today 1988 Goldsmith MA, Weiss A
• The Initiation of Human T Lymphocyte Activation (Part 1 of 2).
  1988 John B. Imboden, Arthur Weiss
• The Initiation of Human T Lymphocyte Activation (Part 2 of 2).
  1988 John B. Imboden, Arthur Weiss
• Early signal transduction by the antigen receptor without commitment to T cell activation.
  Science (New York, N.Y.) 1988 Goldsmith MA, Weiss A
• CHAPTER 4 REGULATION OF INTERLEUKIN 2 PRODUCTION BY THE T CELL ANTIGEN RECEPTOR.
  Interleukin 1988 John B. Imboden, Arthur Weiss
• Function of the antigen receptor in T cell activation.
  Advances in experimental medicine and biology 1988 Goldsmith MA, Weiss A
• Generation and analysis of a T-lymphocyte somatic mutant for studying molecular aspects of signal transduction by the antigen receptor.
  Annals of the New York Academy of Sciences 1988 Goldsmith MA, Weiss A
• Role of the T3/T-Cell Antigen Receptor Complex in T-Cell Activation.
  The T-Cell Receptors 1988 Bernard Manger, John Imboden, Arthur Weiss
• The initiation of human T lymphocyte activation.
  Progress in allergy 1988 Imboden JB, Weiss A
• Identification and sequence of a fourth human T cell antigen receptor chain.
  Nature 1987 Loh EY, Lanier LL, Turck CW, Littman DR, Davis MM, Chien YH, Weiss A
• The activation of T lymphocytes.
  Rheumatic diseases clinics of North America 1987 Bockenstedt LK, Goldsmith MA, Koretzky GA, Weiss A
• Functional competency of T cell antigen receptors in human thymus.
  Journal of immunology (Baltimore, Md. : 1950) 1987 Weiss A, Dazin PF, Shields R, Fu SM, Lanier LL
• Evidence that the T cell antigen receptor may not be involved in cytotoxicity mediated by gamma/delta and alpha/beta thymic cell lines.
  The Journal of experimental medicine 1987 Phillips JH, Weiss A, Gemlo BT, Rayner AA, Lanier LL
• The T-cell antigen receptor regulates sustained increases in cytoplasmic free Ca2+ through extracellular Ca2+ influx and ongoing intracellular Ca2+ mobilization.
  The Biochemical journal 1987 Imboden JB, Weiss A
• The gamma T-cell antigen receptor.
  Journal of clinical immunology 1987 Lanier LL, Serafini AT, Ruitenberg JJ, Cwirla S, Federspiel NA, Phillips JH, Allison JP, Weiss A
• The role of protein kinase C in transmembrane signaling by the T cell antigen receptor complex. Effects of stimulation with soluble or immobilized CD3 antibodies.
  Journal of immunology (Baltimore, Md. : 1950) 1987 Manger B, Weiss A, Imboden J, Laing T, Stobo JD
• Isolation and characterization of a T-lymphocyte somatic mutant with altered signal transduction by the antigen receptor.
  Proceedings of the National Academy of Sciences of the United States of America 1987 Goldsmith MA, Weiss A
• Molecular diversity of the human T-gamma constant region genes.
  Science (New York, N.Y.) 1987 Pelicci PG, Subar M, Weiss A, Dalla-Favera R, Littman DR
• Cell surface T3 expression requires the presence of both alpha- and beta-chains of the T cell receptor.
  Journal of immunology (Baltimore, Md. : 1950) 1987 Saito T, Weiss A, Gunter KC, Shevach EM, Germain RN
• Requirements for triggering of lysis by cytolytic T lymphocyte clones.
  Journal of immunology (Baltimore, Md. : 1950) 1987 Lancki DW, Weiss A, Fitch FW
• Ligand-receptor interactions required for commitment to the activation of the interleukin 2 gene.
  Journal of immunology (Baltimore, Md. : 1950) 1987 Weiss A, Shields R, Newton M, Manger B, Imboden J
• The T cell antigen receptor complex expressed on normal peripheral blood CD4-, CD8- T lymphocytes. A CD3-associated disulfide-linked gamma chain heterodimer.
  The Journal of experimental medicine 1987 Lanier LL, Federspiel NA, Ruitenberg JJ, Phillips JH, Allison JP, Littman D, Weiss A
• Thy-1-mediated T-cell activation requires co-expression of CD3/Ti complex.
  Nature 1987 Gunter KC, Germain RN, Kroczek RA, Saito T, Yokoyama WM, Chan C, Weiss A, Shevach EM
• Characterization of an expressed CD3-associated Ti gamma-chain reveals C gamma domain polymorphism.
  Nature 1987 Littman DR, Newton M, Crommie D, Ang SL, Seidman JG, Gettner SN, Weiss A
• A 275 basepair fragment at the 5' end of the interleukin 2 gene enhances expression from a heterologous promoter in response to signals from the T cell antigen receptor.
  The Journal of experimental medicine 1987 Durand DB, Bush MR, Morgan JG, Weiss A, Crabtree GR
• Cell surface molecules and early events involved in human T lymphocyte activation.
  Advances in immunology 1987 Weiss A, Imboden JB
• Specific antigen-Ia activation of transfected human T cells expressing murine Ti alpha beta-human T3 receptor complexes.
  Nature 1987 Saito T, Weiss A, Miller J, Norcross MA, Germain RN
• The role of the antigen receptor/T3 complex in T-cell activation.
  Advances in experimental medicine and biology 1987 Weiss A, Imboden J, Hardy K, Stobo J
• Presence of Ti (WT31) negative T lymphocytes in normal blood and thymus.
  Nature 1986 Lanier LL, Weiss A
• Distinct epitopes on the T cell antigen receptor of HPB-ALL tumor cells identified by monoclonal antibodies.
  Journal of immunology (Baltimore, Md. : 1950) 1986 Lanier LL, Ruitenberg JJ, Allison JP, Weiss A
• Synergy between the T3/antigen receptor complex and Tp44 in the activation of human T cells.
  Journal of immunology (Baltimore, Md. : 1950) 1986 Weiss A, Manger B, Imboden J
• Differential effect of cyclosporin A on activation signaling in human T cell lines.
  The Journal of clinical investigation 1986 Manger B, Hardy KJ, Weiss A, Stobo JD
• A transferrin receptor antibody represents one signal for the induction of IL 2 production by a human T cell line.
  Journal of immunology (Baltimore, Md. : 1950) 1986 Manger B, Weiss A, Hardy KJ, Stobo JD
• The role of the T3/antigen receptor complex in T-cell activation.
  Annual review of immunology 1986 Weiss A, Imboden J, Hardy K, Manger B, Terhorst C, Stobo J
• T cell activation: differences in the signals required for IL 2 production by nonactivated and activated T cells.
  Journal of immunology (Baltimore, Md. : 1950) 1985 Manger B, Weiss A, Weyand C, Goronzy J, Stobo JD
• Transmembrane signalling by the T3-antigen receptor complex.
  Immunology today 1985 Imboden JB, Weiss A, Stobo JD
• Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer.
  Nature 1985 Ohashi PS, Mak TW, Van den Elsen P, Yanagi Y, Yoshikai Y, Calman AF, Terhorst C, Stobo JD, Weiss A
• Activation of a human T cell line: a two-stimulus requirement in the pretranslational events involved in the coordinate expression of interleukin 2 and gamma-interferon genes.
  Journal of immunology (Baltimore, Md. : 1950) 1985 Wiskocil R, Weiss A, Imboden J, Kamin-Lewis R, Stobo J
• The antigen receptor on a human T cell line initiates activation by increasing cytoplasmic free calcium.
  Journal of immunology (Baltimore, Md. : 1950) 1985 Imboden JB, Weiss A, Stobo JD
• Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line.
  The Journal of experimental medicine 1984 Weiss A, Stobo JD
• Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium.
  Proceedings of the National Academy of Sciences of the United States of America 1984 Weiss A, Imboden J, Shoback D, Stobo J
• The role of T3 surface molecules in the activation of human T cells: a two-stimulus requirement for IL 2 production reflects events occurring at a pre-translational level.
  Journal of immunology (Baltimore, Md. : 1950) 1984 Weiss A, Wiskocil RL, Stobo JD
• The role of T3 in the activation of human T cells.
  Journal of clinical immunology 1984 Weiss A, Imboden J, Wiskocil R, Stobo J
• Inhibition of cytolytic T lymphocyte clones reactive with Moloney leukemia virus-associated antigens by monoclonal antibodies: a direct approach to the study of H-2 restriction.
  Journal of immunology (Baltimore, Md. : 1950) 1981 Weiss A, MacDonald HR, Cerottini JC, Brunner KT
• Antigenic specificity of the cytolytic T lymphocyte response to murine sarcoma virus-induced tumors. III. Characterization of cytolytic T lymphocyte clones specific for Moloney leukemia virus-associated cell surface antigens.
  The Journal of experimental medicine 1980 Weiss A, Brunner KT, MacDonald HR, Cerottini JC
• Suppression of rat renal allograft rejection by antigen and antibody.
  Immunological reviews 1980 Stuart FP, McKearn TJ, Weiss A, Fitch FW
• Selective suppression of humoral and cell-mediated immune responses to rat alloantigens by monoclonal antibodies produced by hybridoma cell lines.
  Transplantation proceedings 1979 McKearn TJ, Weiss A, Stuart FP, Fitch FW
• Immune reactivity of cells from long-term rat renal allograft survivors.
  Transplantation 1978 Weiss A, Stuart FP, Fitch FW
• Immunological memory is regulated in the enhanced rat renal allograft recipient.
  Nature 1978 Weiss A, Fitch FW, McKearn TJ, Stuart FP
• Graft enhancement and antiidiotypic antibody. Lymphocytes from long-term rat renal allograft recipients have normal responsiveness in vitro.
  Transplantation proceedings 1978 Fitch FW, Weiss A, McKearn TJ, Stuart FP
• Suppression of the plaque-forming cell response by macrophages present in the normal rat spleen.
  Journal of immunology (Baltimore, Md. : 1950) 1978 Weiss A, Fitch FW
• Absence of immunologic memory in recipients of enhanced renal allografts.
  Surgical forum 1978 Weiss A, Stuart FP, Fitch FW
• Selective suppression of reactivity to rat histocompatibility antigens by hybridoma antibodies.
  Current topics in microbiology and immunology 1978 McKearn TJ, Sarmiento M, Weiss A, Stuart FP, Fitch FW
• Macrophages suppress CTL generation in rat mixed leukocyte cultures.
  Journal of immunology (Baltimore, Md. : 1950) 1977 Weiss A, Fitch FW
• Suppression of adult rat lymphoid proliferative responses by homologous neonatal serum.
  Journal of immunology (Baltimore, Md. : 1950) 1977 Weiss A
• Antigen cap formation in cultured fibroblasts: a reflection of membrane fluidity and of cell motility.
  Proceedings of the National Academy of Sciences of the United States of America 1972 Edidin M, Weiss A