Arthur Wallace, MD, PhD
Professor Emeritus
Anesthesia
School of Medicine

in engineering and applied science with a specialty in electrical engineering at Yale. He then completed an M.D. and Ph.D. at Johns Hopkins Medical School with his Ph.D. in biomedical engineering with research in systems physiology and autonomic control of the vasculature. He then moved to the University of California, San Francisco where he completed an internship in internal medicine, a residency in anesthesiology, and a cardiac anesthesiology fellowship. His research at UCSF has included numerous projects in animals and patients including device development for monitoring, surgical therapy of heart failure, and the off pump CABG, as well as drug development and testing. He is best known for his work developing medications for the prevention of perioperative cardiac morbidity and mortality. He was one of the developers of perioperative beta blockade and has assisted more than 200 hospitals set up perioperative beta blocker programs. His present work includes development medications to reduce perioperative cardiac risk, development of the ECOM cardiac output monitor, developing a non-invasive respiratory monitor, a device to provide electronic sedation, testing and development of surgical therapies for heart failure, implementation of perioperative beta blockade, developing therapies to prevent perioperative and ICU related PTSD, and developing computer systems to improve systems based medicine. He lectures extensively on cardiac risk reduction and has produced an on-line course on cardiac risk reduction. intelligence.

• Sharing Lessons Learned to Prevent Adverse Events in Anesthesiology Nationwide.
  Journal of patient safety 2021 Soncrant C, Neily J, Sum-Ping SJT, Wallace AW, Mariano ER, Leissner KB, Mills PD, Mazzia L, Paull DE
• Finite-element based optimization of left ventricular passive stiffness in normal volunteers and patients after myocardial infarction: Utility of an inverse deformation gradient calculation of regional diastolic strain.
  Journal of the mechanical behavior of biomedical materials 2021 Zhang Y, Wang VY, Morgan AE, Kim J, Tafreshi R, Wallace AW, Guccione JM, Weinsaft JW, Ge L, Ratcliffe MB
• Combined Intravenous Sildenafil and L-Arginine Administration in a Porcine Animal Model: Hemodynamic Safety Profile and Effects on Coronary Blood Flow.
  Drugs in R&D 2020 Brzezinski M, Dincheva GR, Alloo K, Wong C, Feng CM, Tom WL, Salahieh A, Wallace AW
• Left ventricular geometry during unloading and the end-systolic pressure volume relationship: Measurement with a modified real-time MRI-based method in normal sheep.
  PloS one 2020 Giao DM, Wang Y, Rojas R, Takaba K, Badathala A, Spaulding KA, Soon G, Zhang Y, Wang VY, Haraldsson H, Liu J, Saloner D, Guccione JM, Ge L, Wallace AW, Ratcliffe MB
• Myocardial injection of a thermoresponsive hydrogel with reactive oxygen species scavenger properties improves border zone contractility.
  Journal of biomedical materials research. Part A 2020 Spaulding KA, Zhu Y, Takaba K, Ramasubramanian A, Badathala A, Haraldsson H, Collins A, Aguayo E, Shah C, Wallace AW, Ziats NP, Lovett DH, Baker AJ, Healy KE, Ratcliffe MB
• Freedom From Opioids After Total Knee Arthroplasty.
  The Journal of arthroplasty 2019 Kuo AC, Raghunathan K, Lartigue AM, Bryan WE, Pepin MJ, Takemoto S, Wallace AW
• Investigation of possible aqueous phase formation during vaporization of sevoflurane.
  Journal of anaesthesiology, clinical pharmacology 2019 Varughese S, Kalthod VG, Petzel JP, Bacher HP, Wallace AW
• E-cigarettes versus nicotine patches for perioperative smoking cessation: a pilot randomized trial.
  PeerJ 2018 Lee SM, Tenney R, Wallace AW, Arjomandi M
• Short term doxycycline treatment induces sustained improvement in myocardial infarction border zone contractility.
  PloS one 2018 Spaulding K, Takaba K, Collins A, Faraji F, Wang G, Aguayo E, Ge L, Saloner D, Wallace AW, Baker AJ, Lovett DH, Ratcliffe MB
• Sevoflurane Contamination: Water Accumulation in Sevoflurane Vaporizers Can Allow Bacterial Growth in the Vaporizer.
  A & A case reports 2016 Wallace AW
• Moderate Ischemic Mitral Regurgitation After Posterolateral Myocardial Infarction in Sheep Alters Left Ventricular Shear but Not Normal Strain in the Infarct and Infarct Borderzone.
  The Annals of thoracic surgery 2016 Ge L, Wu Y, Soleimani M, Khazalpour M, Takaba K, Tartibi M, Zhang Z, Acevedo-Bolton G, Saloner DA, Wallace AW, Mishra R, Grossi EA, Guccione JM, Ratcliffe MB
• In Reply.
  Anesthesiology 2016 Lee SM, Takemoto S, Wallace AW
• Association between Withholding Angiotensin Receptor Blockers in the Early Postoperative Period and 30-day Mortality: A Cohort Study of the Veterans Affairs Healthcare System.
  Anesthesiology 2015 Lee SM, Takemoto S, Wallace AW
• Effectiveness of preoperative beta-blockade on intra-operative heart rate in vascular surgery cases conducted under regional or local anesthesia.
  SpringerPlus 2014 Mudumbai SC, Wagner T, Mahajan S, King R, Heidenreich PA, Hlatky M, Wallace AW, Mariano ER
• Thirty-day mortality risk associated with the postoperative nonresumption of angiotensin-converting enzyme inhibitors: a retrospective study of the Veterans Affairs Healthcare System.
  Journal of hospital medicine 2014 Mudumbai SC, Takemoto S, Cason BA, Au S, Upadhyay A, Wallace AW
• Left ventricular myocardial contractility is depressed in the borderzone after posterolateral myocardial infarction.
  The Annals of thoracic surgery 2013 Shimkunas R, Zhang Z, Wenk JF, Soleimani M, Khazalpour M, Acevedo-Bolton G, Wang G, Saloner D, Mishra R, Wallace AW, Ge L, Baker AJ, Guccione JM, Ratcliffe MB
• Left ventricular pressure gating in ovine cardiac studies: a software-based method.
  Journal of biomechanical engineering 2013 Acevedo-Bolton G, Suzuki T, Malhotra D, Zhang Z, Wallace AW, Guccione JM, Saloner DA, Ratcliffe MB
• Risk of acute myocardial infarction in patients with total hip or knee replacement: comment on "Timing of acute myocardial infarction in patients undergoing total hip or knee replacement: a nationwide cohort study".
  Archives of internal medicine 2012 Wallace AW
• The benefit of enhanced contractility in the infarct borderzone: a virtual experiment.
  Frontiers in physiology 2012 Zhang Z, Sun K, Saloner DA, Wallace AW, Ge L, Baker AJ, Guccione JM, Ratcliffe MB
• A coupled biventricular finite element and lumped-parameter circulatory system model of heart failure.
  Computer methods in biomechanics and biomedical engineering 2012 Wenk JF, Ge L, Zhang Z, Soleimani M, Potter DD, Wallace AW, Tseng E, Ratcliffe MB, Guccione JM
• The effect of mitral annuloplasty shape in ischemic mitral regurgitation: a finite element simulation.
  The Annals of thoracic surgery 2012 Wong VM, Wenk JF, Zhang Z, Cheng G, Acevedo-Bolton G, Burger M, Saloner DA, Wallace AW, Guccione JM, Ratcliffe MB, Ge L
• Moderate mitral regurgitation accelerates left ventricular remodeling after posterolateral myocardial infarction.
  The Annals of thoracic surgery 2011 Soleimani M, Khazalpour M, Cheng G, Zhang Z, Acevedo-Bolton G, Saloner DA, Mishra R, Wallace AW, Guccione JM, Ge L, Ratcliffe MB
• A novel method for quantifying in-vivo regional left ventricular myocardial contractility in the border zone of a myocardial infarction.
  Journal of biomechanical engineering 2011 Lee LC, Wenk JF, Klepach D, Zhang Z, Saloner D, Wallace AW, Ge L, Ratcliffe MB, Guccione JM
• Perioperative β-blockade: atenolol is associated with reduced mortality when compared to metoprolol.
  Anesthesiology 2011 Wallace AW, Au S, Cason BA
• Regional left ventricular myocardial contractility and stress in a finite element model of posterobasal myocardial infarction.
  Journal of biomechanical engineering 2011 Wenk JF, Sun K, Zhang Z, Soleimani M, Ge L, Saloner D, Wallace AW, Ratcliffe MB, Guccione JM
• Comparison of the Young-Laplace law and finite element based calculation of ventricular wall stress: implications for postinfarct and surgical ventricular remodeling.
  The Annals of thoracic surgery 2011 Zhang Z, Tendulkar A, Sun K, Saloner DA, Wallace AW, Ge L, Guccione JM, Ratcliffe MB
• Association of the pattern of use of perioperative β-blockade and postoperative mortality.
  Anesthesiology 2010 Wallace AW, Au S, Cason BA
• First finite element model of the left ventricle with mitral valve: insights into ischemic mitral regurgitation.
  The Annals of thoracic surgery 2010 Wenk JF, Zhang Z, Cheng G, Malhotra D, Acevedo-Bolton G, Burger M, Suzuki T, Saloner DA, Wallace AW, Guccione JM, Ratcliffe MB
• Dor procedure for dyskinetic anteroapical myocardial infarction fails to improve contractility in the border zone.
  The Journal of thoracic and cardiovascular surgery 2010 Sun K, Zhang Z, Suzuki T, Wenk JF, Stander N, Einstein DR, Saloner DA, Wallace AW, Guccione JM, Ratcliffe MB
• A computationally efficient formal optimization of regional myocardial contractility in a sheep with left ventricular aneurysm.
  Journal of biomechanical engineering 2009 Sun K, Stander N, Jhun CS, Zhang Z, Suzuki T, Wang GY, Saeed M, Wallace AW, Tseng EE, Baker AJ, Saloner D, Einstein DR, Ratcliffe MB, Guccione JM
• Magnetic resonance imaging-based finite element stress analysis after linear repair of left ventricular aneurysm.
  The Journal of thoracic and cardiovascular surgery 2008 Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Hsu EW, Saloner DA, Guccione JM
• Endoventricular patch plasty for dyskinetic anteroapical left ventricular aneurysm increases systolic circumferential shortening in sheep.
  The Journal of thoracic and cardiovascular surgery 2007 Zhang P, Guccione JM, Nicholas SI, Walker JC, Crawford PC, Shamal A, Acevedo-Bolton G, Guttman MA, Ozturk C, McVeigh ER, Saloner DA, Wallace AW, Ratcliffe MB
• Clonidine and modification of perioperative outcome.
  Current opinion in anaesthesiology 2006 Wallace AW
• The effect of anteroapical aneurysm plication on end-systolic three-dimensional strain in the sheep: a magnetic resonance imaging tagging study.
  The Journal of thoracic and cardiovascular surgery 2006 Guccione JM, Walker JC, Beitler JR, Moonly SM, Zhang P, Guttman MA, Ozturk C, McVeigh ER, Wallace AW, Saloner DA, Ratcliffe MB
• Left ventricular volume and function after endoventricular patch plasty for dyskinetic anteroapical left ventricular aneurysm in sheep.
  The Journal of thoracic and cardiovascular surgery 2005 Zhang P, Guccione JM, Nicholas SI, Walker JC, Crawford PC, Shamal A, Saloner DA, Wallace AW, Ratcliffe MB
• MRI-based finite-element analysis of left ventricular aneurysm.
  American journal of physiology. Heart and circulatory physiology 2005 Walker JC, Ratcliffe MB, Zhang P, Wallace AW, Fata B, Hsu EW, Saloner D, Guccione JM
• Helical myofiber orientation after myocardial infarction and left ventricular surgical restoration in sheep.
  The Journal of thoracic and cardiovascular surgery 2005 Walker JC, Guccione JM, Jiang Y, Zhang P, Wallace AW, Hsu EW, Ratcliffe MB
• Effect of ventricular size and patch stiffness in surgical anterior ventricular restoration: a finite element model study.
  The Annals of thoracic surgery 2005 Dang AB, Guccione JM, Zhang P, Wallace AW, Gorman RC, Gorman JH, Ratcliffe MB
• Akinetic myocardial infarcts must contain contracting myocytes: finite-element model study.
  American journal of physiology. Heart and circulatory physiology 2004 Dang AB, Guccione JM, Mishell JM, Zhang P, Wallace AW, Gorman RC, Gorman JH, Ratcliffe MB
• Effect of clonidine on cardiovascular morbidity and mortality after noncardiac surgery.
  Anesthesiology 2004 Wallace AW, Galindez D, Salahieh A, Layug EL, Lazo EA, Haratonik KA, Boisvert DM, Kardatzke D
• Is it time to get on the fast track or stay on the slow track?
  Anesthesiology 2003 Wallace AW
• Myosplint decreases wall stress without depressing function in the failing heart: a finite element model study.
  The Annals of thoracic surgery 2003 Guccione JM, Salahieh A, Moonly SM, Kortsmit J, Wallace AW, Ratcliffe MB
• A finite element model of left ventricular cellular transplantation in dilated cardiomyopathy.
  ASAIO journal (American Society for Artificial Internal Organs : 1992) 2002 Quarterman RL, Moonly S, Wallace AW, Guccione J, Ratcliffe MB
• Left ventricular volume reduction by radiofrequency heating of chronic myocardial infarction in patients with congestive heart failure.
  Circulation 2002 Victal OA, Teerlink JR, Gaxiola E, Wallace AW, Najar S, Camacho DH, Gutierrez A, Herrera G, Zuniga G, Mercado-Rios F, Ratcliffe MB