Ari Molofsky, MD, PhD
Professor
Laboratory Medicine
School of Medicine
Awards
Show all (16) Hide
- Most Highly Cited Researchers over past decade, top 1%, Clarivate, 2022
- UCSF Medical School Foundations Curriculum Teaching Award, UCSF, 2021
- American Association of Immunology, Travel Award, AAI, 2019
- Nina Ireland Program for Lung Health Award, UCSF, 2019
- AAI Young Investigator Travel Award, UCSF, 2017
- ICIS Milstein Young Investigator Award, UCSF, 2017
- New Frontiers Research Awardee Program for Breakthrough Biomedical Research, UCSF, 2017
- Larry L. Hillblom Foundation Young Investigator Award, UCSF, 2016-2019
- Mentored Clinical Scientist Research Career Development Award (K08), UCSF, 2014
- Molecular Medicine Research Fellowship, UCSF, 2009-2012
- MD graduate with research distinction, U. of Michigan, 2007
- Alpha Omega Alpha Medical Honors Society, U of Michigan, 2006
- Ward J. MacNeal Distinguished Dissertation, U. of Michigan, 2006
- Frederick G. Novy Fellowship, U. of Michigan, 2004-2005
- Dean's Honored Graduate in Molecular Biology, U. of Texas, 1999
- National Merit Finalist Scholarship, U. of Texas, 1995-1999
Interests
Show all (20) Hide
- insulin resistance
- adipose tissue
- flow cytometry
- Interleukin-33
- inflammation
- immunology
- type 2 immunity
- Immune tissue niches
- eosinophils
- allergic immunity
- obesity
- hematopathology
- clinical immunology
- innate lymphoid cells
- regulatory T cells
- alternatively activated macrophages
- type 2 diabetes
- Fibroblasts
- Tissue resident lymphocytes
- Interleukin-5
Websites
Show all (2) Hide
- Posts on X Molofsky_lab (X.com)
- Ari Molofsky lab (arimolofskylab.org)
Grants and Projects
Show all (13) Hide
- Manipulation of macrophage polarization by a fungal meningitis pathogen, NIH, 2022-2027
- Meningeal type 2 immunity in cortical synapse remodeling during brain development and injury, NIH, 2022-2026
- Localization and function of tissue type 2 lymphocytes during mixed inflammation, NIH, 2022-2026
- Role of Myeloid And CD4+ T Immune Cells in Post-Traumatic Plasticity, NIH, 2021-2026
- The IL-33/ILC2 axis in parturition, NIH, 2020-2024
- Defining group 2 innate lymphoid cell lung niches, NIH, 2019-2023
- Activation, Phenotype and Function of CD4 T Cells in Schistosoma-Pulmonary Hypertension, NIH, 2016-2021
- Defining group 2 innate lymphoid cell lung niches, NIH, 2018-2019
- Adipose Tissue type 2 immunity in metabolic health and disease, Larry L. Hillblom Foundation Startup Grant, 2016-2019
- Regulation and function of allergic immune cells in visceral adipose tissue, NIH, 2014-2019
- Regulation of lung type 2 immunity in tobacco-related allergic asthma, California TRDRP, New Investigator Award, 2018
- Ghosts in the machine: Lymphocytes in the developing brain, UCSF Quantitative Biosciences Institute Bold and Basic Research Grant, 2017-2018
- Exploring innate lymphocytes at the brain-immune interface, Program for Breakthrough Biomedical Research: New Frontier Research, 2017-2018
Publications (64)
Top publication keywords:
InterleukinsNervous SystemHelminthiasisLymphocyte SubsetsHypersensitivityTh2 CellsLymphocytesInterferon-gammaAdventitiaMacrophagesLegionella pneumophilaImmunity, InnateInterleukin-33NeuroimmunomodulationStromal Cells
-
Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis.
bioRxiv : the preprint server for biology 2023 Sbierski-Kind J, Cautivo KM, Wagner JC, Dahlgren MW, Nilsson J, Krasilnikov M, Mroz NM, Lizama CO, Gan AL, Matatia PR, Taruselli MT, Chang AA, Caryotakis S, O'Leary CE, Kotas M, Mattis AN, Peng T, … -
The ins and outs of innate and adaptive type 2 immunity.
Immunity 2023 Molofsky AB, Locksley RM -
Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior.
bioRxiv : the preprint server for biology 2023 Barron JJ, Mroz NM, Taloma SE, Dahlgren MW, Ortiz-Carpena J, Dorman LC, Vainchtein ID, Escoubas CC, Molofsky AB, Molofsky AV -
Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir.
Immunity 2023 Wang C, Hyams B, Allen NC, Cautivo K, Monahan K, Zhou M, Dahlgren MW, Lizama CO, Matthay M, Wolters P, Molofsky AB, Peng T -
Interferon gamma constrains type 2 lymphocyte niche boundaries during mixed inflammation.
Immunity 2022 Cautivo KM, Matatia PR, Lizama CO, Mroz NM, Dahlgren MW, Yu X, Sbierski-Kind J, Taruselli MT, Brooks JF, Wade-Vallance A, Caryotakis SE, Chang AA, Liang HE, Zikherman J, Locksley RM, Molofsky AB -
Immune outposts in the adventitia: One foot in sea and one on shore.
Current opinion in immunology 2020 Cautivo KM, Steer CA, Molofsky AB -
Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches.
Immunity 2019 Dahlgren MW, Jones SW, Cautivo KM, Dubinin A, Ortiz-Carpena JF, Farhat S, Yu KS, Lee K, Wang C, Molofsky AV, Tward AD, Krummel MF, Peng T, Molofsky AB -
Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation.
Immunity 2015 Molofsky AB, Van Gool F, Liang HE, Van Dyken SJ, Nussbaum JC, Lee J, Bluestone JA, Locksley RM -
Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages.
The Journal of experimental medicine 2013 Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, Mohapatra A, Chawla A, Locksley RM -
Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection.
The Journal of experimental medicine 2006 Molofsky AB, Byrne BG, Whitfield NN, Madigan CA, Fuse ET, Tateda K, Swanson MS -
The functions of Klarsicht and nuclear lamin in developmentally regulated nuclear migrations of photoreceptor cells in the Drosophila eye.
Molecular biology of the cell 2003 Patterson K, Molofsky AB, Robinson C, Acosta S, Cater C, Fischer JA
Show all (53 more) Hide
-
Dynamic fibroblast-immune interactions shape recovery after brain injury.
Nature 2025 Ewing-Crystal NA, Mroz NM, Larpthaveesarp A, Lizama CO, Pennington R, Chiaranunt P, Dennis JI, Chang AA, Merrill ED, Caryotakis SE, Kirthivasan N, Teo L, Tsukui T, Katewa A, McKinsey GL, Nelson SCK, … -
Myeloid-mesenchymal crosstalk drives ARG1-dependent profibrotic metabolism via ornithine in lung fibrosis.
The Journal of clinical investigation 2025 Yadav P, Gómez Ortega J, Dabral P, Tamaki W, Chien C, Chang KC, Biswas N, Pan S, Nilsson J, Yin X, Bhattacharyya A, Boostanpour K, Jujaray T, Wang JT, Tsukui T, Molina CJ, Auyeung VC, Sheppard D, Li B… -
GM-CSF derived from alveolar type 2 cells promotes CD301b+ cDC2 generation and allergic airway inflammation.
Science immunology 2025 Gschwend J, Lechner A, Sidiropoulos ND, Maier P, Andersson T, Sturzenegger F, Corak B, Brander N, Bejarano DA, Wells E, Melo SP, Martins JRD, Nitschké M, Molofsky AB, Schlitzer A, Arnold IC, Mundt S, … -
0652 The emerging fungal pathogen Candida auris induces IFN? to colonize mammalian hair follicles.
Journal of Investigative Dermatology 2025 E.D. Merrill, V. Prudent, P. Moghadam, A. Rodriguez, C. Hurabielle, E. Wells, P. Basso, T. Scharschmidt, M. Rosenblum, S. Noble, A. Molofsky -
Myeloid-mesenchymal crosstalk drives Arg1-dependent profibrotic metabolism via ornithine in lung fibrosis.
bioRxiv : the preprint server for biology 2025 Yadav P, Gómez Ortega J, Dabral P, Tamaki W, Chien C, Chang KC, Biswas N, Pan S, Nilsson J, Yin X, Bhattacharyya A, Boostanpour K, Jujaray T, Wang J, Tsukui T, Molina C, Auyeung V, Sheppard D, Li B, … -
Cross-regulation between the nervous system and type 2 immunity.
Science immunology 2025 Mroz NM, Chiaranunt P, Molofsky AV, Molofsky AB -
In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313.
Immunity 2025 Nyberg WA, Wang CH, Ark J, Liu C, Clouden S, Qualls A, Caryotakis S, Wells E, Simon K, Garza C, Bernard PL, Lopez-Ichikawa M, Li Z, Seo J, Kimmerly GR, Muldoon JJ, Chen PA, Li M, Liang HE, Kersten K, … -
Monocytes and interstitial macrophages contribute to hypoxic pulmonary hypertension.
The Journal of clinical investigation 2025 Kumar R, Nolan K, Kassa B, Chanana N, Palmo T, Sharma K, Singh K, Mickael C, Fonseca Balladares D, Nilsson J, Prabhakar A, Mishra A, Lee MH, Sanders L, Kumar S, Molofsky AB, Stenmark KR, Sheppard D, … -
The emerging fungal pathogen Candida auris induces IFNγ to colonize mammalian hair follicles.
bioRxiv : the preprint server for biology 2025 Merrill ED, Prudent V, Moghadam P, Rodriguez A, Hurabielle C, Wells EKC, Basso P, Scharschmidt TC, Rosenblum MD, Molofsky AB, Noble SM -
Type 1 lymphocytes and interferon-γ accumulate in the thalamus and restrict seizure susceptibility after traumatic brain injury.
bioRxiv : the preprint server for biology 2024 Mroz NM, Ciesielska A, Ewing-Crystal NA, Dorman LC, Han RT, Barron JJ, Silva NJ, Molofsky AV, Molofsky AB, Paz JT -
Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior.
Science (New York, N.Y.) 2024 Barron JJ, Mroz NM, Taloma SE, Dahlgren MW, Ortiz-Carpena JF, Keefe MG, Escoubas CC, Dorman LC, Vainchtein ID, Chiaranunt P, Kotas ME, Nowakowski TJ, Bender KJ, Molofsky AB, Molofsky AV -
Classical dendritic cells contribute to hypoxia-induced pulmonary hypertension.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mickael C, Sanders LA, Lee MH, Kumar R, Fonseca-Balladares D, Gandjeva A, Cautivo-Reyes K, Kassa B, Kumar S, Irwin D, Swindle D, Phang T, Stearman RS, Molofsky AB, McKee AS, Stenmark KR, Graham BB, … -
Intrapulmonary T Cells Are Sufficient for Schistosoma-Induced Pulmonary Hypertension.
International journal of molecular sciences 2024 Fonseca Balladares DC, Kassa B, Mickael C, Kumar R, Nolan K, Menezes TCF, Lee MH, Lau-Xiao AM, Molofsky AB, Wells E, Graham BB -
Interstitial macrophage phenotypes in Schistosoma-induced pulmonary hypertension.
Frontiers in immunology 2024 Kumar R, Kumar S, Mickael C, Fonseca Balladares D, Nolan K, Lee MH, Sanders L, Nilsson J, Molofsky AB, Tuder RM, Stenmark KR, Graham BB -
Dynamic fibroblast-immune interactions shape wound healing after brain injury.
bioRxiv : the preprint server for biology 2024 Ewing-Crystal NA, Mroz NM, Chang AA, Merrill ED, Caryotakis SE, Teo L, Larpthaveesarp A, Tsukui T, Katewa A, Pennington R, McKinsey GL, Nelson S, Ciesielska A, Dahlgren MW, Paidassi H, Jain S, Aghi MK… -
Type-I-interferon-responsive microglia shape cortical development and behavior.
Cell 2024 Escoubas CC, Dorman LC, Nguyen PT, Lagares-Linares C, Nakajo H, Anderson SR, Barron JJ, Wade SD, Cuevas B, Vainchtein ID, Silva NJ, Guajardo R, Xiao Y, Lidsky PV, Wang EY, Rivera BM, Taloma SE, Kim DK… -
Circumvention of luteolysis reveals parturition pathways in mice dependent upon innate type 2 immunity.
Immunity 2023 Siewiera J, McIntyre TI, Cautivo KM, Mahiddine K, Rideaux D, Molofsky AB, Erlebacher A -
Microglial pattern recognition via IL-33 promotes synaptic refinement in developing corticothalamic circuits in mice.
The Journal of experimental medicine 2022 Han RT, Vainchtein ID, Schlachetzki JCM, Cho FS, Dorman LC, Ahn E, Kim DK, Barron JJ, Nakao-Inoue H, Molofsky AB, Glass CK, Paz JT, Molofsky AV -
Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung.
Science (New York, N.Y.) 2022 Reyes NS, Krasilnikov M, Allen NC, Lee JY, Hyams B, Zhou M, Ravishankar S, Cassandras M, Wang C, Khan I, Matatia P, Johmura Y, Molofsky A, Matthay M, Nakanishi M, Sheppard D, Campisi J, Peng T -
Advancing Lung Immunology Research: An Official American Thoracic Society Workshop Report.
American journal of respiratory cell and molecular biology 2022 Rahimi RA, Cho JL, Jakubzick CV, Khader SA, Lambrecht BN, Lloyd CM, Molofsky AB, Talbot S, Bonham CA, Drake WP, Sperling AI, Singer BD -
Bile acid-sensitive tuft cells regulate biliary neutrophil influx.
Science immunology 2022 O'Leary CE, Sbierski-Kind J, Kotas ME, Wagner JC, Liang HE, Schroeder AW, de Tenorio JC, von Moltke J, Ricardo-Gonzalez RR, Eckalbar WL, Molofsky AB, Schneider C, Locksley RM -
ILC2s - development, divergence, dispersal.
Current opinion in immunology 2022 Ricardo-Gonzalez RR, Molofsky AB, Locksley RM -
Early-life inflammation primes a T helper 2 cell-fibroblast niche in skin.
Nature 2021 Boothby IC, Kinet MJ, Boda DP, Kwan EY, Clancy S, Cohen JN, Habrylo I, Lowe MM, Pauli M, Yates AE, Chan JD, Harris HW, Neuhaus IM, McCalmont TH, Molofsky AB, Rosenblum MD -
Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice.
eLife 2021 Kuhn JA, Vainchtein ID, Braz J, Hamel K, Bernstein M, Craik V, Dahlgren MW, Ortiz-Carpena J, Molofsky AB, Molofsky AV, Basbaum AI -
Perivascular stromal cells: Directors of tissue immune niches.
Immunological reviews 2021 Sbierski-Kind J, Mroz N, Molofsky AB -
Early Life Imprinting of a Th2-Stromal Cell Niche in Skin.
The Journal of Immunology 2021 Ian C Boothby, Devi P Boda, Elaine Y Kwan, Jarish N Cohen, Ireneusz Habrylo, Ari B Molofsky, Michael D Rosenblum -
Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung.
Nature cell biology 2020 Cassandras M, Wang C, Kathiriya J, Tsukui T, Matatia P, Matthay M, Wolters P, Molofsky A, Sheppard D, Chapman H, Peng T -
Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity.
Cell 2020 Nguyen PT, Dorman LC, Pan S, Vainchtein ID, Han RT, Nakao-Inoue H, Taloma SE, Barron JJ, Molofsky AB, Kheirbek MA, Molofsky AV -
Tissue immunity broadcasts near and far.
Nature reviews. Immunology 2020 Molofsky AB, Locksley RM -
Adventitial Cuffs: Regional Hubs for Tissue Immunity.
Trends in immunology 2019 Dahlgren MW, Molofsky AB -
Group 2 Innate Lymphoid Cells Are Redundant in Experimental Renal Ischemia-Reperfusion Injury.
Frontiers in immunology 2019 Cameron GJM, Cautivo KM, Loering S, Jiang SH, Deshpande AV, Foster PS, McKenzie ANJ, Molofsky AB, Hansbro PM, Starkey MR -
Nur77 Links Chronic Antigen Stimulation to B Cell Tolerance by Restricting the Survival of Self-Reactive B Cells in the Periphery.
Journal of immunology (Baltimore, Md. : 1950) 2019 Tan C, Mueller JL, Noviski M, Huizar J, Lau D, Dubinin A, Molofsky A, Wilson PC, Zikherman J -
Tissue signals imprint ILC2 identity with anticipatory function.
Nature immunology 2018 Ricardo-Gonzalez RR, Van Dyken SJ, Schneider C, Lee J, Nussbaum JC, Liang HE, Vaka D, Eckalbar WL, Molofsky AB, Erle DJ, Locksley RM -
All along the watchtower: group 2 innate lymphoid cells in allergic responses.
Current opinion in immunology 2018 Dahlgren MW, Molofsky AB -
Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development.
Science (New York, N.Y.) 2018 Vainchtein ID, Chin G, Cho FS, Kelley KW, Miller JG, Chien EC, Liddelow SA, Nguyen PT, Nakao-Inoue H, Dorman LC, Akil O, Joshita S, Barres BA, Paz JT, Molofsky AB, Molofsky AV -
B Lymphoblastic Leukemia/Lymphoma With Burkitt-like Morphology and IGH/MYC Rearrangement: Report of 3 Cases in Adult Patients.
The American journal of surgical pathology 2018 Li Y, Gupta G, Molofsky A, Xie Y, Shihabi N, McCormick J, Jaffe ES -
The Skinny: Pancreatic ILC2s Promote Insulin Secretion.
Immunity 2017 Cautivo KM, Molofsky AB -
A tissue checkpoint regulates type 2 immunity.
Nature immunology 2016 Van Dyken SJ, Nussbaum JC, Lee J, Molofsky AB, Liang HE, Pollack JL, Gate RE, Haliburton GE, Ye CJ, Marson A, Erle DJ, Locksley RM -
Regulation of metabolic health and adipose tissue function by group 2 innate lymphoid cells.
European journal of immunology 2016 Cautivo KM, Molofsky AB -
Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation.
Immunity 2015 Molofsky AB, Savage AK, Locksley RM -
A worm of one's own: how helminths modulate host adipose tissue function and metabolism.
Trends in parasitology 2015 Guigas B, Molofsky AB -
Activated type 2 innate lymphoid cells regulate beige fat biogenesis.
Cell 2014 Lee MW, Odegaard JI, Mukundan L, Qiu Y, Molofsky AB, Nussbaum JC, Yun K, Locksley RM, Chawla A -
Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy.
Blood 2014 Van Gool F, Molofsky AB, Morar MM, Rosenzwajg M, Liang HE, Klatzmann D, Locksley RM, Bluestone JA -
Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells.
Immunity 2014 Van Dyken SJ, Mohapatra A, Nussbaum JC, Molofsky AB, Thornton EE, Ziegler SF, McKenzie AN, Krummel MF, Liang HE, Locksley RM -
Peripheral T-Cell Lymphoma, Not Otherwise Specified Presenting as Erythroderma
Pathology Case Reviews 2014 Dawson, A.L., LeBoit, P.E., Molofsky, A.B., Ai, W.Z., and Pincus, L.B -
Type 2 innate lymphoid cells control eosinophil homeostasis.
Nature 2013 Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM -
Two septic transfusion reactions presenting as transfusion-related acute lung injury from a split plateletpheresis unit.
Critical care medicine 2012 Rollins MD, Molofsky AB, Nambiar A, Pandey S, Weiskopf RB, Toy P -
Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis.
Science (New York, N.Y.) 2011 Wu D, Molofsky AB, Liang HE, Ricardo-Gonzalez RR, Jouihan HA, Bando JK, Chawla A, Locksley RM -
Inflammatory Immune Response to Cytosolic Flagellin Protects Mice from Legionella pneumophila Infection.
2006 Michele S. Swanson, Brenda G. Byrne, Natalie W. Whitfield, Etsu T. Fuse, Kazuhiro Tateda, Ari B. Molofsky -
Autophagy and inflammatory cell death, partners of innate immunity.
Autophagy 2005 Swanson MS, Molofsky AB -
Components of the Legionella pneumophila flagellar regulon contribute to multiple virulence traits, including lysosome avoidance and macrophage death.
Infection and immunity 2005 Molofsky AB, Shetron-Rama LM, Swanson MS -
Differentiate to thrive: lessons from the Legionella pneumophila life cycle.
Molecular microbiology 2004 Molofsky AB, Swanson MS -
Legionella pneumophila CsrA is a pivotal repressor of transmission traits and activator of replication.
Molecular microbiology 2003 Molofsky AB, Swanson MS