Argentina Lario Lago, PhD
Associate Researcher
Neurology
School of Medicine

To address this question, she used a multidisciplinary approach combining a plethora of techniques from biochemistry to imaging and electrophysiology, amongst others. During her postdoc, she continued working on the molecular mechanisms underlying synaptic plasticity using electrophysiology as her main tool in the laboratory of Dr. Roger Nicoll at UCSF. She then became the electrophysiologist of Dr. Lisa Gunaydin's laboratory, also at UCSF, where she contributed to a better understanding of the brain circuits underlying anxiety-related behaviors. Argentina joined the MAC in 2020 to put all those years of basic research to good use outside the bench, but not far from the science.

• Sex-specific effects of SNAP-25 genotype on verbal memory and Alzheimer's disease biomarkers in clinically normal older adults.
  Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 Saloner R, Paolillo EW, Wojta KJ, Fonseca C, Gontrum EQ, Lario-Lago A, Rabinovici GD, Yokoyama JS, Rexach JE, Kramer JH, Casaletto KB
• CSF tau microtubule-binding region identifies pathological changes in primary tauopathies.
  Nature medicine 2022 Horie K, Barthélemy NR, Spina S, VandeVrede L, He Y, Paterson RW, Wright BA, Day GS, Davis AA, Karch CM, Seeley WW, Perrin RJ, Koppisetti RK, Shaikh F, Lago AL, Heuer HW, Ghoshal N, Gabelle A, Miller …
• Temporal order of clinical and biomarker changes in familial frontotemporal dementia.
  Nature medicine 2022 Staffaroni AM, Quintana M, Wendelberger B, Heuer HW, Russell LL, Cobigo Y, Wolf A, Goh SM, Petrucelli L, Gendron TF, Heller C, Clark AL, Taylor JC, Wise A, Ong E, Forsberg L, Brushaber D, Rojas JC, …
• Hepatic and renal function impact concentrations of plasma biomarkers of neuropathology.
  Alzheimer's & dementia (Amsterdam, Netherlands) 2022 Berry K, Asken BM, Grab JD, Chan B, Lario Lago A, Wong R, Seetharaman S, LaHue SC, Possin KL, Rojas JC, Kramer JH, Boxer AL, Lai JC, VandeVrede L
• Plasma neurofilament light chain levels suggest neuroaxonal stability following therapeutic remyelination in people with multiple sclerosis.
  Journal of neurology, neurosurgery, and psychiatry 2022 Abdelhak A, Cordano C, Boscardin WJ, Caverzasi E, Kuhle J, Chan B, Gelfand JM, Yiu HH, Oertel FC, Beaudry-Richard A, Condor Montes S, Oksenberg JR, Lario Lago A, Boxer A, Rojas-Martinez JC, Elahi FM, …
• Ketamine increases activity of a fronto-striatal projection that regulates compulsive behavior in SAPAP3 knockout mice.
  Nature communications 2021 Davis GL, Minerva AR, Lario A, Simmler LD, Rodriguez CI, Gunaydin LA
• Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study.
  The Lancet. Neurology 2021 Thijssen EH, La Joie R, Strom A, Fonseca C, Iaccarino L, Wolf A, Spina S, Allen IE, Cobigo Y, Heuer H, VandeVrede L, Proctor NK, Lago AL, Baker S, Sivasankaran R, Kieloch A, Kinhikar A, Yu L, Valentin…
• A kinesin 1-protrudin complex mediates AMPA receptor synaptic removal during long-term depression.
  Cell reports 2021 Brachet A, Lario A, Fernández-Rodrigo A, Heisler FF, Gutiérrez Y, Lobo C, Kneussel M, Esteban JA
• KIF13A drives AMPA receptor synaptic delivery for long-term potentiation via endosomal remodeling.
  The Journal of cell biology 2021 Gutiérrez Y, López-García S, Lario A, Gutiérrez-Eisman S, Delevoye C, Esteban JA
• MAP1B Light Chain Modulates Synaptic Transmission via AMPA Receptor Intracellular Trapping.
  The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Palenzuela R, Gutiérrez Y, Draffin JE, Lario A, Benoist M, Esteban JA
• PTEN counteracts PIP3 upregulation in spines during NMDA-receptor-dependent long-term depression.
  Journal of cell science 2014 Arendt KL, Benoist M, Lario A, Draffin JE, Muñoz M, Esteban JA
• PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression.
  The EMBO journal 2010 Jurado S, Benoist M, Lario A, Knafo S, Petrok CN, Esteban JA