Aras Mattis, MD, PhD
Associate Professor
Pathology
School of Medicine

Education & Training

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• PhD Biochemistry University of Illinois Urbana-Champaign 2007
• MD Medicine University of Illinois Urbana-Champaign 2007
• BA Molecular and Cell Biology - Genetics University of California Berkeley 1998

Grants and Projects

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• Establishing patient-derived iPSCs as a platform for discovery research in NAFLD, NIDDK, 2023-2028
• Modeling and Characterization of NAFLD Phenotypes in a Severely Affected Family, NIH/NIDDK, 2024-2027
• Genetic Regulation of Nonalcoholic Fatty Liver Disease, NIH, 2021-2025
• Regulation of Lipid Metabolism by miR-29a within Hepatocytes, NIH, 2013-2019

Publications (50)

Top publication keywords:
Diet, High-FatAdenomatous Polyposis ColiAdenomaHepatocytesLipoprotein LipaseFactor VIIIBile Duct NeoplasmsEndodermFlow CytometryInduced Pluripotent Stem CellsProto-Oncogene Proteins c-aktAneuploidyLiverDoxycyclineDNA, Neoplasm

• AMPK stimulation inhibits YAP/TAZ signaling to ameliorate hepatic fibrosis.
  Scientific reports 2024 Shihan MH, Sharma S, Cable C, Prathigudupu V, Chen A, Mattis AN, Chen JY
• Fluoride-related changes in the fetal cord blood proteome; a pilot study.
  Research square 2024 Tuomivaara ST, Goin DE, Fisher SJ, Hall SC, Mattis AN, Den Besten PK
• MicroRNAs Associated with Metformin Treatment in the Diabetes Prevention Program.
  Research square 2024 Lewis KA, Stroebel B, Zhang L, Aouizerat B, Mattis A, Flowers E
• Hyperpolarized [1-13 C] pyruvate MRSI to detect metabolic changes in liver in a methionine and choline-deficient diet rat model of fatty liver disease.
  Magnetic resonance in medicine 2023 Piraquive Agudelo J, Kim Y, Agarwal S, Sriram R, Bok R, Kurhanewicz J, Mattis AN, Maher JJ, von Morze C, Ohliger MA
• Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis.
  bioRxiv : the preprint server for biology 2023 Sbierski-Kind J, Cautivo KM, Wagner JC, Dahlgren MW, Nilsson J, Krasilnikov M, Mroz NM, Lizama CO, Gan AL, Matatia PR, Taruselli MT, Chang AA, Caryotakis S, O'Leary CE, Kotas M, Mattis AN, Peng T, …

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• Metastatic colorectal adenocarcinoma tumor purity assessment from whole exome sequencing data.
  PloS one 2023 Tbeileh N, Timmerman L, Mattis AN, Toriguchi K, Kasai Y, Corvera C, Nakakura E, Hirose K, Donner DB, Warren RS, Karelehto E
• DNA content abnormality frequently develops in the right/proximal colon in patients with primary sclerosing cholangitis and inflammatory bowel disease and is highly predictive of subsequent detection of dysplasia.
  Histopathology 2023 Zhang R, Rabinovitch PS, Mattis AN, Lauwers GY, Choi WT
• Self-Assembled Matrigel-Free iPSC-Derived Liver Organoids Demonstrate Wide-Ranging Highly Differentiated Liver Functions.
  Stem cells (Dayton, Ohio) 2023 Weng Y, Han S, Sekyi MT, Su T, Mattis AN, Chang TT
• Fundic Gland Polyps Lack DNA Content Abnormality Characteristic of Other Adenomatous Precursor Lesions in the Gastrointestinal Tract.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2023 Akanuma N, Rabinovitch PS, Mattis AN, Lauwers GY, Choi WT
• Transient expression of factor VIII and a chronic high-fat diet induces ER stress and late hepatocyte oncogenesis.
  Molecular therapy : the journal of the American Society of Gene Therapy 2022 Pierce GF, Mattis AN
• Targeting acid ceramidase ameliorates fibrosis in mouse models of non-alcoholic steatohepatitis.
  Frontiers in medicine 2022 Yu A, Cable C, Sharma S, Shihan MH, Mattis AN, Mileva I, Hannun YA, Duwaerts CC, Chen JY
• Undifferentiated Induced Pluripotent Stem Cells as a Genetic Model for Nonalcoholic Fatty Liver Disease.
  Cellular and molecular gastroenterology and hepatology 2022 Muñoz A, Theusch E, Kuang YL, Nalula G, Peaslee C, Dorlhiac G, Landry MP, Streets A, Krauss RM, Iribarren C, Mattis AN, Medina MW
• Clinical Application of Induced Hepatocyte-like Cells Produced from Mesenchymal Stromal Cells: A Literature Review.
  Cells 2022 Bogliotti Y, Vander Roest M, Mattis AN, Gish RG, Peltz G, Anwyl R, Kivlighn S, Schuur ER
• Interindividual variability in transgene mRNA and protein production following adeno-associated virus gene therapy for hemophilia A.
  Nature medicine 2022 Fong S, Yates B, Sihn CR, Mattis AN, Mitchell N, Liu S, Russell CB, Kim B, Lawal A, Rangarajan S, Lester W, Bunting S, Pierce GF, Pasi KJ, Wong WY
• Nonampullary Duodenal Adenomas in Familial Adenomatous Polyposis and Sporadic Patients Lack the DNA Content Abnormality That Is Characteristic of the Adenoma-Carcinoma Sequence Involved in the Development of Other Gastrointestinal Malignancies.
  The American journal of surgical pathology 2021 Mohammed N, Rabinovitch PS, Wang D, Kovári BP, Mattis AN, Lauwers GY, Choi WT
• Doxycycline Significantly Enhances Induction of Induced Pluripotent Stem Cells to Endoderm by Enhancing Survival Through Protein Kinase B Phosphorylation.
  Hepatology (Baltimore, Md.) 2021 Peaslee C, Esteva-Font C, Su T, Munoz-Howell A, Duwaerts CC, Liu Z, Rao S, Liu K, Medina M, Sneddon JB, Maher JJ, Mattis AN
• Gastric Intestinal Metaplasia in Mucosa Adjacent to Gastric Cancers Is Rarely Associated With the Aneuploidy That Is Characteristic of Gastric Dysplasia or Cancer.
  The American journal of surgical pathology 2021 Zhang R, Rabinovitch PS, Mattis AN, Lauwers GY, Choi WT
• Persistent or recurrent Barrett's neoplasia after an endoscopic therapy session is associated with DNA content abnormality and can be detected by DNA flow cytometric analysis of paraffin-embedded tissue.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2021 Bowman CJ, Zhang R, Balitzer D, Wang D, Rabinovitch PS, Kovári BP, Mattis AN, Kakar S, Lauwers GY, Choi WT
• Induced Pluripotent Stem Cell-derived Hepatocytes From Patients With Nonalcoholic Fatty Liver Disease Display a Disease-specific Gene Expression Profile.
  Gastroenterology 2021 Duwaerts CC, Le Guillou D, Her CL, Phillips NJ, Willenbring H, Mattis AN, Maher JJ
• Non-conventional dysplasia in inflammatory bowel disease is more frequently associated with advanced neoplasia and aneuploidy than conventional dysplasia.
  Histopathology 2020 Lee H, Rabinovitch PS, Mattis AN, Lauwers GY, Choi WT
• Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α.
  Cell death and differentiation 2020 Duwaerts CC, Siao K, Soon RK, Her C, Iwawaki T, Kohno K, Mattis AN, Maher JJ
• Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice.
  Science translational medicine 2020 Alsamman S, Christenson SA, Yu A, Ayad NME, Mooring MS, Segal JM, Hu JK, Schaub JR, Ho SS, Rao V, Marlow MM, Turner SM, Sedki M, Pantano L, Ghoshal S, Ferreira DDS, Ma HY, Duwaerts CC, Espanol-Suner R…
• Ly6cLo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation.
  Scientific reports 2020 Alkhani A, Levy CS, Tsui M, Rosenberg KA, Polovina K, Mattis AN, Mack M, Van Dyken S, Wang BM, Maher JJ, Nijagal A
• Utility of DNA flow cytometry in distinguishing between malignant and benign intrahepatic biliary lesions.
  Virchows Archiv : an international journal of pathology 2020 Wen KW, Rabinovitch PS, Wang D, Mattis AN, Ferrell LD, Choi WT
• DNA flow cytometric analysis of paraffin-embedded tissue for the diagnosis of malignancy in bile duct biopsies.
  Human pathology 2020 Lee H, Rabinovitch PS, Mattis AN, Kakar S, Choi WT
• De novo somatic mutations and KRAS amplification are associated with cholangiocarcinoma in a patient with a history of choledochal cyst.
  Journal of pediatric surgery 2020 Schwab ME, Song H, Mattis A, Phelps A, Vu LT, Huang FW, Nijagal A
• Adipocyte JAK2 mediates spontaneous metabolic liver disease and hepatocellular carcinoma.
  JCI insight 2019 Corbit KC, Wilson CG, Lowe D, Tran JL, Vera NB, Clasquin M, Mattis AN, Weiss EJ
• Diagnosis, risk stratification, and management of ampullary dysplasia by DNA flow cytometric analysis of paraffin-embedded tissue.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2019 Wen KW, Kim GE, Rabinovitch PS, Wang D, Mattis AN, Choi WT
• Evaluation of commonly used ectoderm markers in iPSC trilineage differentiation.
  Stem cell research 2019 Kuang YL, Munoz A, Nalula G, Santostefano KE, Sanghez V, Sanchez G, Terada N, Mattis AN, Iacovino M, Iribarren C, Krauss RM, Medina MW
• Utility of DNA Flow Cytometric Analysis of Paraffin-embedded Tissue in the Risk Stratification and Management of 'Indefinite for dysplasia' in Patients With Inflammatory Bowel Disease.
  Journal of Crohn's & colitis 2019 Wen KW, Rabinovitch PS, Wang D, Huang D, Mattis AN, Choi WT
• Depletion of murine fetal hematopoietic stem cells with c-Kit receptor and CD47 blockade improves neonatal engraftment.
  Blood advances 2018 Witt RG, Wang B, Nguyen QH, Eikani C, Mattis AN, MacKenzie TC
• DNA content analysis of colorectal serrated lesions detects an aneuploid subset of inflammatory bowel disease-associated serrated epithelial change and traditional serrated adenomas.
  Histopathology 2018 Choi WT, Wen KW, Rabinovitch PS, Huang D, Mattis AN, Gill RM
• Use of DNA flow cytometry in the diagnosis, risk stratification, and management of gastric epithelial dysplasia.
  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2018 Wen KW, Rabinovitch PS, Huang D, Mattis AN, Lauwers GY, Choi WT
• De novo formation of the biliary system by TGFβ-mediated hepatocyte transdifferentiation.
  Nature 2018 Schaub JR, Huppert KA, Kurial SNT, Hsu BY, Cast AE, Donnelly B, Karns RA, Chen F, Rezvani M, Luu HY, Mattis AN, Rougemont AL, Rosenthal P, Huppert SS, Willenbring H
• CD18 deficiency improves liver injury in the MCD model of steatohepatitis.
  PloS one 2017 Pierce AA, Duwaerts CC, Siao K, Mattis AN, Goodsell A, Baron JL, Maher JJ
• Association of Aneuploidy and Flat Dysplasia With Development of High-Grade Dysplasia or Colorectal Cancer in Patients With Inflammatory Bowel Disease.
  Gastroenterology 2017 Tsai JH, Rabinovitch PS, Huang D, Small T, Mattis AN, Kakar S, Choi WT
• Diagnosis and risk stratification of Barrett's dysplasia by flow cytometric DNA analysis of paraffin-embedded tissue.
  Gut 2017 Choi WT, Tsai JH, Rabinovitch PS, Small T, Huang D, Mattis AN, Kakar S
• Diffusion-weighted imaging of hyperpolarized [13 C]urea in mouse liver.
  Journal of magnetic resonance imaging : JMRI 2017 Marco-Rius I, Gordon JW, Mattis AN, Bok R, Delos Santos R, Sukumar S, Larson PEZ, Vigneron DB, Ohliger MA
• A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models.
  Journal of medicinal chemistry 2016 Spangler B, Fontaine SD, Shi Y, Sambucetti L, Mattis AN, Hann B, Wells JA, Renslo AR
• Heightened Immune Activation in Fetuses with Gastroschisis May Be Blocked by Targeting IL-5.
  Journal of immunology (Baltimore, Md. : 1950) 2016 Frascoli M, Jeanty C, Fleck S, Moradi PW, Keating S, Mattis AN, Tang Q, MacKenzie TC
• Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification.
  Development (Cambridge, England) 2015 Zdravkovic T, Nazor KL, Larocque N, Gormley M, Donne M, Hunkapillar N, Giritharan G, Bernstein HS, Wei G, Hebrok M, Zeng X, Genbacev O, Mattis A, McMaster MT, Krtolica A, Valbuena D, Simón C, Laurent …
• A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver.
  Hepatology (Baltimore, Md.) 2014 Mattis AN, Song G, Hitchner K, Kim RY, Lee AY, Sharma AD, Malato Y, McManus MT, Esau CC, Koller E, Koliwad S, Lim LP, Maher JJ, Raffai RL, Willenbring H
• Mouse liver repopulation with hepatocytes generated from human fibroblasts.
  Nature 2014 Zhu S, Rezvani M, Harbell J, Mattis AN, Wolfe AR, Benet LZ, Willenbring H, Ding S
• A ZFN/piggyBac step closer to autologous liver cell therapy.
  Hepatology (Baltimore, Md.) 2012 Mattis AN, Willenbring H
• Expression of glypican-3 in undifferentiated embryonal sarcoma and mesenchymal hamartoma of the liver.
  Human pathology 2011 Levy M, Trivedi A, Zhang J, Miles L, Mattis AN, Kim GE, Lassman C, Anders RA, Misdraji J, Yerian LM, Xu H, Dhall D, Wang HL
• Clinical diagnosis of segmental arterial mediolysis: differentiation from vasculitis and other mimics.
  Arthritis care & research 2010 Baker-LePain JC, Stone DH, Mattis AN, Nakamura MC, Fye KH
• Purification and characterization of bacteriophage P22 Xis protein.
  Journal of bacteriology 2008 Mattis AN, Gumport RI, Gardner JF
• IntDOT interactions with core- and arm-type sites of the conjugative transposon CTnDOT.
  Journal of bacteriology 2007 Dichiara JM, Mattis AN, Gardner JF
• Integration host factor: putting a twist on protein-DNA recognition.
  Journal of molecular biology 2003 Lynch TW, Read EK, Mattis AN, Gardner JF, Rice PA
• 20q13.2 amplification in intraductal hyperplasia adjacent to in situ and invasive ductal carcinoma of the breast.
  Virchows Archiv : an international journal of pathology 1999 Werner M, Mattis A, Aubele M, Cummings M, Zitzelsberger H, Hutzler P, Höfler H