Aparna Sundaram, MD
Associate Professor
Medicine
School of Medicine
Dr. Sundaram is a biomedical engineer, physician, and scientist with an interest in airway smooth muscle biology. Her laboratory focuses on tethering pathways used by muscle to transmit force.
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Through a more nuanced understanding of pathways that contribute to force transmission and the influence on pro-inflammatory cytokines on regulating these pathways, Dr. Sundaram hopes to identify novel drug targets to mitigate exaggerated airway narrowing in chronic airways diseases. Her work leverages ex vivo and in vivo disease models, transgenic mouse models, and advanced microscopy to map force transmission pathways on a cellular level.
Dr. Sundaram also attends in the Moffitt-Long Intensive Care Units. She serves as the Associate Director for the Molecular Medicine Residency Program. Her primary interests in physician-scientist training are related to longitudinal mentoring, work-life integration, and supporting women and minorities in science.
Education & Training
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- Diversity, Equity, and Inclusion Champion University of California, San Francisco 2019
- Fellowship Pulmonary and Critical Care University of California, San Francisco 2012
- Internship/Residency Internal Medicine Northwestern University 2009
- M.D. Medicine Northwestern University 2006
- B.S. Biomedical Engineering Northwestern University 2003
Websites
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- Sundaram Lab (sundaramlab.ucsf.edu)
Grants and Projects
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- Role of cadherin-11 in regulating force transmission in allergic asthma, American Lung Association, 2022-2024
- Mitigation of Exaggerated Smooth Muscle Force with Inhibitors of Integrin Alpha2Beta1, NIH, 2022-2024
- Inhibitors of Integrin Alpha5Beta1 to Mitigate Exaggerated Smooth Muscle Contraction in Asthma, UCSF, 2020-2022
- Role of Human Chymase in Smooth Muscle Contraction in Asthma, NIH, 2015-2021
- Regulation of Allergic Asthma by TGF-beta-induced Modulation of mMCP-1 and mMCP-4, NIH, 2012-2014
Publications (10)
Top publication keywords:
IsoproterenolMyocytes, Smooth MuscleIntegrinsReceptors, VitronectinCell AdhesionMarfan SyndromeCollagen Type IAdamantaneMuscle RelaxationFibrillin-1Integrin alpha2beta1TracheaIntegrin alpha5beta1Respiratory HypersensitivityAsthma
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Integrin α2β1 regulates collagen I tethering to modulate hyperresponsiveness in reactive airway disease models.
The Journal of clinical investigation 2021 Liu S, Ngo U, Tang XZ, Ren X, Qiu W, Huang X, DeGrado W, Allen CD, Jo H, Sheppard D, Sundaram AB -
Dual antagonists of α5β1/αvβ1 integrin for airway hyperresponsiveness.
Bioorganic & medicinal chemistry letters 2020 Sundaram A, Chen C, Isik Reed N, Liu S, Ki Yeon S, McIntosh J, Tang YZ, Yang H, Adler M, Beresis R, Seiple IB, Sheppard D, DeGrado WF, Jo H -
G protein-regulated endocytic trafficking of adenylyl cyclase type 9.
eLife 2020 Lazar AM, Irannejad R, Baldwin TA, Sundaram AB, Gutkind JS, Inoue A, Dessauer CW, Von Zastrow M -
A disease-associated mutation in fibrillin-1 differentially regulates integrin-mediated cell adhesion.
The Journal of biological chemistry 2019 Del Cid JS, Reed NI, Molnar K, Liu S, Dang B, Jensen SA, DeGrado W, Handford PA, Sheppard D, Sundaram AB -
IL-17A Recruits Rab35 to IL-17R to Mediate PKCα-Dependent Stress Fiber Formation and Airway Smooth Muscle Contractility.
Journal of immunology (Baltimore, Md. : 1950) 2019 Bulek K, Chen X, Parron V, Sundaram A, Herjan T, Ouyang S, Liu C, Majors A, Zepp J, Gao J, Dongre A, Bodaszewska-Lubas M, Echard A, Aronica M, Carman J, Garantziotis S, Sheppard D, Li X
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Targeting integrin α5β1 ameliorates severe airway hyperresponsiveness in experimental asthma.
The Journal of clinical investigation 2016 Sundaram A, Chen C, Khalifeh-Soltani A, Atakilit A, Ren X, Qiu W, Jo H, DeGrado W, Huang X, Sheppard D -
G Protein-Coupled Receptor Endocytosis Confers Uniformity in Responses to Chemically Distinct Ligands.
Molecular pharmacology 2016 Tsvetanova NG, Trester-Zedlitz M, Newton BW, Riordan DP, Sundaram AB, Johnson JR, Krogan NJ, von Zastrow M -
IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction.
The Journal of clinical investigation 2014 Bhattacharya M, Sundaram A, Kudo M, Farmer J, Ganesan P, Khalifeh-Soltani A, Arjomandi M, Atabai K, Huang X, Sheppard D -
The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases.
The Journal of clinical investigation 2013 Katsumoto TR, Kudo M, Chen C, Sundaram A, Callahan EC, Zhu JW, Lin J, Rosen CE, Manz BN, Lee JW, Matthay MA, Huang X, Sheppard D, Weiss A -
The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells.
The Journal of clinical investigation 2012 Sugimoto K, Kudo M, Sundaram A, Ren X, Huang K, Bernstein X, Wang Y, Raymond WW, Erle DJ, Abrink M, Caughey GH, Huang X, Sheppard D